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Literature summary for 2.4.2.12 extracted from

  • Pittelli, M.; Cavone, L.; Lapucci, A.; Oteri, C.; Felici, R.; Niccolai, E.; Amedei, A.; Chiarugi, A.
    Nicotinamide phosphoribosyltransferase (NAMPT) activity is essential for survival of resting lymphocytes (2014), Immunol. Cell Biol., 92, 191-199.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
FK866
-
Homo sapiens
FK866
-
Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate Mus musculus
-
nicotinamide D-ribonucleotide + diphosphate
-
?
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate Homo sapiens
-
nicotinamide D-ribonucleotide + diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P43490
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lymphocyte
-
Mus musculus
-
lymphocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
Mus musculus nicotinamide D-ribonucleotide + diphosphate
-
?
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
Homo sapiens nicotinamide D-ribonucleotide + diphosphate
-
?

Synonyms

Synonyms Comment Organism
Nampt
-
Mus musculus
Nampt
-
Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme inhibition induces NAD depletion in various mouse organs but selectively causes dramatic atrophy of the spleen red pulp Mus musculus
physiological function enzyme activity is essential for survival of resting lymphocytes Mus musculus
physiological function enzyme activity is essential for survival of resting lymphocytes Homo sapiens