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2-hydroxyhexadecanal + NAD+ + H2O
2-hydroxyhexadecanoic acid + NADH + 2 H+
-
-
-
-
?
4,4'-diapolycopendial + NAD+ + H2O
4,4'-diapolycopen-4'-al-4-oic acid + NADH + H+
-
-
-
-
?
a long-chain aldehyde + NAD+ + H2O
a long-chain carboxylate + NADH + 2 H+
-
-
-
?
acetaldehyde + NAD+ + H2O
acetate + NADH + H+
arachidic aldehyde + NAD+ + H2O
arachidic acid + NADH
-
-
-
?
behenic aldehyde + NAD+ + H2O
behenic acid + NADH
-
-
-
?
benzaldehyde + NAD+ + H2O
benzoate + NADH + 2 H+
-
-
-
-
?
benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
betaine aldehyde + NAD+ + H2O
?
-
-
-
?
cis,cis-9,12-octadecadienal + NAD+ + H2O
cis,cis-9,12-octadecadienoic acid + NADH
cis-11-hexadecenal + NAD+ + H2O
cis-11-hexadecenoic acid + NADH + H+
-
-
-
-
?
cis-9-hexadecenal + NAD+ + H2O
cis-9-hexadecenoic acid + NADH
cis-9-octadecenal + NAD+ + H2O
cis-9-octadecenoic acid + NADH
-
-
-
?
crotonaldehyde + NAD+ + H2O
crotonic acid + NADH
-
-
-
?
decanal + NAD+ + H2O
decanoate + NADH + 2 H+
Marinobacter nauticus
-
-
-
-
?
decanal + NAD+ + H2O
decanoic acid + NADH
decanal + NAD+ + H2O
decanoic acid + NADH + H+
-
-
-
-
?
dihydrophytal + NAD+ + H2O
(3R,S,7R,11R)-3,7,11,15-tetramethylhexadecanoic acid + NADH
-
-
-
?
dodecanal + NAD+ + H2O
dodecanoate + NADH + 2 H+
Marinobacter nauticus
-
-
-
-
?
dodecanal + NAD+ + H2O
dodecanoic acid + NADH
dodecanal + NAD+ + H2O
dodecanoic acid + NADH + H+
farnesal + NAD+ + H2O
farnesoic acid + NADH + H+
-
-
-
-
?
glutaraldehyde + NAD+
glutaric acid + NADH
-
-
-
?
glyceraldehyde + NAD+ + H2O
?
-
-
-
?
heptanal + NAD+ + H2O
heptanoic acid + NADH
-
-
-
?
heptanal + NAD+ + H2O
heptanoic acid + NADH + H+
-
-
-
-
?
hexadecanal + NAD+ + H2O
hexadecanoate + NADH + 2 H+
hexadecanal + NAD+ + H2O
hexadecanoic acid + NADH
hexadecanal + NAD+ + H2O
hexadecanoic acid + NADH + H+
-
-
-
-
?
hexanal + NAD+ + H2O
?
-
-
-
?
hexanal + NAD+ + H2O
hexanoate + NADH + H+
-
-
-
?
hexanal + NAD+ + H2O
hexanoic acid + NADH + H+
50% of the activity with tetradecanal
-
-
?
long-chain aldehyde + NAD+
?
long-chain aldehyde + NAD+ + H2O
long-chain acid anion + NADH
long-chain aldehyde + NAD+ + H2O
long-chain carboxylate + NADH
m-fluorobenzaldehyde + NAD+ + H2O
m-fluorobenzoic acid + NADH + H+
-
-
-
?
m-methylbenzaldehyde + NAD+ + H2O
m-methylbenzoic acid + NADH
-
36% activity toward tetradecanal
-
?
nonanal + NAD+ + H2O
nonanoic acid + NADH + H+
-
-
-
?
o-fluorobenzaldehyde + NAD+ + H2O
o-fluorobenzoic acid + NADH + H+
-
-
-
?
octadecanal + NAD+ + H2O
octadecanoic acid + NADH
-
-
-
?
octadecanal + NAD+ + H2O
octadecanoic acid + NADH + H+
-
-
-
-
?
octadecanal + NADP+
octadecanoic acid + NADPH + H+
-
-
-
-
r
octanal + NAD+ + H2O
octanoate + NADH + H+
octanal + NAD+ + H2O
octanoic acid + NADH + H+
oleyl aldehyde + NAD+ + H2O
oleate + NADH + 2 H+
Marinobacter nauticus
-
-
-
-
?
p-chlorobenzaldehyde + NAD+ + H2O
p-chlorobenzoic acid + NADH + H+
-
-
-
?
p-cumic aldehyde + NAD+ + H2O
?
-
-
-
?
p-fluorobenzaldehyde + NAD+ + H2O
p-fluorobenzoic acid + NADH + H+
-
-
-
?
palmitoleyl aldehyde + NAD+ + H2O
palmitoleate + NADH + 2 H+
Marinobacter nauticus
-
-
-
-
?
pentadecanal + NAD+ + H2O
pentadecanoic acid + NADH
-
-
-
?
pentadecanal + NAD+ + H2O
pentadecanoic acid + NADH + 2 H+
-
-
-
-
?
phytenal + NAD+
phytenic acid + NADH
propionaldehyde + NAD+ + H2O
propionic acid + NADH
-
-
-
?
pyrenedecanal + NAD+ + H2O
pyrenedecanoic acid + NADH
retinal + NAD+ + H2O
?
-
-
-
?
tetradecanal + NAD+ + H2O
tetradecanoate + NADH + 2 H+
Marinobacter nauticus
-
-
-
-
?
tetradecanal + NAD+ + H2O
tetradecanoic acid + NADH
tetradecanal + NAD+ + H2O
tetradecanoic acid + NADH + H+
tetraeicosanal + NAD+ + H2O
tetraeicosanoic acid + NADH
-
-
-
?
trans-2-decenal + NAD+ + H2O
trans-2-decenoic acid + NADH
-
32% activity toward tetradecanal
-
?
trans-2-hexadecenal + NAD+ + H2O
trans-2-decenoic acid + NADH
-
-
-
-
?
trans-cinnamaldehyde + NAD+ + H2O
trans-cinnamic acid + NADH
-
38% activity toward tetradecanal
-
?
additional information
?
-
acetaldehyde + NAD+ + H2O
acetate + NADH + H+
-
-
-
?
acetaldehyde + NAD+ + H2O
acetate + NADH + H+
-
-
-
?
acetaldehyde + NAD+ + H2O
acetate + NADH + H+
-
-
-
?
benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
-
66% activity toward tetradecanal
-
?
benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
-
66% activity toward tetradecanal
-
?
benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
-
-
-
?
benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
-
-
-
?
benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
-
-
-
?
cis,cis-9,12-octadecadienal + NAD+ + H2O
cis,cis-9,12-octadecadienoic acid + NADH
-
-
-
?
cis,cis-9,12-octadecadienal + NAD+ + H2O
cis,cis-9,12-octadecadienoic acid + NADH
-
major substrate
-
-
?
cis,cis-9,12-octadecadienal + NAD+ + H2O
cis,cis-9,12-octadecadienoic acid + NADH
-
major substrate
-
-
?
cis,cis-9,12-octadecadienal + NAD+ + H2O
cis,cis-9,12-octadecadienoic acid + NADH
-
major substrate
-
-
?
cis-9-hexadecenal + NAD+ + H2O
cis-9-hexadecenoic acid + NADH
-
31% activity toward tetradecanal
-
?
cis-9-hexadecenal + NAD+ + H2O
cis-9-hexadecenoic acid + NADH
-
-
-
?
decanal + NAD+ + H2O
decanoic acid + NADH
-
-
-
?
decanal + NAD+ + H2O
decanoic acid + NADH
-
-
-
?
decanal + NAD+ + H2O
decanoic acid + NADH
-
-
-
?
decanal + NAD+ + H2O
decanoic acid + NADH
-
-
-
?
dodecanal + NAD+ + H2O
dodecanoic acid + NADH
-
-
-
?
dodecanal + NAD+ + H2O
dodecanoic acid + NADH
-
-
-
-
?
dodecanal + NAD+ + H2O
dodecanoic acid + NADH
-
best substrate
-
-
?
dodecanal + NAD+ + H2O
dodecanoic acid + NADH
-
best substrate
-
-
?
dodecanal + NAD+ + H2O
dodecanoic acid + NADH + H+
50% of the activity with tetradecanal
-
-
?
dodecanal + NAD+ + H2O
dodecanoic acid + NADH + H+
-
-
-
-
?
hexadecanal + NAD+ + H2O
hexadecanoate + NADH + 2 H+
Marinobacter nauticus
-
-
-
-
?
hexadecanal + NAD+ + H2O
hexadecanoate + NADH + 2 H+
-
-
-
?
hexadecanal + NAD+ + H2O
hexadecanoic acid + NADH
-
-
-
?
hexadecanal + NAD+ + H2O
hexadecanoic acid + NADH
-
high activity
-
-
?
hexadecanal + NAD+ + H2O
hexadecanoic acid + NADH
-
-
-
?
hexadecanal + NAD+ + H2O
hexadecanoic acid + NADH
-
-
-
?
long-chain aldehyde + NAD+
?
-
the enzyme plays a significant role in n-alkane utilization, especially in intracellular wax ester synthesis
-
-
?
long-chain aldehyde + NAD+
?
-
in microsomes and mitochondria: provides long-chain fatty acids to be utilized for lipid synthesis
-
-
?
long-chain aldehyde + NAD+
?
-
in peroxisomes: provides long-chain fatty acids to be degraded via beta-oxidation to yield energy and cell constituents
-
-
?
long-chain aldehyde + NAD+
?
-
-
-
-
?
long-chain aldehyde + NAD+
?
-
-
-
-
?
long-chain aldehyde + NAD+
?
-
mobilization of intracellular wax esters in the cotyledon during germination
-
-
?
long-chain aldehyde + NAD+
?
-
enzyme is a functional part of the bioluminescent system
-
-
?
long-chain aldehyde + NAD+
?
-
in microsomes and mitochondria: provides long-chain fatty acids to be utilized for lipid synthesis
-
-
?
long-chain aldehyde + NAD+
?
-
in peroxisomes: provides long-chain fatty acids to be degraded via beta-oxidation to yield energy and cell constituents
-
-
?
long-chain aldehyde + NAD+ + H2O
long-chain acid anion + NADH
-
-
-
?
long-chain aldehyde + NAD+ + H2O
long-chain acid anion + NADH
-
-
-
?
long-chain aldehyde + NAD+ + H2O
long-chain acid anion + NADH
-
-
-
?
long-chain aldehyde + NAD+ + H2O
long-chain acid anion + NADH
-
-
-
?
long-chain aldehyde + NAD+ + H2O
long-chain acid anion + NADH
-
-
-
?
long-chain aldehyde + NAD+ + H2O
long-chain acid anion + NADH
-
-
-
?
long-chain aldehyde + NAD+ + H2O
long-chain acid anion + NADH
-
-
-
-
?
long-chain aldehyde + NAD+ + H2O
long-chain acid anion + NADH
-
-
-
?
long-chain aldehyde + NAD+ + H2O
long-chain acid anion + NADH
-
-
-
?
long-chain aldehyde + NAD+ + H2O
long-chain acid anion + NADH
-
-
-
?
long-chain aldehyde + NAD+ + H2O
long-chain acid anion + NADH
-
-
-
?
long-chain aldehyde + NAD+ + H2O
long-chain acid anion + NADH
-
-
-
?
long-chain aldehyde + NAD+ + H2O
long-chain carboxylate + NADH
-
-
-
-
?
long-chain aldehyde + NAD+ + H2O
long-chain carboxylate + NADH
-
-
-
-
?
octanal + NAD+ + H2O
octanoate + NADH + H+
-
-
-
?
octanal + NAD+ + H2O
octanoate + NADH + H+
-
-
-
?
octanal + NAD+ + H2O
octanoic acid + NADH + H+
50% of the activity with tetradecanal
-
-
?
octanal + NAD+ + H2O
octanoic acid + NADH + H+
-
-
-
?
octanal + NAD+ + H2O
octanoic acid + NADH + H+
-
-
-
-
?
octanal + NAD+ + H2O
octanoic acid + NADH + H+
-
-
-
?
phytenal + NAD+
phytenic acid + NADH
-
-
-
-
?
phytenal + NAD+
phytenic acid + NADH
-
the enzyme is involved in the breakdown of phytol
-
-
?
pyrenedecanal + NAD+ + H2O
pyrenedecanoic acid + NADH
-
-
-
-
?
pyrenedecanal + NAD+ + H2O
pyrenedecanoic acid + NADH
-
-
-
-
?
pyrenedecanal + NAD+ + H2O
pyrenedecanoic acid + NADH
-
-
-
-
?
tetradecanal + NAD+ + H2O
tetradecanoic acid + NADH
-
highest activity
-
?
tetradecanal + NAD+ + H2O
tetradecanoic acid + NADH
-
highest activity
-
?
tetradecanal + NAD+ + H2O
tetradecanoic acid + NADH
-
-
-
?
tetradecanal + NAD+ + H2O
tetradecanoic acid + NADH
-
-
-
?
tetradecanal + NAD+ + H2O
tetradecanoic acid + NADH
-
-
-
?
tetradecanal + NAD+ + H2O
tetradecanoic acid + NADH + H+
-
-
-
?
tetradecanal + NAD+ + H2O
tetradecanoic acid + NADH + H+
-
-
-
-
?
additional information
?
-
-
not: acetaldehyde
-
-
?
additional information
?
-
-
not: propionaldehyde
-
-
?
additional information
?
-
-
not: acetaldehyde
-
-
?
additional information
?
-
-
not: propionaldehyde
-
-
?
additional information
?
-
enzyme has high activity against aliphatic long-chain aldehydes such as tetradecanal, Bt-Aldh represents thermophilic aldehyde dehydrogenases responsible for degradation of long-chain alkanes
-
-
?
additional information
?
-
enzyme displays high activity against aliphatic long-chain aldehydes such as tetradecanal
-
-
?
additional information
?
-
enzyme has high activity against aliphatic long-chain aldehydes such as tetradecanal, Bt-Aldh represents thermophilic aldehyde dehydrogenases responsible for degradation of long-chain alkanes
-
-
?
additional information
?
-
enzyme displays high activity against aliphatic long-chain aldehydes such as tetradecanal
-
-
?
additional information
?
-
-
poor substrates: acetaldehyde, propionaldehyde, crotonaldehyde, glutaraldehyde, benzaldehyde, retinaldehyde
-
-
?
additional information
?
-
-
Sjögren-Larsson syndrom is an inherited neurocutaneous disease caused by mutations in the ALDH3A2 gene that codes for fatty aldehyde dehydrogenase, an enzyme involved in lipid metabolism. A rich diversity of mutations and haplotype associations is demonstrated in Sjögren-Larsson syndrom
-
-
?
additional information
?
-
-
catalytically important residues to be involved in alcohol and aldehyde oxidation are Gln-120, Glu-207, Cys-241, Phe-333, Tyr-410 and His-411
-
-
?
additional information
?
-
the C-terminal gatekeeper helix is important for directing the substrate specificity of FALDH towards long-chain fatty aldehydes. Substrate funnel properties and substrate specificity, overview
-
-
?
additional information
?
-
-
the C-terminal gatekeeper helix is important for directing the substrate specificity of FALDH towards long-chain fatty aldehydes. Substrate funnel properties and substrate specificity, overview
-
-
?
additional information
?
-
the enzyme ALDH3B2 exhibits broad substrate preferences from medium- to long-chain aldehydes
-
-
?
additional information
?
-
the enzyme ALDH3B2 exhibits broad substrate preferences from medium- to long-chain aldehydes
-
-
?
additional information
?
-
-
the enzyme ALDH3B2 exhibits broad substrate preferences from medium- to long-chain aldehydes
-
-
?
additional information
?
-
the enzyme ALDH3B3 exhibits broad substrate preferences from medium- to long-chain aldehydes
-
-
?
additional information
?
-
the enzyme ALDH3B3 exhibits broad substrate preferences from medium- to long-chain aldehydes
-
-
?
additional information
?
-
-
the enzyme ALDH3B3 exhibits broad substrate preferences from medium- to long-chain aldehydes
-
-
?
additional information
?
-
-
the enzyme plays an important role in insulin action and is deregulated in states associated with altered insulin signaling
-
-
?
additional information
?
-
-
not: acetaldehyde
-
-
?
additional information
?
-
-
not: acetaldehyde
-
-
?
additional information
?
-
-
not: acetaldehyde
-
-
?
additional information
?
-
-
not: pentanal
-
-
?
additional information
?
-
-
not: propionaldehyde
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
a long-chain aldehyde + NAD+ + H2O
a long-chain carboxylate + NADH + 2 H+
-
-
-
?
acetaldehyde + NAD+ + H2O
acetate + NADH + H+
benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
betaine aldehyde + NAD+ + H2O
?
-
-
-
?
cis,cis-9,12-octadecadienal + NAD+ + H2O
cis,cis-9,12-octadecadienoic acid + NADH
glyceraldehyde + NAD+ + H2O
?
-
-
-
?
hexadecanal + NAD+ + H2O
hexadecanoic acid + NADH
-
high activity
-
-
?
hexanal + NAD+ + H2O
?
-
-
-
?
long-chain aldehyde + NAD+
?
long-chain aldehyde + NAD+ + H2O
long-chain acid anion + NADH
-
-
-
-
?
long-chain aldehyde + NAD+ + H2O
long-chain carboxylate + NADH
octanal + NAD+ + H2O
octanoate + NADH + H+
p-cumic aldehyde + NAD+ + H2O
?
-
-
-
?
phytenal + NAD+
phytenic acid + NADH
-
the enzyme is involved in the breakdown of phytol
-
-
?
retinal + NAD+ + H2O
?
-
-
-
?
trans-2-hexadecenal + NAD+ + H2O
trans-2-decenoic acid + NADH
-
-
-
-
?
additional information
?
-
acetaldehyde + NAD+ + H2O
acetate + NADH + H+
-
-
-
?
acetaldehyde + NAD+ + H2O
acetate + NADH + H+
-
-
-
?
benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
-
-
-
?
benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
-
-
-
?
cis,cis-9,12-octadecadienal + NAD+ + H2O
cis,cis-9,12-octadecadienoic acid + NADH
-
major substrate
-
-
?
cis,cis-9,12-octadecadienal + NAD+ + H2O
cis,cis-9,12-octadecadienoic acid + NADH
-
major substrate
-
-
?
cis,cis-9,12-octadecadienal + NAD+ + H2O
cis,cis-9,12-octadecadienoic acid + NADH
-
major substrate
-
-
?
long-chain aldehyde + NAD+
?
-
the enzyme plays a significant role in n-alkane utilization, especially in intracellular wax ester synthesis
-
-
?
long-chain aldehyde + NAD+
?
-
in microsomes and mitochondria: provides long-chain fatty acids to be utilized for lipid synthesis
-
-
?
long-chain aldehyde + NAD+
?
-
in peroxisomes: provides long-chain fatty acids to be degraded via beta-oxidation to yield energy and cell constituents
-
-
?
long-chain aldehyde + NAD+
?
-
-
-
-
?
long-chain aldehyde + NAD+
?
-
-
-
-
?
long-chain aldehyde + NAD+
?
-
mobilization of intracellular wax esters in the cotyledon during germination
-
-
?
long-chain aldehyde + NAD+
?
-
enzyme is a functional part of the bioluminescent system
-
-
?
long-chain aldehyde + NAD+
?
-
in microsomes and mitochondria: provides long-chain fatty acids to be utilized for lipid synthesis
-
-
?
long-chain aldehyde + NAD+
?
-
in peroxisomes: provides long-chain fatty acids to be degraded via beta-oxidation to yield energy and cell constituents
-
-
?
long-chain aldehyde + NAD+ + H2O
long-chain carboxylate + NADH
-
-
-
-
?
long-chain aldehyde + NAD+ + H2O
long-chain carboxylate + NADH
-
-
-
-
?
octanal + NAD+ + H2O
octanoate + NADH + H+
-
-
-
?
octanal + NAD+ + H2O
octanoate + NADH + H+
-
-
-
?
additional information
?
-
enzyme has high activity against aliphatic long-chain aldehydes such as tetradecanal, Bt-Aldh represents thermophilic aldehyde dehydrogenases responsible for degradation of long-chain alkanes
-
-
?
additional information
?
-
enzyme has high activity against aliphatic long-chain aldehydes such as tetradecanal, Bt-Aldh represents thermophilic aldehyde dehydrogenases responsible for degradation of long-chain alkanes
-
-
?
additional information
?
-
-
Sjögren-Larsson syndrom is an inherited neurocutaneous disease caused by mutations in the ALDH3A2 gene that codes for fatty aldehyde dehydrogenase, an enzyme involved in lipid metabolism. A rich diversity of mutations and haplotype associations is demonstrated in Sjögren-Larsson syndrom
-
-
?
additional information
?
-
-
the enzyme plays an important role in insulin action and is deregulated in states associated with altered insulin signaling
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.00879
-
glucose-grown cell
0.0932
-
stearyl alcohol-grown cell
0.098
-
alkane-grown cell
10.9
-
purified recombinant enzyme from Escherichia coli, tetradecanal used as substrate
additional information
110% relative activity with 2 mM MnCl2 compared to the activity without metal ions, pH 10, 50 mM glycine buffer, 37°C, 1 mM hexanal, 1 mM NAD+
additional information
120% relative activity with 2 mM CoCl2 compared to the activity without metal ions, pH 10, 50 mM glycine buffer, 37°C, 1 mM hexanal, 1 mM NAD+
additional information
14% relative activity with 2 mM MgCl2 compared to the activity without metal ions, pH 10, 50 mM glycine buffer, 37°C, 1 mM hexanal, 1 mM NAD+
additional information
190% relative activity with 2 mM CaCl2 EDTA compared to the activity without metal ions, pH 10, 50 mM glycine buffer, 37°C, 1 mM hexanal, 1 mM NAD+
additional information
210% relative activity with 2 mM BaCl2 compared to the activity without metal ions, pH 10, 50 mM glycine buffer, 37°C, 1 mM hexanal, 1 mM NAD+
additional information
340% relative activity with 2 mM SrCl2 compared to the activity without metal ions, pH 10, 50 mM glycine buffer, 37°C, 1 mM hexanal, 1 mM NAD+
additional information
63% relative activity with 2 mM EDTA compared to the activity without metal ions, pH 10, 50 mM glycine buffer, 37°C, 1 mM hexanal, 1 mM NAD+
additional information
87% relative activity with 2 mM CuCl2 compared to the activity without metal ions, pH 10, 50 mM glycine buffer, 37°C, 1 mM hexanal, 1 mM NAD+
additional information
97% relative activity with 2 mM NiCl2 compared to the activity without metal ions, pH 10, 50 mM glycine buffer, 37°C, 1 mM hexanal, 1 mM NAD+
additional information
in the range of substrate aldehydes with carbon numbers C2 to C14, Bt-Aldh is the most active against C14, tetradecanal at 55°C, the activity against tetradecanal is 73times higher than that against octanal
additional information
relative activity is above 1% with 2 mM ZnCl2 compared to the activity without metal ions, pH 10, 50 mM glycine buffer, 37°C, 1 mM hexanal, 1 mM NAD+
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