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Information on EC 2.4.2.12 - nicotinamide phosphoribosyltransferase and Organism(s) Mus musculus and UniProt Accession Q99KQ4

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EC Tree
     2 Transferases
         2.4 Glycosyltransferases
             2.4.2 Pentosyltransferases
                2.4.2.12 nicotinamide phosphoribosyltransferase
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This record set is specific for:
Mus musculus
UNIPROT: Q99KQ4 not found.
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The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Synonyms
visfatin, nampt, nicotinamide phosphoribosyltransferase, enampt, nicotinamide phosphoribosyl transferase, naprt, pre-b-cell colony-enhancing factor, inampt, nampt/visfatin, nampt/pbef/visfatin, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
extracellular nicotinamide phosphoribosyltrasferase
-
Nam phosphoribosyltransferase
-
nicotinamide phosphoribosyltransferase
-
pre-B-cell colony-enhancing factor
-
NAmPRTase
-
-
-
-
nicotinamide mononucleotide pyrophosphorylase
-
-
-
-
nicotinamide mononucleotide synthetase
-
-
-
-
nicotinamide phosphoribosyltransferase
-
-
NMN pyrophosphorylase
-
-
-
-
NMN synthetase
-
-
-
-
phosphoribosyltransferase, nicotinamide
-
-
-
-
pre-B-cell colony-enhancing factor
-
-
-
-
Visfatin
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pentosyl group transfer
-
pentosyl group transfer
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-
SYSTEMATIC NAME
IUBMB Comments
nicotinamide-D-ribonucleotide:diphosphate phospho-alpha-D-ribosyltransferase
-
CAS REGISTRY NUMBER
COMMENTARY hide
9030-27-7
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinamide D-ribonucleotide + diphosphate
show the reaction diagram
nicotinamide + alpha-D-5-phosphoribosyl 1-diphosphate
nicotinamide mononucleotide + diphosphate
show the reaction diagram
nicotinamide clearance
NMN synthesis is rate-limiting step for NAD+ synthesis
-
r
nicotinamide D-ribonucleotide + diphosphate
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
show the reaction diagram
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinamide D-ribonucleotide + diphosphate
show the reaction diagram
nicotinamide + 5-phosphoribosyl 1-diphosphate
nicotinamide mononucleotide + diphosphate
show the reaction diagram
-
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinamide D-ribonucleotide + diphosphate
show the reaction diagram
nicotinamide + alpha-D-5-phosphoribosyl 1-diphosphate
nicotinamide mononucleotide + diphosphate
show the reaction diagram
nicotinamide clearance
NMN synthesis is rate-limiting step for NAD+ synthesis
-
r
nicotinamide D-ribonucleotide + diphosphate
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
show the reaction diagram
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
nicotinamide D-ribonucleotide + diphosphate
show the reaction diagram
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
10 mM used in assay conditions
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2E)-3-(6-aminopyridin-3-yl)-N-((5-[4-(4,4-difluoropiperidine-1-carbonyl)phenyl]-7-(4-fluorophenyl)-1-benzofuran-2-yl)methyl)prop-2-enamide
KPT-9274
(2E)-N-[4-(1-benzoylpiperidin-4-yl)butyl]-3-(pyridin-3-yl)prop-2-enamide
FK866, potent inhibitor
1-([1,1'-biphenyl]-2-yl)-3-(7-(4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl)heptyl)urea
-
3-(1-(4-(2-([1,1'-biphenyl]-2-yloxy)ethyl)benzyl)-1H-1,2,3-triazol-4-yl)pyridine
-
3-(1-(6-([1,1'-biphenyl]-2-yloxy)hexyl)-1H-1,2,3-triazol-4-yl)-pyridine
-
3-(1-(7-(4-([1,1'-biphenyl]-2-yl)-1H-1,2,3-triazol-1-yl)-heptyl)-1H-1,2,3-triazol-4-yl)pyridine
-
3-(1-(7-([1,1'-biphenyl]-2-yloxy)heptyl)-1H-1,2,3-triazol-4-yl)pyridine
-
3-(1-(8-([1,1'-biphenyl]-2-yloxy)octyl)-1H-1,2,3-triazol-4-yl)-pyridine
-
APO866
FK866
N-(7-(4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl)heptyl)-[1,1'-biphenyl]-2-carboxamide
-
N-(8-(4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl)octyl)biphenyl-2-sulfonamide
-
N-([1,1'-biphenyl]-2-yl)-8-(2-(pyridin-3-yl)thiazol-5-yl)-octanamide
-
N-([1,1'-biphenyl]-2-yl)-8-(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-yl)octanamide
-
N-([1,1'-biphenyl]-2-yl)-8-(5-(pyridin-3-yl)-1H-pyrazol-3-yl)-octanamide
-
N-([1,1'-biphenyl]-2-yl)-8-(5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)octanamide
-
N-([1,1'-biphenyl]-2-yl)-8-(5-(pyridin-3-yl)isoxazol-3-yl)-octanamide
-
N-([1,1'-biphenyl]-2-yl)-8-[4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl]octanamide
GPP78
N-[6-(4-chlorophenoxy)hexyl]-N''-cyano-N'-phenylguanidine
CHS828, potent inhibitor
(4',5,7-trihydroxyflavone)-(3'->8)-(4',5,7-trihydroxyflavone)
-
-
(4',7-dimethoxy-5-hydroxyflavone)-(3'->8)-(4',7-dimethoxy-5-hydroxyflavone)
-
-
FK-866
-
i.e. (2E)-N-[4-(1-benzoylpiperidin-4-yl)butyl]-3-phenylprop-2-enamide
gallotanine
-
i.e. (2R,3S,5R,6S)-tetrahydro-2H-pyran-2,3,4,5,6-pentaylpentakis(oxycarbonyl-5,6-dihydroxybenzene-3,1-diyl) pentakis(3,4,5-trihydroxybenzoate)
GMX1777
-
i.e. 1-[2-(2-(2-(2-methoxyethoxy)-ethoxy)ethoxy)-ethoxy-carbonyloxymethyl]-4-[N'-cyano-N''-(6-(4-chlorophenyl)-hexyl)-N-guanidino]pyridinium chloride, prodrug of GMX1778. A dose of 75 mg/kg administered over a 24 h intravenous infusion produces GMX1778 steady-state plasma levels of about 1 microg/ml and causes nicotinamide dinucleotide levels to decrease significnantly in tumors. Nicotinic acid protects mice treated with a lethal dose of GMX1777
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.92
nicotinamide
pH 7.4, 37°C, recombinant enzyme
0.00124
nicotinamide
-
-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.02
nicotinamide
pH 7.4, 37°C, recombinant enzyme
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0000049
(2E)-N-[4-(1-benzoylpiperidin-4-yl)butyl]-3-(pyridin-3-yl)prop-2-enamide
Mus musculus
at pH 7.5 and 37°C
0.0000324
1-([1,1'-biphenyl]-2-yl)-3-(7-(4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl)heptyl)urea
Mus musculus
at pH 7.5 and 37°C
0.0000156
3-(1-(4-(2-([1,1'-biphenyl]-2-yloxy)ethyl)benzyl)-1H-1,2,3-triazol-4-yl)pyridine
Mus musculus
at pH 7.5 and 37°C
0.0000038
3-(1-(6-([1,1'-biphenyl]-2-yloxy)hexyl)-1H-1,2,3-triazol-4-yl)-pyridine
Mus musculus
at pH 7.5 and 37°C
0.0000081
3-(1-(7-(4-([1,1'-biphenyl]-2-yl)-1H-1,2,3-triazol-1-yl)-heptyl)-1H-1,2,3-triazol-4-yl)pyridine
Mus musculus
at pH 7.5 and 37°C
0.0000313
3-(1-(7-([1,1'-biphenyl]-2-yloxy)heptyl)-1H-1,2,3-triazol-4-yl)pyridine
Mus musculus
at pH 7.5 and 37°C
0.0000254
3-(1-(8-([1,1'-biphenyl]-2-yloxy)octyl)-1H-1,2,3-triazol-4-yl)-pyridine
Mus musculus
at pH 7.5 and 37°C
0.0000031
N-(7-(4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl)heptyl)-[1,1'-biphenyl]-2-carboxamide
Mus musculus
at pH 7.5 and 37°C
0.000047
N-(8-(4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl)octyl)biphenyl-2-sulfonamide
Mus musculus
at pH 7.5 and 37°C
0.000269
N-([1,1'-biphenyl]-2-yl)-8-(5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)octanamide
Mus musculus
at pH 7.5 and 37°C
0.0000499
N-([1,1'-biphenyl]-2-yl)-8-(5-(pyridin-3-yl)isoxazol-3-yl)-octanamide
Mus musculus
at pH 7.5 and 37°C
0.0000102
N-([1,1'-biphenyl]-2-yl)-8-[4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl]octanamide
Mus musculus
at pH 7.5 and 37°C
0.0066
(4',5,7-trihydroxyflavone)-(3'->8)-(4',5,7-trihydroxyflavone)
Mus musculus
-
pH 7.5, 37°C
0.0175
(4',7-dimethoxy-5-hydroxyflavone)-(3'->8)-(4',7-dimethoxy-5-hydroxyflavone)
Mus musculus
-
pH 7.5, 37°C
0.0000009
FK-866
Mus musculus
-
i.e. (2E)-N-[4-(1-benzoylpiperidin-4-yl)butyl]-3-phenylprop-2-enamide, pH 7.5, 37°C
0.0013
gallotanine
Mus musculus
-
i.e. (2R,3S,5R,6S)-tetrahydro-2H-pyran-2,3,4,5,6-pentaylpentakis(oxycarbonyl-5,6-dihydroxybenzene-3,1-diyl) pentakis(3,4,5-trihydroxybenzoate), pH 7.5, 37°C
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.4
assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37
assay at
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
positive staining in blood vessels from arthritic joints as revealed by immunohistochemistry using rat monoclonal anti-murine NAMPT antibody
Manually annotated by BRENDA team
some positive staining in cells of both normal and arthritic joints as revealed by immunohistochemistry using rat monoclonal anti-murine NAMPT antibody
Manually annotated by BRENDA team
enzyme and Sir2 expression levels
Manually annotated by BRENDA team
massive expression in synoviocytes of the synovial lining layer, sub-intimal synovium and pannus in joints from mice with type II collagen induced arthritis (CIA) compared to non-arthritic naive DBA/1 mice as revealed by immunohistochemistry using rat monoclonal anti-murine NAMPT antibody, some positive staining in chondrocytes from normal and arthritic joints and in blood vessels and inflammatory cells from arthritic joints
Manually annotated by BRENDA team
elevated levels in mice with type II collagen induced arthritis (CIA) compared to non-arthritic naive DBA/1 mice as revealed by ELISA using a mouse visfatin/PBEF ELISA kit
Manually annotated by BRENDA team
(PEC) isolated from naive C57BL/6 mice of from lipopolysaccharide-treated mice
Manually annotated by BRENDA team
elevated levels upon type II collagen induced arthritis (CIA) compared to non-arthritic naive DBA/1 mice as revealed by ELISA using a mouse visfatin/PBEF ELISA kit
Manually annotated by BRENDA team
additional information
-
ubiquitous in all tissues
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
the enzyme is localized in the nucleus in non-dividing adipocytes and is present in both the cytoplasm and the nucleus in dividing cells
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
physiological function
malfunction
-
enzyme inhibition induces NAD depletion in various mouse organs but selectively causes dramatic atrophy of the spleen red pulp
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
NAMPT_MOUSE
491
0
55447
Swiss-Prot
other Location (Reliability: 1)
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
crystal structures at up to 2.1 A resolution of NMPRTase, alone and in complex with the reaction product nicotinamide mononucleotide or the inhibitor FK866. Crystals of wild-type murine NMPRTase free enzyme are obtained by sitting drop vapor diffusion at 4°C
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D219A
inactive
D313A
inactive
R311A
inactive
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
Ni-NTA resin column chromatography
recombinant His-tagged enzyme from Escherichia coli strain BL21(DE3) by nickel affinity chromatography
immobilized metal ion affinity chromatography
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
DNA sequence determination and analysis, phylogenetic analysis, expression of His-tagged enzyme and of enzyme fused to Sir2 in Escherichia coli strain BL21(DE3)
expressed in Escherichia coli BL21(DE3) cells
expressed in Escherichia coli strain Shuffle with SUMO and hexa-His tags
expression in Escherichia coli
expressed in Escherichia coli BL21-CodonPlus(DE3)-RIL
-
pre-B-cell colony enhancing factor
-
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
high fat diet reduces enzyme expression in the atrial tissues
the enzyme is significantly upregulated in the ventral tegmental area of cocaine-conditioned mice
expression of Nampt in the heart is significantly decreased by ischemia, ischemia/reperfusion and pressure overload. Downregulation of Nampt increases caspase 3 cleavage, cytochrome c release, and TUNEL-positive cells, which are inhibited in the presence of Bcl-xL, but do not increase hairpin 2–positive cells, suggesting that endogenous Nampt negatively regulates apoptosis but not necrosis. Downregulation of Nampt also impairs autophagic flux
-
upon aging: enzyme level increases in serum but decreases in brain, decreases in cortex and hippocampus but remains unchanged in cerebellum and striatum in brain, and increases in microglia but likely decreases in neuron
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
specific inhibition of enzyme transport into the nucleus might be a potential avenue for managing cancer
medicine
-
a dose of 75 mg/kg GMX1777, i.e. 1-[2-(2-(2-(2-methoxyethoxy)-ethoxy)ethoxy)-ethoxy-carbonyloxymethyl]-4-[N'-cyano-N''-(6-(4-chlorophenyl)-hexyl)-N-guanidino]pyridinium chloride, prodrug of GMX1778, administered over a 24 h intravenous infusion produces GMX1778 steady-state plasma levels of about 1 microg/ml and causes nicotinamide dinucleotide levels to decrease significnantly in tumors. Nicotinic acid protects mice treated with a lethal dose of GMX1777
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Rongvaux, A.; Shea, R.J.; Mulks, M.H.; Gigot, D.; Urbain, J.; Leo, O.; Andris, F.
Pre-B-cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis
Eur. J. Immunol.
32
3225-3234
2002
Mus musculus
Manually annotated by BRENDA team
Revollo, J.R.; Grimm, A.A.; Imai, S.
The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells
J. Biol. Chem.
279
50754-50763
2004
Mus musculus (Q99KQ4), Mus musculus
Manually annotated by BRENDA team
Khan, J.A.; Tao, X.; Tong, L.
Molecular basis for the inhibition of human NMPRTase, a novel target for anticancer agents
Nat. Struct. Mol. Biol.
13
582-588
2006
Homo sapiens (P43490), Homo sapiens, Mus musculus (Q99KQ4), Mus musculus
Manually annotated by BRENDA team
Busso, N.; Karababa, M.; Nobile, M.; Rolaz, A.; Van Gool, F.; Galli, M.; Leo, O.; So, A.; De Smedt, T.
Pharmacological inhibition of nicotinamide phosphoribosyltransferase/visfatin enzymatic activity identifies a new inflammatory pathway linked to NAD
PLoS ONE
3
e2267
2008
Homo sapiens (P43490), Mus musculus (Q99KQ4)
Manually annotated by BRENDA team
Beauparlant, P.; Bedard, D.; Bernier, C.; Chan, H.; Gilbert, K.; Goulet, D.; Gratton, M.O.; Lavoie, M.; Roulston, A.; Turcotte, E.; Watson, M.
Preclinical development of the nicotinamide phosphoribosyl transferase inhibitor prodrug GMX1777
Anticancer Drugs
20
346-354
2009
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Hsu, C.P.; Oka, S.; Shao, D.; Hariharan, N.; Sadoshima, J.
Nicotinamide phosphoribosyltransferase regulates cell survival through NAD+ synthesis in cardiac myocytes
Circ. Res.
105
481-491
2009
Mus musculus
Manually annotated by BRENDA team
Zhang, R.Y.; Qin, Y.; Lv, X.Q.; Wang, P.; Xu, T.Y.; Zhang, L.; Miao, C.Y.
A fluorometric assay for high-throughput screening targeting nicotinamide phosphoribosyltransferase
Anal. Biochem.
412
18-25
2011
Mus musculus
Manually annotated by BRENDA team
Liu, L.; Wang, F.; Zhang, X.; Huang, P.; Lu, Y.; Wei, E.; Zhang, W.
Nicotinamide phosphoribosyltransferase may be involved in age-related brain diseases
PLoS ONE
7
e44933
2012
Mus musculus
Manually annotated by BRENDA team
Pittelli, M.; Cavone, L.; Lapucci, A.; Oteri, C.; Felici, R.; Niccolai, E.; Amedei, A.; Chiarugi, A.
Nicotinamide phosphoribosyltransferase (NAMPT) activity is essential for survival of resting lymphocytes
Immunol. Cell Biol.
92
191-199
2014
Mus musculus, Homo sapiens (P43490), Homo sapiens
Manually annotated by BRENDA team
Molugu, T.R.; Oita, R.C.; Chawla, U.; Camp, S.M.; Brown, M.F.; Garcia, J.G.N.
Nicotinamide phosphoribosyltransferase purification using SUMO expression system
Anal. Biochem.
598
113597
2020
Mus musculus (Q99KQ4)
Manually annotated by BRENDA team
Zhang, L.Q.; Van Haandel, L.; Xiong, M.; Huang, P.; Heruth, D.P.; Bi, C.; Gaedigk, R.; Jiang, X.; Li, D.Y.; Wyckoff, G.; Grigoryev, D.N.; Gao, L.; Li, L.; Wu, M.; Leeder, J.S.; Ye, S.Q.
Metabolic and molecular insights into an essential role of nicotinamide phosphoribosyltransferase
Cell Death Dis.
8
e2705
2017
Mus musculus (Q99KQ4), Mus musculus
Manually annotated by BRENDA team
Torretta, S.; Colombo, G.; Travelli, C.; Boumya, S.; Lim, D.; Genazzani, A.A.; Grolla, A.A.
The cytokine nicotinamide phosphoribosyltransferase (eNAMPT; PBEF; visfatin) acts as a natural antagonist of C-C chemokine receptor type 5 (CCR5)
Cells
9
496
2020
Homo sapiens (P43490), Mus musculus (Q99KQ4)
Manually annotated by BRENDA team
Kong, J.; Du, C.; Jiang, L.; Jiang, W.; Deng, P.; Shao, X.; Zhang, B.; Li, Y.; Zhu, R.; Zhao, Q.; Fu, D.; Gu, H.; Luo, L.; Long, H.; Zhao, Y.; Cen, X.
Nicotinamide phosphoribosyltransferase regulates cocaine reward through sirtuin 1
Exp. Neurol.
307
52-61
2018
Mus musculus (Q99KQ4)
Manually annotated by BRENDA team
Feng, D.; Xu, D.; Murakoshi, N.; Tajiri, K.; Qin, R.; Yonebayashi, S.; Okabe, Y.; Li, S.; Yuan, Z.; Aonuma, K.; Ieda, M.
Nicotinamide phosphoribosyltransferase (Nampt)/nicotinamide adenine dinucleotide (NAD) axis suppresses atrial fibrillation by modulating the calcium handling pathway
Int. J. Mol. Sci.
21
4655
2020
Mus musculus (Q99KQ4)
Manually annotated by BRENDA team
Svoboda, P.; Krizova, E.; Sestakova, S.; Vapenkova, K.; Knejzlik, Z.; Rimpelova, S.; Rayova, D.; Volfova, N.; Krizova, I.; Rumlova, M.; Sykora, D.; Kizek, R.; Haluzik, M.; Zidek, V.; Zidkova, J.; Skop, V.
Nuclear transport of nicotinamide phosphoribosyltransferase is cell cycle-dependent in mammalian cells, and its inhibition slows cell growth
J. Biol. Chem.
294
8676-8689
2019
Homo sapiens (P43490), Mus musculus (Q99KQ4)
Manually annotated by BRENDA team
Travelli, C.; Aprile, S.; Rahimian, R.; Grolla, A.A.; Rogati, F.; Bertolotti, M.; Malagnino, F.; di Paola, R.; Impellizzeri, D.; Fusco, R.; Mercalli, V.; Massarotti, A.; Stortini, G.; Terrazzino, S.; Del Grosso, E.; Fakhfouri, G.; Troiani, M.P.; Alisi, M.A.; Grosa, G.; Sorba, G.; Canonico, P.L.; Orsomando, G.
Identification of novel triazole-based nicotinamide phosphoribosyltransferase (NAMPT) inhibitors endowed with antiproliferative and antiinflammatory activity
J. Med. Chem.
60
1768-1792
2017
Mus musculus (Q99KQ4)
Manually annotated by BRENDA team
Hara, N.; Osago, H.; Hiyoshi, M.; Kobayashi-Miura, M.; Tsuchiya, M.
Quantitative analysis of the effects of nicotinamide phosphoribosyltransferase induction on the rates of NAD+ synthesis and breakdown in mammalian cells using stable isotope-labeling combined with mass spectrometry
PLoS ONE
14
e0214000
2019
Homo sapiens (P43490), Rattus norvegicus (Q80Z29), Mus musculus (Q99KQ4)
Manually annotated by BRENDA team