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trehalose-6-phosphate synthase
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trehalose-6-phosphate synthase 1
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alpha,alpha-trehalose phosphate synthase (UDP-forming)
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-
-
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alpha,alpha-trehalose-phosphate synthase (UDP-forming)
-
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glucosyltransferase, uridine diphosphoglucose phosphate
-
-
-
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phosphotrehalose-uridine diphosphate transglucosylase
-
-
-
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trehalose 6-phosphate synthase
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-
-
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trehalose 6-phosphate synthase 1
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trehalose 6-phosphate synthetase
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-
-
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trehalose phosphate synthase
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-
-
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trehalose phosphate synthetase
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-
-
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trehalose phosphate-uridine diphosphate glucosyltransferase
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-
-
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trehalose-6-phosphate synthase
trehalose-6-phosphate synthase 1
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trehalose-P synthetase
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-
-
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trehalosephosphate-UDP glucosyl transferase
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-
-
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UDPglucose-glucose-phosphate glucosyltransferase
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-
-
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TPS
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-
-
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trehalose-6-phosphate synthase
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trehalose-6-phosphate synthase
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key subunit of the trehalose synthase complex
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UDP-alpha-D-glucose + D-glucose 6-phosphate
UDP + alpha,alpha-trehalose 6-phosphate
-
-
-
?
UDP-glucose + D-glucose 6-phosphate
UDP + alpha,alpha-trehalose 6-phosphate
-
-
-
?
GDP-alpha-D-glucose + D-glucose 6-phosphate
GDP + alpha,alpha-1,1-trehalose 6-phosphate
-
-
-
-
?
TDP-alpha-D-glucose + D-glucose 6-phosphate
TDP + alpha,alpha-1,1-trehalose 6-phosphate
-
-
-
-
?
UDP-alpha-D-glucose + D-fructose 6-phosphate
UDP + alpha,alpha-1,1-trehalose 6-phosphate
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maximum activity with glucose 6-phosphate, followed by mannose 6-phosphate and fructose 6-phosphate
-
-
?
UDP-alpha-D-glucose + D-glucose 6-phosphate
UDP + alpha,alpha-1,1-trehalose 6-phosphate
-
maximum activity with glucose 6-phosphate, followed by mannose 6-phosphate and fructose 6-phosphate
-
-
?
UDP-alpha-D-glucose + D-glucose 6-phosphate
UDP + alpha,alpha-trehalose 6-phosphate
UDP-alpha-D-glucose + D-mannose 6-phosphate
UDP + alpha,alpha-1,1-trehalose 6-phosphate
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maximum activity with glucose 6-phosphate, followed by mannose 6-phosphate and fructose 6-phosphate
-
-
?
UDPglucose + glucose 6-phosphate
trehalose 6-phosphate + UDP
additional information
?
-
-
trehalose is able to protect the integrity of the cells against a variety of environmental stresses such as desiccation, dehydration, heat, cold, and oxidation, probably via reduction of protein denaturation through protein-trehalose interactions, the enzyme might be a radical scavenger
-
-
?
UDP-alpha-D-glucose + D-glucose 6-phosphate
UDP + alpha,alpha-trehalose 6-phosphate
-
-
-
-
?
UDP-alpha-D-glucose + D-glucose 6-phosphate
UDP + alpha,alpha-trehalose 6-phosphate
-
-
-
?
UDP-alpha-D-glucose + D-glucose 6-phosphate
UDP + alpha,alpha-trehalose 6-phosphate
-
step in trehalose biosynthesis
-
-
?
UDPglucose + glucose 6-phosphate
trehalose 6-phosphate + UDP
-
-
-
-
?
UDPglucose + glucose 6-phosphate
trehalose 6-phosphate + UDP
-
-
-
?
UDPglucose + glucose 6-phosphate
trehalose 6-phosphate + UDP
-
-
-
-
?
UDPglucose + glucose 6-phosphate
trehalose 6-phosphate + UDP
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TPS1-encoded trehalose-6-phosphate synthase exerts an essential control on the influx into glycolysis. Tps1-mediated protein-protein interactions are important for control of glucose influx into yeast glycolysis
-
?
UDPglucose + glucose 6-phosphate
trehalose 6-phosphate + UDP
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key enzyme for biosynthesis of trehalose, the major soluble carbohydrate in resting cells
-
?
UDPglucose + glucose 6-phosphate
trehalose 6-phosphate + UDP
-
the enzyme plays a role in the control of glycolysis
-
?
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UDP-alpha-D-glucose + D-glucose 6-phosphate
UDP + alpha,alpha-trehalose 6-phosphate
-
-
-
?
UDP-glucose + D-glucose 6-phosphate
UDP + alpha,alpha-trehalose 6-phosphate
-
-
-
?
UDP-alpha-D-glucose + D-glucose 6-phosphate
UDP + alpha,alpha-trehalose 6-phosphate
UDPglucose + glucose 6-phosphate
trehalose 6-phosphate + UDP
additional information
?
-
-
trehalose is able to protect the integrity of the cells against a variety of environmental stresses such as desiccation, dehydration, heat, cold, and oxidation, probably via reduction of protein denaturation through protein-trehalose interactions, the enzyme might be a radical scavenger
-
-
?
UDP-alpha-D-glucose + D-glucose 6-phosphate
UDP + alpha,alpha-trehalose 6-phosphate
-
-
-
-
?
UDP-alpha-D-glucose + D-glucose 6-phosphate
UDP + alpha,alpha-trehalose 6-phosphate
-
-
-
?
UDP-alpha-D-glucose + D-glucose 6-phosphate
UDP + alpha,alpha-trehalose 6-phosphate
-
step in trehalose biosynthesis
-
-
?
UDPglucose + glucose 6-phosphate
trehalose 6-phosphate + UDP
-
TPS1-encoded trehalose-6-phosphate synthase exerts an essential control on the influx into glycolysis. Tps1-mediated protein-protein interactions are important for control of glucose influx into yeast glycolysis
-
?
UDPglucose + glucose 6-phosphate
trehalose 6-phosphate + UDP
-
key enzyme for biosynthesis of trehalose, the major soluble carbohydrate in resting cells
-
?
UDPglucose + glucose 6-phosphate
trehalose 6-phosphate + UDP
-
the enzyme plays a role in the control of glycolysis
-
?
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0.01
-
preparation of trehalose-6-phosphate synthase from Saccharomyces cerevisiae, preparation step soluble supernatant
0.011
-
TPS specific activity in glucose, yeast mutant strain tps2delta + pSAL4
0.013
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TPS specific activity in galactose, yeast mutant strain tps1delta_tps2delta + pSAL4::TPS1
0.02
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TPS specific activity in glucose, yeast mutant strain tps1delta_tps2delta + pSAL4::TPS1
0.055
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TPS specific activity in galactose, yeast wild type + pSAL4
0.063
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TPS specific activity in galactose, yeast mutant strain tps2delta + pSAL4::TPS2
0.067
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TPS specific activity in glucose, yeast mutant strain tps2delta + pSAL4::TPS2
0.073
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TPS specific activity in glucose, yeast mutant strain tps2delta + pSAL4::TPS1-TPS2
0.078
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TPS specific activity in galactose, yeast mutant strain tps2delta + pSAL4::TPS1-TPS2
0.079
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TPS specific activity in glucose, yeast wild type + pSAL4
0.081
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TPS specific activity in galactose, yeast mutant strain tps1delta + pSAL4::TPS1-TPS2
0.086
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TPS specific activity in glucose, yeast mutant strain tps1delta + pSAL4::TPS1-TPS2
0.088
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TPS specific activity in galactose, yeast mutant strain tps1delta_tps2delta + pSAL4::TPS1-TPS2
0.093
-
TPS specific activity in glucose, yeast mutant strain tps1delta_tps2delta + pSAL4::TPS1-TPS2
0.144
-
TPS specific activity in glucose, yeast mutant strain tps1delta + pSAL4::TPS1
0.163
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TPS specific activity in galactose, yeast mutant strain tps1delta + pSAL4::TPS1
0.49
-
preparation of trehalose-6-phosphate synthase from Saccharomyces cerevisiae, preparation step ammonimum sulfate fractionation
0.74
-
preparation of trehalose-6-phosphate synthase from Saccharomyces cerevisiae, preparation step HPGPLC on TSK G2000SW
additional information
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the activity of trehalose-6-phosphate synthase is concentration dependent
1.58
-
preparation of trehalose-6-phosphate synthase from Saccharomyces cerevisiae, preparation step HPGPLC on HiLoad 16/60 Superdex 200
1.58
-
pH 8.5, 37°C, presence of heparin
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100000
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x * 55000, isozyme TPS1, x * 100000, isozyme TPS2, x * 105000, isozyme TPS3, SDS-PAGE
105000
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x * 55000, isozyme TPS1, x * 100000, isozyme TPS2, x * 105000, isozyme TPS3, SDS-PAGE
115000
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x * 115000 + x * 57000, complex of EC 2.4.1.15/EC 3.1.3.12, SDS-PAGE
300000
-
complex of EC 2.4.1.15/EC 3.1.3.12, gel filtration
55000
-
x * 55000, isozyme TPS1, x * 100000, isozyme TPS2, x * 105000, isozyme TPS3, SDS-PAGE
56200
-
x * 56200, calculation from nucleotide sequence
56210
-
calculated from sequence of cDNA
57000
-
x * 115000 + x * 57000, complex of EC 2.4.1.15/EC 3.1.3.12, SDS-PAGE
59000
-
estimated by HPGPLC using a Ultropak G2000SW column and by SDS-PAGE
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D156G
site-directed mutagenesis of a catalytic site residue, catalytically inactive Tps1 mutant variant
W111S
site-directed mutagenesis of a catalytic site residue
Y102V
site-directed mutagenesis of a catalytic site residue
H223Y
-
catalytically more active than wild-type enzyme
additional information
transgenic Solanum tunerosum plants expressing the yeast TPS1 gene show enhanced drought tolerance, 379 genes of known function in potato show at least a 2fold change in expression across genotypes, stress levels or the interaction between these factors, wild-type leaves have twice as many genes with altered expression in response to stress than TPS1 transgenic leaves, the transgenic and wildtype plants show different contents in sugar metabolites in leaves under drought conditions, four transcription factors are uniquely up-regulated in TPS1 transgenic leaves, phenotypes, overview. Microarray transcriptional and metabolic analysis of the transgenic, drought-tolerant potato line
additional information
transgenic Solanum tunerosum plants expressing the yeast TPS1 gene show enhanced drought tolerance, 379 genes of known function in potato show at least a 2fold change in expression across genotypes, stress levels or the interaction between these factors, wild-type leaves have twice as many genes with altered expression in response to stress than TPS1 transgenic leaves, the transgenic and wildtype plants show different contents in sugar metabolites in leaves under drought conditions, four transcription factors are uniquely up-regulated in TPS1 transgenic leaves, phenotypes, overview. Microarray transcriptional and metabolic analysis of the transgenic, drought-tolerant potato line
additional information
-
transgenic Solanum tunerosum plants expressing the yeast TPS1 gene show enhanced drought tolerance, 379 genes of known function in potato show at least a 2fold change in expression across genotypes, stress levels or the interaction between these factors, wild-type leaves have twice as many genes with altered expression in response to stress than TPS1 transgenic leaves, the transgenic and wildtype plants show different contents in sugar metabolites in leaves under drought conditions, four transcription factors are uniquely up-regulated in TPS1 transgenic leaves, phenotypes, overview. Microarray transcriptional and metabolic analysis of the transgenic, drought-tolerant potato line
additional information
construction of a tps1DELTA and a tps1-156 deletion mutant
additional information
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construction of a tps1DELTA and a tps1-156 deletion mutant
additional information
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activity of T6P synthase and the accumulation of trehalose during ethanol fermentation are significantly improved by overexpression of TPS1, and especially at 38°C cmpared to 30°C, no obvious difference occurs in the activity of T6P synthase and the trehalose concentration for wild-type strain 10151, and transformed strains 10151-URA3 and 10151-pI-RED1, indicating that the expression of URA3 and YAP1 genes, markers of the expression plasmid, does not affect the synthesis of trehalose
additional information
transgenic Solanum tunerosum plants expressing the yeast TPS1 gene show enhanced drought tolerance, 379 genes of known function in potato show at least a 2fold change in expression across genotypes, stress levels or the interaction between these factors, wild-type leaves have twice as many genes with altered expression in response to stress than TPS1 transgenic leaves, the transgenic and wildtype plants show different contents in sugar metabolites in leaves under drought conditions, four transcription factors are uniquely up-regulated in TPS1 transgenic leaves, phenotypes, overview. Microarray transcriptional and metabolic analysis of the transgenic, drought-tolerant potato line
additional information
transgenic Solanum tunerosum plants expressing the yeast TPS1 gene show enhanced drought tolerance, 379 genes of known function in potato show at least a 2fold change in expression across genotypes, stress levels or the interaction between these factors, wild-type leaves have twice as many genes with altered expression in response to stress than TPS1 transgenic leaves, the transgenic and wildtype plants show different contents in sugar metabolites in leaves under drought conditions, four transcription factors are uniquely up-regulated in TPS1 transgenic leaves, phenotypes, overview. Microarray transcriptional and metabolic analysis of the transgenic, drought-tolerant potato line
additional information
-
transgenic Solanum tunerosum plants expressing the yeast TPS1 gene show enhanced drought tolerance, 379 genes of known function in potato show at least a 2fold change in expression across genotypes, stress levels or the interaction between these factors, wild-type leaves have twice as many genes with altered expression in response to stress than TPS1 transgenic leaves, the transgenic and wildtype plants show different contents in sugar metabolites in leaves under drought conditions, four transcription factors are uniquely up-regulated in TPS1 transgenic leaves, phenotypes, overview. Microarray transcriptional and metabolic analysis of the transgenic, drought-tolerant potato line
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Londesborough, J.; Vuorio, O.
Trehalose-6-phosphate synthase/phosphatase complex from bakers' yeast: purification of a proteolytically activated form
J. Gen. Microbiol.
137
323-330
1991
Saccharomyces cerevisiae
brenda
Bell, W.; Klaassen, P.; Ohnacker, M.; Boller, T.; Herweijer, M.; Schoppink, P.; van der Zee, P.; Wiemken, A.
Characterization of the 56-kDa subunit of yeast trehalose-6-phosphate synthase and cloning of its gene reveal its identity with the product of CIF1, a regulator of carbon catabolite inactivation
Eur. J. Biochem.
209
951-959
1992
Saccharomyces cerevisiae, Saccharomyces cerevisiae C13-ABYS86
brenda
Vandercammen, A.; Francois, J.; Hers, H.G.
Characterization of trehalose-6-phosphate synthase and trehalose-6-phosphate phosphatase of Saccharomyces cerevisiae
Eur. J. Biochem.
182
613-620
1989
Saccharomyces cerevisiae
brenda
De Silva-Udawatta, M.N.; Cannon, J.F.
Roles of trehalose phosphate synthase in yeast glycogen metabolism and sporulation
Mol. Microbiol.
40
1345-1356
2001
Saccharomyces cerevisiae
brenda
Noubhani, A.; Bunoust, O.; Rigoulet, M.; Thevelein, J.M.
Reconstitution of ethanolic fermentation in permeabilized spheroplasts of wild-type and trehalose-6-phosphate synthase mutants of the yeast Saccharomyces cerevisiae
Eur. J. Biochem.
267
4566-4576
2000
Saccharomyces cerevisiae
brenda
Blazquez, M.A.; Stucka, R.; Feldmann, H.; Gancedo, C.
Trehalose-6-P synthase is dispensable for growth on glucose but not for spore germination in Schizosaccharomyces pombe
J. Bacteriol.
176
3895-3902
1994
Saccharomyces cerevisiae, Schizosaccharomyces pombe
brenda
Chen, Q.; Haddad, G.G.
Role of trehalose phosphate synthase and trehalose during hypoxia: from flies to mammals
J. Exp. Biol.
207
3125-3129
2004
Candida albicans, Drosophila melanogaster, Escherichia coli, Saccharomyces cerevisiae, Schizosaccharomyces pombe
brenda
Miranda, J.A.; Avonce, N.; Suarez, R.; Thevelein, J.M.; Van Dijck, P.; Iturriaga, G.
A bifunctional TPS-TPP enzyme from yeast confers tolerance to multiple and extreme abiotic-stress conditions in transgenic Arabidopsis
Planta
226
1411-1421
2007
Saccharomyces cerevisiae
brenda
Chaudhuri, P.; Basu, A.; Ghosh, A.K.
Aggregation dependent enhancement of trehalose-6-phosphate synthase activity in Saccharomyces cerevisiae
Biochim. Biophys. Acta
1780
289-297
2008
Saccharomyces cerevisiae
brenda
Stiller, I.; Dulai, S.; Kondrak, M.; Tarnai, R.; Szabo, L.; Toldi, O.; Banfalvi, Z.
Effects of drought on water content and photosynthetic parameters in potato plants expressing the trehalose-6-phosphate synthase gene of Saccharomyces cerevisiae
Planta
227
299-308
2008
Saccharomyces cerevisiae
brenda
Chaudhuri, P.; Basu, A.; Sengupta, S.; Lahiri, S.; Dutta, T.; Ghosh, A.K.
Studies on substrate specificity and activity regulating factors of trehalose-6-phosphate synthase of Saccharomyces cerevisiae
Biochim. Biophys. Acta
1790
368-374
2009
Saccharomyces cerevisiae
brenda
Tao, D.; Mu, Y.; Fu, F-L.; Li, W-C.
Transformation of maize with trehalose synthase gene cloned from Saccharomyces cerevisiae
Biotechnology
7
258-265
2008
Saccharomyces cerevisiae, Saccharomyces cerevisiae AS.1416
-
brenda
An, M.Z.; Tang, Y.Q.; Mitsumasu, K.; Liu, Z.S.; Shigeru, M.; Kenji, K.
Enhanced thermotolerance for ethanol fermentation of Saccharomyces cerevisiae strain by overexpression of the gene coding for trehalose-6-phosphate synthase
Biotechnol. Lett.
33
1367-1374
2011
Saccharomyces cerevisiae
brenda
Kondrak, M.; Marincs, F.; Antal, F.; Juhasz, Z.; Banfalvi, Z.
Effects of yeast trehalose-6-phosphate synthase 1 on gene expression and carbohydrate contents of potato leaves under drought stress conditions
BMC Plant Biol.
12
74
2012
Saccharomyces cerevisiae (P31688), Saccharomyces cerevisiae (Q00764), Saccharomyces cerevisiae
brenda
Sengupta, S.; Banerjee, S.; Lahiri, S.; Dutta, T.; Dhar, T.K.; Ghosh, A.K.
Purification, characterization, sequencing and molecular cloning of a novel cysteine methyltransferase that regulates trehalose-6-phosphate synthase from Saccharomyces cerevisiae
Biochim. Biophys. Acta
1840
1861-1871
2014
Saccharomyces cerevisiae (Q00764), Saccharomyces cerevisiae
brenda
Petitjean, M.; Teste, M.A.; Francois, J.M.; Parrou, J.L.
Yeast tolerance to various stresses relies on the trehalose-6P synthase (Tps1) protein, not on trehalose
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290
16177-16190
2015
Saccharomyces cerevisiae (Q00764), Saccharomyces cerevisiae
brenda