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2-butenoyl-CoA + an [acyl-carrier protein]
CoA + 2-butenoyl-[acyl carrier protein]
-
the reaction is catalyzed by mutant enzyme R117A
-
-
?
2-hydroxybutyryl-CoA + an [acyl-carrier protein]
CoA + 2-hydroxybutyryl-[acyl carrier protein]
-
the reaction is catalyzed by mutant enzyme R117A
-
-
?
acetoacetyl-CoA + acyl-carrier protein
CoA + acetoacetyl-[acyl-carrier protein]
-
-
-
?
acetoacetyl-CoA + an [acyl-carrier protein]
CoA + acetoacetyl-[acyl carrier protein]
-
the reaction is catalyzed by the wild type enzyme (very weak activity) and mutant enzyme R117A
-
-
?
acetoacetyl-CoA + an [acyl-carrier protein]
CoA + an acetoacetyl-[acyl-carrier protein]
-
-
-
-
?
acetyl-CoA + an [acyl-carrier protein]
CoA + acetyl-[acyl carrier protein]
-
the reaction is catalyzed by mutant enzyme R117A
-
-
?
acetyl-CoA + an [acyl-carrier protein]
CoA + an acetyl-[acyl-carrier protein]
butanoyl-CoA + acyl-carrier protein
CoA + butanoyl-[acyl-carrier protein]
-
-
-
?
butyryl-CoA + an [acyl-carrier protein]
CoA + butyryl-[acyl carrier protein]
-
the reaction is catalyzed by mutant enzyme R117A
-
-
?
isobutyryl-CoA + an [acyl-carrier protein]
CoA + isobutyryl-[acyl carrier protein]
-
the reaction is catalyzed by mutant enzyme R117A
-
-
?
isovaleryl-CoA + an [acyl-carrier protein]
CoA + isovaleryl-[acyl carrier protein]
-
the reaction is catalyzed by mutant enzyme R117A
-
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-acyl-carrier protein
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
malonyl-CoA + an [acyl-carrier protein]
CoA + a malonyl-[acyl-carrier protein]
malonyl-CoA + N-(N-acetyl-beta-alanyl)cysteamine
CoA + N-(N-acetyl-beta-alanyl)-S-malonylcysteamine
-
-
-
-
?
malonyl-CoA + N-acetylcysteamine
CoA + N-acetyl-S-malonylcysteamine
malonyl-CoA + pantetheine
malonyl-pantetheine + CoA
malonyl-CoA + [acyl-carrier protein]
CoA + malonyl-[acyl-carrier protein]
malonyl-pantetheine + acyl-carrier protein
pantetheine + malonyl-[acyl-carrier protein]
-
-
-
-
?
methylmalonyl-CoA + acyl-carrier protein
CoA + methylmalonyl-[acyl-carrier protein]
methylmalonyl-CoA + an [acyl-carrier protein]
CoA + methylmalonyl-[acyl carrier protein]
-
the reaction is catalyzed by the wild type enzyme (low activity) and mutant enzyme R117A
-
-
?
methylmalonyl-CoA + an [acyl-carrier protein]
CoA + methylmalonyl-[acyl-carrier protein]
-
-
-
-
?
propionyl-CoA + acyl-carrier protein
CoA + propionyl-[acyl-carrier protein]
-
-
-
?
propionyl-CoA + an [acyl-carrier protein]
CoA + propionyl-[acyl carrier protein]
-
the reaction is catalyzed by mutant enzyme R117A
-
-
?
succinyl-CoA + an [acyl-carrier protein]
CoA + succinyl-[acyl carrier protein]
-
the reaction is catalyzed by mutant enzyme R117A
-
-
?
additional information
?
-
acetyl-CoA + an [acyl-carrier protein]
CoA + an acetyl-[acyl-carrier protein]
-
activity with mutant enzyme R117A, no activity with wild-type enzyme
-
-
?
acetyl-CoA + an [acyl-carrier protein]
CoA + an acetyl-[acyl-carrier protein]
-
-
-
-
?
acetyl-CoA + an [acyl-carrier protein]
CoA + an acetyl-[acyl-carrier protein]
-
-
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-acyl-carrier protein
-
initial reaction in de novo fatty acid synthesis, part of non-associated fatty acid synthase system of plants and prokaryotes
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-acyl-carrier protein
-
initial reaction in de novo fatty acid synthesis, part of non-associated fatty acid synthase system of plants and prokaryotes
-
r
malonyl-CoA + acyl-carrier protein
CoA + malonyl-acyl-carrier protein
-
-
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-acyl-carrier protein
-
-
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-acyl-carrier protein
-
the enzyme is a component of the fatty acid synthetase system
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
via stable covalent malonyl-enzyme intermediate
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
via stable covalent malonyl-enzyme intermediate
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
via stable covalent malonyl-enzyme intermediate
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
via stable covalent malonyl-enzyme intermediate
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
alpha-ketoglutarate dehydrogenase (KDH)-coupled assay system is used: KDH-dependent consumption of coenzyme A (CoA) generated by MCAT is accompanied by a reduction of nicotinamide adenine dinucleotide (NAD+) to NADH
-
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
-
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
-
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
-
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
-
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
-
-
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
-
-
r
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
acetyl-CoA cannot replace malonyl-CoA
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
acetyl-CoA cannot replace malonyl-CoA
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
acetyl-CoA cannot replace malonyl-CoA
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
acetyl-CoA cannot replace malonyl-CoA
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
acetyl-CoA cannot replace malonyl-CoA
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
acetyl-CoA cannot replace malonyl-CoA
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
the enzyme is very specific for the malonyl group
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
the enzyme is very specific for the malonyl group
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
characterization of acyl-carrier protein
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
characterization of acyl-carrier protein
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
via stable covalent malonyl-enzyme intermediate
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
via stable covalent malonyl-enzyme intermediate
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
participation of a malonyl-enzyme intermediate in the reaction
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
via stable covalent malonyl-enzyme intermediate
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
via stable covalent malonyl-enzyme intermediate
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
both isozymes may not be completely specific for malonyl-CoA as the substrate
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
acetyl-CoA cannot replace malonyl-CoA
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
via stable covalent malonyl-enzyme intermediate
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
-
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
holo-acyl-carrier-protein from Mycobacterium tuberculosis constitutes the preferred substrate for the enzyme, however the enzyme uses both E. coli holo-acyl-carrier-protein and Mycobacterium tuberculosis holo-acyl-carrier-protein as substrates for transacylation in vivo and in vitro
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
via stable covalent malonyl-enzyme intermediate
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
via stable covalent malonyl-enzyme intermediate
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
-
-
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
characterization of acyl-carrier protein
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
-
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
via stable covalent malonyl-enzyme intermediate
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
via stable covalent malonyl-enzyme intermediate
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
alpha-ketoglutarate dehydrogenase (KDH)-coupled assay system is used: KDH-dependent consumption of coenzyme A (CoA) generated by MCAT is accompanied by a reduction of nicotinamide adenine dinucleotide (NAD+) to NADH
-
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
alpha-ketoglutarate dehydrogenase (KDH)-coupled assay system is used: KDH-dependent consumption of coenzyme A (CoA) generated by MCAT is accompanied by a reduction of nicotinamide adenine dinucleotide (NAD+) to NADH
-
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
-
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
-
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
Streptomyces coelicolor actinorhodin polyketide synthase acyl carrier protein can catalyze transfer of malonate to type II Streptomyces coelicolor fatty acid synthase and other polyketide synthase acyl carrier protein in vitro
-
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
the recombinant enzyme is able to use E. coli acyl-carrier-protein, Streptomyces glaucescens acyl-carrier-protein as well as the tetracenomycin M acyl-carrier-protein component of the tetracenomycin type II polyketide synthase
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
characterization of acyl-carrier protein
-
?
malonyl-CoA + acyl-carrier protein
CoA + malonyl-[acyl-carrier protein]
-
via stable covalent malonyl-enzyme intermediate
-
?
malonyl-CoA + an [acyl-carrier protein]
CoA + a malonyl-[acyl-carrier protein]
-
-
-
?
malonyl-CoA + an [acyl-carrier protein]
CoA + a malonyl-[acyl-carrier protein]
-
-
-
-
?
malonyl-CoA + an [acyl-carrier protein]
CoA + a malonyl-[acyl-carrier protein]
-
-
-
-
?
malonyl-CoA + an [acyl-carrier protein]
CoA + a malonyl-[acyl-carrier protein]
-
-
-
?
malonyl-CoA + an [acyl-carrier protein]
CoA + a malonyl-[acyl-carrier protein]
-
the wild type enzyme is highly specific for malonyl-CoA
-
-
?
malonyl-CoA + an [acyl-carrier protein]
CoA + a malonyl-[acyl-carrier protein]
-
the reaction is catalyzed by the wild type enzyme and mutant enzyme R117A
-
-
?
malonyl-CoA + an [acyl-carrier protein]
CoA + a malonyl-[acyl-carrier protein]
-
-
-
-
?
malonyl-CoA + an [acyl-carrier protein]
CoA + a malonyl-[acyl-carrier protein]
-
-
-
?
malonyl-CoA + an [acyl-carrier protein]
CoA + a malonyl-[acyl-carrier protein]
-
-
-
?
malonyl-CoA + an [acyl-carrier protein]
CoA + a malonyl-[acyl-carrier protein]
-
-
-
-
?
malonyl-CoA + an [acyl-carrier protein]
CoA + a malonyl-[acyl-carrier protein]
-
-
-
-
?
malonyl-CoA + an [acyl-carrier protein]
CoA + a malonyl-[acyl-carrier protein]
-
-
-
?
malonyl-CoA + an [acyl-carrier protein]
CoA + a malonyl-[acyl-carrier protein]
-
-
-
?
malonyl-CoA + an [acyl-carrier protein]
CoA + a malonyl-[acyl-carrier protein]
-
-
-
?
malonyl-CoA + an [acyl-carrier protein]
CoA + a malonyl-[acyl-carrier protein]
-
-
-
?
malonyl-CoA + an [acyl-carrier protein]
CoA + a malonyl-[acyl-carrier protein]
-
-
-
-
?
malonyl-CoA + N-acetylcysteamine
CoA + N-acetyl-S-malonylcysteamine
-
-
-
-
?
malonyl-CoA + N-acetylcysteamine
CoA + N-acetyl-S-malonylcysteamine
-
in the presence of high N-acetylcysteamine concentrations the forward reaction can be driven to completion
-
-
?
malonyl-CoA + pantetheine
malonyl-pantetheine + CoA
-
-
-
-
?
malonyl-CoA + pantetheine
malonyl-pantetheine + CoA
-
-
-
-
?
malonyl-CoA + pantetheine
malonyl-pantetheine + CoA
-
reaction catalysed by the malonyl transferase domain of EC 2.3.1.85
-
-
?
malonyl-CoA + [acyl-carrier protein]
CoA + malonyl-[acyl-carrier protein]
-
key enzyme in fatty acid synthesis
malonyl-[acyl-carrier protein] is the key building block for de novo fatty acid synthesis
-
?
malonyl-CoA + [acyl-carrier protein]
CoA + malonyl-[acyl-carrier protein]
-
transfer to the free thiol group of the phosphopantetheine arm of the [acyl-carrier protein]
-
-
?
malonyl-CoA + [acyl-carrier protein]
CoA + malonyl-[acyl-carrier protein]
-
absolutely specific for the substrates, type II [acyl-carrier protein]
-
-
?
malonyl-CoA + [acyl-carrier protein]
CoA + malonyl-[acyl-carrier protein]
-
absolutely specific for the substrates, recombinant type II [acyl-carrier protein] lacking the N-terminal 68 amino acid residues from human, or recombinant ACP-A from Bacillus subtilis
-
-
?
malonyl-CoA + [acyl-carrier protein]
CoA + malonyl-[acyl-carrier protein]
-
type II [acyl-carrier protein] from Plasmodium falsiparum
-
-
?
malonyl-CoA + [acyl-carrier protein]
CoA + malonyl-[acyl-carrier protein]
-
-
-
-
?
malonyl-CoA + [acyl-carrier protein]
CoA + malonyl-[acyl-carrier protein]
-
enzyme is involved in both fatty acid and polyketide synthesis pathways
-
-
?
malonyl-CoA + [acyl-carrier protein]
CoA + malonyl-[acyl-carrier protein]
-
enzyme provides acyl-ACP thioesters for the biosynthesis of aromatic polyketides, overview, and thus is the primary gatekeeper of substrate specificity in type II polyketide synthase
-
-
?
malonyl-CoA + [acyl-carrier protein]
CoA + malonyl-[acyl-carrier protein]
-
enzyme is active with a type II [acyl-carrier protein] from a recombinant modular polyketid synthase with inactivated acyl transferase domain, overview
-
-
?
malonyl-CoA + [acyl-carrier protein]
CoA + malonyl-[acyl-carrier protein]
-
the active site is rigorously ordered around the acyl-thioester moiety of the acyl-CoA to facilitate rapid and efficient transacylation to an ACP
-
-
?
methylmalonyl-CoA + acyl-carrier protein
CoA + methylmalonyl-[acyl-carrier protein]
-
-
-
?
methylmalonyl-CoA + acyl-carrier protein
CoA + methylmalonyl-[acyl-carrier protein]
-
-
-
?
additional information
?
-
-
mercaptoethanol is inactive as a substitute for acyl-carrier-protein
-
-
?
additional information
?
-
-
the wild type enzyme shows no activity with acetyl-CoA, propionyl-CoA, succinyl-CoA, butyryl-CoA, 2-butenoyl-CoA, 2-hydroxybutyryl-CoA, isobutyryl-CoA, and isovaleryl-CoA
-
-
-
additional information
?
-
-
development of a continuous fluorometric coupled assay method in microplates by coupling of the enzyme to alpha-ketoglutarate dehydrogenase consuming CoA, overview
-
-
?
additional information
?
-
-
enzyme is part of the malonyl-CoA-dependent type II fatty acid synthase complex in mitochondria
-
-
?
additional information
?
-
presence of malonyl-CoA:ACP transacylase MdcH is required for catalytic activity of malonate decarboxylase. Substrates for MdcH are malonyl-CoA or methylmalonyl-CoA but not acetyl-CoA. Transfer of the methylmalonyl-residue to the prosthetic group proceeds via the covalent methylmalonyl-MdcH intermediate
-
-
?
additional information
?
-
-
presence of malonyl-CoA:ACP transacylase MdcH is required for catalytic activity of malonate decarboxylase. Substrates for MdcH are malonyl-CoA or methylmalonyl-CoA but not acetyl-CoA. Transfer of the methylmalonyl-residue to the prosthetic group proceeds via the covalent methylmalonyl-MdcH intermediate
-
-
?
additional information
?
-
-
enzyme is part of the malonyl-CoA-dependent type II fatty acid synthase complex in mitochondria, reaction sequence of the involved enzymes, overview
-
-
?
additional information
?
-
-
the beta-ketoacyl ACP synthase also catalyzes the reaction with low activity, overview, no activity with a recombinant type II [acyl-carrier protein] from Plasmodium falsiparum containing an N-terminal apicoplast transit peptide
-
-
?
additional information
?
-
-
the enzyme is responsible for charging the tetracenomycin M acyl-carrier-protein with malonate in vivo, a key step in the synthesis of the deca(polyketide) precursor of tetracenomycin C. This implies the existence of a functional connection between fatty acid and polyketide metabolism in this bacterium
-
-
?
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0.11
acetoacetyl-CoA
-
mutant enzyme R117A, pH and temperature not specified in the publication
0.2
acetyl-CoA
-
mutant enzyme R117A, pH and temperature not specified in the publication
0.042 - 1.3
acyl-carrier protein
0.011 - 0.04
an [acyl-carrier protein]
0.0141
holo-acyl-carrier protein
-
holo-acyl-carrier protein from Mycobacterium tuberculosis
0.0094 - 0.015
malonyl CoA
0.016 - 0.58
methylmalonyl-CoA
0.075 - 3.5
[acyl-carrier protein]
additional information
additional information
-
the Km for N-acetylcysteamine is significantly higher than for an acyl-carrier-protein
-
0.042
acyl-carrier protein
-
-
0.073
acyl-carrier protein
-
hexahistidine-tagged fusion protein, reaction with Streptomyces coelicolor acyl-carrier-protein
0.351
acyl-carrier protein
-
reaction with E. coli acyl-carrier-protein
0.4
acyl-carrier protein
-
sequential mechanism
0.4
acyl-carrier protein
-
sequential mechanism
0.6
acyl-carrier protein
-
ping-pong mechanism
0.776
acyl-carrier protein
-
reaction with E. coli acyl-carrier-protein
1.3
acyl-carrier protein
-
ping-pong mechanism
0.011
an [acyl-carrier protein]
-
mutant enzyme R117A, with methylmalonyl-CoA as cosubstrate, pH and temperature not specified in the publication
0.02
an [acyl-carrier protein]
-
wild type enzyme, with methylmalonyl-CoA as cosubstrate, pH and temperature not specified in the publication
0.03
an [acyl-carrier protein]
-
mutant enzyme R117A, with acetoacetyl-CoA as cosubstrate, pH and temperature not specified in the publication
0.03
an [acyl-carrier protein]
-
mutant enzyme R117A, with malonyl-CoA as cosubstrate, pH and temperature not specified in the publication
0.04
an [acyl-carrier protein]
-
mutant enzyme R117A, with acetyl-CoA as cosubstrate, pH and temperature not specified in the publication
0.04
an [acyl-carrier protein]
-
wild type enzyme, with malonyl-CoA as cosubstrate, pH and temperature not specified in the publication
0.0094
malonyl CoA
-
-
0.0013
malonyl-CoA
-
R606K mutant
0.0019
malonyl-CoA
-
wild-type
0.011
malonyl-CoA
-
wild-type and mutant
0.0126
malonyl-CoA
-
recombinant enzyme
0.015
malonyl-CoA
-
pH 6.8, recombinant mutant M137L
0.016
malonyl-CoA
pH 7.5, 37°C
0.0162
malonyl-CoA
-
R606A mutant
0.0167
malonyl-CoA
wild-type enzyme, Vmax (RFU/min): 123
0.01733
malonyl-CoA
recombinant enzyme, pH 6.8, temperature not specified in the publication
0.0175
malonyl-CoA
mutant N155A, Vmax (RFU/min): 63.06
0.019
malonyl-CoA
-
pH 6.8, 28°C, recombinant enzyme
0.019
malonyl-CoA
-
pH 6.8, recombinant wild-type enzyme
0.0191
malonyl-CoA
mutant H90A, Vmax (RFU/min): 39.65
0.02
malonyl-CoA
-
acyl carrier protein mutant E20A, pH 7.5, 25°C
0.0208
malonyl-CoA
-
wild-type enzyme
0.0228
malonyl-CoA
-
pH 6.8, 28°C
0.023
malonyl-CoA
-
pH 6.8, recombinant mutant M126I
0.0239
malonyl-CoA
-
S97A mutant
0.032
malonyl-CoA
-
pH 6.8, recombinant mutant V98Q
0.033
malonyl-CoA
-
acyl carrier protein mutant Q67R, pH 7.5, 25°C
0.034
malonyl-CoA
-
pH 6.8, recombinant mutant A197D
0.034
malonyl-CoA
-
acyl carrier protein mutant T65A, pH 7.5, 25°C
0.049
malonyl-CoA
-
acyl carrier protein mutant Q66R, pH 7.5, 25°C
0.049
malonyl-CoA
-
wild-type acyl carrier protein, pH 7.5, 25°C
0.05
malonyl-CoA
-
pH 6.8, recombinant mutant F200S
0.06
malonyl-CoA
-
hexahistidine-tagged fusion protein, reaction with Streptomyces coelicolor acyl-carrier-protein
0.06
malonyl-CoA
-
pH 6.8, recombinant mutants G198Y and G198A
0.06
malonyl-CoA
-
wild type enzyme, pH and temperature not specified in the publication
0.06
malonyl-CoA
-
wild-type enzyme, pH and temperature not specified in the publication
0.08
malonyl-CoA
-
mutant enzyme R117A, pH and temperature not specified in the publication
0.083
malonyl-CoA
-
pH 6.8, recombinant mutant F200A
0.095
malonyl-CoA
-
pH 6.8, recombinant mutant F200Y
0.15
malonyl-CoA
-
pH 6.8, recombinant mutant R122A
0.2
malonyl-CoA
-
pH 6.8, recombinant mutant Q9A
0.25
malonyl-CoA
-
reaction with E. coli acyl-carrier-protein
0.3
malonyl-CoA
-
sequential mechanism
0.327
malonyl-CoA
-
hexahistidine-tagged fusion protein, reaction with E. coli acyl-carrier-protein
0.4
malonyl-CoA
-
ping-pong mechanism
0.4
malonyl-CoA
-
pH 6.8, recombinant mutant T57V
0.5
malonyl-CoA
-
sequential mechanism
0.7
malonyl-CoA
-
pH 6.8, recombinant mutant R122K
1.4
malonyl-CoA
-
ping-pong mechanism
0.016
methylmalonyl-CoA
pH 7.5, 37°C
0.33
methylmalonyl-CoA
-
mutant enzyme R117A, pH and temperature not specified in the publication
0.58
methylmalonyl-CoA
-
wild type enzyme, pH and temperature not specified in the publication
0.58
methylmalonyl-CoA
-
wild-type enzyme, pH and temperature not specified in the publication
0.075
[acyl-carrier protein]
-
pH 6.8, recombinant mutant F200Y
0.1
[acyl-carrier protein]
-
pH 6.8, recombinant mutants M137L and F200S
0.12
[acyl-carrier protein]
-
pH 6.8, recombinant wild-type enzyme and mutant V98Q
0.13
[acyl-carrier protein]
-
pH 6.8, recombinant mutants A197D and G198Y
0.15
[acyl-carrier protein]
-
pH 6.8, recombinant mutants M126I and G198A
0.24
[acyl-carrier protein]
-
pH 6.8, recombinant mutant F200A
0.57
[acyl-carrier protein]
-
pH 6.8, recombinant mutant T57V
0.92
[acyl-carrier protein]
-
pH 6.8, recombinant mutant Q9A
1.1
[acyl-carrier protein]
-
pH 6.8, recombinant mutant R122A
3.5
[acyl-carrier protein]
-
pH 6.8, recombinant mutant R122K
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