Literature summary for 1.5.1.3 extracted from

Carrasco, M.P.; Fotoran, W.L.; Cubillos, E.F.G.; Wunderlich, G.; Grotli, M.; Hollfelder, F.; Jackson, V.; King, R.D.; Oliver, S.G.
Plasmodium dihydrofolate reductase is a second enzyme target for the antimalarial action of triclosan (2018), Sci. Rep., 8, 1038 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
triclosan	specifically targets both wild-type and pyrimethamine-resistant Plasmodium falciparum dihydrofolate reductases and selectively inhibits both the wild-type and pyrimethamine-resistant enzymes compared to human DHFR	Plasmodium falciparum
triclosan	specifically targets both wild-type and pyrimethamine-resistant Plasmodium vivax dihydrofolate reductases and selectively inhibits both the wild-type and pyrimethamine-resistant enzymes compared to human DHFR	Plasmodium vivax

Organism

Organism	UniProt	Comment	Textmining
Plasmodium falciparum	-	-	-
Plasmodium vivax	-	-	-

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Release 2023.1 (January 2023)