Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Reference on EC 1.5.3.6 - (R)-6-hydroxynicotine oxidase

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Schenk, S.; Hoelz, A.; Krauss, B.; Decker, K.
Gene structures and properties of enzymes of the plasmid-encoded nicotine catabolism of Arthrobacter nicotinovorans
J. Mol. Biol.
284
1323-1339
1998
BRENDA: Paenarthrobacter nicotinovorans
Textmining: Escherichia coli, bacterium
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Grether-Beck, S.; Igloi, G.L.; Pust, S.; Schilz, E.; Decker, K.; Brandsch, R.
Structural analysis and molybdenum-dependent expression of the pAO1-encoded nicotine dehydrogenase genes of Arthrobacter nicotinovorans
Mol. Microbiol.
13
929-936
1994
Paenarthrobacter nicotinovorans
Manually annotated by BRENDA team
Brandsch, R.; Hinkkanen, A.E.; Mauch, L.; Nagursky, H.; Decker, K.
6-Hydroxy-D-nicotine oxidase of Arthrobacter oxidans. Gene structure of the flavoenzyme and its relationship to 6-hydroxy-L-nicotine oxidase
Eur. J. Biochem.
167
315-320
1987
BRENDA: Paenarthrobacter nicotinovorans
Textmining: Pseudarthrobacter oxydans
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Swafford, J.R.; Reeves, H.C.; Brandsch, R.
Localization of the enantiozymes of 6-hydroxy-nicotine oxidase in Arthrobacter oxidans by electron immunochemistry
J. Bacteriol.
163
792-795
1985
BRENDA: Paenarthrobacter nicotinovorans
Textmining: Pseudarthrobacter oxydans, Electron
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Hinkkanen, A.; Lilius, E.M.; Nowack, J.; Maas, R.; Decker, K.
Purification of the flavoproteins 6-hydroxy-D- and 6-hydroxy-L-nicotine oxidase using hydrophobic affinity chromatography
Hoppe-Seyler's Z. Physiol. Chem.
364
801-806
1983
Paenarthrobacter nicotinovorans
Manually annotated by BRENDA team
Decker, K.; Dai, V.D.; Mhler, H.; Bruhmuller, M.
D- and L-6-hydroxynicotine oxidase, enantioenzymes of Arthrobacter oxidans
Z. Naturforsch. B
27
1072-1073
1972
Paenarthrobacter nicotinovorans
Manually annotated by BRENDA team
Dai, V.D.; Decker, K.; Sund, H.
Purification and properties of L-6-hydroxynicotine oxidase
Eur. J. Biochem.
4
95-102
1968
Paenarthrobacter nicotinovorans
Manually annotated by BRENDA team
Decker, K.; Dai, V.D.
Mechanism and specifcity of L- and D-6-hydroxynicotine oxidase
Eur. J. Biochem.
3
132-138
1967
Paenarthrobacter nicotinovorans
Manually annotated by BRENDA team
Decker, K.; Bleeg, H.
Induction and purification of stereospecific nicotine oxidizing enzymes from Arthrobacter oxidans
Biochim. Biophys. Acta
105
313-324
1965
Paenarthrobacter nicotinovorans
Manually annotated by BRENDA team
Schenk, S.; Decker, K.
Horizontal gene transfer involved in the convergent evolution of the plasmid-encoded enantioselective 6-hydroxynicotine oxidases
J. Mol. Evol.
48
178-186
1999
BRENDA: Paenarthrobacter nicotinovorans
Textmining: Bacteria, Arthrobacter, Mycobacterium tuberculosis, Streptomyces lavendulae, Aspergillus niger, Oncorhynchus mykiss, Homo sapiens, bacterium
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Stoltz, M.; Brandsch, R.
The conformational change induced by FAD in covalently flavinylated 6-hydroxy-D-nicotine oxidase does not require (8alpha)FAD(N3)histidyl bond formation
J. Biochem.
123
445-449
1998
Paenarthrobacter nicotinovorans
Manually annotated by BRENDA team
Stoltz, M.; Rassow, J.; Bueckmann, A.F.; Brandsch, R.
Covalent attachment of FAD derivatives to a fusion protein consisting of 6-hydroxy-D-nicotine oxidase and a mitochondrial presequence. Folding, enzyme activity, and import of the modified protein into yeast mitochondria
J. Biol. Chem.
271
25208-25212
1996
BRENDA: Paenarthrobacter nicotinovorans
Textmining: Saccharomyces cerevisiae, insertion sequences, Neurospora crassa, Oryctolagus cuniculus
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Stoltz, M.; Henninger, H.P.; Brandsch, R.
The design of an alternative, covalently flavinylated 6-hydroxy-D-nicotine oxidase by replacing the FAD-binding histidine by cysteine and reconstitution of the holoenzyme with 8-(methylsulfonyl)FAD
FEBS Lett.
386
194-196
1996
Paenarthrobacter nicotinovorans
Manually annotated by BRENDA team
Stoltz, M.; Rysavy, P.; Kalousek, F.; Brandsch, R.
Folding, flavinylation, and mitochondrial import of 6-hydroxy-D-nicotine oxidase fused to the presequence of rat dimethylglycine dehydrogenase
J. Biol. Chem.
270
8016-8022
1995
BRENDA: Paenarthrobacter nicotinovorans
Textmining: Rattus, Oryctolagus cuniculus
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Brandsch, R.; Bichler, V.; Mauch, L.; Decker, K.
Cysteine to serine replacements in 6-hydroxy-D-nicotine oxidase. Consequences for enzyme activity, cofactor incorporation, and formation of high molecular weight protein complexes with molecular chaperones (GroEL)
J. Biol. Chem.
268
12724-12729
1993
Paenarthrobacter nicotinovorans
Manually annotated by BRENDA team
Brandsch, R.; Bichler, V.; Schmidt, M.; Buchner, J.
GroE dependence of refolding and holoenzyme formation of 6-hydroxy-D-nicotine oxidase
J. Biol. Chem.
267
20844-20849
1992
BRENDA: Paenarthrobacter nicotinovorans
Textmining: Escherichia coli
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Brandsch, R.; Bichler, V.
Autoflavinylation of apo6-hydroxy-D-nicotine oxidase
J. Biol. Chem.
266
19056-19062
1991
BRENDA: Paenarthrobacter nicotinovorans
Textmining: Escherichia coli JM109
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Mauch, L.; Bichler, V.; Brandsch, R.
Lysine can replace arginine 67 in the mediation of covalent attachment of FAD to histidine 71 of 6-hydroxy-D-nicotine oxidase
J. Biol. Chem.
265
12761-12762
1990
BRENDA: Paenarthrobacter nicotinovorans
Textmining: Escherichia coli
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Brandsch, R.; Bichler, V.; Krauss, B.
Binding of FAD to 6-hydroxy-D-nicotine oxidase apoenzyme prevents degradation of the holoenzyme
Biochem. J.
258
187-192
1989
BRENDA: Paenarthrobacter nicotinovorans
Textmining: Escherichia coli, Pseudarthrobacter oxydans
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Brandsch, R.; Bichler, V.
Covalent cofactor binding to flavoenzymes requires specific effectors
Eur. J. Biochem.
182
125-128
1989
BRENDA: Paenarthrobacter nicotinovorans
Textmining: Escherichia coli, Pseudarthrobacter oxydans
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Brandsch, R.; Faller, W.; Schneider, K.
Plasmid pAO1 of Arthrobacter oxidans encodes 6-hydroxy-D-nicotine oxidase: cloning and expression of the gene in Escherichia coli
Mol. Gen. Genet.
202
96-101
1986
BRENDA: Paenarthrobacter nicotinovorans
Textmining: Escherichia coli, Pseudarthrobacter oxydans, Expression vector pKK223-3
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Brandsch, R.; Bichler, V.
In vivo and in vitro expression of the 6-hydroxy-D-nicotine oxidase gene of Arthrobacter oxidans, cloned into Escherichia coli, as an enzymatically active, covalently flavinylated polypeptide
FEBS Lett.
192
204-208
1985
BRENDA: Paenarthrobacter nicotinovorans
Textmining: Escherichia coli, Pseudarthrobacter oxydans, Expression vector pKK223-3, Ursidae
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Decker, K.
Structure and synthesis of a flavoprotein with covalently bound FAD
Trends Biochem. Sci.
1
184-185
1976
Paenarthrobacter nicotinovorans
-
Manually annotated by BRENDA team
Bruhmuller, M.; Mhler, H.; Decker, K.
Covalently bound flavin in D-6-hydroxynicotine oxidase from Arthrobacter oxidans. Purification and properties of D-6-hydroxynicotine oxidase
Eur. J. Biochem.
29
143-151
1972
BRENDA: Paenarthrobacter nicotinovorans
Textmining: Pseudarthrobacter oxydans
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Mhler, H.; Bruhmuller, M.; Decker, K.
Covalently bound flavin in D-6-hydroxynicotine oxidase from Arthrobacter oxidans. Identification of the 8 -(N-3-histidyl)-riboflavin-linkage between FAD and apoenzyme
Eur. J. Biochem.
29
152-155
1972
BRENDA: Paenarthrobacter nicotinovorans
Textmining: Pseudarthrobacter oxydans
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Sandu, C.; Chiribau, C.B.; Brandsch, R.
Characterization of HdnoR, the transcriptional repressor of the 6-hydroxy-D-nicotine oxidase gene of Arthrobacter nicotinovorans pAO1, and its DNA-binding activity in response to L- and D-nicotine Derivatives
J. Biol. Chem.
278
51307-51315
2003
Paenarthrobacter nicotinovorans, Paenarthrobacter nicotinovorans (Q59127), Paenarthrobacter nicotinovorans (Q59128), Paenarthrobacter nicotinovorans (Q59129), Bacteria
Automatic Mining of ENzyme DAta
Koetter, J.W.; Schulz, G.E.
Crystal structure of 6-hydroxy-D-nicotine oxidase from Arthrobacter nicotinovorans
J. Mol. Biol.
352
418-428
2005
Paenarthrobacter nicotinovorans
Manually annotated by BRENDA team
Kachalova, G.S.; Bourenkov, G.P.; Mengesdorf, T.; Schenk, S.; Maun, H.R.; Burghammer, M.; Riekel, C.; Decker, K.; Bartunik, H.D.
Crystal structure analysis of free and substrate-bound 6-hydroxy-L-nicotine oxidase from Arthrobacter nicotinovorans
J. Mol. Biol.
396
785-799
2010
Paenarthrobacter nicotinovorans
Manually annotated by BRENDA team
Fitzpatrick, P.F.; Dougherty, V.; Subedi, B.; Quilantan, J.; Hinck, C.S.; Lujan, A.I.; Tormos, J.R.
Mechanism of the flavoprotein D-6-hydroxynicotine oxidase Substrate specificity, pH and solvent isotope effects, and roles of key active-site residues
Biochemistry
58
2534-2541
2019
Paenarthrobacter nicotinovorans (Q8GAG1)
Manually annotated by BRENDA team
Brandsch, R; Decker, K
The effect of gyrase inhibitors and cyclic AMP on induction and glucose repression of the 6-hydroxy-nicotine oxidases in Arthrobacter oxidans.
Arch Microbiol
133
274-7
1982
Pseudarthrobacter oxydans, Escherichia coli
Automatic Mining of ENzyme DAta
Reeves, HC; Messmer, L; Decker, K
Induction of D-6-hydroxynicotine oxidase in resting cells of Arthrobacter oxidans.
Arch Microbiol
111
111-5
1976
Pseudarthrobacter oxydans
Automatic Mining of ENzyme DAta
Bernauer, H; Mauch, L; Brandsch, R
Interaction of the regulatory protein NicR1 with the promoter region of the pAO1-encoded 6-hydroxy-D-nicotine oxidase gene of Arthrobacter oxidans.
Mol Microbiol
6
1809-20
1992
Pseudarthrobacter oxydans, Escherichia coli, bacterium
Automatic Mining of ENzyme DAta
Mauch, L; Bichler, V; Brandsch, R
Functional analysis of the 5' regulatory region and the UUG translation initiation codon of the Arthrobacter oxidans 6-hydroxy-D-nicotine oxidase gene.
Mol Gen Genet
221
427-34
1990
Pseudarthrobacter oxydans, Escherichia coli, Bacillus subtilis
Automatic Mining of ENzyme DAta
Brühmüller, M; Möhler, H; Decker, K
Covalently bound flavin in D-6-hydroxynicotine oxidase from Arthrobacter oxidans.
Z Naturforsch [B]
27
1073-4
1972
Pseudarthrobacter oxydans
Automatic Mining of ENzyme DAta
Brühmüller, M; Decker, K
Covalently bound flavin in D-6-hydroxynicotine oxidase from Arthrobacter oxidans. Amino-acid sequence of the FAD-peptide.
Eur J Biochem
37
256-8
1973
Pseudarthrobacter oxydans
Automatic Mining of ENzyme DAta
Stähle, I; Brizzio, C; Barile, M; Brandsch, R
Anti-mitochondrial flavoprotein autoantibodies of patients with myocarditis and dilated cardiomyopathy (anti-M7): interaction with flavin-carrying proteins, effect of vitamin B2 and epitope mapping.
Clin Exp Immunol
115
404-8
1999
Oryctolagus cuniculus, Metazoa
Automatic Mining of ENzyme DAta
Otto, A; Stähle, I; Klein, R; Berg, PA; Pankuweit, S; Brandsch, R
Anti-mitochondrial antibodies in patients with dilated cardiomyopathy (anti-M7) are directed against flavoenzymes with covalently bound FAD.
Clin Exp Immunol
111
541-7
1998
Oryctolagus cuniculus
Automatic Mining of ENzyme DAta
Cicek, G; Vuorinen, T; Stähle, I; Stepanek, P; Freudenberg, N; Brandsch, R
Coxsackievirus B3 infection induces anti-flavoprotein antibodies in mice.
Clin Exp Immunol
122
404-9
2000
Mus sp., Coxsackievirus B3, Homo sapiens, enterovirus
Automatic Mining of ENzyme DAta
Hamm, HH; Decker, K
Regulation of flavoprotein synthesis studied in vivo in a riboflavin-requiring mutant of Arthrobacter oxidans.
Arch Microbiol
119
65-70
1978
Pseudarthrobacter oxydans
Automatic Mining of ENzyme DAta
Brandsch, R; Bichler, V
Riboflavin-dependent expression of flavoenzymes of the nicotine regulon of Arthrobacter oxidans.
Biochem J
270
673-8
1990
Pseudarthrobacter oxydans
Automatic Mining of ENzyme DAta
Brühmüller, M; Schimz, A; Messmer, L; Decker, K
Covalently bound FAD in d-6-hydroxynicotine oxidase. Immunological studies of D- and L-6-hydroxynicotine oxidase: evidence for a D-enzyme precursor.
J Biol Chem
250
7747-51
1975
Pseudarthrobacter oxydans
Automatic Mining of ENzyme DAta
Hamm, HH; Decker, K
FAD is covalently attached to peptidyl-tRNA during cell-free synthesis of 6-hydroxy-D-nicotine oxidase.
Eur J Biochem
92
449-54
1978
Clostridium kluyveri, Pseudarthrobacter oxydans
Automatic Mining of ENzyme DAta
Brandsch, R; Bichler, V; Nagursky, H
Covalent flavinylation of 6-hydroxy-D-nicotine oxidase analyzed by partial deletions of the gene.
Eur J Biochem
165
559-64
1987
Pseudarthrobacter oxydans, Escherichia, plasmids
Automatic Mining of ENzyme DAta
Nagursky, H; Bichler, V; Brandsch, R
Phosphoenolpyruvate-dependent flavinylation of 6-hydroxy-D-nicotine oxidase.
Eur J Biochem
177
319-25
1988
Escherichia coli
Automatic Mining of ENzyme DAta
Brandsch, R; Bichler, V
Covalent flavinylation of 6-hydroxy-D-nicotine oxidase involves an energy-requiring process.
FEBS Lett
224
121-4
1987
Escherichia coli
Automatic Mining of ENzyme DAta
Brandsch, R; Bichler, V
Studies in vitro on the flavinylation of 6-hydroxy-D-nicotine oxidase.
Eur J Biochem
160
285-9
1986
Escherichia coli, Pseudarthrobacter oxydans
Automatic Mining of ENzyme DAta
Hinkkanen, A; Maly, FE; Decker, K
Quantitation of immunoadsorbed flavoprotein oxidases by luminol-mediated chemiluminescence.
Hoppe Seylers Z Physiol Chem
364
407-12
1983
Escherichia coli, Arthrobacter
Automatic Mining of ENzyme DAta
Hamm, HH; Decker, K
Cell-free synthesis of a flavoprotein containing the 8 alpha-(N3-histidyl)-riboflavin linkage.
Eur J Biochem
104
391-5
1980
Escherichia coli, Pseudarthrobacter oxydans
Automatic Mining of ENzyme DAta