Information on EC 2.4.1.37 - fucosylgalactoside 3-alpha-galactosyltransferase

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The expected taxonomic range for this enzyme is: Eukaryota

EC NUMBER
COMMENTARY
2.4.1.37
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RECOMMENDED NAME
GeneOntology No.
fucosylgalactoside 3-alpha-galactosyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
UDP-alpha-D-galactose + alpha-L-fucosyl-(1->2)-D-galactosyl-R = UDP + alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl(1->2)]-D-galactosyl-R (where R can be OH, an oligosaccharide or a glycoconjugate)
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
hexosyl group transfer
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PATHWAY
KEGG Link
MetaCyc Link
Glycosphingolipid biosynthesis - lacto and neolacto series
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Metabolic pathways
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SYSTEMATIC NAME
IUBMB Comments
UDP-galactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase
Acts on blood group substance, and can use a number of 2-fucosyl-galactosides as acceptors.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
ABO(H) blood group B glycosyltransferase
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ABO(H) blood-group glycosyltransferase B
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alpha(1-3)galactosyltransferase
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alpha-(1,3)-galactosyltransferase
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alpha-(1-3)-galactosyltransferase
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B glycosyltransferase
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B transferase
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blood group alpha-(1-3)-galactosyltransferase
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blood group B alpha-(1,3)-galactosyltransferase
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blood group B galactosyltransferase
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blood group B glycosyltransferase
A5X6H3, A5X6H4, A5X6H5, A5X6H7, A5X6H8, Q6L638
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blood group B glycosyltransferase GTB
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blood group B glycosyltransferases
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blood group B-glycosyltransferase
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blood-group substance B-dependent galactosyltransferase
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glycoprotein-fucosylgalactoside alpha-galactosyltransferase
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glycosyltransferases B
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histo-blood group B enzyme
Q8CFC4
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histo-blood group B transferase
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histo-blood group B transferase
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UDP-galactose:fucoside alpha1,3-galactosyltransferase
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UDP-galactose:O-alpha-L-fucosyl(1-2)D-galactose alpha-D-galactosyltransferase
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UDPgalactose:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-alpha-D-galactosyltransferase
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[blood group substance] alpha-galactosyltransferase
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histo-blood substance B-dependent galactosyltransferase
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additional information
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the enzyme belongs to the ABO glycosyltransferases
CAS REGISTRY NUMBER
COMMENTARY
37257-33-3
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ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
Skp1B overexpressing strain HW302
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Manually annotated by BRENDA team
blood group B donors
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Manually annotated by BRENDA team
fragment; ABO gene
UniProt
Manually annotated by BRENDA team
genotype Wu4, P234A-mutant, heterozygot B/0; only four amino acids are responsible for B and A blood group enzymes R176G, G235S, L266M and G268A, the latter two amino acids are responsible for the difference in donor specificity and the first two have roles in acceptor binding and turnover
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Manually annotated by BRENDA team
only four amino acids are responsible for B and A blood group enzymes R176G, G235S, L266M and G268A, the latter two amino acids are responsible for the difference in donor specificity and the first two have roles in acceptor binding and turnover
Uniprot
Manually annotated by BRENDA team
only four amino acids are responsible for B and A blood group enzymes R176G, G235S, L266M and G268A, the latter two amino acids are responsible for the difference in donor specificity and the first two have roles in acceptor binding and turnover
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Manually annotated by BRENDA team
recombinantly expressed in Escherichia coli
Uniprot
Manually annotated by BRENDA team
recombinantly expressed in Escherichia coli
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Manually annotated by BRENDA team
white-handed gibbon
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Manually annotated by BRENDA team
japanese monkey
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Manually annotated by BRENDA team
strain BFM/2Msf, has a cis-AB gene that encodes an enzyme with both A and B transferase activities
Uniprot
Manually annotated by BRENDA team
Mus musculus brevirostris BFM/2Msf
strain BFM/2Msf, has a cis-AB gene that encodes an enzyme with both A and B transferase activities
Uniprot
Manually annotated by BRENDA team
strain CAST/Ei and HMI/Msf, has a cis-AB gene that encodes an enzyme with both A and B transferase activities
Uniprot
Manually annotated by BRENDA team
Mus musculus castaneus CAST/Ei
strain CAST/Ei and HMI/Msf, has a cis-AB gene that encodes an enzyme with both A and B transferase activities
Uniprot
Manually annotated by BRENDA team
strain BALB/c, has a cis-AB gene that encodes an enzyme with both A and B transferase activities
Uniprot
Manually annotated by BRENDA team
Mus musculus domesticus BALB/c
strain BALB/c, has a cis-AB gene that encodes an enzyme with both A and B transferase activities
Uniprot
Manually annotated by BRENDA team
strain ZBN, has a cis-AB gene that encodes an enzyme with both A and B transferase activities
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Manually annotated by BRENDA team
Mus spicilegus ZBN
strain ZBN, has a cis-AB gene that encodes an enzyme with both A and B transferase activities
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Manually annotated by BRENDA team
2 distinct alpha-3-D-galactosyltransferases: one which is more tightly membrane-bound, resembles the human B-gene-specific transferase in its acceptor specificity, and the second, which is a more soluble enzyme transfers D-galactose to the same positional linkage in unsubstituted beta-D-galactosyl residues
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Manually annotated by BRENDA team
blood group B donors
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Manually annotated by BRENDA team
B-type gene Abo2
SwissProt
Manually annotated by BRENDA team
PDB
SCOP
CATH
ORGANISM