Reference on EC 2.4.2.8 - hypoxanthine phosphoribosyltransferase and Organism(s) Plasmodium falciparum and UniProt Accession P20035
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Keough, D.T.; Ng, A.L.; Winzor, D.J.; Emmerson, B.T.; de Jersey, J.
Purification and characterization of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase and comparison with the human enzyme
Mol. Biochem. Parasitol.
98
29-41
1999
Homo sapiens, Plasmodium falciparum
Sujay Subbayya, I.N.; Sukumaran, S.; Shivashankar, K.; Balaram, H.
Unusual substrate specificity of a chimeric hypoxanthine-guanine phosphoribosyltransferase containing segments from the Plasmodium falciparum and human enzymes
Biochem. Biophys. Res. Commun.
272
596-602
2000
Homo sapiens, Plasmodium falciparum
Raman, J.; Sumathy, K.; Anand, R.P.; Balaram, H.
A non-active site mutation in human hypoxanthine guanine phosphoribosyltransferase expands substrate specificity
Arch. Biochem. Biophys.
427
116-122
2004
Plasmodium falciparum, Homo sapiens (P00492), Homo sapiens
Raman, J.; Ashok, C.S.; Subbayya, S.I.; Anand, R.P.; Selvi, S.T.; Balaram, H.
Plasmodium falciparum hypoxanthine guanine phosphoribosyltransferase. Stability studies on the product-activated enzyme
FEBS J.
272
1900-1911
2005
Plasmodium falciparum
Mbewe, B.; Chibale, K.; McIntosh, D.B.
Purification of human malaria parasite hypoxanthine guanine xanthine phosphoribosyltransferase (HGXPRT) using immobilized Reactive Red 120
Protein Expr. Purif.
52
153-158
2007
Plasmodium falciparum
Keough, D.T.; Hockova, D.; Holy, A.; Naesens, L.M.; Skinner-Adams, T.S.; Jersey, J.; Guddat, L.W.
Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics
J. Med. Chem.
52
4391-4399
2009
Plasmodium falciparum, Homo sapiens (P00492), Homo sapiens
Gayathri, P.; Sujay Subbayya, I.; Ashok, C.; Senthamizh Selvi, T.; Balaram, H.; Murthy, M.
Crystal structure of a chimera of human and Plasmodium falciparum hypoxanthine guanine phosphoribosyltransferases provides insights into oligomerization
Proteins
73
1010-1020
2008
Homo sapiens (P00492), Homo sapiens, Plasmodium falciparum (P20035), Plasmodium falciparum
Gogia, S.; Balaram, H.; Puranik, M.
Hypoxanthine guanine phosphoribosyltransferase distorts the purine ring of nucleotide substrates and perturbs the pKa of bound xanthosine monophosphate
Biochemistry
50
4184-4193
2011
Plasmodium falciparum, Homo sapiens (P00492), Homo sapiens
Hazleton, K.Z.; Ho, M.C.; Cassera, M.B.; Clinch, K.; Crump, D.R.; Rosario, I.; Merino, E.F.; Almo, S.C.; Tyler, P.C.; Schramm, V.L.
Acyclic immucillin phosphonates: second-generation inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase
Chem. Biol.
19
721-730
2012
Plasmodium falciparum
Clinch, K.; Crump, D.R.; Evans, G.B.; Hazleton, K.Z.; Mason, J.M.; Schramm, V.L.; Tyler, P.C.
Acyclic phosph(on)ate inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase
Bioorg. Med. Chem.
21
5629-5646
2013
Homo sapiens, Plasmodium falciparum (P20035)
Karnawat, V.; Gogia, S.; Balaram, H.; Puranik, M.
Differential distortion of purine substrates by human and Plasmodium falciparum hypoxanthine-guanine phosphoribosyltransferase to catalyse the formation of mononucleotides
ChemPhysChem
16
2172-2181
2015
Homo sapiens (P00492), Homo sapiens, Plasmodium falciparum (P20035), Plasmodium falciparum
Roy, S.; Nagappa, L.K.; Prahladarao, V.S.; Balaram, H.
Kinetic mechanism of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase
Mol. Biochem. Parasitol.
204
111-120
2015
Plasmodium falciparum (P20035), Plasmodium falciparum
Roy, S.; Karmakar, T.; Prahlada Rao, V.S.; Nagappa, L.K.; Balasubramanian, S.; Balaram, H.
Slow ligand-induced conformational switch increases the catalytic rate in Plasmodium falciparum hypoxanthine guanine xanthine phosphoribosyltransferase
Mol. Biosyst.
11
1410-1424
2015
Plasmodium falciparum (P20035), Plasmodium falciparum
Keough, D.T.; Rejman, D.; Pohl, R.; Zbornikova, E.; Hockova, D.; Croll, T.; Edstein, M.D.; Birrell, G.W.; Chavchich, M.; Naesens, L.M.J.; Pierens, G.K.; Brereton, I.M.; Guddat, L.W.
Design of Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase inhibitors as potential antimalarial therapeutics
ACS Chem. Biol.
13
82-90
2018
Plasmodium falciparum (A0A1G4HBT9), Plasmodium falciparum (Q8IJS1), Plasmodium falciparum, Homo sapiens (P00492)
Ducati, R.G.; Firestone, R.S.; Schramm, V.L.
Kinetic isotope effects and transition state structure for hypoxanthine-guanine-xanthine phosphoribosyltransferase from Plasmodium falciparum
Biochemistry
56
6368-6376
2017
Plasmodium falciparum (Q8IJS1)
Opoku, F.; Govender, P.P.; Pooe, O.J.; Simelane, M.B.C.
Evaluating iso-mukaadial acetate and ursolic acid acetate as Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase inhibitors
Biomolecules
9
861
2019
Plasmodium falciparum (Q8IJS1)
Spacek, P.; Keough, D.T.; Chavchich, M.; Dracinsky, M.; Janeba, Z.; Naesens, L.; Edstein, M.D.; Guddat, L.W.; Hockova, D.
Synthesis and evaluation of asymmetric acyclic nucleoside bisphosphonates as inhibitors of Plasmodium falciparum and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferase
J. Med. Chem.
60
7539-7554
2017
Homo sapiens (P00492), Homo sapiens, Plasmodium falciparum (Q8IJS1), Plasmodium falciparum
Roy, S.; Karmakar, T.; Nagappa, L.K.; Prahlada Rao, V.S.; Balasubramanian, S.; Balaram, H.
Role of W181 in modulating kinetic properties of Plasmodium falciparum hypoxanthine guanine xanthine phosphoribosyltransferase
Proteins
84
1658-1669
2016
Plasmodium falciparum (Q8IJS1), Plasmodium falciparum
