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Literature summary for 1.8.4.12 extracted from
- Thioredoxin as a reducing agent for mammalian methionine sulfoxide reductases B lacking resolving cysteine (2008), Biochem. Biophys. Res. Commun., 371, 490-494.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q8IXL7 | - |
- |
| Homo sapiens | Q8IXL7 | overexpressed in Escherichia coli BL21 | - |
| Mus musculus | Q78J03 | - |
- |
| Mus musculus | Q78J03 | overexpressed in Escherichia coli BL21 | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.071 | - |
substrate: cytosolic human thioredoxin 1 | Homo sapiens |
| 0.106 | - |
substrate: cytosolic human thioredoxin 1 | Mus musculus |
| 0.12 | - |
substrate: Escherichia coli thioredoxin | Homo sapiens |
| 0.128 | - |
substrate: mitochondrial rat thioredoxin 2 lacking a mitochondrial signal peptid | Mus musculus |
| 0.142 | - |
substrate: Escherichia coli thioredoxin | Mus musculus |
| 0.173 | - |
substrate: mitochondrial rat thioredoxin 2 lacking a mitochondrial signal peptid | Homo sapiens |
| 0.179 | - |
substrate: dithiothreitol | Homo sapiens |
| 0.291 | - |
substrate: dithiothreitol | Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dabsyl L-methionine (R)-sulfoxide + thioredoxin | cytosolic human thioredoxin 1, mitochondrial rat thioredoxin 2 lacking a mitochondrial signal peptide or Escherichia coli thioredoxin | Mus musculus | dabsyl L-methionine + thioredoxin disulfide + H2O | - |
? |  |
| dabsyl L-methionine (R)-sulfoxide + thioredoxin | cytosolic human thioredoxin 1, mitochondrial rat thioredoxin 2 lacking a mitochondrial signal peptide or Escherichia coli thioredoxin | Homo sapiens | dabsyl L-methionine + thioredoxin disulfide + H2O | - |
? | |
| dabsyl-L-methionine (R)-sulfoxide + dithiothreitol | - |
Mus musculus | dabsyl-L-methionine + dithiothreitol disulfide + H2O | - |
? | |
| dabsyl-L-methionine (R)-sulfoxide + dithiothreitol | - |
Homo sapiens | dabsyl-L-methionine + dithiothreitol disulfide + H2O | - |
? | |
| dabsyl-L-methionine (R)-sulfoxide + thioredoxin | rTrx2 physically interacts with oxidized MsrB2 through a disulfide bond | Mus musculus | dabsyl-L-methionine + thioredoxin disulfide + H2O | - |
? | |
| dabsyl-L-methionine (R)-sulfoxide + thioredoxin | rTrx2 physically interacts with oxidized MsrB2 through a disulfide bond. Thioredoxin- and dithiothreitol-dependent activities are approximately equal | Homo sapiens | dabsyl-L-methionine + thioredoxin disulfide + H2O | - |
? | |
| dabsyl-L-methionine-(R)-S-oxide + dithiothreitol | - |
Mus musculus | dabsyl-L-methionine + DTT disulfide + H2O | - |
? | |
| dabsyl-L-methionine-(R)-S-oxide + dithiothreitol | - |
Homo sapiens | dabsyl-L-methionine + DTT disulfide + H2O | - |
? | |
| additional information | MsrB3 physically interacts with the sulfenic acid intermediate of these oxidized enzymes to directly form an intermolecular disulfide bond | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| methionine sulfoxide reductases B | - |
Mus musculus |
| methionine sulfoxide reductases B | - |
Homo sapiens |
| More | possibly 1.8.4.B3 | Homo sapiens |
| More | possibly EC 1.8.4.B3 | Mus musculus |
| MsrB2 | - |
Mus musculus |
| MsrB3 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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