Information on EC 1.16.3.1 - ferroxidase

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The expected taxonomic range for this enzyme is: Eukaryota, Archaea, Bacteria

EC NUMBER
COMMENTARY
1.16.3.1
-
RECOMMENDED NAME
GeneOntology No.
ferroxidase
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
Porphyrin and chlorophyll metabolism
-
SYSTEMATIC NAME
IUBMB Comments
Fe(II):oxygen oxidoreductase
The enzyme in blood plasma (ceruloplasmin) belongs to the family of multicopper oxidases. In humans it accounts for 95% of plasma copper. It oxidizes Fe(II) to Fe(III), which allows the subsequent incorporation of the latter into proteins such as apotransferrin and lactoferrin. An enzyme from iron oxidizing bacterium strain TI-1 contains heme a.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
apoferritin
-
-
bacterioferritin
-
-
BFR
P0ABD3
-
blue copper oxidase
-
-
caeruloplasmin
-
-
-
-
ceruloplasmin
-
-
-
-
Cp115
-
-
Cp135
-
-
Cp200
-
-
DdBfr
-
Desulfovibrio desulfuricans bacterioferritin
Dpr
Q99YU7
DNA-binding protein from starved cells
Dps
Q7CN02
i.e. DNA-binding proteins from starved cells
Dps protein
P80725
-
Dps-like peroxide resistance protein
Q7CN02
-
Dps-like peroxide resistance protein
-
-
ferritin
-
-
ferro-O2-oxidoreductase
-
-
ferro:O2 oxidoreductase
-
-
-
-
ferroxidase
A8IZT9
-
ferroxidase
Chlamydomonas reinhardtii 17D-
-
-
-
ferroxidase
Rattus norvegicus Sprague-Dawley
-
-
-
ferroxidase center of bacterioferritin
P0ABD3
-
ferroxidase I
-
-
-
-
ferroxidase II
-
-
ferroxidase, iron II:oxygen oxidoreductase
-
-
-
-
FET3 gene product
-
-
FOX1
Chlamydomonas reinhardtii 17D-
-
-
-
H ferritin
P02794
-
H-chain ferritin
-
-
hephaestin
-
-
hephaestin
-
-
HuHF
-
-
HuHF
P02794
-
human ceruloplasmin form I
-
-
human H ferritin
P02794
-
human H-chain ferritin
-
-
iron(II): oxygen oxidoreductase
-
-
-
-
monophenol-o-monoxygenase
-
-
mouse ceruloplasmin
-
ceruloplasmin with ferroxidase activity detected by native PAGE
multicopper ferroxidase
-
-
multicopper oxidase
-
-
mushroom tyrosinase
-
-
non-ceruloplasmin ferroxidase
-
-
rHuHF
-
recombinant human H-chain ferritin
serum ferroxidase
-
-
xanthine oxidoreductase
-
-
CAS REGISTRY NUMBER
COMMENTARY
9031-37-2
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
mushroom
-
-
Manually annotated by BRENDA team
goose
-
-
Manually annotated by BRENDA team
cow
-
-
Manually annotated by BRENDA team
turtle
-
-
Manually annotated by BRENDA team
Chlamydomonas reinhardtii 17D-
strain 17D-
-
-
Manually annotated by BRENDA team
strain JM109 and strain BL21(DE3)pLysS
UniProt
Manually annotated by BRENDA team
children with Henoch-Schoenlein purpura
-
-
Manually annotated by BRENDA team
Cohn's fraction F-IV-1 of normal human pooled plasma; human
-
-
Manually annotated by BRENDA team
commercial product ceruloplasmin
-
-
Manually annotated by BRENDA team
ferritin heavy chain
UniProt
Manually annotated by BRENDA team
human; human hepatoblastoma cell line HepG2
-
-
Manually annotated by BRENDA team
multicopper oxidase hephaestin, with additional ferroxidase activity. Expression in baby hamster kidney cells
-
-
Manually annotated by BRENDA team
patients with chronic lymphocytic leukemia
-
-
Manually annotated by BRENDA team
patients with Parkinson's disease, Alzheimer's disease, Huntington's disease and lateral amyotrophic sclerosis
-
-
Manually annotated by BRENDA team
patients with Wilson disease and ATP7B genotypes
-
-
Manually annotated by BRENDA team
hypoxic mice
-
-
Manually annotated by BRENDA team
wild-type and ceruloplasmin knockout mice
Uniprot
Manually annotated by BRENDA team
wild-type and ceruloplasmin knockout mice based on strain C57BL/6 J
-
-
Manually annotated by BRENDA team
no activity in Rana catesbeiana
bullfrog
-
-
Manually annotated by BRENDA team
frog
-
-
Manually annotated by BRENDA team
rat; Sprague-Dawley
-
-
Manually annotated by BRENDA team
strain Sprague-Dawley
-
-
Manually annotated by BRENDA team
Rattus norvegicus Sprague-Dawley
Sprague-Dawley
-
-
Manually annotated by BRENDA team
Rattus norvegicus Sprague-Dawley
strain Sprague-Dawley
-
-
Manually annotated by BRENDA team
hog; pig, porcine
-
-
Manually annotated by BRENDA team
two Dps proteins, DpsA-Te and Dps-Te, encoded by the two genes tll2470 and tll0614 or dpsA-Te and dps-Te, respectively
UniProt
Manually annotated by BRENDA team
TEMPERATURE RANGE
TEMPERATURE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
10
50
Q8DL82
assay range
PDB
SCOP
CATH
ORGANISM
Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Desulfovibrio desulfuricans (strain ATCC 27774 / DSM 6949)
Desulfovibrio desulfuricans (strain ATCC 27774 / DSM 6949)
Desulfovibrio desulfuricans (strain ATCC 27774 / DSM 6949)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Helicobacter pylori (strain J99 / ATCC 700824)
Helicobacter pylori (strain J99 / ATCC 700824)
Helicobacter pylori (strain J99 / ATCC 700824)
Helicobacter pylori (strain J99 / ATCC 700824)
Helicobacter pylori (strain J99 / ATCC 700824)
Helicobacter pylori (strain J99 / ATCC 700824)
Lithobates catesbeiana
Lithobates catesbeiana
Lithobates catesbeiana
Lithobates catesbeiana
Lithobates catesbeiana
Lithobates catesbeiana
Lithobates catesbeiana
Lithobates catesbeiana
Lithobates catesbeiana
Lithobates catesbeiana
Lithobates catesbeiana
Lithobates catesbeiana
Lithobates catesbeiana
Lithobates catesbeiana
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
GENERAL STABILITY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
unstable
-
unusually resistant to aging and proteolysis
-
EXPRESSION
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
the enzyme expression is upregulated under acid stress at pH 5.0 compared to pH 7.0
-