Reference on EC 1.5.1.3 - dihydrofolate reductase and Organism(s) Plasmodium falciparum and UniProt Accession P13922
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Reyes, P.; Rathod, P.K.
Dihydrofolate reductase: a coupled radiometric assay
Methods Enzymol.
122
360-367
1986
Bos taurus, Plasmodium falciparum
Sirawaraporn, W.; Yongkiettrakul, S.; Sirawaraporn, R.; Yuthavong, Y.; Santi, D.V.
Plasmodium falciparum: asparagine mutant at residue 108 of dihydrofolate reductase is an optimal antifolate-resistant single mutant
Exp. Parasitol.
87
245-252
1997
Plasmodium falciparum
Chitnumsub, P.; Yuvaniyama, J.; Vanichtanankul, J.; Kamchonwongpaisan, S.; Walkinshaw, M.D.; Yuthavong, Y.
Characterization, crystallization and preliminary X-ray analysis of bifunctional dihydrofolate reductase-thymidylate synthase from Plasmodium falciparum
Acta Crystallogr. Sect. D
60
780-783
2004
Plasmodium falciparum
Kamchonwongpaisan, S.; Vanichtanankul, J.; Tarnchompoo, B.; Yuvaniyama, J.; Taweechai, S.; Yuthavong, Y.
Stoichiometric selection of tight-binding inhibitors by wild-type and mutant forms of malarial (Plasmodium falciparum) dihydrofolate reductase
Anal. Chem.
77
1222-1227
2005
Homo sapiens, Plasmodium falciparum
Djaman, J.A.; Mazabraud, A.; Basco, L.
Sulfadoxine-pyrimethamine susceptibilities and analysis of the dihydrofolate reductase and dihydropteroate synthase of Plasmodium falciparum isolates from Cote d'Ivoire
Ann. Trop. Med. Parasitol.
101
103-112
2007
Plasmodium falciparum
Ahmed, A.; Das, M.K.; Dev, V.; Saifi, M.A.; Wajihullah, M.A.; Sharma, Y.D.
Quadruple mutations in dihydrofolate reductase of Plasmodium falciparum isolates from Car Nicobar Island, India
Antimicrob. Agents Chemother.
50
1546-1549
2006
Plasmodium falciparum
Japrung, D.; Chusacultanachai, S.; Yuvaniyama, J.; Wilairat, P.; Yuthavong, Y.
A simple dual selection for functionally active mutants of Plasmodium falciparum dihydrofolate reductase with improved solubility
Protein Eng. Des. Sel.
18
457-464
2005
Plasmodium falciparum (P13922), Plasmodium falciparum
Tahar, R.; Basco, L.K.
Molecular epidemiology of malaria in Cameroon. XXVII. Clinical and parasitological response to sulfadoxine-pyrimethamine treatment and Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase alleles in Cameroonian children
Acta Trop.
103
81-89
2007
Plasmodium falciparum
Raman, J.; Sharp, B.; Kleinschmidt, I.; Roper, C.; Streat, E.; Kelly, V.; Barnes, K.I.
Differential effect of regional drug pressure on dihydrofolate reductase and dihydropteroate synthetase mutations in southern Mozambique
Am. J. Trop. Med. Hyg.
78
256-261
2008
Plasmodium falciparum
Juliano, J.J.; Trottman, P.; Mwapasa, V.; Meshnick, S.R.
Detection of the dihydrofolate reductase-164L mutation in Plasmodium falciparum infections from Malawi by heteroduplex tracking assay
Am. J. Trop. Med. Hyg.
78
892-894
2008
Plasmodium falciparum
Japrung, D.; Leartsakulpanich, U.; Chusacultanachai, S.; Yuthavong, Y.
Conflicting requirements of Plasmodium falciparum dihydrofolate reductase mutations conferring resistance to pyrimethamine-WR99210 combination
Antimicrob. Agents Chemother.
51
4356-4360
2007
Plasmodium falciparum
Dasgupta, T.; Anderson, K.S.
Probing the role of parasite-specific, distant structural regions on communication and catalysis in the bifunctional thymidylate synthase-dihydrofolate reductase from Plasmodium falciparum
Biochemistry
47
1336-1345
2008
Plasmodium falciparum (P13922), Plasmodium falciparum
Kamchonwongpaisan, S.; Vanichtanankul, J.; Taweechai, S.; Chitnumsub, P.; Yuthavong, Y.
The role of tryptophan-48 in catalysis and binding of inhibitors of Plasmodium falciparum dihydrofolate reductase
Int. J. Parasitol.
37
787-793
2007
Plasmodium falciparum
Fogel, G.B.; Cheung, M.; Pittman, E.; Hecht, D.
Modeling the inhibition of quadruple mutant Plasmodium falciparum dihydrofolate reductase by pyrimethamine derivatives
J. Comput. Aided Mol. Des.
22
29-38
2008
Plasmodium falciparum
Maitarad, P.; Saparpakorn, P.; Hannongbua, S.; Kamchonwongpaisan, S.; Tarnchompoo, B.; Yuthavong, Y.
Particular interaction between pyrimethamine derivatives and quadruple mutant type dihydrofolate reductase of Plasmodium falciparum: CoMFA and quantum chemical calculations studies
J. Enzyme Inhib. Med. Chem.
24
471-479
2008
Plasmodium falciparum (P13922), Plasmodium falciparum
Fogel, G.B.; Cheung, M.; Pittman, E.; Hecht, D.
In silico screening against wild-type and mutant Plasmodium falciparum dihydrofolate reductase
J. Mol. Graph. Model.
26
1145-1152
2008
Plasmodium falciparum (P13922), Plasmodium falciparum
A-Elbasit, I.E.; Alifrangis, M.; Khalil, I.F.; Bygbjerg, I.C.; Masuadi, E.M.; Elbashir, M.I.; Giha, H.A.
The implication of dihydrofolate reductase and dihydropteroate synthetase gene mutations in modification of Plasmodium falciparum characteristics
Malar. J.
6
108
2007
Plasmodium falciparum
Fernandes, N.; Figueiredo, P.; do Rosario, V.E.; Cravo, P.
Analysis of sulphadoxine/pyrimethamine resistance-conferring mutations of Plasmodium falciparum from Mozambique reveals the absence of the dihydrofolate reductase 164L mutant
Malar. J.
6
35
2007
Plasmodium falciparum
Sandefur, C.I.; Wooden, J.M.; Quaye, I.K.; Sirawaraporn, W.; Sibley, C.H.
Pyrimethamine-resistant dihydrofolate reductase enzymes of Plasmodium falciparum are not enzymatically compromised in vitro
Mol. Biochem. Parasitol.
154
1-5
2007
Plasmodium falciparum
Hamel, M.J.; Poe, A.; Bloland, P.; McCollum, A.; Zhou, Z.; Shi, Y.P.; Ouma, P.; Otieno, K.; Vulule, J.; Escalante, A.; Udhayakumar, V.; Slutsker, L.
Dihydrofolate reductase I164L mutations in Plasmodium falciparum isolates: clinical outcome of 14 Kenyan adults infected with parasites harbouring the I164L mutation
Trans. R. Soc. Trop. Med. Hyg.
102
338-345
2008
Plasmodium falciparum
Adane, L.; Patel, D.S.; Bharatam, P.V.
Shape- and chemical feature-based 3D-pharmacophore model generation and virtual screening: identification of potential leads for P. falciparum DHFR enzyme inhibition
Chem. Biol. Drug Des.
75
115-126
2009
Plasmodium falciparum
Adane, L.; Bharatam, P.V.
Modelling and informatics in the analysis of P. falciparum DHFR enzyme inhibitors
Curr. Med. Chem.
15
1552-1569
2008
Plasmodium falciparum
Ojha, H.; Gahlot, P.; Tiwari, A.K.; Pathak, M.; Kakkar, R.
Quantitative Structure Activity Relationship Study of 2,4,6-Trisubstituted-s-triazine Derivatives as Antimalarial Inhibitors of Plasmodium Falciparum Dihydrofolate Reductase
Chem. Biol. Drug Des.
77
57-62
2011
Plasmodium falciparum
Carrasco, M.P.; Fotoran, W.L.; Cubillos, E.F.G.; Wunderlich, G.; Grotli, M.; Hollfelder, F.; Jackson, V.; King, R.D.; Oliver, S.G.
Plasmodium dihydrofolate reductase is a second enzyme target for the antimalarial action of triclosan
Sci. Rep.
8
1038
2018
Plasmodium falciparum, Plasmodium vivax
