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dabsyl L-methionine (R)-sulfoxide + thioredoxin
dabsyl L-methionine + thioredoxin disulfide + H2O
cytosolic human thioredoxin 1, mitochondrial rat thioredoxin 2 lacking a mitochondrial signal peptide or Escherichia coli thioredoxin
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-
?
dabsyl-L-methionine (R)-sulfoxide + dithiothreitol
dabsyl-L-methionine + dithiothreitol disulfide + H2O
-
-
-
?
dabsyl-L-methionine (R)-sulfoxide + thioredoxin
dabsyl-L-methionine + thioredoxin disulfide + H2O
rTrx2 physically interacts with oxidized MsrB2 through a disulfide bond. Thioredoxin- and dithiothreitol-dependent activities are approximately equal
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-
?
dabsyl-L-methionine-(R)-S-oxide + dithiothreitol
dabsyl-L-methionine + DTT disulfide + H2O
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-
-
?
peptide-L-methionine + thioredoxin disulfide + H2O
peptide-L-methionine (R)-S-oxide + thioredoxin
the study reveals a mechanism to shuttle oxidizing equivalents from the primary MsrB3 active site toward the enzyme surface, where they would be available for further dithiol-disulfide exchange reactions
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-
?
(R)-methyl 4-tolyl sulfoxide + thioredoxin
?
-
-
-
-
?
calmodulin-L-methionine (R)-sulfoxide + thioredoxin
calmodulin-L-methionine + thioredoxin disulfide + H2O
dabsyl-L-methionine (R)-sulfoxide + dithiothreitol
dabsyl-L-methionine + dithiothreitol disulfide + H2O
-
-
-
-
?
dabsyl-L-methionine (R)-sulfoxide + thioredoxin
dabsyl-L-methionine + thioredoxin disulfide + H2O
-
FMsr is specific for the R-isomer
-
-
?
L-methionine (R)-sulfoxide + thioredoxin
L-methionine + thioredoxin disulfide + H2O
L-methionine-(R)-S-oxide + DTT
L-methionine + DTT disulfide + H2O
-
-
-
-
?
L-methionine-(R)-S-oxide + thioredoxin
L-methionine + thioredoxin disulfide + H2O
peptide-L-methionine-(R)-S-oxide + thioredoxin
peptide-L-methionine + thioredoxin disulfide + H2O
upon oxidative stress, the overexpression of methionine sulfoxide reductase B2 leads to the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance
-
-
?
protein L-methionine (R)-sulfoxide + thioredoxin
protein L-methionine + thioredoxin disulfide
-
type B enzyme CBS1 is stereospecific for the R-stereomer of methionine residues of peptides and proteins
-
-
?
protein-L-methionine (R)-sulfoxide + dithiothreitol
protein-L-methionine + dithiothreitol disulfide + H2O
-
type B enzyme CBS1 is stereospecific for the R-stereomer of methionine residues of peptides and proteins
-
-
?
additional information
?
-
calmodulin-L-methionine (R)-sulfoxide + thioredoxin
calmodulin-L-methionine + thioredoxin disulfide + H2O
-
MsrB is specific for the R-form, enzyme provides protection against oxidative damage by reactive oxygen species and has a repair function for oxidized protein methionine residues, which restores the calmodulin binding to adenylate cyclase of the pathogen Bordetella pertussis, which is an essential step for the bacterium to enter host cells, overview
-
-
?
calmodulin-L-methionine (R)-sulfoxide + thioredoxin
calmodulin-L-methionine + thioredoxin disulfide + H2O
-
MsrB is specific for the R-form, recombinant human calmodulin, recombinant human enzyme, artificial system, determination of oxidized methionine residues being reduced by the enzyme, overview
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-
?
L-methionine (R)-sulfoxide + thioredoxin
L-methionine + thioredoxin disulfide + H2O
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-
-
-
?
L-methionine (R)-sulfoxide + thioredoxin
L-methionine + thioredoxin disulfide + H2O
-
Msr is specific for the R-isomer
-
-
?
L-methionine (R)-sulfoxide + thioredoxin
L-methionine + thioredoxin disulfide + H2O
-
MsrB is specific for the R-form
-
-
?
L-methionine (R)-sulfoxide + thioredoxin
L-methionine + thioredoxin disulfide + H2O
-
MsrB is specific for the R-form, enzyme variants with specificities for either free or protein-bound methionine
-
-
?
L-methionine (R)-sulfoxide + thioredoxin
L-methionine + thioredoxin disulfide + H2O
MsrB is specific for the R-isomer, no activity with the S-isomer
-
-
?
L-methionine-(R)-S-oxide + thioredoxin
L-methionine + thioredoxin disulfide + H2O
-
-
-
-
?
L-methionine-(R)-S-oxide + thioredoxin
L-methionine + thioredoxin disulfide + H2O
-
stereospecific reduction
-
-
?
L-methionine-(R)-S-oxide + thioredoxin
L-methionine + thioredoxin disulfide + H2O
-
MsrB is involved in regulation of protein function and in elimination of reactive oxygen species via reversible methionine formation besides protein repair in human skin
-
-
r
L-methionine-(R)-S-oxide + thioredoxin
L-methionine + thioredoxin disulfide + H2O
-
stereospecific reduction, the isozymes of MsrB are involved in lens cell viability and oxidative stress protection
-
-
?
L-methionine-(R)-S-oxide + thioredoxin
L-methionine + thioredoxin disulfide + H2O
-
substrates are HIV-2, which is inactivated by oxidation of its methionine residues M76 and M95, the potassium channel of the brain, the inhibitor IkappaB-alpha, or calmodulin, overview
-
-
?
L-methionine-(R)-S-oxide + thioredoxin
L-methionine + thioredoxin disulfide + H2O
-
the cofactor thioredoxin can be recycled in vivo by thionein due to its high content of cysteines, overview
-
-
?
L-methionine-(R)-S-oxide + thioredoxin
L-methionine + thioredoxin disulfide + H2O
-
isozymes MsrB1, MsrB2, and MsrB3
-
-
?
L-methionine-(R)-S-oxide + thioredoxin
L-methionine + thioredoxin disulfide + H2O
-
stereospecific reduction, MsrB accepts free and protein-bound substrates
-
-
r
additional information
?
-
MsrB3 physically interacts with the sulfenic acid intermediate of these oxidized enzymes to directly form an intermolecular disulfide bond
-
-
?
additional information
?
-
stereospecificity towards R-methionine sulfoxide
-
-
-
additional information
?
-
-
substrate specificity
-
-
?
additional information
?
-
-
cellular system of balancing native proteins and oxidatively damaged proteins by use of protein biosynthesis, protein oxidative modification, protein elimination, and oxidized protein repair involving the enzyme, overview, enzyme protects against oxidative damage of proteins, loss of enzyme activity is age-related
-
-
?
additional information
?
-
-
downregulation of CBS-1 during replicative senescence of cells leads to accumulation of oxidized proteins and age-related increased oxidative damage
-
-
?
additional information
?
-
-
recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging and age-related diseases, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrB has several different physiological repair and regulatory functions, overview
-
-
?
additional information
?
-
-
the enzyme protects cells against oxidative damage and plays a role in age-related and neurological diseases, like Parkinsons or Alzheimers disease
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-
?
additional information
?
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-
enzyme reduces oxidized methionine residues of the alpha-1-proteinase inhibitor, calmodulin, and thrombomodulin, which become reversibly inactivated upon oxidation
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?
additional information
?
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roles of methionine sulfoxide reductases in antioxidant defense, protein regulation via alternating it between active and inactive form, and survival, MsrB protects cells from the cytotoxic effects of reactive oxygen species, ROS, overview, the enzyme is involved in age-related diseases such as Alzheimer's or Parkinson's diseases as well as in diseases caused by prions, mechanism, overview, enzyme involvement in protein repair and associated factors, protein regulation pathway, overview
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?
additional information
?
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-
the enzyme utilizes free and protein-bound methionine-(R)-S-oxide as substrate, but prefers the latter, methionine oxidation inactivates the proteins showing equal distribution of S-MetO and R-MetO
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?
additional information
?
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-
the thioredoxin dependence is different for selenocysteine- and cysteine-containing enzyme, overview
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-
?
additional information
?
-
Sp1 transcription factor may play a central role in expression of the human MsrB1 gene. The MsrB1 promoter activity appears to be controlled by epigenetic modifications such as methylation
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-
?
additional information
?
-
-
Sp1 transcription factor may play a central role in expression of the human MsrB1 gene. The MsrB1 promoter activity appears to be controlled by epigenetic modifications such as methylation
-
-
?
additional information
?
-
-
methionine-oxidized amyloid fibrils (methionine-oxidized monomer and fibrillar apoC-II) are poor substrates for human methionine sulfoxide reductase B2. At Msr concentrations of more than 0.0005 mM, approximately 90% of monomeric MetO-apoCII is reduced. In contrast, at 0.0005 mM Msr, only 35% of fibrillar MetO-apoC-II is reduced, which increased to only 37% after incubation with a 4fold higher enzyme concentration
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?
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calmodulin-L-methionine (R)-sulfoxide + thioredoxin
calmodulin-L-methionine + thioredoxin disulfide + H2O
-
MsrB is specific for the R-form, enzyme provides protection against oxidative damage by reactive oxygen species and has a repair function for oxidized protein methionine residues, which restores the calmodulin binding to adenylate cyclase of the pathogen Bordetella pertussis, which is an essential step for the bacterium to enter host cells, overview
-
-
?
L-methionine (R)-sulfoxide + thioredoxin
L-methionine + thioredoxin disulfide + H2O
L-methionine-(R)-S-oxide + thioredoxin
L-methionine + thioredoxin disulfide + H2O
peptide-L-methionine-(R)-S-oxide + thioredoxin
peptide-L-methionine + thioredoxin disulfide + H2O
upon oxidative stress, the overexpression of methionine sulfoxide reductase B2 leads to the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance
-
-
?
protein L-methionine (R)-sulfoxide + thioredoxin
protein L-methionine + thioredoxin disulfide
-
type B enzyme CBS1 is stereospecific for the R-stereomer of methionine residues of peptides and proteins
-
-
?
protein-L-methionine (R)-sulfoxide + dithiothreitol
protein-L-methionine + dithiothreitol disulfide + H2O
-
type B enzyme CBS1 is stereospecific for the R-stereomer of methionine residues of peptides and proteins
-
-
?
additional information
?
-
L-methionine (R)-sulfoxide + thioredoxin
L-methionine + thioredoxin disulfide + H2O
-
-
-
-
?
L-methionine (R)-sulfoxide + thioredoxin
L-methionine + thioredoxin disulfide + H2O
-
Msr is specific for the R-isomer
-
-
?
L-methionine (R)-sulfoxide + thioredoxin
L-methionine + thioredoxin disulfide + H2O
-
MsrB is specific for the R-form
-
-
?
L-methionine (R)-sulfoxide + thioredoxin
L-methionine + thioredoxin disulfide + H2O
-
MsrB is specific for the R-form, enzyme variants with specificities for either free or protein-bound methionine
-
-
?
L-methionine-(R)-S-oxide + thioredoxin
L-methionine + thioredoxin disulfide + H2O
-
-
-
-
?
L-methionine-(R)-S-oxide + thioredoxin
L-methionine + thioredoxin disulfide + H2O
-
MsrB is involved in regulation of protein function and in elimination of reactive oxygen species via reversible methionine formation besides protein repair in human skin
-
-
r
L-methionine-(R)-S-oxide + thioredoxin
L-methionine + thioredoxin disulfide + H2O
-
stereospecific reduction, the isozymes of MsrB are involved in lens cell viability and oxidative stress protection
-
-
?
L-methionine-(R)-S-oxide + thioredoxin
L-methionine + thioredoxin disulfide + H2O
-
substrates are HIV-2, which is inactivated by oxidation of its methionine residues M76 and M95, the potassium channel of the brain, the inhibitor IkappaB-alpha, or calmodulin, overview
-
-
?
L-methionine-(R)-S-oxide + thioredoxin
L-methionine + thioredoxin disulfide + H2O
-
the cofactor thioredoxin can be recycled in vivo by thionein due to its high content of cysteines, overview
-
-
?
additional information
?
-
-
cellular system of balancing native proteins and oxidatively damaged proteins by use of protein biosynthesis, protein oxidative modification, protein elimination, and oxidized protein repair involving the enzyme, overview, enzyme protects against oxidative damage of proteins, loss of enzyme activity is age-related
-
-
?
additional information
?
-
-
downregulation of CBS-1 during replicative senescence of cells leads to accumulation of oxidized proteins and age-related increased oxidative damage
-
-
?
additional information
?
-
-
recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging and age-related diseases, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrB has several different physiological repair and regulatory functions, overview
-
-
?
additional information
?
-
-
the enzyme protects cells against oxidative damage and plays a role in age-related and neurological diseases, like Parkinsons or Alzheimers disease
-
-
?
additional information
?
-
-
roles of methionine sulfoxide reductases in antioxidant defense, protein regulation via alternating it between active and inactive form, and survival, MsrB protects cells from the cytotoxic effects of reactive oxygen species, ROS, overview, the enzyme is involved in age-related diseases such as Alzheimer's or Parkinson's diseases as well as in diseases caused by prions, mechanism, overview, enzyme involvement in protein repair and associated factors, protein regulation pathway, overview
-
-
?
additional information
?
-
Sp1 transcription factor may play a central role in expression of the human MsrB1 gene. The MsrB1 promoter activity appears to be controlled by epigenetic modifications such as methylation
-
-
?
additional information
?
-
-
Sp1 transcription factor may play a central role in expression of the human MsrB1 gene. The MsrB1 promoter activity appears to be controlled by epigenetic modifications such as methylation
-
-
?
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Acidosis
Anoxia, acidosis and intergenic interactions selectively regulate methionine sulfoxide reductase transcriptions in mouse embryonic stem cells.
Alzheimer Disease
Decrease in peptide methionine sulfoxide reductase in Alzheimer's disease brain.
Alzheimer Disease
Direct Interaction of Selenoprotein R with Clusterin and Its Possible Role in Alzheimer's Disease.
Alzheimer Disease
Methionine Sulfoxide Reductase-B3 (MsrB3) Protein Associates with Synaptic Vesicles and its Expression Changes in the Hippocampi of Alzheimer's Disease Patients.
Alzheimer Disease
Methionine Sulfoxide Reductase-B3 Risk Allele Implicated in Alzheimer's Disease Associates with Increased Odds for Brain Infarcts.
Alzheimer Disease
Mitochondrial methionine sulfoxide reductase B2 links oxidative stress to Alzheimer's disease-like pathology.
Alzheimer Disease
Oxidation of methionine 35 reduces toxicity of the amyloid beta-peptide(1-42) in neuroblastoma cells (IMR-32) via enzyme methionine sulfoxide reductase A expression and function.
Brain Diseases
Methionine sulfoxide reductase (Msr) dysfunction in human brain disease.
Brain Infarction
Methionine Sulfoxide Reductase-B3 Risk Allele Implicated in Alzheimer's Disease Associates with Increased Odds for Brain Infarcts.
Brain Injuries
Methionine Sulfoxide Reductase-B3 Risk Allele Implicated in Alzheimer's Disease Associates with Increased Odds for Brain Infarcts.
Breast Neoplasms
Important roles of multiple Sp1 binding sites and epigenetic modifications in the regulation of the methionine sulfoxide reductase B1 (MsrB1) promoter.
Carcinogenesis
Actin reduction by MsrB2 is a key component of the cytokinetic abscission checkpoint and prevents tetraploidy.
Carcinogenesis
[Expression of methionine sulfoxide reductase in colorectal cancer stem cells in vitro].
Carcinoma
MSRB3 promotes the progression of clear cell renal cell carcinoma via regulating endoplasmic reticulum stress.
Carcinoma, Hepatocellular
Methionine Sulfoxide Reductase B1 Regulates Hepatocellular Carcinoma Cell Proliferation and Invasion via the Mitogen-Activated Protein Kinase Pathway and Epithelial-Mesenchymal Transition.
Carcinoma, Renal Cell
MSRB3 promotes the progression of clear cell renal cell carcinoma via regulating endoplasmic reticulum stress.
Cataract
Effect of blood-retinal barrier development on formation of selenite nuclear cataract in rat.
Cataract
Effects of Sodium Selenite on Oxidative Damage in the Liver, Kidney and Brain in a Selenite Cataract Rat Model.
Cataract
Involvement of MsrB1 in the regulation of redox balance and inhibition of peroxynitrite-induced apoptosis in human lens epithelial cells.
Citrullinemia
Metabolic studies in older mentally retarded patients: significance of metabolic testing and correlation with the clinical phenotype.
Colonic Neoplasms
MsrB3 deficiency induces cancer cell apoptosis through p53-independent and ER stress-dependent pathways.
Colorectal Neoplasms
[Expression of methionine sulfoxide reductase in colorectal cancer stem cells in vitro].
Craniosynostoses
Genome-wide association analysis uncovers variants for reproductive variation across dog breeds and links to domestication.
Deafness
Down-regulation of msrb3 and destruction of normal auditory system development through hair cell apoptosis in zebrafish.
Deafness
Functional null mutations of MSRB3 encoding methionine sulfoxide reductase are associated with human deafness DFNB74.
Deafness
Methionine sulfoxide reductase B3 deficiency causes hearing loss due to stereocilia degeneration and apoptotic cell death in cochlear hair cells.
Dehydration
Peptide-Bound Methionine Sulfoxide (MetO) Levels and MsrB2 Abundance Are Differentially Regulated during the Desiccation Phase in Contrasted Acer Seeds.
Dementia
Methionine Sulfoxide Reductase-B3 (MsrB3) Protein Associates with Synaptic Vesicles and its Expression Changes in the Hippocampi of Alzheimer's Disease Patients.
Dementia
Methionine Sulfoxide Reductase-B3 Risk Allele Implicated in Alzheimer's Disease Associates with Increased Odds for Brain Infarcts.
Diabetes Mellitus
Metabolic studies in older mentally retarded patients: significance of metabolic testing and correlation with the clinical phenotype.
Diabetes Mellitus
Mitochondrial MsrB2 serves as a switch and transducer for mitophagy.
Eye Diseases
Mitochondrial function and redox control in the aging eye: Role of MsrA and other repair systems in cataract and macular degenerations.
Hearing Loss
Functional null mutations of MSRB3 encoding methionine sulfoxide reductase are associated with human deafness DFNB74.
Hearing Loss
Methionine Sulfoxide Reductase A, B1 and B2 Are Likely to Be Involved in the Protection against Oxidative Stress in the Inner Ear.
Hearing Loss
Methionine sulfoxide reductase B3 deficiency causes hearing loss due to stereocilia degeneration and apoptotic cell death in cochlear hair cells.
Hearing Loss
Methionine Sulfoxide Reductase B3-Targeted In Utero Gene Therapy Rescues Hearing Function in a Mouse Model of Congenital Sensorineural Hearing Loss.
Hearing Loss, Sensorineural
Methionine Sulfoxide Reductase B3-Targeted In Utero Gene Therapy Rescues Hearing Function in a Mouse Model of Congenital Sensorineural Hearing Loss.
Infections
A Novel, Molybdenum-Containing Methionine Sulfoxide Reductase Supports Survival of Haemophilus influenzae in an In vivo Model of Infection.
Infections
A strain-specific catalase mutation and mutation of the metal-binding transporter gene mntC attenuate Neisseria gonorrhoeae in vivo but not by increasing susceptibility to oxidative killing by phagocytes.
Infections
Contribution of methionine sulfoxide reductase B (MsrB) to Francisella tularensis infection in mice.
Infections
NIa-pro of Papaya ringspot virus interacts with papaya methionine sulfoxide reductase B1.
Infections
Peptide Methionine Sulfoxide Reductase from Haemophilus influenzae Is Required for Protection against HOCl and Affects the Host Response to Infection.
Influenza, Human
Effects of selenium supplementation on selenoprotein gene expression and response to influenza vaccine challenge: a randomised controlled trial.
Insulin Resistance
Methionine sulfoxide reductase B1 deficiency does not increase high-fat diet-induced insulin resistance in mice.
Insulin Resistance
Methionine sulfoxide reductase B3 deficiency inhibits the development of diet-induced insulin resistance in mice.
Leukemia
Overexpression of methionine sulfoxide reductases A and B2 protects MOLT-4 cells against zinc-induced oxidative stress.
Leukemia
Overexpression of mitochondrial methionine sulfoxide reductase B2 protects leukemia cells from oxidative stress-induced cell death and protein damage.
Lipoma
NFIB rearrangement in superficial, retroperitoneal, and colonic lipomas with aberrations involving chromosome band 9p22.
Lymphatic Metastasis
Increased expression of methionine sulfoxide reductases B3 is associated with poor prognosis in gastric cancer.
Myositis
The Protein Oxidation Repair Enzyme Methionine Sulfoxide Reductase A Modulates A? Aggregation and Toxicity In Vivo.
Myositis, Inclusion Body
The Protein Oxidation Repair Enzyme Methionine Sulfoxide Reductase A Modulates A? Aggregation and Toxicity In Vivo.
Neoplasm Metastasis
Identification of Key Gene and Pathways for the Prediction of Peritoneal Metastasis of Gastric Cancer by Co-expression Analysis.
Neoplasm Metastasis
Increased expression of methionine sulfoxide reductases B3 is associated with poor prognosis in gastric cancer.
Neoplasms
DNA methylation by dimethyl sulfoxide and methionine sulfoxide triggered by hydroxyl radical and implications for epigenetic modifications.
Neoplasms
Down-regulation of MsrB3 induces cancer cell apoptosis through reactive oxygen species production and intrinsic mitochondrial pathway activation.
Neoplasms
Genetic regulation of longevity and age-associated diseases through the methionine sulfoxide reductase system.
Neoplasms
Increased expression of methionine sulfoxide reductases B3 is associated with poor prognosis in gastric cancer.
Neoplasms
Methionine Sulfoxide Reductase B1 Regulates Hepatocellular Carcinoma Cell Proliferation and Invasion via the Mitogen-Activated Protein Kinase Pathway and Epithelial-Mesenchymal Transition.
Neoplasms
Methionine sulfoxide reductase B1 regulates proliferation and invasion by affecting mitogen-activated protein kinase pathway and epithelial-mesenchymal transition in u2os cells.
Neoplasms
MsrB3 deficiency induces cancer cell apoptosis through p53-independent and ER stress-dependent pathways.
Neoplasms
MSRB3 promotes the progression of clear cell renal cell carcinoma via regulating endoplasmic reticulum stress.
Nervous System Diseases
Dopamine D2 receptor function is compromised in the brain of the methionine sulfoxide reductase A knockout mouse.
Neurodegenerative Diseases
Age-associated neurodegeneration and oxidative damage to lipids, proteins and DNA.
Neurodegenerative Diseases
Genetic regulation of longevity and age-associated diseases through the methionine sulfoxide reductase system.
Obesity
12q14 microduplication: a new clinical entity reciprocal to the microdeletion syndrome?
Obesity
Obesity reduces methionine sulphoxide reductase activity in visceral adipose tissue.
Parkinson Disease
Mitochondrial MsrB2 serves as a switch and transducer for mitophagy.
peptide-methionine (r)-s-oxide reductase deficiency
Down-regulation of MsrB3 induces cancer cell apoptosis through reactive oxygen species production and intrinsic mitochondrial pathway activation.
peptide-methionine (r)-s-oxide reductase deficiency
In Vivo Effects of Methionine Sulfoxide Reductase Deficiency in Drosophila melanogaster.
peptide-methionine (r)-s-oxide reductase deficiency
Metabolic studies in older mentally retarded patients: significance of metabolic testing and correlation with the clinical phenotype.
peptide-methionine (r)-s-oxide reductase deficiency
Methionine Sulfoxide Reductase A, B1 and B2 Are Likely to Be Involved in the Protection against Oxidative Stress in the Inner Ear.
peptide-methionine (r)-s-oxide reductase deficiency
Methionine sulfoxide reductase B1 deficiency does not increase high-fat diet-induced insulin resistance in mice.
peptide-methionine (r)-s-oxide reductase deficiency
Methionine sulfoxide reductase B3 deficiency causes hearing loss due to stereocilia degeneration and apoptotic cell death in cochlear hair cells.
peptide-methionine (r)-s-oxide reductase deficiency
Methionine sulfoxide reductase B3 deficiency inhibits cell growth through the activation of p53-p21 and p27 pathways.
peptide-methionine (r)-s-oxide reductase deficiency
Methionine sulfoxide reductase B3 deficiency inhibits the development of diet-induced insulin resistance in mice.
peptide-methionine (r)-s-oxide reductase deficiency
Methionine sulfoxide reductase B3 deficiency stimulates heme oxygenase-1 expression via ROS-dependent and Nrf2 activation pathways.
peptide-methionine (r)-s-oxide reductase deficiency
Methionine Sulfoxide Reductase B3-Targeted In Utero Gene Therapy Rescues Hearing Function in a Mouse Model of Congenital Sensorineural Hearing Loss.
peptide-methionine (r)-s-oxide reductase deficiency
MsrB1 (methionine-R-sulfoxide reductase 1) knock-out mice: roles of MsrB1 in redox regulation and identification of a novel selenoprotein form.
peptide-methionine (r)-s-oxide reductase deficiency
MsrB3 deficiency induces cancer cell apoptosis through p53-independent and ER stress-dependent pathways.
peptide-methionine (r)-s-oxide reductase deficiency
Reaction mechanism, evolutionary analysis, and role of zinc in Drosophila methionine-R-sulfoxide reductase.
peptide-methionine (r)-s-oxide reductase deficiency
Selenoprotein MsrB1 deficiency exacerbates acetaminophen-induced hepatotoxicity via increased oxidative damage.
Starvation
Analyses of fruit flies that do not express selenoproteins or express the mouse selenoprotein, methionine sulfoxide reductase b1, reveal a role of selenoproteins in stress resistance.
Stillbirth
Genome-wide association analysis uncovers variants for reproductive variation across dog breeds and links to domestication.
Stomach Neoplasms
Identification of Key Gene and Pathways for the Prediction of Peritoneal Metastasis of Gastric Cancer by Co-expression Analysis.
Stroke
Methionine Sulfoxide Reductase-B3 Risk Allele Implicated in Alzheimer's Disease Associates with Increased Odds for Brain Infarcts.
Tuberculosis
Peptide methionine sulfoxide reductase from Escherichia coli and Mycobacterium tuberculosis protects bacteria against oxidative damage from reactive nitrogen intermediates.
Tularemia
Contribution of methionine sulfoxide reductase B (MsrB) to Francisella tularensis infection in mice.
Uterine Cervical Neoplasms
A three-gene novel predictor for improving the prognosis of cervical cancer.
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Moskovitz, J.; Poston, J.M.; Berlett, B.S.; Nosworthy, N.J.; Szczepanowski, R.; Stadtman, E.R.
Identification and characterization of a putative active site for peptide methionine sulfoxide reductase (MsrA) and its substrate stereospecificity
J. Biol. Chem.
275
14167-14172
2000
Homo sapiens
brenda
Weissbach, H.; Resnick, L.; Brot, N.
Methionine sulfoxide reductases: history and cellular role in protecting against oxidative damage
Biochim. Biophys. Acta
1703
203-212
2005
Bos taurus, Escherichia coli, Haemophilus influenzae, Helicobacter pylori, Homo sapiens, Mus musculus, Neisseria gonorrhoeae, Neisseria meningitidis, Saccharomyces cerevisiae, Streptococcus gordonii, Streptococcus gordonii (Q9LAM9), Streptococcus pneumoniae
brenda
Moskovitz, J.
Methionine sulfoxide reductases: ubiquitous enzymes involved in antioxidant defense, protein regulation, and prevention of aging-associated diseases
Biochim. Biophys. Acta
1703
213-219
2005
Arabidopsis thaliana, Saccharomyces cerevisiae, Escherichia coli, Homo sapiens, Staphylococcus aureus, Mus musculus, Sus scrofa
brenda
Petropoulos, I.; Friguet, B.
Protein maintenance in aging and replicative senescence: a role for the peptide methionine sulfoxide reductases
Biochim. Biophys. Acta
1703
261-266
2005
Saccharomyces cerevisiae, Drosophila melanogaster, Escherichia coli, Homo sapiens, Rattus norvegicus
brenda
Jung, S.; Hansel, A.; Kasperczyk, H.; Hoshi, T.; Heinemann, S.H.
Activity, tissue distribution and site-directed mutagenesis of a human peptide methionine sulfoxide reductase of type B: hCBS1
FEBS Lett.
527
91-94
2002
Homo sapiens
brenda
Picot, C.R.; Perichon, M.; Cintrat, J.C.; Friguet, B.; Petropoulos, I.
The peptide methionine sulfoxide reductases, MsrA and MsrB (hCBS-1), are downregulated during replicative senescence of human WI-38 fibroblasts
FEBS Lett.
558
74-78
2004
Homo sapiens
brenda
Vougier, S.; Mary, J.; Dautin, N.; Vinh, J.; Friguet, B.; Ladant, D.
Essential role of methionine residues in calmodulin binding to Bordetelle pertussis adenylate cyclase, as probed by selective oxidation and repair by the peptide methionine sulfoxide reductases
J. Biol. Chem.
279
30210-30218
2004
Homo sapiens
brenda
Lowther, W.T.; Weissbach, H.; Etienne, F.; Brot, N.; Matthews, B.W.
The mirrored methionine sulfoxide reductases of Neisseria gonorrhoeae pilB
Nat. Struct. Biol.
9
348-352
2002
Escherichia coli (P0A746), Neisseria gonorrhoeae (P14930), Neisseria gonorrhoeae, Homo sapiens (Q9Y3D2)
brenda
Schallreuter, K.U.; Rubsam, K.; Chavan, B.; Zothner, C.; Gillbro, J.M.; Spencer, J.D.; Wood, J.M.
Functioning methionine sulfoxide reductases A and B are present in human epidermal melanocytes in the cytosol and in the nucleus
Biochem. Biophys. Res. Commun.
342
145-152
2006
Homo sapiens
brenda
Moskovitz, J.
Roles of methionine suldfoxide reductases in antioxidant defense, protein regulation and survival
Curr. Pharm. Des.
11
1451-1457
2005
Arabidopsis thaliana, Saccharomyces cerevisiae, Homo sapiens, Mus musculus
brenda
Marchetti Maria, A.; Pizarro Gresin, O.; Sagher, D.; Deamicis, C.; Brot, N.; Hejtmancik, J.F.; Weissbach, H.; Kantorow, M.
Methionine sulfoxide reductases B1, B2, and B3 are present in the human lens and confer oxidative stress resistance to lens cells
Invest. Ophthalmol. Vis. Sci.
46
2107-2112
2005
Homo sapiens
brenda
Kim, H.Y.; Gladyshev, V.N.
Different catalytic mechanisms in mammalian selenocysteine- and cysteine-containing methionine-R-sulfoxide reductases
PLoS Biol.
3
2080-2089
2005
Homo sapiens, Mus musculus
-
brenda
Sagher, D.; Brunell, D.; Hejtmancik, J.F.; Kantorow, M.; Brot, N.; Weissbach, H.
Thionein can serve as a reducing agent for the methionine sulfoxide reductases
Proc. Natl. Acad. Sci. USA
103
8656-8661
2006
Escherichia coli, Homo sapiens
brenda
Cabreiro, F.; Picot, C.R.; Perichon, M.; Friguet, B.; Petropoulos, I.
Overexpression of methionine sulfoxide reductases A and B2 protects MOLT-4 cells against zinc-induced oxidative stress
Antioxid. Redox Signal.
11
215-225
2009
Homo sapiens (Q9Y3D2)
brenda
Kim, H.Y.; Kim, J.R.
Thioredoxin as a reducing agent for mammalian methionine sulfoxide reductases B lacking resolving cysteine
Biochem. Biophys. Res. Commun.
371
490-494
2008
Mus musculus (Q78J03), Homo sapiens (Q8IXL7)
brenda
Kim, H.Y.; Gladyshev, V.N.
Methionine sulfoxide reductases: selenoprotein forms and roles in antioxidant protein repair in mammals
Biochem. J.
407
321-329
2007
Drosophila melanogaster, Neisseria meningitidis, Bacillus subtilis (P54155), Mus musculus (Q8BU85), Homo sapiens (Q8IXL7)
brenda
De Luca, A.; Sacchetta, P.; Nieddu, M.; Di Ilio, C.; Favaloro, B.
Important roles of multiple Sp1 binding sites and epigenetic modifications in the regulation of the methionine sulfoxide reductase B1 (MsrB1) promoter
BMC Mol. Biol.
8
39
2007
Homo sapiens (Q9NZV6), Homo sapiens
brenda
Picot, C.R.; Moreau, M.; Juan, M.; Noblesse, E.; Nizard, C.; Petropoulos, I.; Friguet, B.
Impairment of methionine sulfoxide reductase during UV irradiation and photoaging
Exp. Gerontol.
42
859-863
2007
Homo sapiens (Q8IXL7), Homo sapiens (Q9Y3D2), Homo sapiens
brenda
Cabreiro, F.; Picot, C.R.; Perichon, M.; Castel, J.; Friguet, B.; Petropoulos, I.
Overexpression of mitochondrial methionine sulfoxide reductase B2 protects leukemia cells from oxidative stress-induced cell death and protein damage
J. Biol. Chem.
283
16673-16681
2008
Homo sapiens (Q9Y3D2)
brenda
Schallreuter, K.U.; Ruebsam, K.; Gibbons, N.C.; Maitland, D.J.; Chavan, B.; Zothner, C.; Rokos, H.; Wood, J.M.
Methionine sulfoxide reductases A and B are deactivated by hydrogen peroxide (H2O2) in the epidermis of patients with vitiligo
J. Invest. Dermatol.
128
808-815
2008
Homo sapiens (Q9NZV6), Homo sapiens
brenda
Binger, K.J.; Griffin, M.D.; Heinemann, S.H.; Howlett, G.J.
Methionine-oxidized amyloid fibrils are poor substrates for human methionine sulfoxide reductases A and B2
Biochemistry
49
2981-2983
2010
Homo sapiens
brenda
Pascual, I.; Larrayoz, I.M.; Campos, M.M.; Rodriguez, I.R.
Methionine sulfoxide reductase B2 is highly expressed in the retina and protects retinal pigmented epithelium cells from oxidative damage
Exp. Eye Res.
90
420-428
2010
Homo sapiens, Macaca mulatta
brenda
Lim, D.H.; Han, J.Y.; Kim, J.R.; Lee, Y.S.; Kim, H.Y.
Methionine sulfoxide reductase B in the endoplasmic reticulum is critical for stress resistance and aging in Drosophila
Biochem. Biophys. Res. Commun.
419
20-26
2012
Homo sapiens
brenda
Kwak, G.H.; Lim, D.H.; Han, J.Y.; Lee, Y.S.; Kim, H.Y.
Methionine sulfoxide reductase B3 protects from endoplasmic reticulum stress in Drosophila and in mammalian cells
Biochem. Biophys. Res. Commun.
420
130-135
2012
Homo sapiens
brenda
Javitt, G.; Cao, Z.; Resnick, E.; Gabizon, R.; Bulleid, N.J.; Fass, D.
Structure and electron-transfer pathway of the human methionine sulfoxide reductase MsrB3
Antioxid. Redox Signal.
33
665-678
2020
Homo sapiens (Q8IXL7), Homo sapiens
brenda
Lourenco Dos Santos, S.; Petropoulos, I.; Friguet, B.
The oxidized protein repair enzymes methionine sulfoxide reductases and their roles in protecting against oxidative stress, in ageing and in regulating protein function
Antioxidants (Basel)
7
191
2018
Homo sapiens (Q8IXL7), Homo sapiens (Q9NZV6)
brenda
Cao, Z.; Mitchell, L.; Hsia, O.; Scarpa, M.; Caldwell, S.T.; Alfred, A.D.; Gennaris, A.; Collet, J.F.; Hartley, R.C.; Bulleid, N.J.
Methionine sulfoxide reductase B3 requires resolving cysteine residues for full activity and can act as a stereospecific methionine oxidase
Biochem. J.
475
827-838
2018
Homo sapiens (Q8IXL7)
brenda
He, Q.; Li, H.; Meng, F.; Sun, X.; Feng, X.; Chen, J.; Li, L.; Liu, J.
Methionine sulfoxide reductase B1 regulates hepatocellular carcinoma cell proliferation and invasion via the mitogen-activated protein kinase pathway and epithelial-mesenchymal transition
Oxid. Med. Cell. Longev.
2018
5287971
2018
Homo sapiens (Q9NZV6), Homo sapiens
brenda