Reference on EC 1.14.11.29 - hypoxia-inducible factor-proline dioxygenase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Cha, K.W.; Jacobson, K.B.; Yim, J.J.
Isolation and characterization of GTP cyclohydrolase I from mouse liver. Comparison of normal and the hph-1 mutant
J. Biol. Chem.
266
12294-12300
1991
Mus musculus
Hirsila, M.; Koivunen, P.; Gunzler, V.; Kivirikko, K.I.; Myllyharju, J.
Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor
J. Biol. Chem.
278
30772-30780
2003
Homo sapiens, Homo sapiens (Q9GZT9), Homo sapiens (Q9H6Z9)
Leite, R.B.; Brito, A.B.; Cancela, M.L.
An oxygen molecular sensor, the HIF prolyl 4-hydroxylase, in the marine protist Perkinsus olseni
Protist
159
355-368
2008
Perkinsus olseni (A7LD83), Perkinsus olseni
Tatham, A.L.; Crabtree, M.J.; Warrick, N.; Cai, S.; Alp, N.J.; Channon, K.M.
GTP cyclohydrolase I expression, protein, and activity determine intracellular tetrahydrobiopterin levels, independent of GTP cyclohydrolase feedback regulatory protein expression
J. Biol. Chem.
284
13660-13668
2009
Mus musculus
Gunasekera, R.S.; Hyland, K.
In vivo regulation of phenylalanine hydroxylase in the genetic mutant hph-1 mouse model
Mol. Genet. Metab.
98
264-272
2009
Mus musculus, Mus sp.
Ivan, M.; Kondo, K.; Yang, H.F.; Kim, W.; Valiando, J.; Ohh, M.; Salic, A.; Asara, J.M.; Lane, W.S.; Kaelin, W.G.
HIF alpha targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing
Science
292
464-468
2001
Homo sapiens
Jaakkola, P.; Mole, D.R.; Tian, Y.M.; Wilson, M.I.; Gielbert, J.; Gaskell, S.J.; von Kriegsheim, A.; Hebestreit, H.F.; Mukherji, M.; Schofield, C.J.; Maxwell, P.H.; Pugh, C.W.; Ratcliffe, P.J.
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
Science
292
468-472
2001
Homo sapiens
Bruick, R.K.; McKnight, S.L.
A conserved family of prolyl-4-hydroxylases that modify HIF
Science
294
1337-1340
2001
Drosophila melanogaster, Homo sapiens, Homo sapiens (Q96KS0), Homo sapiens (Q9GZT9)
Tennant, D.A.; Gottlieb, E.
HIF prolyl hydroxylase-3 mediates alpha-ketoglutarate-induced apoptosis and tumor suppression
J. Mol. Med.
88
839-849
2010
Areas
Pappalardi, M.B.; McNulty, D.E.; Martin, J.D.; Fisher, K.E.; Jiang, Y.; Burns, M.C.; Zhao, H.; Ho, T.; Sweitzer, S.; Schwartz, B.; Annan, R.S.; Copeland, R.A.; Tummino, P.J.; Luo, L.
Biochemical characterization of human HIF hydroxylases using HIF protein substrates that contain all three hydroxylation sites
Biochem. J.
436
363-369
2011
Homo sapiens (Q96KS0), Homo sapiens (Q9GZT9), Homo sapiens (Q9H6Z9)
Kwon, H.S.; Choi, Y.K.; Kim, J.W.; Park, Y.K.; Yang, E.G.; Ahn, D.R.
Inhibition of a prolyl hydroxylase domain (PHD) by substrate analog peptides
Bioorg. Med. Chem. Lett.
21
4325-4328
2011
Homo sapiens
Cavadas, M.A.; Nguyen, L.K.; Cheong, A.
Hypoxia-inducible factor (HIF) network: insights from mathematical models
Cell Commun. Signal.
11
42
2013
Homo sapiens
Masson, N.; Singleton, R.S.; Sekirnik, R.; Trudgian, D.C.; Ambrose, L.J.; Miranda, M.X.; Tian, Y.M.; Kessler, B.M.; Schofield, C.J.; Ratcliffe, P.J.
The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity
EMBO Rep.
13
251-257
2012
Homo sapiens
Nguyen, L.K.; Cavadas, M.A.; Scholz, C.C.; Fitzpatrick, S.F.; Bruning, U.; Cummins, E.P.; Tambuwala, M.M.; Manresa, M.C.; Kholodenko, B.N.; Taylor, C.T.; Cheong, A.
A dynamic model of the hypoxia-inducible factor 1alpha (HIF-1alpha) network
J. Cell Sci.
126
1454-1463
2013
Homo sapiens
Geng, Z.; Zhu, J.; Cao, J.; Geng, J.; Song, X.; Zhang, Z.; Bian, N.; Wang, Z.
Effects of polynitrogen compounds on the activity of recombinant human HIF-1alpha prolyl hydroxylase 3 in E. coli
J. Inorg. Biochem.
105
391-399
2011
Homo sapiens
Flagg, S.C.; Martin, C.B.; Taabazuing, C.Y.; Holmes, B.E.; Knapp, M.J.
Screening chelating inhibitors of HIF-prolyl hydroxylase domain 2 (PHD2) and factor inhibiting HIF (FIH)
J. Inorg. Biochem.
113
25-30
2012
BRENDA: Homo sapiens
Textmining: Electron
Pektas, S.; Knapp, M.J.
Substrate preference of the HIF-prolyl hydroxylase-2 (PHD2) and substrate-induced conformational change
J. Inorg. Biochem.
126
55-60
2013
Homo sapiens
Cao, J.; Geng, Z.; Ma, X.; Wen, J.; Yin, Y.; Wang, Z.
Evidence for inhibition of HIF-1alpha prolyl hydroxylase 3 activity by four biologically active tetraazamacrocycles
Org. Biomol. Chem.
10
3913-3923
2012
Homo sapiens
Chen, N.; Huang, C.H.; Chen, B.X.; Liu, H.; Wang, W.M.; Gul, Y.; Wang, H.L.
Alternative splicing transcription of Megalobrama amblycephala HIF prolyl hydroxylase PHD3 and up-regulation of PHD3 by HIF-1alpha
Biochem. Biophys. Res. Commun.
469
737-742
2016
Megalobrama amblycephala (A0A140EDB6)
Tarhonskaya, H.; Chowdhury, R.; Leung, I.K.; Loik, N.D.; McCullagh, J.S.; Claridge, T.D.; Schofield, C.J.; Flashman, E.
Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen
Biochem. J.
463
363-372
2014
Homo sapiens (Q9GZT9), Homo sapiens
Pektas, S.; Taabazuing, C.Y.; Knapp, M.J.
Increased turnover at limiting O2 concentrations by the Thr387 -> Ala variant of HIF-prolyl hydroxylase PHD2
Biochemistry
54
2851-2857
2015
BRENDA: Homo sapiens (Q9GZT9), Homo sapiens
Textmining: Electron
Osipyants, A.; Smirnova, N.; Khristichenko, A.; Hushpulian, D.; Nikulin, S.; Chubar, T.; Zakhariants, A.; Tishkov, V.; Gazaryan, I.; Poloznikov, A.
Enzymesubstrate reporters for evaluation of substrate specificity of HIF prolyl hydroxylase isoforms
Biochemistry
82
1207-1214
2017
Homo sapiens (Q96KS0), Homo sapiens (Q9GZT9), Homo sapiens (Q9H6Z9)
Fan, L.; Li, J.; Yu, Z.; Dang, X.; Wang, K.
The hypoxia-inducible factor pathway, prolyl hydroxylase domain protein inhibitors, and their roles in bone repair and regeneration
BioMed Res. Int.
2014
239356
2014
Homo sapiens
Hong, Y.R.; Kim, H.T.; Ro, S.; Cho, J.M.; Lee, S.H.; Kim, I.S.; Jung, Y.H.
Discovery of novel 2-[2-(3-hydroxy-pyridin-2-yl)-thiazol-4-yl]-acetamide derivatives as HIF prolyl 4-hydroxylase inhibitors; SAR, synthesis and modeling evaluation
Bioorg. Med. Chem. Lett.
24
3142-3145
2014
Homo sapiens
Miikkulainen, P.; Hoegel, H.; Rantanen, K.; Suomi, T.; Kouvonen, P.; Elo, L.L.; Jaakkola, P.M.
HIF prolyl hydroxylase PHD3 regulates translational machinery and glucose metabolism in clear cell renal cell carcinoma
Cancer Metab.
5
5-5
2017
Homo sapiens (Q9H6Z9)
Bishop, T.; Ratcliffe, P.J.
HIF hydroxylase pathways in cardiovascular physiology and medicine
Circ. Res.
117
65-79
2015
Homo sapiens
Badawi, Y.; Shi, H.
Relative contribution of prolyl hydroxylase-dependent and -independent degradation of HIF-1alpha by proteasomal pathways in cerebral ischemia
Front. Neurosci.
11
239
2017
Homo sapiens
Wang, L.; Cui, S.; Ma, L.; Kong, L.; Geng, X.
Current advances in the novel functions of hypoxia-inducible factor and prolyl hydroxylase in invertebrates
Insect Mol. Biol.
24
634-648
2015
Caenorhabditis elegans, Drosophila melanogaster
Chan, M.C.; Ilott, N.E.; Schoedel, J.; Sims, D.; Tumber, A.; Lippl, K.; Mole, D.R.; Pugh, C.W.; Ratcliffe, P.J.; Ponting, C.P.; Schofield, C.J.
Tuning the transcriptional response to hypoxia by inhibiting hypoxia-inducible factor (HIF) prolyl and asparaginyl hydroxylases
J. Biol. Chem.
291
20661-20673
2016
Homo sapiens
Giannetto, A.; Maisano, M.; Cappello, T.; Oliva, S.; Parrino, V.; Natalotto, A.; De Marco, G.; Barberi, C.; Romeo, O.; Mauceri, A.; Fasulo, S.
Hypoxia-inducible factor alpha and Hif-prolyl hydroxylase characterization and gene expression in short-time air-exposed Mytilus galloprovincialis
Mar. Biotechnol.
17
768-781
2015
BRENDA: Mytilus galloprovincialis (A0A0K0M9M3), Mytilus galloprovincialis
Textmining: Bivalvia, Mytilus, Metazoa, Areas, animal
Kapitsinou, P.P.; Rajendran, G.; Astleford, L.; Michael, M.; Schonfeld, M.P.; Fields, T.; Shay, S.; French, J.L.; West, J.; Haase, V.H.
The endothelial prolyl-4-hydroxylase domain 2/hypoxia-inducible factor 2 axis regulates pulmonary artery pressure in mice
Mol. Cell. Biol.
36
1584-1594
2016
Mus musculus
Arsenault, P.R.; Song, D.; Chung, Y.J.; Khurana, T.S.; Lee, F.S.
The zinc finger of prolyl hydroxylase domain protein 2 is essential for efficient hydroxylation of hypoxia-inducible factor alpha
Mol. Cell. Biol.
36
2328-2343
2016
Mus musculus (Q91YE2)
Kozlova, N.; Wottawa, M.; Katschinski, D.M.; Kristiansen, G.; Kietzmann, T.
Hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) is a direct regulator of epidermal growth factor receptor (EGFR) signaling in breast cancer
Oncotarget
8
9885-9898
2017
Homo sapiens
Chan, M.C.; Atasoylu, O.; Hodson, E.; Tumber, A.; Leung, I.K.; Chowdhury, R.; Gomez-Perez, V.; Demetriades, M.; Rydzik, A.M.; Holt-Martyn, J.; Tian, Y.M.; Bishop, T.; Claridge, T.D.; Kawamura, A.; Pugh, C.W.; Ratcliffe, P.J.; Schofield, C.J.
Potent and selective triazole-based inhibitors of the hypoxia-inducible factor prolyl-hydroxylases with activity in the murine brain
PLoS ONE
10
e0132004
2015
Mus musculus (Q91UZ4), Mus musculus (Q91YE2), Mus musculus (Q91YE3), Homo sapiens (Q96KS0), Homo sapiens (Q9GZT9), Homo sapiens (Q9H6Z9)
Sun, W.; Jelkmann, W.; Depping, R.
Prolyl-4-hydroxylase 2 enhances hypoxia-induced glioblastoma cell death by regulating the gene expression of hypoxia-inducible factor-alpha
Cell Death Dis.
5
e1322
2014
Homo sapiens (Q9GZT9)
Sun, W.; Kosyna, F.K.; Jelkmann, W.; Depping, R.
Prolyl-4-hydroxylase 2 potentially contributes to hepatocellular carcinoma-associated erythrocytosis by maintaining hepatocyte nuclear factor-4alpha expression
Cell. Physiol. Biochem.
37
2257-2264
2015
Homo sapiens (Q9GZT9), Homo sapiens
Li, J.; Yuan, W.; Jiang, S.; Ye, W.; Yang, H.; Shapiro, I.M.; Risbud, M.V.
Prolyl-4-hydroxylase domain protein 2 controls NF-kappaB/p65 transactivation and enhances the catabolic effects of inflammatory cytokines on cells of the nucleus pulposus
J. Biol. Chem.
290
7195-7207
2015
Rattus norvegicus (P59722), Homo sapiens (Q9GZT9)
Taylor, C.T.; Scholz, C.C.
A PHD in macrophage survival
J. Leukoc. Biol.
96
365-375
2014
Mus musculus (Q91UZ4)
Schnicker, N.J.; Razzaghi, M.; Guha Thakurta, S.; Chakravarthy, S.; Dey, M.
Bacillus anthracis prolyl 4-hydroxylase interacts with and modifies elongation factor Tu
Biochemistry
56
5771-5785
2017
Bacteria
Osipyants, A.I.; Poloznikov, A.A.; Smirnova, N.A.; Hushpulian, D.M.; Khristichenko, A.Y.; Chubar, T.A.; Zakhariants, A.A.; Ahuja, M.; Gaisina, I.N.; Thomas, B.; Brown, A.M.; Gazaryan, I.G.; Tishkov, V.I.
L-ascorbic acid A true substrate for HIF prolyl hydroxylase?
Biochimie
147
46-54
2018
Homo sapiens (Q9GZT9)
Tong, J.; Yu, F.C.; Li, Y.; Wei, Q.; Li, C.; Zhen, P.; Zhang, G.
Prolyl 4-hydroxylase domain protein 3-inhibited smooth-muscle-cell dedifferentiation improves cardiac perivascular fibrosis induced by obstructive sleep apnea
BioMed Res. Int.
2019
9174218
2019
Mus musculus (Q91UZ4)
Hamada, M.; Takayama, T.; Shibata, T.; Hiratate, A.; Takahashi, M.; Yashiro, M.; Takayama, N.; Okumura-Kitajima, L.; Koretsune, H.; Kajiyama, H.; Naruse, T.; Kato, S.; Takano, H.; Kakinuma, H.
Discovery of novel 2-[(4-hydroxy-6-oxo-2,3-dihydro-1H-pyridine-5-carbonyl)amino]acetic acid derivatives as HIF prolyl hydroxylase inhibitors for treatment of renal anemia
Bioorg. Med. Chem. Lett.
28
1725-1730
2018
Homo sapiens (Q9GZT9)
Mbenza, N.M.; Nasarudin, N.; Vadakkedath, P.G.; Patel, K.; Ismail, A.Z.; Hanif, M.; Wright, L.J.; Sarojini, V.; Hartinger, C.G.; Leung, I.K.H.
Carbon monoxide is an inhibitor of HIF prolyl hydroxylase domain 2
ChemBioChem
22
2521-2525
2021
BRENDA: Homo sapiens (Q9GZT9)
Textmining: Metazoa
Holt-Martyn, J.P.; Chowdhury, R.; Tumber, A.; Yeh, T.L.; Abboud, M.I.; Lippl, K.; Lohans, C.T.; Langley, G.W.; Figg, W.; McDonough, M.A.; Pugh, C.W.; Ratcliffe, P.J.; Schofield, C.J.
Structure-activity relationship and crystallographic studies on 4-hydroxypyrimidine HIF prolyl hydroxylase domain inhibitors
ChemMedChem
15
270-273
2020
Homo sapiens (Q9GZT9)
Poloznikov, A.A.; Nikulin, S.V.; Zakhariants, A.A.; Khristichenko, A.Y.; Hushpulian, D.M.; Gazizov, I.N.; Tishkov, V.I.; Gazaryan, I.G.
''Branched Tail'' oxyquinoline inhibitors of HIF prolyl hydroxylase early evaluation of toxicity and metabolism using liver-on-a-chip
Drug Metab. Lett.
13
45-52
2019
Homo sapiens
Cockman, M.E.; Lippl, K.; Tian, Y.M.; Pegg, H.B.; Figg, W.D.; Abboud, M.I.; Heilig, R.; Fischer, R.; Myllyharju, J.; Schofield, C.J.; Ratcliffe, P.J.
Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
eLife
8
e46490
2019
Homo sapiens (Q96KS0), Homo sapiens (Q9GZT9), Homo sapiens (Q9H6Z9), Homo sapiens
Dengler, F.; Sova, S.; Salo, A.M.; Maeki, J.M.; Koivunen, P.; Myllyharju, J.
Expression and roles of individual HIF prolyl 4-hydroxylase isoenzymes in the regulation of the hypoxia response pathway along the murine gastrointestinal epithelium
Int. J. Mol. Sci.
22
4038
2021
BRENDA: Mus musculus (Q8BG58), Mus musculus
Textmining: Mus sp., Caecum
Myllykoski, M.; Sutinen, A.; Koski, M.; Kallio, J.; Raasakka, A.; Myllyharju, J.; Wierenga, R.; Koivunen, P.
Structure of transmembrane prolyl 4-hydroxylase reveals unique organization of EF and dioxygenase domains
J. Biol. Chem.
296
100197
2021
BRENDA: Homo sapiens (Q9NXG6), Homo sapiens
Textmining: Metazoa
Chong, M.; Toh, L.; Tumber, A.; Chan, Y.; Chan, M.; Abboud, M.; Schofield, C.; Yeoh, K.
Evaluation of 3-carbamoylpropanoic acid analogs as inhibitors of human hypoxia-inducible factor (HIF) prolyl hydroxylase domain enzymes
Med. Chem. Res.
30
977-986
2021
Homo sapiens (Q9GZT9)
-
Pickel, C.; Taylor, C.; Scholz, C.
Genetic knockdown and pharmacologic inhibition of hypoxia-inducible factor (HIF) hydroxylases
Methods Mol. Biol.
1742
1-14
2018
Homo sapiens
Koivunen, P.; Myllyharju, J.
Kinetic analysis of HIF prolyl hydroxylases
Methods Mol. Biol.
1742
15-25
2018
Homo sapiens (Q9GZT9)
Jacobson, KB; Manos, RE
Effects of sepiapterin and 6-acetyldihydrohomopterin on the guanosine triphosphate cyclohydrolase I of mouse, rat and the fruit-fly Drosophila.
Biochem J
260
135-41
1989
Mus musculus
Gütlich, M; Ziegler, I; Witter, K; Hemmens, B; Hültner, L; McDonald, JD; Werner, T; Rödl, W; Bacher, A
Molecular characterization of HPH-1: a mouse mutant deficient in GTP cyclohydrolase I activity.
Biochem Biophys Res Commun
203
1675-81
1994
Mus musculus
Shimoji, M; Hirayama, K; Hyland, K; Kapatos, G
GTP cyclohydrolase I gene expression in the brains of male and female hph-1 mice.
J Neurochem
72
757-64
1999
Mus sp., Mus musculus
Belik, J; McIntyre, BA; Enomoto, M; Pan, J; Grasemann, H; Vasquez-Vivar, J
Pulmonary hypertension in the newborn GTP cyclohydrolase I-deficient mouse.
Free Radic Biol Med
51
2227-33
2011
Mus musculus, Mus sp., Metazoa
Nasser, A; Bjerrum, OJ; Heegaard, AM; Mller, AT; Larsen, M; Dalbge, LS; Dupont, E; Jensen, TS; Mller, LB
Impaired behavioural pain responses in hph-1 mice with inherited deficiency in GTP cyclohydrolase 1 in models of inflammatory pain.
Mol Pain
9
5
2013
Cell fusing agent virus, Mus sp.
Maeda, T; Haeno, S; Oda, K; Mori, D; Ichinose, H; Nagatsu, T; Suzuki, T
Studies on the genotype-phenotype relation in the hph-1 mouse mutant deficient in guanosine triphosphate (GTP) cyclohydrolase I activity.
Brain Dev
22 Suppl 1
S50-3
2000
Mus musculus
Takano, H; Yamaguchi, JI; Kato, S; Hamada, M; Tada, M; Endo, H
Downregulation of CYP1A2, CYP2B6, and CYP3A4 in Human Hepatocytes by Prolyl Hydroxylase Domain 2 Inhibitors via Hypoxia-Inducible Factor-? Stabilization.
Drug Metab Dispos
49
20-30
2021
Homo sapiens
Brand, MP; Heales, SJ; Land, JM; Clark, JB
Tetrahydrobiopterin deficiency and brain nitric oxide synthase in the hph1 mouse.
J Inherit Metab Dis
18
33-9
1995
Mus musculus
Honda, F; Hane, Y; Toma, T; Yachie, A; Kim, ES; Lee, SK; Takagi, M; Mizutani, S; Morio, T
Transducible form of p47phox and p67phox compensate for defective NADPH oxidase activity in neutrophils of patients with chronic granulomatous disease.
Biochem Biophys Res Commun
417
162-8
2012
Homo sapiens
Wetterau, M; George, F; Weinstein, A; Nguyen, PD; Tutela, JP; Knobel, D; Cohen Ba, O; Warren, SM; Saadeh, PB
Topical prolyl hydroxylase domain-2 silencing improves diabetic murine wound closure.
Wound Repair Regen
19
481-6
2011
Mus musculus, Mus sp.
Heindryckx, F; Kuchnio, A; Casteleyn, C; Coulon, S; Olievier, K; Colle, I; Geerts, A; Libbrecht, L; Carmeliet, P; Van Vlierberghe, H
Effect of prolyl hydroxylase domain-2 haplodeficiency on the hepatocarcinogenesis in mice.
J Hepatol
2012
Mus sp., Homo sapiens, Mus musculus
Orgeig, S; McGillick, EV; Botting, KJ; Zhang, S; McMillen, IC; Morrison, JL
Increased lung prolyl hydroxylase and decreased glucocorticoid receptor are related to decreased surfactant protein in the growth-restricted sheep fetus.
Am J Physiol Lung Cell Mol Physiol
309
L84-97
2015
Ovis aries
Bush, JT; Le?niak, RK; Yeh, TL; Belle, R; Kramer, H; Tumber, A; Chowdhury, R; Flashman, E; Mecinovi?, J; Schofield, CJ
Small-molecules that covalently react with a human prolyl hydroxylase - towards activity modulation and substrate capture.
Chem Commun (Camb)
55
1020-1023
2019
Homo sapiens
Yu, G; Li, X; Zhou, Z; Tang, J; Wang, J; Liu, X; Fan, S; Ouyang, G; Xiao, W
Zebrafish phd3 Negatively Regulates Antiviral Responses via Suppression of Irf7 Transactivity Independent of Its Prolyl Hydroxylase Activity.
J Immunol
205
1135-1146
2020
Caenorhabditis elegans
Hsieh, MM; Linde, NS; Wynter, A; Metzger, M; Wong, C; Langsetmo, I; Lin, A; Smith, R; Rodgers, GP; Donahue, RE; Klaus, SJ; Tisdale, JF
HIF prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques.
Blood
110
2140-7
2007
Metazoa, Mus sp.
Albiero, E; Ruggeri, M; Fortuna, S; Finotto, S; Bernardi, M; Madeo, D; Rodeghiero, F
Isolated erythrocytosis: study of 67 patients and identification of three novel germ-line mutations in the prolyl hydroxylase domain protein 2 (PHD2) gene.
Haematologica
2011
Homo sapiens
Myllymki, MN; Mtt, J; Dimova, EY; Izzi, V; Visnen, T; Myllyharju, J; Koivunen, P; Serpi, R
Notch Downregulation and Extramedullary Erythrocytosis in Hypoxia-Inducible Factor Prolyl 4-Hydroxylase 2-Deficient Mice.
Mol Cell Biol
37
2017
Mus sp.
Flamme, I; Ellinghaus, P; Urrego, D; Krger, T
FGF23 expression in rodents is directly induced via erythropoietin after inhibition of hypoxia inducible factor proline hydroxylase.
PLoS One
12
e0186979
2017
Mus musculus, Mus sp., Rattus, Rodentia, Homo sapiens
Bur, H; Haapasaari, KM; Turpeenniemi-Hujanen, T; Kuittinen, O; Auvinen, P; Marin, K; Soini, Y; Karihtala, P
Strong Prolyl Hydroxylase Domain 1 Expression Predicts Poor Outcome in Radiotherapy-treated Patients with Classical Hodgkin's Lymphoma.
Anticancer Res
38
329-336
2018
Homo sapiens
Wakashima, T; Tanaka, T; Fukui, K; Komoda, Y; Shinozaki, Y; Kobayashi, H; Matsuo, A; Nangaku, M
JTZ-951, an HIF prolyl hydroxylase inhibitor, suppresses renal interstitial fibroblast transformation and expression of fibrosis-related factors.
Am J Physiol Renal Physiol
318
F14-F24
2020
Transformation
Laitakari, A; Huttunen, R; Kuvaja, P; Hannuksela, P; Szabo, Z; Heikkil, M; Kerkel, R; Myllyharju, J; Dimova, EY; Serpi, R; Koivunen, P
Systemic long-term inactivation of hypoxia-inducible factor prolyl 4-hydroxylase 2 ameliorates aging-induced changes in mice without affecting their life span.
FASEB J
2020
Mus sp.
Signore, PE; Guo, G; Wei, Z; Zhang, W; Lin, A; Del Balzo, U
A small-molecule inhibitor of hypoxia-inducible factor prolyl hydroxylase improves obesity, nephropathy and cardiomyopathy in obese ZSF1 rats.
PLoS One
16
e0255022
2021
Homo sapiens, animal
Barker, JE; Strangward, HM; Brand, MP; Hurst, RD; Land, JM; Clark, JB; Heales, SJ
Increased inducible nitric oxide synthase protein but limited nitric oxide formation occurs in astrocytes of the hph-1 (tetrahydrobiopterin deficient) mouse.
Brain Res
804
1-6
1998
Mus musculus
Santhanam, AV; d'Uscio, LV; He, T; Katusic, ZS
PPAR? agonist GW501516 prevents uncoupling of endothelial nitric oxide synthase in cerebral microvessels of hph-1 mice.
Brain Res
2012
Mus sp.
Loeffler, I; Liebisch, M; Daniel, C; Amann, K; Wolf, G
Heterozygosity of mitogen-activated protein kinase organizer 1 ameliorates diabetic nephropathy and suppresses epithelial-to-mesenchymal transition-like changes in db/db mice.
Nephrol Dial Transplant
32
2017-2034
2017
Mus sp., Mus musculus
McDonald, JD; Cotton, RG; Jennings, I; Ledley, FD; Woo, SL; Bode, VC
Biochemical defect of the hph-1 mouse mutant is a deficiency in GTP-cyclohydrolase activity.
J Neurochem
50
655-7
1988
Mus musculus, Mus sp.
McDonald, JD; Bode, VC
Hyperphenylalaninemia in the hph-1 mouse mutant.
Pediatr Res
23
63-7
1988
Mus musculus
Bode, VC; McDonald, JD; Guenet, JL; Simon, D
hph-1: a mouse mutant with hereditary hyperphenylalaninemia induced by ethylnitrosourea mutagenesis.
Genetics
118
299-305
1988
Mus musculus
Hyland, K; Gunasekera, RS; Engle, T; Arnold, LA
Tetrahydrobiopterin and biogenic amine metabolism in the hph-1 mouse.
J Neurochem
67
752-9
1996
Mus musculus, Mus sp.
Brand, MP; Hyland, K; Engle, T; Smith, I; Heales, SJ
Neurochemical effects following peripheral administration of tetrahydropterin derivatives to the hph-1 mouse.
J Neurochem
66
1150-6
1996
Mus musculus
Brand, MP; Briddon, A; Land, JM; Clark, JB; Heales, SJ
Impairment of the nitric oxide/cyclic GMP pathway in cerebellar slices prepared from the hph-1 mouse.
Brain Res
735
169-72
1996
Mus musculus
Canevari, L; Land, JM; Clark, JB; Heales, SJ
Stimulation of the brain NO/cyclic GMP pathway by peripheral administration of tetrahydrobiopterin in the hph-1 mouse.
J Neurochem
73
2563-8
1999
Mus musculus, Mus sp., Metazoa
Schlemminger, I; Mole, DR; McNeill, LA; Dhanda, A; Hewitson, KS; Tian, YM; Ratcliffe, PJ; Pugh, CW; Schofield, CJ
Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases.
Bioorg Med Chem Lett
13
1451-4
2003
Homo sapiens
Hyland, K; Gunasekara, RS; Munk-Martin, TL; Arnold, LA; Engle, T
The hph-1 mouse: a model for dominantly inherited GTP-cyclohydrolase deficiency.
Ann Neurol
54 Suppl 6
S46-8
2003
Mus musculus, Homo sapiens
Abel, RM; Dorè, CJ; Bishop, AE; Facer, P; Polak, JM; Spitz, L
A histological study of the hph-1 mouse mutant: an animal model of phenylketonuria and infantile hypertrophic pyloric stenosis.
Anat Histol Embryol
33
125-30
2004
Mus musculus, Stenosis, animal, Homo sapiens, Mus sp.
Khoo, JP; Nicoli, T; Alp, NJ; Fullerton, J; Flint, J; Channon, KM
Congenic mapping and genotyping of the tetrahydrobiopterin-deficient hph-1 mouse.
Mol Genet Metab
82
251-4
2004
Mus musculus, Mus sp., Metazoa
Kato, H; Inoue, T; Asanoma, K; Nishimura, C; Matsuda, T; Wake, N
Induction of human endometrial cancer cell senescence through modulation of HIF-1alpha activity by EGLN1.
Int J Cancer
118
1144-53
2006
Homo sapiens
William, C; Maxwell, PH; Nichols, L; Lygate, C; Tian, YM; Bernhardt, W; Wiesener, M; Ratcliffe, PJ; Eckardt, KU; Pugh, CW
HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.
J Mol Cell Cardiol
41
68-77
2006
Rattus, Metazoa, Areas
Lam, AA; Hyland, K; Heales, SJ
Tetrahydrobiopterin availability, nitric oxide metabolism and glutathione status in the hph-1 mouse; implications for the pathogenesis and treatment of tetrahydrobiopterin deficiency states.
J Inherit Metab Dis
30
256-62
2007
Mus musculus
Kaelin, WG; Ratcliffe, PJ
Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.
Mol Cell
30
393-402
2008
Metazoa
Li, X; Sutherland, S; Takeda, K; Fong, GH; Lee, FS
Integrity of the prolyl hydroxylase domain protein 2:erythropoietin pathway in aging mice.
Blood Cells Mol Dis
2010
Mus musculus, Mus sp.
Hyvarinen, J; Parikka, M; Sormunen, R; Ramet, M; Tryggvason, K; Kivirikko, KI; Myllyharju, J; Koivunen, P
Deficiency of a transmembrane prolyl 4-hydroxylase in the zebrafish leads to basement membrane defects and compromised kidney function.
J Biol Chem
2010
Danio rerio
Piontkivska, H; Chung, JS; Ivanina, AV; Sokolov, EP; Techa, S; Sokolova, IM
Molecular characterization and mRNA expression of two key enzymes of hypoxia-sensing pathways in eastern oysters Crassostrea virginica (Gmelin): Hypoxia-inducible factor ? (HIF-?) and HIF-prolyl hydroxylase (PHD).
Comp Biochem Physiol Part D Genomics Proteomics
2010
Ostreidae, Crassostrea virginica
Klotzsche-von Ameln, A; Muschter, A; Mamlouk, S; Kalucka, J; Prade, I; Franke, K; Rezaei, M; Poitz, DM; Breier, G; Wielockx, B
Inhibition of HIF Prolyl Hydroxylase-2 Blocks Tumor Growth in Mice through the Anti-Proliferative Activity of Transforming Growth Factor{beta}
Cancer Res
2011
Mus sp.
d'Uscio, LV; Smith, LA; Katusic, ZS
Differential effects of eNOS uncoupling on conduit and small arteries in GTP-cyclohydrolase I-deficient hph-1 mice.
Am J Physiol Heart Circ Physiol
301
H2227-34
2011
Mus sp., Mus musculus
Manalo, DJ; Baek, JH; Buehler, PW; Struble, E; Abraham, B; Alayash, AI
Inactivation of prolyl hydroxylase domain (PHD) protein by epigallocatechin (EGCG) stabilizes hypoxia-inducible factor (HIF-1?) and induces hepcidin (Hamp) in rat kidney.
Biochem Biophys Res Commun
416
421-6
2011
Rattus
Kamphues, C; Wittschieber, D; Klauschen, F; Kasajima, A; Dietel, M; Schmidt, SC; Glanemann, M; Bahra, M; Neuhaus, P; Weichert, W; Stenzinger, A
Prolyl hydroxylase domain 2 protein is a strong prognostic marker in human gastric cancer.
Pathobiology
79
11-7
2012
Homo sapiens
Santhanam, AV; d'Uscio, LV; Smith, LA; Katusic, ZS
Uncoupling of eNOS causes superoxide anion production and impairs NO signaling in the cerebral microvessels of hph-1 mice.
J Neurochem
122
1211-8
2012
Mus sp.
Wottawa, M; Leisering, P; Ahlen, MV; Schnelle, M; Vogel, S; Malz, C; Bordoli, MR; Camenisch, G; Hesse, A; Napp, J; Alves, F; Kristiansen, G; Farhat, K; Katschinski, DM
Knockdown of prolyl-4-hydroxylase domain 2 inhibits tumor growth of human breast cancer MDA-MB-231 cells by affecting TGF-?1 processing.
Int J Cancer
2012
Homo sapiens, Mus musculus
Kalucka, J; Ettinger, A; Franke, K; Mamlouk, S; Singh, RP; Farhat, K; Muschter, A; Olbrich, S; Breier, G; Katschinski, DM; Huttner, W; Weidemann, A; Wielockx, B
Loss of epithelial hypoxia-inducible factor prolyl hydroxylase 2 accelerates skin wound healing in mice.
Mol Cell Biol
33
3426-38
2013
Mus sp., Mammalia
Yum, S; Park, H; Hong, S; Jeong, S; Kim, W; Jung, Y
N-(2-Mercaptopropionyl)-glycine, a diffusible antioxidant, activates HIF-1 by inhibiting HIF prolyl hydroxylase-2: implication in amelioration of rat colitis by the antioxidant.
Biochem Biophys Res Commun
443
1008-13
2014
Rattus
Duan, LJ; Takeda, K; Fong, GH
Hematological, hepatic, and retinal phenotypes in mice deficient for prolyl hydroxylase domain proteins in the liver.
Am J Pathol
184
1240-50
2014
Mus sp.
Caprara, V; Scappa, S; Garrafa, E; Di Castro, V; Rosan, L; Bagnato, A; Spinella, F
Endothelin-1 regulates hypoxia-inducible factor-1? and -2? stability through prolyl hydroxylase domain 2 inhibition in human lymphatic endothelial cells.
Life Sci
2014
Homo sapiens
Nasser, A; Mller, LB; Olesen, JH; Konradsen Refsgaard, L; Konradsen, LS; Andreasen, JT
Anxiety- and depression-like phenotype of hph-1 mice deficient in tetrahydrobiopterin.
Neurosci Res
89
44-53
2014
Mus sp., Mus musculus
Abrams, MT; Koser, M; Burchard, J; Strapps, W; Mehmet, H; Gindy, M; Zaller, D; Sepp-Lorenzino, L; Stickens, D
A single dose of EGLN1 siRNA yields increased erythropoiesis in nonhuman primates.
Nucleic Acid Ther
24
405-12
2014
Primates, Homo sapiens
Welsh, C; Shifrin, Y; Pan, J; Belik, J
Infantile hypertrophic pyloric stenosis (IHPS): a study of its pathophysiology utilizing the newborn hph-1 mouse model of the disease.
Am J Physiol Gastrointest Liver Physiol
307
G1198-206
2014
Mus musculus, Stenosis, Mus sp., Metazoa
Rishi, MT; Selvaraju, V; Thirunavukkarasu, M; Shaikh, IA; Takeda, K; Fong, GH; Palesty, JA; Sanchez, JA; Maulik, N
Deletion of prolyl hydroxylase domain proteins (PHD1, PHD3) stabilizes hypoxia inducible factor-1 alpha, promotes neovascularization, and improves perfusion in a murine model of hind-limb ischemia.
Microvasc Res
97
181-8
2015
Mus musculus
Wang, H; Huang, C; Chen, N; Zhu, K; Chen, B; Wang, W; Wang, H
Molecular characterization and mRNA expression of HIF-prolyl hydroxylase-2 (phd2) in hypoxia-sensing pathways from Megalobrama amblycephala.
Comp Biochem Physiol B Biochem Mol Biol
186
28-35
2015
Megalobrama amblycephala, Chondrichthyes
Li, L; Saliba, P; Reischl, S; Marti, HH; Kunze, R
Neuronal deficiency of HIF prolyl 4-hydroxylase 2 in mice improves ischemic stroke recovery in an HIF dependent manner.
Neurobiol Dis
91
221-235
2016
Mus sp.
Li, Z; Xing, YQ; Cui, W; Lu, Q
Expression and effect of proline hydroxylase domain 2 in retina of diabetic rats.
Int J Ophthalmol
9
357-62
2016
Rattus
Nunomiya, A; Shin, J; Kitajima, Y; Dan, T; Miyata, T; Nagatomi, R
Activation of the hypoxia-inducible factor pathway induced by prolyl hydroxylase domain 2 deficiency enhances the effect of running training in mice.
Acta Physiol (Oxf)
2016
Mus sp.
Leinonen, H; Rossi, M; Salo, AM; Tiainen, P; Hyvrinen, J; Pitknen, M; Sormunen, R; Miinalainen, I; Zhang, C; Soininen, R; Kivirikko, KI; Koskelainen, A; Tanila, H; Myllyharju, J; Koivunen, P
Lack of P4H-TM in mice results in age-related retinal and renal alterations.
Hum Mol Genet
2016
Mus sp., Mus musculus
Li, SH; Li, S; Sun, L; Bai, ZZ; Yang, QY; Ga, Q; Jin, GE
[Correlation between EGLN1 gene, protein express in lung tissue of rats and pulmonary artery pressure at different altitude].
Zhonghua Yi Xue Za Zhi
96
2592-7
2016
Homo sapiens, Rattus
Urrutia, AA; Afzal, A; Nelson, J; Davidoff, O; Gross, KW; Haase, VH
Prolyl-4-hydroxylase 2 and 3 coregulate murine erythropoietin in brain pericytes.
Blood
128
2550-2560
2016
Mus musculus, Mus sp.
Gruneberg, D; Montellano, FA; Plaschke, K; Li, L; Marti, HH; Kunze, R
Neuronal prolyl-4-hydroxylase 2 deficiency improves cognitive abilities in a murine model of cerebral hypoperfusion.
Exp Neurol
286
93-106
2016
Mus musculus, Mus sp., Rodentia, Metazoa, Hippocampus
Belik, J; Shifrin, Y; Arning, E; Bottiglieri, T; Pan, J; Daigneault, MC; Allen-Vercoe, E
Intestinal microbiota as a tetrahydrobiopterin exogenous source in hph-1 mice.
Sci Rep
7
39854
2017
Mus sp., Microbiota, Bacteria, Mus musculus, Microbacterium schleiferi
Wang, S; Zeng, H; Chen, ST; Zhou, L; Xie, XJ; He, X; Tao, YK; Tuo, QH; Deng, C; Liao, DF; Chen, JX
Ablation of endothelial prolyl hydroxylase domain protein-2 promotes renal vascular remodelling and fibrosis in mice.
J Cell Mol Med
21
1967-1978
2017
Mus sp.
Bogaerts, E; Paridaens, A; Verhelst, X; Carmeliet, P; Geerts, A; Van Vlierberghe, H; Devisscher, L
Effect of prolyl hydroxylase domain 2 haplodeficiency on liver progenitor cell characteristics in early mouse hepatocarcinogenesis.
EXCLI J
15
687-698
2016
Mus musculus, Mus sp.
Belik, J; Shifrin, Y; Arning, E; Bottiglieri, T; Pan, J; Daigneault, MC; Allen-Vercoe, E
Corrigendum: Intestinal microbiota as a tetrahydrobiopterin exogenous source in hph-1 mice.
Sci Rep
7
44161
2017
Mus sp., Microbiota
Grover, SP; Saha, P; Humphries, J; Lyons, OT; Patel, AS; Serneels, J; Modarai, B; Mazzone, M; Smith, A
Inhibition of prolyl hydroxylase domain proteins selectively enhances venous thrombus neovascularisation.
Thromb Res
169
105-112
2018
Thrombus, Mus sp.
Zeng, L; Huang, B; Li, F; Chen, N; Ma, Z; Qu, K; Chen, H; Lei, C
EGLN1 gene variation in Chinese native cattle and yaks.
Anim Genet
49
655-656
2018
Bos taurus
Price, C; Gill, S; Ho, ZV; Davidson, SM; Merkel, E; McFarland, JM; Leung, L; Tang, A; Kost-Alimova, M; Tsherniak, A; Jonas, O; Vazquez, F; Hahn, WC
Genome-Wide Interrogation of Human Cancers Identifies EGLN1 Dependency in Clear Cell Ovarian Cancers.
Cancer Res
79
2564-2579
2019
Homo sapiens
Saito, H; Tanaka, T; Sugahara, M; Tanaka, S; Fukui, K; Wakashima, T; Nangaku, M
Inhibition of prolyl hydroxylase domain (PHD) by JTZ-951 reduces obesity-related diseases in the liver, white adipose tissue, and kidney in mice with a high-fat diet.
Lab Invest
99
1217-1232
2019
Mus sp., Homo sapiens
Leinonen, H; Koivisto, H; Lipponen, HR; Matilainen, A; Salo, AM; Dimova, EY; Hmlinen, E; Stavn, S; Miettinen, P; Myllyharju, J; Koivunen, P; Tanila, H
Null mutation in P4h-tm leads to decreased fear and anxiety and increased social behavior in mice.
Neuropharmacology
153
63-72
2019
Areas, Mus musculus, Mus sp.
Brutsaert, TD; Kiyamu, M; Elias Revollendo, G; Isherwood, JL; Lee, FS; Rivera-Ch, M; Leon-Velarde, F; Ghosh, S; Bigham, AW
Association of EGLN1 gene with high aerobic capacity of Peruvian Quechua at high altitude.
Proc Natl Acad Sci U S A
116
24006-24011
2019
Quechua
Sugahara, M; Tanaka, S; Tanaka, T; Saito, H; Ishimoto, Y; Wakashima, T; Ueda, M; Fukui, K; Shimizu, A; Inagi, R; Yamauchi, T; Kadowaki, T; Nangaku, M
Prolyl Hydroxylase Domain Inhibitor Protects against Metabolic Disorders and Associated Kidney Disease in Obese Type 2 Diabetic Mice.
J Am Soc Nephrol
31
560-577
2020
Mus sp.
Correction for Brutsaert et al., Association of EGLN1 gene with high aerobic capacity of Peruvian Quechua at high altitude.
Proc Natl Acad Sci U S A
117
3339
2020
Quechua
Settelmeier, S; Schreiber, T; Mki, J; Byts, N; Koivunen, P; Myllyharju, J; Fandrey, J; Winning, S
Prolyl hydroxylase domain 2 reduction enhances skeletal muscle tissue regeneration after soft tissue trauma in mice.
PLoS One
15
e0233261
2020
Mus sp., Mus musculus, Areas
Rahimi, N; Azizi, M; Bahari, G; Narouie, B; Hashemi, M
Association of EGLN2 rs10680577 Polymorphism with the Risk and Clinicopathological Features of Patients with Prostate Cancer.
Asian Pac J Cancer Prev
21
1221-1226
2020
Homo sapiens
Francis, I; Arcot, M; Mohiyuddin S M, A; Balakrishna, S
Hypoxia responsiveness linked variant in EGLN1 gene is enriched in oral cancer patients.
Arch Oral Biol
116
104767
2020
Homo sapiens
Liu, G; Zhao, W; Zhang, H; Wang, T; Han, Z; Ji, X
rs1769793 variant reduces EGLN1 expression in skeletal muscle and hippocampus and contributes to high aerobic capacity in hypoxia.
Proc Natl Acad Sci U S A
117
29283-29285
2020
Hippocampus
Mtt, J; Serpi, R; Hrkk, S; Izzi, V; Myllyharju, J; Dimova, EY; Koivunen, P
Genetic Ablation of Transmembrane Prolyl 4-Hydroxylase Reduces Atherosclerotic Plaques in Mice.
Arterioscler Thromb Vasc Biol
41
2128-2140
2021
Mus sp.
Demandt, JAF; van Kuijk, K; Theelen, TL; Marsch, E; Heffron, SP; Fisher, EA; Carmeliet, P; Biessen, EAL; Sluimer, JC
Whole-Body Prolyl Hydroxylase Domain (PHD) 3 Deficiency Increased Plasma Lipids and Hematocrit Without Impacting Plaque Size in Low-Density Lipoprotein Receptor Knockout Mice.
Front Cell Dev Biol
9
664258
2021
Mus sp.
Koren, A; Rijavec, M; Krumpestar, T; Kern, I; Sadikov, A; ?ufer, T; Koroec, P
Gene Expression Levels of the Prolyl Hydroxylase Domain Proteins PHD1 and PHD2 but Not PHD3 Are Decreased in Primary Tumours and Correlate with Poor Prognosis of Patients with Surgically Resected Non-Small-Cell Lung Cancer.
Cancers (Basel)
13
2021
Homo sapiens
Evans, CE; Humphries, J; Mattock, K; Waltham, M; Wadoodi, A; Saha, P; Modarai, B; Smith, A
Hypoxia and Upregulation of Hypoxia-Inducible Factor 1{alpha} Stimulate Venous Thrombus Recanalization.
Arterioscler Thromb Vasc Biol
2010
Thrombus, Mus sp.
Basic, VT; Tadele, E; Elmabsout, AA; Yao, H; Rahman, I; Sirsj, A; Abdel-Halim, SM
Exposure to cigarette smoke induces overexpression of von Hippel-Lindau tumor suppressor in mouse skeletal muscle.
Am J Physiol Lung Cell Mol Physiol
303
L519-27
2012
Mus sp., Mus musculus, Metazoa
Roda, JM; Wang, Y; Sumner, LA; Phillips, GS; Marsh, CB; Eubank, TD
Stabilization of HIF-2? Induces sVEGFR-1 Production from Tumor-Associated Macrophages and Decreases Tumor Growth in a Murine Melanoma Model.
J Immunol
189
3168-77
2012
Mus musculus, Mus sp.
Wu, C; Zhou, Y; Chang, J; Xiao, Y
Delivery of dimethyloxallyl glycine in mesoporous bioactive glass scaffolds to improve angiogenesis and osteogenesis of human bone marrow stromal cells.
Acta Biomater
9
9159-9168
2013
Marburg marburgvirus
Benderro, GF; Tsipis, CP; Sun, X; Kuang, Y; Lamanna, JC
Increased HIF-1? and HIF-2? Accumulation, but Decreased Microvascular Density, in Chronic Hyperoxia and Hypercapnia in the Mouse Cerebral Cortex.
Adv Exp Med Biol
789
29-35
2013
Mus musculus, Mus sp.
Wu, L; Hu, Y; Jiang, L; Liang, N; Liu, P; Hong, H; Yang, S; Chen, W
Zhuyu Annao decoction promotes angiogenesis in mice with cerebral hemorrhage by inhibiting the activity of PHD3.
Hum Exp Toxicol
9603271211008523
2021
Mus sp.
Beemelmanns, A; Zanuzzo, FS; Xue, X; Sandrelli, RM; Rise, ML; Gamperl, AK
The transcriptomic responses of Atlantic salmon (Salmo salar) to high temperature stress alone, and in combination with moderate hypoxia.
BMC Genomics
22
261
2021
Chondrichthyes
Cosentino, F; Barker, JE; Brand, MP; Heales, SJ; Werner, ER; Tippins, JR; West, N; Channon, KM; Volpe, M; Lüscher, TF
Reactive oxygen species mediate endothelium-dependent relaxations in tetrahydrobiopterin-deficient mice.
Arterioscler Thromb Vasc Biol
21
496-502
2001
Mus sp., Mus musculus
Zeng, BY; Heales, SJ; Canevari, L; Rose, S; Jenner, P
Alterations in expression of dopamine receptors and neuropeptides in the striatum of GTP cyclohydrolase-deficient mice.
Exp Neurol
190
515-24
2004
Mus sp., Homo sapiens, Mus musculus
Nandi, M; Miller, A; Stidwill, R; Jacques, TS; Lam, AA; Haworth, S; Heales, S; Vallance, P
Pulmonary hypertension in a GTP-cyclohydrolase 1-deficient mouse.
Circulation
111
2086-90
2005
Mus musculus, Mus sp.
Welsh, C; Jarrin, J; Daneman, A; Belik, J
In vivo ultrasound assessment of gastric emptying in newborn mice.
J Pediatr Gastroenterol Nutr
60
322-6
2015
Mus sp.
Yogev, O; Lagos, D; Enver, T; Boshoff, C
Kaposi's sarcoma herpesvirus microRNAs induce metabolic transformation of infected cells.
PLoS Pathog
10
e1004400
2014
Human gammaherpesvirus 8
Wang, G; Zhen, Y; Yu, Z; Shi, Y; Zhao, Q; Wang, J; Mi, T
The physiological and molecular response of Aurelia sp.1 under hypoxia.
Sci Rep
7
1558
2017
Aurelia
Law, AY; Ching, LY; Lai, KP; Wong, CK
Identification and characterization of the hypoxia-responsive element in human stanniocalcin-1 gene.
Mol Cell Endocrinol
2009
Homo sapiens
Siu, KL; Miao, XN; Cai, H
Recoupling of eNOS with folic acid prevents abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E null mice.
PLoS One
9
e88899
2014
Mus sp.
Miao, XN; Siu, KL; Cai, H
Nifedipine attenuation of abdominal aortic aneurysm in hypertensive and non-hypertensive mice: Mechanisms and implications.
J Mol Cell Cardiol
87
152-9
2015
Mus sp.
Ferreira, BL; Leite, GGF; Brunialti, MKC; Assuncao, M; Azevedo, LCP; Freitas, F; Salomao, R
HIF-1? and Hypoxia Responsive Genes are Differentially Expressed in Leukocytes From Survivors and Non-Survivors Patients During Clinical Sepsis.
Shock
56
80-91
2021
Homo sapiens
Peng, H; Purkerson, JM; Freeman, RS; Schwaderer, AL; Schwartz, GJ
Acidosis induces antimicrobial peptide expression and resistance to uropathogenic E. coli infection in kidney collecting duct cells via HIF-1?.
Am J Physiol Renal Physiol
318
F468-F474
2020
Escherichia coli
Adesida, AB; Grady, LM; Khan, WS; Millward-Sadler, SJ; Salter, DM; Hardingham, TE
Human meniscus cells express hypoxia inducible factor-1alpha and increased SOX9 in response to low oxygen tension in cell aggregate culture.
Arthritis Res Ther
9
R69
2007
Meniscus
Welsh, C; Enomoto, M; Pan, J; Shifrin, Y; Belik, J
Tetrahydrobiopterin deficiency induces gastroparesis in newborn mice.
Am J Physiol Gastrointest Liver Physiol
305
G47-57
2013
Mus sp., Metazoa
Elberson, VD; Nielsen, LC; Wang, H; Kumar, HS
Effects of intermittent hypoxia and hyperoxia on angiogenesis and lung development in newborn mice.
J Neonatal Perinatal Med
8
313-22
2016
Mus sp.
Jang, JH; Seo, JY; Jang, J; Jung, CW; Lee, KO; Kim, SH; Kim, HJ
Hereditary gene mutations in Korean patients with isolated erythrocytosis.
Ann Hematol
2014
Homo sapiens
Bento, C; Almeida, H; Maia, TM; Relvas, L; Oliveira, AC; Rossi, C; Girodon, F; Fernandez-Lago, C; Aguado-Diaz, A; Fraga, C; Costa, RM; Arajo, AL; Silva, J; Vitria, H; Miguel, N; Silveira, MP; Martin-Nuez, G; Ribeiro, ML
Molecular study of congenital erythrocytosis in 70 unrelated patients revealed a potential causal mutation in less than half of the cases (Where is/are the missing gene(s)?).
Eur J Haematol
91
361-8
2013
Homo sapiens
Petousi, N; Robbins, PA
Human adaptation to the hypoxia of high altitude: the Tibetan paradigm from the pregenomic to the postgenomic era.
J Appl Physiol (1985)
116
875-84
2014
Homo sapiens, Mus sp.
Hua, X; Ying, H; Qiang, Y; Wen-Bing, LI; Hui, LU; Zheng-Ping, J; Rong, W
[Expression of plateau adaptation gene of rat tissues after plain acute exposure to high altitude].
Zhejiang Da Xue Xue Bao Yi Xue Ban
44
571-7
2015
Rattus, Rattus norvegicus
Raichoudhury, R; Spinowitz, BS
Treatment of anemia in difficult-to-manage patients with chronic kidney disease.
Kidney Int Suppl (2011)
11
26-34
2021
Homo sapiens
Yang, Y; Gao, C; Yang, T; Sha, Y; Cai, Y; Wang, X; Yang, Q; Liu, C; Wang, B; Zhao, S
Characteristics of Tibetan pig lung tissue in response to a hypoxic environment on the Qinghai-Tibet Plateau.
Arch Anim Breed
64
283-292
2021
Suidae
Rolfe, VE; Brand, MP; Heales, SJ; Lindley, KJ; Milla, PJ
Tetrahydrobiopterin regulates cyclic GMP-dependent electrogenic Cl- secretion in mouse ileum in vitro.
J Physiol
503 ( Pt 2)
347-52
1997
Mus musculus, Mus sp.
Suginaka, R; Izui, R; Inoue, J; Muraoka, Y; Yamaguchi, K; Otsuka, M; Umezawa, K
Induction of apoptosis in human pancreatic carcinoma cells by a synthetic bleomycin-like ligand.
Jpn J Cancer Res
89
947-53
1998
Homo sapiens
Hosono, T; Yokomizo, K; Hamasaki, A; Okamoto, Y; Okawara, T; Otsuka, M; Mukai, R; Suzuki, K
Antiviral activities against herpes simplex virus type 1 by HPH derivatives and their structure-activity relationships.
Bioorg Med Chem Lett
18
371-4
2008
Human alphaherpesvirus 1
Ozolinš, TR; Fisher, TS; Nadeau, DM; Stock, JL; Klein, AS; Milici, AJ; Morton, D; Wilhelms, MB; Brissette, WH; Li, B
Defect in embryonic development of EGLN1/PHD2 knockdown transgenic mice is associated with induction of Igfbp in the placenta.
Biochem Biophys Res Commun
2009
Mus musculus, Mus sp.
Charchar, FJ; Kaiser, M; Bingham, AJ; Fotinatos, N; Ahmady, F; Tomaszewski, M; Samani, NJ
Whole genome survey of copy number variation in the spontaneously hypertensive rat: relationship to quantitative trait loci, gene expression, and blood pressure.
Hypertension
55
1231-8
2010
Rattus, Metazoa, Candida dubliniensis
Ren, H; Liu, NY; Song, XF; Ma, YS; Zhai, XY
A novel specific application of pyruvate protects the mouse retina against white light damage: differential stabilization of HIF-1{alpha} and HIF-2{alpha}
Invest Ophthalmol Vis Sci
2011
Mus musculus, Mus sp.
Peurala, E; Koivunen, P; Bloigu, R; Haapasaari, KM; Jukkola-Vuorinen, A
Expressions of individual PHDs associate with good prognostic factors and increased proliferation in breast cancer patients.
Breast Cancer Res Treat
2011
Homo sapiens
Ladroue, C; Hoogewijs, D; Gad, S; Carcenac, R; Storti, F; Barrois, M; Gimenez-Roqueplo, AP; Leporrier, M; Casadevall, N; Hermine, O; Kiladjian, JJ; Baruchel, A; Fakhoury, F; Bressac-de Paillerets, B; Feunteun, J; Mazure, N; Pouyssgur, J; Wenger, RH; Richard, S; Gardie, B
Distinct deregulation of the hypoxia inducible factor by PHD2 mutants identified in germline DNA of patients with polycythemia.
Haematologica
97
9-14
2012
Homo sapiens
Ji, LD; Qiu, YQ; Xu, J; Irwin, DM; Tam, SC; Tang, NL; Zhang, YP
Genetic Adaptation of the Hypoxia-Inducible Factor Pathway to Oxygen Pressure among Eurasian Human Populations.
Mol Biol Evol
2012
Homo sapiens
Han, D; Wen, L; Chen, Y
Molecular cloning of phd1 and comparative analysis of phd1, 2, and 3 expression in Xenopus laevis.
ScientificWorldJournal
2012
689287
2012
vertebrata, Mus musculus, Mus sp.
Bishop, T; Talbot, NP; Turner, PJ; Nicholls, LG; Pascual, A; Hodson, EJ; Douglas, G; Fielding, JW; Smith, TG; Demetriades, M; Schofield, CJ; Robbins, PA; Pugh, CW; Buckler, KJ; Ratcliffe, PJ
Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2.
J Physiol
591
3565-77
2013
Mus sp., Metazoa
Takeda, K; Duan, LJ; Takeda, H; Fong, GH
Improved vascular survival and growth in the mouse model of hindlimb ischemia by a remote signaling mechanism.
Am J Pathol
184
686-96
2014
Mus musculus, Mus sp.
Gupta, R; Chaudhary, AR; Shah, BN; Jadhav, AV; Zambad, SP; Gupta, RC; Deshpande, S; Chauthaiwale, V; Dutt, C
Therapeutic treatment with a novel hypoxia-inducible factor hydroxylase inhibitor (TRC160334) ameliorates murine colitis.
Clin Exp Gastroenterol
7
13-23
2014
Mus musculus, animal
Snell, CE; Turley, H; McIntyre, A; Li, D; Masiero, M; Schofield, CJ; Gatter, KC; Harris, AL; Pezzella, F
Proline-hydroxylated hypoxia-inducible factor 1? (HIF-1?) upregulation in human tumours.
PLoS One
9
e88955
2014
Areas
Dai, Z; Li, M; Wharton, J; Zhu, MM; Zhao, YY
Prolyl-4 Hydroxylase 2 (PHD2) Deficiency in Endothelial Cells and Hematopoietic Cells Induces Obliterative Vascular Remodeling and Severe Pulmonary Arterial Hypertension in Mice and Humans Through Hypoxia-Inducible Factor-2?.
Circulation
133
2447-58
2016
Mus sp.
Heber-Katz, E
Oxygen, Metabolism, and Regeneration: Lessons from Mice.
Trends Mol Med
23
1024-1036
2017
Mus musculus
Zhang, X; Liu, Z; Xiao, Q; Zeng, C; Lai, CH; Fan, X; Ye, Q; Wang, Y; Xiong, Y
Donor Treatment With a Hypoxia-Inducible Factor-1 Agonist Prevents Donation After Cardiac Death Liver Graft Injury in a Rat Isolated Perfusion Model.
Artif Organs
42
280-289
2018
Rattus, Metazoa
Chandrasekhar, C; Pasupuleti, SK; Sarma, PVGK
Novel mutations in the EPO-R, VHL and EPAS1 genes in the Congenital Erythrocytosis patients.
Blood Cells Mol Dis
85
102479
2020
Homo sapiens
Liu, X; Li, Z; Yan, Y; Li, Y; Wu, H; Pei, J; Yan, P; Yang, R; Guo, X; Lan, X
Selection and introgression facilitated the adaptation of Chinese native endangered cattle in extreme environments.
Evol Appl
14
860-873
2021
Bos taurus, Bos grunniens
D'Hulst, G; Soro-Arnaiz, I; Masschelein, E; Veys, K; Fitzgerald, G; Smeuninx, B; Kim, S; Deldicque, L; Blaauw, B; Carmeliet, P; Breen, L; Koivunen, P; Zhao, SM; De Bock, K
PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase.
Nat Commun
11
174
2020
Mus sp.
Fukui, K; Shinozaki, Y; Kobayashi, H; Deai, K; Yoshiuchi, H; Matsui, T; Matsuo, A; Matsushita, M; Tanaka, T; Nangaku, M
JTZ-951 (enarodustat), a hypoxia-inducibe factor prolyl hydroxylase inhibitor, stabilizes HIF-? protein and induces erythropoiesis without effects on the function of vascular endothelial growth factor.
Eur J Pharmacol
859
172532
2019
Homo sapiens
Palese, F; Pontis, S; Realini, N; Piomelli, D
A protective role for N-acylphosphatidylethanolamine phospholipase D in 6-OHDA-induced neurodegeneration.
Sci Rep
9
15927
2019
Mus sp.
Montañez, CS; McDonald, JD
Linkage analysis of the hph-1 mutation and the GTP cyclohydrolase I structural gene.
Mol Genet Metab
68
91-2
1999
Homo sapiens, Mus musculus
Xie, HH; Zhou, S; Chen, DD; Channon, KM; Su, DF; Chen, AF
GTP cyclohydrolase I/BH4 pathway protects EPCs via suppressing oxidative stress and thrombospondin-1 in salt-sensitive hypertension.
Hypertension
56
1137-44
2010
Mus sp.
Adlam, D; Herring, N; Douglas, G; De Bono, JP; Li, D; Danson, EJ; Tatham, A; Lu, CJ; Jennings, KA; Cragg, SJ; Casadei, B; Paterson, DJ; Channon, KM
Regulation of ?-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin.
Cardiovasc Res
93
694-701
2012
Mus musculus
Tie, L; Chen, LY; Chen, DD; Xie, HH; Channon, KM; Chen, AF
GTP Cyclohydrolase I Prevents Diabetic Impaired Endothelial Progenitor Cells and Wound Healing by Suppressing Oxidative Stress/Thrombospondin-1.
Am J Physiol Endocrinol Metab
2014
Mus sp.
Rane, A; Rajagopalan, S; Ahuja, M; Thomas, B; Chinta, SJ; Andersen, JK
Hsp90 Co-chaperone p23 contributes to dopaminergic mitochondrial stress via stabilization of PHD2: Implications for Parkinson's disease.
Neurotoxicology
65
166-173
2018
Compacta
Crabtree, MJ; Hale, AB; Channon, KM
Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency.
Free Radic Biol Med
2011
Mus musculus, Mus sp.
Ellinghaus, P; Heisler, I; Unterschemmann, K; Haerter, M; Beck, H; Greschat, S; Ehrmann, A; Summer, H; Flamme, I; Oehme, F; Thierauch, K; Michels, M; Hess-Stumpp, H; Ziegelbauer, K
BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I.
Cancer Med
2
611-24
2013
Homo sapiens
Hay, E; Wilson, LC; Hoskins, B; Samuels, M; Munot, P; Rahman, S
Biallelic P4HTM variants associated with HIDEA syndrome and mitochondrial respiratory chain complex I deficiency.
Eur J Hum Genet
2021
animal
Ivan, M; Haberberger, T; Gervasi, DC; Michelson, KS; Günzler, V; Kondo, K; Yang, H; Sorokina, I; Conaway, RC; Conaway, JW; Kaelin, WG
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor.
Proc Natl Acad Sci U S A
99
13459-64
2002
collection
Warshakoon, NC; Wu, S; Boyer, A; Kawamoto, R; Sheville, J; Renock, S; Xu, K; Pokross, M; Evdokimov, AG; Walter, R; Mekel, M
A novel series of imidazo[1,2-a]pyridine derivatives as HIF-1alpha prolyl hydroxylase inhibitors.
Bioorg Med Chem Lett
16
5598-601
2006
Homo sapiens
Schultz, K; Murthy, V; Tatro, JB; Beasley, D
Prolyl hydroxylase 2 deficiency limits proliferation of vascular smooth muscle cells by HIF-1{alpha}-dependent mechanisms.
Am J Physiol Lung Cell Mol Physiol
2009
Homo sapiens
Zhang, Q; Gu, J; Li, L; Liu, J; Luo, B; Cheung, HW; Boehm, JS; Ni, M; Geisen, C; Root, DE; Polyak, K; Brown, M; Richardson, AL; Hahn, WC; Kaelin, WG; Bommi-Reddy, A
Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase.
Cancer Cell
16
413-24
2009
Drosophila
Marsch, E; Demandt, JA; Theelen, TL; Tullemans, BM; Wouters, K; Boon, MR; van Dijk, TH; Gijbels, MJ; Dubois, LJ; Meex, SJ; Mazzone, M; Hung, G; Fisher, EA; Biessen, EA; Daemen, MJ; Rensen, PC; Carmeliet, P; Groen, AK; Sluimer, JC
Deficiency of the oxygen sensor prolyl hydroxylase 1 attenuates hypercholesterolaemia, atherosclerosis, and hyperglycaemia.
Eur Heart J
2016
Mus sp.
Aglan, A; Longen, S; Dehne, N; Khler, Y; Hassan, M; Beck, M; Tredup, C; Boosen, M; Hsieh, TL; Schaefer, L; Beck, KF; Pfeilschifter, J
Nitric oxide mediates prolyl hydroxylase 3 expression in mesangial cells and in glomerulonephritis.
J Mol Med (Berl)
95
257-271
2017
Mus musculus
Neck?, J; Hsu, A; Hye Khan, MA; Gross, GJ; Nithipatikom, K; Cyprov, M; Benk, D; Hlav?kov, M; Sotkov-Kaparov, D; Falck, JR; Sedmera, D; Kol?, F; Imig, JD
Infarct size-limiting effect of epoxyeicosatrienoic acid analog EET-B is mediated by hypoxia-inducible factor-1? via downregulation of prolyl hydroxylase 3.
Am J Physiol Heart Circ Physiol
315
H1148-H1158
2018
Areas, Septa
Kampantais, S; Kounatidis, I; Kotoula, V; Vakalopoulos, I; Gkagkalidis, K; Dimitriadis, G
Decreased prolyl hydroxylase 3 mRNA expression in oncocytomas compared with clear cell renal cell carcinoma.
Int J Biol Markers
35
80-86
2020
Homo sapiens
To, KK; Huang, LE
Suppression of hypoxia-inducible factor 1alpha (HIF-1alpha) transcriptional activity by the HIF prolyl hydroxylase EGLN1.
J Biol Chem
280
38102-7
2005
Mammalia
Siddiq, A; Ayoub, IA; Chavez, JC; Aminova, L; Shah, S; LaManna, JC; Patton, SM; Connor, JR; Cherny, RA; Volitakis, I; Bush, AI; Langsetmo, I; Seeley, T; Gunzler, V; Ratan, RR
Hypoxia-inducible factor prolyl 4-hydroxylase inhibition. A target for neuroprotection in the central nervous system.
J Biol Chem
280
41732-43
2005
Rattus
Hatzimichael, E; Dasoula, A; Shah, R; Syed, N; Papoudou-Bai, A; Coley, HM; Dranitsaris, G; Bourantas, KL; Stebbing, J; Crook, T
The prolyl-hydroxylase EGLN3 and not EGLN1 is inactivated by methylation in plasma cell neoplasia.
Eur J Haematol
2009
Homo sapiens
Tambuwala, MM; Cummins, EP; Lenihan, CR; Kiss, J; Stauch, M; Scholz, CC; Fraisl, P; Lasitschka, F; Mollenhauer, M; Saunders, SP; Maxwell, PH; Carmeliet, P; Fallon, PG; Schneider, M; Taylor, CT
Loss of Prolyl Hydroxylase-1 Protects Against Colitis Through Reduced Epithelial Cell Apoptosis and Increased Barrier Function.
Gastroenterology
2010
Mus sp., Homo sapiens, Mus musculus
Flagg, SC; Giri, N; Pektas, S; Maroney, MJ; Knapp, MJ
Inverse Solvent Isotope Effects Demonstrate Slow Aquo Release from Hypoxia Inducible Factor-Prolyl Hydroxylase (PHD2).
Biochemistry
51
6654-66
2012
Homo sapiens
Huo, Z; Ye, JC; Chen, J; Lin, X; Zhou, ZN; Xu, XR; Li, CM; Qi, M; Liang, D; Liu, Y; Li, J
Prolyl hydroxylase domain protein 2 regulates the intracellular cyclic AMP level in cardiomyocytes through its interaction with phosphodiesterase 4D.
Biochem Biophys Res Commun
2012
Rattus
Yum, S; Doh, HJ; Hong, S; Jeong, S; Kim, DD; Park, M; Jung, Y
Piceatannol, a hydroxystilbene natural product, stabilizes HIF-1? protein by inhibiting HIF prolyl hydroxylase.
Eur J Pharmacol
699
124-31
2013
Homo sapiens
Reischl, S; Li, L; Walkinshaw, G; Flippin, LA; Marti, HH; Kunze, R
Inhibition of HIF prolyl-4-hydroxylases by FG-4497 reduces brain tissue injury and edema formation during ischemic stroke.
PLoS One
9
e84767
2014
Mus sp.
Del Balzo, U; Signore, PE; Walkinshaw, G; Seeley, TW; Brenner, MC; Wang, Q; Guo, G; Arend, MP; Flippin, LA; Chow, FA; Gervasi, DC; Kjaergaard, CH; Langsetmo, I; Guenzler, V; Liu, DY; Klaus, SJ; Lin, A; Neff, TB
Nonclinical Characterization of the Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat, a Novel Treatment of Anemia of Chronic Kidney Disease.
J Pharmacol Exp Ther
374
342-353
2020
animal
Maruno, S; Tanaka, T; Nangaku, M
[Renal anemia and hypoxia-inducible factor prolyl hydroxylase inhibitor].
Rinsho Ketsueki
62
371-377
2021
Homo sapiens, Dialysis, animal
Huang, KT; Mikeska, T; Dobrovic, A; Fox, SB
DNA methylation analysis of the HIF-1? prolyl hydroxylase domain genes PHD1, PHD2, PHD3 and the factor inhibiting HIF gene FIH in invasive breast carcinomas.
Histopathology
57
451-60
2010
Homo sapiens
Gao, L; Siu, KL; Chalupsky, K; Nguyen, A; Chen, P; Weintraub, NL; Galis, Z; Cai, H
Role of uncoupled endothelial nitric oxide synthase in abdominal aortic aneurysm formation: treatment with folic acid.
Hypertension
59
158-66
2012
Mus sp.
Yasukochi, Y; Nishimura, T; Ugarte, J; Ohnishi, M; Nishihara, M; Alvarez, G; Fukuda, H; Mendoza, V; Aoyagi, K
Effect of EGLN1 Genetic Polymorphisms on Hemoglobin Concentration in Andean Highlanders.
Biomed Res Int
2020
3436581
2020
Homo sapiens
Takeda, K; Aguila, HL; Parikh, NS; Li, X; Lamothe, K; Duan, LJ; Takeda, H; Lee, FS; Fong, GH
Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins.
Blood
111
3229-35
2008
Mus sp.
Mecinović, J; Chowdhury, R; Flashman, E; Schofield, CJ
Use of mass spectrometry to probe the nucleophilicity of cysteinyl residues of prolyl hydroxylase domain 2.
Anal Biochem
393
215-21
2009
Homo sapiens
Mecinović, J; Loenarz, C; Chowdhury, R; Schofield, CJ
2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2.
Bioorg Med Chem Lett
19
6192-5
2009
Homo sapiens
Flashman, E; Hoffart, LM; Hamed, RB; Bollinger Jr, JM; Krebs, C; Schofield, CJ
Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen.
FEBS J
2010
Homo sapiens
Flashman, E; Hoffart, LM; Hamed, RB; Bollinger, JM; Krebs, C; Schofield, CJ
Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen.
FEBS J
277
4089-99
2010
Homo sapiens
Aggarwal, S; Negi, S; Jha, P; Singh, PK; Stobdan, T; Pasha, MA; Ghosh, S; Agrawal, A; , ; Prasher, B; Mukerji, M; ,
EGLN1 involvement in high-altitude adaptation revealed through genetic analysis of extreme constitution types defined in Ayurveda.
Proc Natl Acad Sci U S A
107
18961-18966
2010
Pitta, Homo sapiens
Hlscher, M; Silter, M; Krull, S; von Ahlen, M; Hesse, A; Schwartz, P; Wielockx, B; Breier, G; Katschinski, DM; Zieseniss, A
Cardiomyocyte-specific Prolyl-4-hydroxylase Domain 2 Knock Out Protects from Acute Myocardial Ischemic Injury.
J Biol Chem
286
11185-94
2011
Mus sp.
Su, Y; Loos, M; Giese, N; Metzen, E; Bchler, MW; Friess, H; Kornberg, A; Bchler, P
Prolyl hydroxylase-2 (PHD2) exerts tumor-suppressive activity in pancreatic cancer.
Cancer
2011
Homo sapiens, Mus musculus
Su, C; Huang, K; Sun, L; Yang, D; Zheng, H; Gao, C; Tong, J; Zhang, Q
Overexpression of the HIF hydroxylase PHD3 is a favorable prognosticator for gastric cancer.
Med Oncol
2012
Homo sapiens
Klotzsche-von Ameln, A; Muschter, A; Heimesaat, MM; Breier, G; Wielockx, B
HIF prolyl hydroxylase-2 inhibition diminishes tumor growth through matrix metalloproteinase-induced TGF? activation.
Cancer Biol Ther
13
216-23
2012
Mus musculus
Buroker, NE; Ning, XH; Zhou, ZN; Li, K; Cen, WJ; Wu, XF; Zhu, WZ; Scott, CR; Chen, SH
EPAS1 and EGLN1 associations with high altitude sickness in Han and Tibetan Chinese at the Qinghai-Tibetan Plateau.
Blood Cells Mol Dis
49
67-73
2012
Homo sapiens
Kunze, R; Zhou, W; Veltkamp, R; Wielockx, B; Breier, G; Marti, HH
Neuron-Specific Prolyl-4-Hydroxylase Domain 2 Knockout Reduces Brain Injury After Transient Cerebral Ischemia.
Stroke
2012
Mus sp., Metazoa
Yeoh, KK; Chan, MC; Thalhammer, A; Demetriades, M; Chowdhury, R; Tian, YM; Stolze, I; McNeill, LA; Lee, MK; Woon, EC; Mackeen, MM; Kawamura, A; Ratcliffe, PJ; Mecinovi?, J; Schofield, CJ
Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion.
Org Biomol Chem
11
732-45
2013
Homo sapiens
Xiang, K; Ouzhuluobu, ; Peng, Y; Yang, Z; Zhang, X; Cui, C; Zhang, H; Li, M; Zhang, Y; Bianba, ; Gonggalanzi, ; Basang, ; Ciwangsangbu, ; Wu, T; Chen, H; Shi, H; Qi, X; Su, B
Identification of a Tibetan-specific mutation in the hypoxic gene EGLN1 and its contribution to high-altitude adaptation.
Mol Biol Evol
30
1889-98
2013
insertion sequences, Homo sapiens
Mamlouk, S; Kalucka, J; Singh, RP; Franke, K; Muschter, A; Langer, A; Jakob, C; Gassmann, M; Baretton, GB; Wielockx, B
Loss of prolyl hydroxylase-2 in myeloid cells and T-lymphocytes impairs tumor development.
Int J Cancer
2013
Mus sp., Homo sapiens
Rajagopalan, S; Chinta, SJ; Andersen, JK
Pharmacological Prolyl Hydroxylase Domain Inhibition as a Therapeutic Target for Parkinson's Disease.
CNS Neurol Disord Drug Targets
2013
Homo sapiens, Metazoa, Compacta
Hong, YR; Kim, HT; Lee, SC; Ro, S; Cho, JM; Kim, IS; Jung, YH
[(4-Hydroxyl-benzo[4,5]thieno[3,2-c]pyridine-3-carbonyl)-amino]-acetic acid derivatives; HIF prolyl 4-hydroxylase inhibitors as oral erythropoietin secretagogues.
Bioorg Med Chem Lett
23
5953-5957
2013
animal
Lijkwan, M; Hellingman, A; Bos, E; van der Bogt, K; Huang, M; Kooreman, N; de Vries, M; Peters, H; Robbins, RC; Hammings, J; Quax, P; Wu, JC
Short Hairpin RNA Gene Silencing of Prolyl Hydroxylase-2 with a Minicircle Vector Improves Neovascularization of Hindlimb Ischemia.
Hum Gene Ther
2013
Mus musculus, Mus sp.
Howangyin, KY; Loinard, C; Bakker, W; Gurin, CL; Vilar, J; D'Audigier, C; Mauge, L; Bruneval, P; Emmerich, J; Lvy, B; Pouyssgur, J; Smadja, DM; Silvestre, JS
HIF-prolyl hydroxylase 2 inhibition enhances the efficiency of mesenchymal stem cells-based therapies for the treatment of critical limb ischemia.
Stem Cells
2013
Homo sapiens, Mus musculus, Mus sp.
Watanabe, A; Ichiki, T; Sankoda, C; Takahara, Y; Ikeda, J; Inoue, E; Tokunou, T; Kitamoto, S; Sunagawa, K
Suppression of abdominal aortic aneurysm formation by inhibition of prolyl hydroxylase domain protein through attenuation of inflammation and extracellular matrix disruption.
Clin Sci (Lond)
126
671-8
2014
Mus sp.
Kim, J; Kwak, HJ; Cha, JY; Jeong, YS; Rhee, SD; Cheon, HG
The role of prolyl hydroxylase domain protein (PHD) during rosiglitazone-induced adipocyte differentiation.
J Biol Chem
289
2755-64
2014
Mus musculus
Wang, J; Zhang, J; Zhou, C; Chen, L; Yu, Q
An Insertion/Deletion Polymorphism Within the Proximal Promoter of EGLN2 Is Associated With Susceptibility for Gastric Cancer in the Chinese Population.
Genet Test Mol Biomarkers
18
269-73
2014
Homo sapiens
Rahtu-Korpela, L; Karsikas, S; Hrkk, S; Blanco Sequeiros, R; Lammentausta, E; Mkel, KA; Herzig, KH; Walkinshaw, G; Kivirikko, KI; Myllyharju, J; Serpi, R; Koivunen, P
HIF Prolyl 4-Hydroxylase-2 Inhibition Improves Glucose and Lipid Metabolism and Protects Against Obesity and Metabolic Dysfunction.
Diabetes
63
3324-33
2014
Mus sp.
Zhang, E; Zhang, J; Jin, J; Qin, J; Li, H; Huang, L
Variants of the low oxygen sensors EGLN1 and HIF-1AN associated with acute mountain sickness.
Int J Mol Sci
15
21777-87
2014
Homo sapiens
Yum, S; Jeong, S; Lee, S; Kim, W; Nam, J; Jung, Y
HIF-prolyl hydroxylase is a potential molecular target for esculetin-mediated anti-colitic effects.
Fitoterapia
103
55-62
2015
Homo sapiens, Rattus
Aggarwal, S; Gheware, A; Agrawal, A; Ghosh, S; Prasher, B; Mukerji, M; ,
Combined genetic effects of EGLN1 and VWF modulate thrombotic outcome in hypoxia revealed by Ayurgenomics approach.
J Transl Med
13
184
2015
Pitta, Mus musculus
Kang, JH; Kwak, HJ; Choi, HE; Kim, J; Hong, S; Kim, OH; Oh, BC; Cheon, HG
Involvement of Prolyl Hydroxylase Domain Protein in the Rosiglitazone-Induced Suppression of Osteoblast Differentiation.
PLoS One
10
e0139093
2015
Homo sapiens, Mus sp., Metazoa
Olenchock, BA; Moslehi, J; Baik, AH; Davidson, SM; Williams, J; Gibson, WJ; Pierce, KA; Miller, CM; Hanse, EA; Kelekar, A; Sullivan, LB; Wagers, AJ; Clish, CB; Vander Heiden, MG; Kaelin, WG
EGLN1 Inhibition and Rerouting of ?-Ketoglutarate Suffice for Remote Ischemic Protection.
Cell
164
884-95
2016
Mus musculus, Mus sp.
Shin, J; Nunomiya, A; Kitajima, Y; Dan, T; Miyata, T; Nagatomi, R
Prolyl hydroxylase domain 2 deficiency promotes skeletal muscle fiber-type transition via a calcineurin/NFATc1-dependent pathway.
Skelet Muscle
6
5
2015
Mus musculus, Mus sp.
Huang, M; Paglialunga, S; Wong, JM; Hoang, M; Pillai, R; Joseph, JW
Role of prolyl hydroxylase domain proteins in the regulation of insulin secretion.
Physiol Rep
4
2016
Homo sapiens, Rattus
Zhu, K; Song, P; Lai, Y; Liu, C; Xiao, G
Prolyl hydroxylase domain proteins regulate bone mass through their expression in osteoblasts.
Gene
2016
Mus musculus, Mus sp.
Takada, M; Zhuang, M; Inuzuka, H; Zhang, J; Zurlo, G; Zhang, J; Zhang, Q
EglN2 contributes to triple negative breast tumorigenesis by functioning as a substrate for the FBW7 tumor suppressor.
Oncotarget
8
6787-6795
2017
Mus musculus, Mus sp.
Zhang, L; Peng, S; Dai, X; Gan, W; Nie, X; Wei, W; Hu, G; Guo, J
Tumor suppressor SPOP ubiquitinates and degrades EglN2 to compromise growth of prostate cancer cells.
Cancer Lett
390
11-20
2017
Homo sapiens
Hulley, PA; Bishop, T; Vernet, A; Schneider, JE; Edwards, JR; Athanasou, NA; Knowles, HJ
Hypoxia-inducible factor 1-alpha does not regulate osteoclastogenesis but enhances bone resorption activity via prolyl-4-hydroxylase 2.
J Pathol
242
322-333
2017
Mus musculus, Mus sp.
Sugahara, M; Tanaka, T; Nangaku, M
Prolyl hydroxylase domain inhibitors as a novel therapeutic approach against anemia in chronic kidney disease.
Kidney Int
92
306-312
2017
Homo sapiens
Abboud, MI; McAllister, TE; Leung, IKH; Chowdhury, R; Jorgensen, C; Domene, C; Mecinovi?, J; Lippl, K; Hancock, RL; Hopkinson, RJ; Kawamura, A; Claridge, TDW; Schofield, CJ
2-Oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2.
Chem Commun (Camb)
54
3130-3133
2018
Metazoa
Drevytska, T; Gonchar, E; Okhai, I; Lynnyk, O; Mankovska, I; Klionsky, D; Dosenko, V
The protective effect of Hif3a RNA interference and HIF-prolyl hydroxylase inhibition on cardiomyocytes under anoxia-reoxygenation.
Life Sci
202
131-139
2018
Rattus
Hashemi, M; Danesh, H; Bizhani, F; Sattarifard, H; Hashemi, SM; Bahari, G
Detection of a 4-bp Insertion/deletion Polymorphism within the Promoter of EGLN2 Using Mismatch PCR-RFLP and Its Association with Susceptibility to Breast Cancer
Asian Pac J Cancer Prev
19
923-926
2018
Homo sapiens
Minassi, A; Rogati, F; Cruz, C; Prados, ME; Galera, N; Jinnez, C; Appendino, G; Bellido, ML; Calzado, MA; Caprioglio, D; Muoz, E
Triterpenoid Hydroxamates as HIF Prolyl Hydrolase Inhibitors.
J Nat Prod
81
2235-2243
2018
Transformation
Graham, AM; McCracken, KG
Convergent evolution on the hypoxia-inducible factor (HIF) pathway genes EGLN1 and EPAS1 in high-altitude ducks.
Heredity (Edinb)
2019
Homo sapiens
Zhou, Y; Ouyang, N; Liu, L; Tian, J; Huang, X; Lu, T
An EGLN1 mutation may regulate hypoxic response in cyanotic congenital heart disease through the PHD2/HIF-1A pathway.
Genes Dis
6
35-42
2019
Homo sapiens
Devi, U; Singh, M; Roy, S; Gupta, PS; Ansari, MN; Saeedan, AS; Kaithwas, G
Activation of prolyl hydroxylase-2 for stabilization of mitochondrial stress along with simultaneous downregulation of HIF-1?/FASN in ER+breast cancer subtype.
Cell Biochem Funct
37
216-227
2019
Rattus, Rattus norvegicus, Electron
Kumar K S, P; Arcot, M; Munisamaiah, M; Balakrishna, S
Novel association of SNP rs479200 in EGLN1 gene with predisposition to preeclampsia.
Gene
705
1-4
2019
Homo sapiens
Bembenek, SD; Venkatesan, H; Peltier, HM; Rosen, MD; Barrett, TD; Kanelakis, KC; Palomino, HL; Brondstetter, TI; Mirzadegan, T; Rabinowitz, MH
Beyond Traditional Structure-Based Drug Design: The Role of Iron Complexation, Strain, and Water in the Binding of Inhibitors for Hypoxia-Inducible Factor Prolyl Hydroxylase 2.
ACS Omega
4
6703-6708
2019
Mus musculus
Sulser, P; Pickel, C; Gnter, J; Leissing, TM; Crean, D; Schofield, CJ; Wenger, RH; Scholz, CC
HIF hydroxylase inhibitors decrease cellular oxygen consumption depending on their selectivity.
FASEB J
34
2344-2358
2020
Homo sapiens
Chiang, HL; Chen, CM; Chen, YC; Chao, CY; Wu, YR; Lee-Chen, GJ
Genetic Analysis of EGLN1 C127S Variant in Taiwanese Parkinson's Disease.
Parkinsons Dis
2020
9582317
2020
Homo sapiens
Moore, JA; Hubbi, ME; Wang, C; Wang, Y; Luo, W; Hofmann, S; Rambally, S
Isolated Erythrocytosis Associated With 3 Novel Missense Mutations in the EGLN1 Gene.
J Investig Med High Impact Case Rep
8
2324709620947256
0
Homo sapiens
Li, Z; Zhen, S; Su, K; Tumber, A; Yu, Q; Dong, Y; McDonough, M; Schofield, CJ; Zhang, X
A small-molecule probe for monitoring binding to prolyl hydroxylase domain 2 by fluorescence polarisation.
Chem Commun (Camb)
56
14199-14202
2020
Homo sapiens
Byts, N; Sharma, S; Laurila, J; Paudel, P; Miinalainen, I; Ronkainen, VP; Hinttala, R; Trnquist, K; Koivunen, P; Myllyharju, J
Transmembrane Prolyl 4-Hydroxylase is a Novel Regulator of Calcium Signaling in Astrocytes.
eNeuro
8
0
Homo sapiens, Mus musculus
Chowdhury, R; Abboud, MI; McAllister, TE; Banerji, B; Bhushan, B; Sorensen, JL; Kawamura, A; Schofield, CJ
Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2.
Sci Rep
10
21964
2020
Homo sapiens
Rivera, JC; Noueihed, B; Madaan, A; Lahaie, I; Pan, J; Belik, J; Chemtob, S
Tetrahydrobiopterin (BH4) deficiency is associated with augmented inflammation and microvascular degeneration in the retina.
J Neuroinflammation
14
181
2017
Mus sp.
Li, Q; Liu, J; Michaud, M; Schwartz, ML; Madri, JA
Modeling the Neurovascular Niche. Strain Differences in Behavioral and Cellular Responses to Perinatal Hypoxia and Relationships to Neural Stem Cell Survival and Self-Renewal.
Am J Pathol
2009
Homo sapiens, Mus musculus, Mus sp.
Sato, R; Iiizumi, S; Kim, ES; Honda, F; Lee, SK; Adachi, N; Koyama, H; Mizutani, S; Morio, T
Impaired cell adhesion, apoptosis, and signaling in WASP gene-disrupted Nalm-6 pre-B cells and recovery of cell adhesion using a transducible form of WASp.
Int J Hematol
95
299-310
2012
Escherichia coli
Hewitson, KS; McNeill, LA; Schofield, CJ
Modulating the hypoxia-inducible factor signaling pathway: applications from cardiovascular disease to cancer.
Curr Pharm Des
10
821-33
2004
Homo sapiens
Lee, H; Kim, IK; Park, TG
Intracellular trafficking and unpacking of siRNA/quantum dot-PEI complexes modified with and without cell penetrating peptide: confocal and flow cytometric FRET analysis.
Bioconjug Chem
21
289-95
2010
Homo sapiens
Jia, P; Teng, J; Zou, J; Fang, Y; Jiang, S; Yu, X; Kriegel, AJ; Liang, M; Ding, X
Intermittent exposure to xenon protects against gentamicin-induced nephrotoxicity.
PLoS One
8
e64329
2013
Rattus
Panariti, A; Miserocchi, G; Rivolta, I
mRNA expression profile of selected oxygen sensing genes in the lung during recovery from chronic hypoxia.
Biol Res
46
169-76
2013
Rattus
Wu, J; Ke, X; Wang, W; Zhang, H; Ma, N; Fu, W; Zhao, M; Gao, X; Hao, X; Zhang, Z
Aloe-emodin suppresses hypoxia-induced retinal angiogenesis via inhibition of HIF-1?/VEGF pathway.
Int J Biol Sci
12
1363-1371
2016
Homo sapiens
Hu, H; Petousi, N; Glusman, G; Yu, Y; Bohlender, R; Tashi, T; Downie, JM; Roach, JC; Cole, AM; Lorenzo, FR; Rogers, AR; Brunkow, ME; Cavalleri, G; Hood, L; Alpatty, SM; Prchal, JT; Jorde, LB; Robbins, PA; Simonson, TS; Huff, CD
Evolutionary history of Tibetans inferred from whole-genome sequencing.
PLoS Genet
13
e1006675
2017
Homo sapiens, Homo sapiens subsp. 'Denisova'
Gong, H; Rehman, J; Tang, H; Wary, K; Mittal, M; Chatturvedi, P; Zhao, Y; Komorova, YA; Vogel, SM; Malik, AB
HIF2? signaling inhibits adherens junctional disruption in acute lung injury.
J Clin Invest
125
652-64
2015
Mus sp.
Sen Banerjee, S; Thirunavukkarasu, M; Tipu Rishi, M; Sanchez, JA; Maulik, N; Maulik, G
HIF-prolyl hydroxylases and cardiovascular diseases.
Toxicol Mech Methods
22
347-58
2012
Mus musculus
Khoo, JP; Zhao, L; Alp, NJ; Bendall, JK; Nicoli, T; Rockett, K; Wilkins, MR; Channon, KM
Pivotal role for endothelial tetrahydrobiopterin in pulmonary hypertension.
Circulation
111
2126-33
2005
Mus musculus, Mus sp.
Nasser, A; Mller, LB
GCH1 variants, tetrahydrobiopterin and their effects on pain sensitivity.
Scand J Pain
5
121-128
2014
Homo sapiens, Mus musculus, Mus sp., animal
Simonet, S; Gosgnach, W; Billou, L; Lucats, L; Royere, E; Crespo, C; Lapret, I; Ragonnet, L; Moreau, K; Vayssettes-Courchay, C; Berson, P; Bourguignon, MP
GTP-cyclohydrolase deficiency induced peripheral and deep microcirculation dysfunction with age.
Microvasc Res
104078
2020
Mus sp.
Wang, CH; Li, SH; Weisel, RD; Fedak, PW; Hung, A; Li, RK; Rao, V; Hyland, K; Cherng, WJ; Errett, L; Leclerc, Y; Bonneau, D; Latter, DA; Verma, S
Tetrahydrobiopterin deficiency exaggerates intimal hyperplasia after vascular injury.
Am J Physiol Regul Integr Comp Physiol
289
R299-304
2005
Mus sp.
Tarhonskaya, H; Rydzik, AM; Leung, IK; Loik, ND; Chan, MC; Kawamura, A; McCullagh, JS; Claridge, TD; Flashman, E; Schofield, CJ
Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases.
Nat Commun
5
3423
2014
Homo sapiens
Lu, N; Hui, H; Yang, H; Zhao, K; Chen, Y; You, QD; Guo, QL
Gambogic acid inhibits angiogenesis through inhibiting PHD2-VHL-HIF-1? pathway.
Eur J Pharm Sci
2013
Mus musculus
Ognibene, M; Cangelosi, D; Morini, M; Segalerba, D; Bosco, MC; Sementa, AR; Eva, A; Varesio, L
Immunohistochemical analysis of PDK1, PHD3 and HIF-1? expression defines the hypoxic status of neuroblastoma tumors.
PLoS One
12
e0187206
2017
Homo sapiens
Crabtree, MJ; Channon, KM
Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease.
Nitric Oxide
25
81-8
2011
Mus musculus
Oguri, Y; Fujita, Y; Abudukadier, A; Ohashi, A; Goto, T; Furuya, F; Obara, A; Fukushima, T; Matsuo, N; Kim, M; Hosokawa, M; Kawada, T; Hasegawa, H; Inagaki, N
Tetrahydrobiopterin activates brown adipose tissue and regulates systemic energy metabolism.
JCI Insight
2
2017
bat, Mus musculus, Mus sp.
Siu, KL; Li, Q; Zhang, Y; Guo, J; Youn, JY; Du, J; Cai, H
NOX isoforms in the development of abdominal aortic aneurysm.
Redox Biol
11
118-125
2017
Mus sp.
Zhu, J; Luo, JZ; Li, CB
Correlations of an Insertion/Deletion Polymorphism (rs10680577) in the RERT-lncRNA with the Susceptibility, Clinicopathological Features, and Prognosis of Lung Cancer.
Biochem Genet
2018
Homo sapiens
Fielding, JW; Hodson, EJ; Cheng, X; Ferguson, DJP; Eckardt, L; Adam, J; Lip, P; Maton-Howarth, M; Ratnayaka, I; Pugh, CW; Buckler, KJ; Ratcliffe, PJ; Bishop, T
PHD2 inactivation in Type I cells drives HIF-2?-dependent multilineage hyperplasia and the formation of paraganglioma-like carotid bodies.
J Physiol
2018
Mus sp.
Zhu, Z; Gao, X; He, Y; Zhao, H; Yu, Q; Jiang, D; Zhang, P; Ma, X; Huang, H; Dong, D; Wan, J; Gu, Z; Jiang, X; Yu, L; Gao, Y
An insertion/deletion polymorphism within RERT-lncRNA modulates hepatocellular carcinoma risk.
Cancer Res
72
6163-72
2012
insertion sequences, Homo sapiens
Tang, H; Babicheva, A; McDermott, KM; Gu, Y; Ayon, RJ; Song, S; Wang, Z; Gupta, A; Zhou, T; Sun, X; Dash, S; Wang, Z; Balistrieri, A; Zheng, Q; Cordery, AG; Desai, AA; Rischard, F; Khalpey, Z; Wang, J; Black, SM; Garcia, JGN; Makino, A; Yuan, JX
Endothelial HIF-2? contributes to severe pulmonary hypertension due to endothelial-to-mesenchymal transition.
Am J Physiol Lung Cell Mol Physiol
314
L256-L275
2018
Mus sp.
Hasegawa, T; Koiwa, F; Akizawa, T
Anemia in conventional hemodialysis: Finding the optimal treatment balance.
Semin Dial
2018
Homo sapiens
Taylor, MS
Characterization and comparative analysis of the EGLN gene family.
Gene
275
125-32
2001
Homo sapiens, Rattus
Marxsen, JH; Stengel, P; Doege, K; Heikkinen, P; Jokilehto, T; Wagner, T; Jelkmann, W; Jaakkola, P; Metzen, E
Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-alpha-prolyl-4-hydroxylases.
Biochem J
381
761-7
2004
Homo sapiens
Landázuri, MO; Vara-Vega, A; Vitón, M; Cuevas, Y; del Peso, L
Analysis of HIF-prolyl hydroxylases binding to substrates.
Biochem Biophys Res Commun
351
313-20
2006
Saccharomyces cerevisiae
Sakashita, M; Tanaka, T; Nangaku, M
Hypoxia-Inducible Factor-Prolyl Hydroxylase Domain Inhibitors to Treat Anemia in Chronic Kidney Disease.
Contrib Nephrol
198
112-123
2019
Homo sapiens
Fukui, K; Tanaka, T; Nangaku, M
Enarodustat to treat anemia in chronic kidney disease.
Drugs Today (Barc)
57
491-497
2021
Homo sapiens, Dialysis
Sekirnik, R; Rose, NR; Mecinovi?, J; Schofield, CJ
2-Oxoglutarate oxygenases are inhibited by a range of transition metals.
Metallomics
2
397-9
2010
Homo sapiens
Flamme, I; Oehme, F; Ellinghaus, P; Jeske, M; Keldenich, J; Thuss, U
Mimicking hypoxia to treat anemia: HIF-stabilizer BAY 85-3934 (Molidustat) stimulates erythropoietin production without hypertensive effects.
PLoS One
9
e111838
2014
Macaca fascicularis, Rattus norvegicus, Homo sapiens, Rattus, Metazoa
Francis, BN; Wilkins, MR; Zhao, L
Tetrahydrobiopterin (BH4) and the regulation of hypoxic pulmonary vasoconstriction.
Eur Respir J
2010
Mus sp., Rattus
Siu, KL; Cai, H
Circulating tetrahydrobiopterin as a novel biomarker for abdominal aortic aneurysm.
Am J Physiol Heart Circ Physiol
307
H1559-64
2014
Mus sp.
Huang, M; Chan, DA; Jia, F; Xie, X; Li, Z; Hoyt, G; Robbins, RC; Chen, X; Giaccia, AJ; Wu, JC
Short hairpin RNA interference therapy for ischemic heart disease.
Circulation
118
S226-33
2008
Homo sapiens, Mus musculus, Mus sp., Rattus, Metazoa
Huang, M; Wu, JC
Molecular imaging of RNA interference therapy targeting PHD2 for treatment of myocardial ischemia.
Methods Mol Biol
709
211-21
2011
Homo sapiens, Mus musculus, Rattus
Xie, L; Pi, X; Mishra, A; Fong, G; Peng, J; Patterson, C
PHD3-dependent hydroxylation of HCLK2 promotes the DNA damage response.
J Clin Invest
122
2827-36
2012
Caenorhabditis elegans, Homo sapiens, Mus sp.
Zeng, H; He, X; Tuo, QH; Liao, DF; Zhang, GQ; Chen, JX
LPS causes pericyte loss and microvascular dysfunction via disruption of Sirt3/angiopoietins/Tie-2 and HIF-2?/Notch3 pathways.
Sci Rep
6
20931
2016
Mus sp.
Watts, D; Bechmann, N; Meneses, A; Poutakidou, IK; Kaden, D; Conrad, C; Krger, A; Stein, J; El-Armouche, A; Chavakis, T; Eisenhofer, G; Peitzsch, M; Wielockx, B
HIF2? regulates the synthesis and release of epinephrine in the adrenal medulla.
J Mol Med (Berl)
2021
Mus sp.
Scheinfeldt, LB; Soi, S; Thompson, S; Ranciaro, A; Woldemeskel, D; Beggs, W; Lambert, C; Jarvis, JP; Abate, D; Belay, G; Tishkoff, SA
Genetic adaptation to high altitude in the Ethiopian highlands.
Genome Biol
13
R1
2012
Andes
Petousi, N; Croft, QP; Cavalleri, GL; Cheng, HY; Formenti, F; Ishida, K; Lunn, D; McCormack, M; Shianna, KV; Talbot, NP; Ratcliffe, PJ; Robbins, PA
Tibetans living at sea level have a hyporesponsive hypoxia-inducible factor (HIF) system and blunted physiological responses to hypoxia.
J Appl Physiol (1985)
2013
Homo sapiens
Del Vecchio, L; Minutolo, R
ESA, Iron Therapy and New Drugs: Are There New Perspectives in the Treatment of Anaemia?
J Clin Med
10
2021
Homo sapiens
Weir, MR
Managing Anemia across the Stages of Kidney Disease in Those Hyporesponsive to Erythropoiesis-Stimulating Agents.
Am J Nephrol
52
450-466
2021
Homo sapiens, Dialysis
Liang, Q; Li, ZY; Zhou, Y; Liu, QL; Ou, WT; Huang, ZG
Construction of a recombinant eukaryotic expression vector containing PHD3 gene and its expression in HepG2 cells.
J Exp Clin Cancer Res
31
64
2012
Homo sapiens
Riopel, M; Moon, JS; Bandyopadhyay, GK; You, S; Lam, K; Liu, X; Kisseleva, T; Brenner, D; Lee, YS
Inhibition of prolyl hydroxylases increases hepatic insulin and decreases glucagon sensitivity by an HIF-2?-dependent mechanism.
Mol Metab
41
101039
2020
Homo sapiens, Mus sp.
Taylor, MS; Devon, RS; Millar, JK; Porteous, DJ
Evolutionary constraints on the Disrupted in Schizophrenia locus.
Genomics
81
67-77
2003
Mammalia
Dayan, F; Roux, D; Brahimi-Horn, MC; Pouyssegur, J; Mazure, NM
The oxygen sensor factor-inhibiting hypoxia-inducible factor-1 controls expression of distinct genes through the bifunctional transcriptional character of hypoxia-inducible factor-1alpha.
Cancer Res
66
3688-98
2006
Homo sapiens
Choi, JM; Ahn, MH; Chae, WJ; Jung, YG; Park, JC; Song, HM; Kim, YE; Shin, JA; Park, CS; Park, JW; Park, TK; Lee, JH; Seo, BF; Kim, KD; Kim, ES; Lee, DH; Lee, SK; Lee, SK
Intranasal delivery of the cytoplasmic domain of CTLA-4 using a novel protein transduction domain prevents allergic inflammation.
Nat Med
12
574-9
2006
Homo sapiens
Ehrismann, D; Flashman, E; Genn, DN; Mathioudakis, N; Hewitson, KS; Ratcliffe, PJ; Schofield, CJ
Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay.
Biochem J
401
227-34
2007
Homo sapiens
Taylor, CT; Colgan, SP
Hypoxia and gastrointestinal disease.
J Mol Med
85
1295-300
2007
Mus musculus
Youn, JI; Park, SH; Jin, HT; Lee, CG; Seo, SH; Song, MY; Lee, CW; Sung, YC
Enhanced delivery efficiency of recombinant adenovirus into tumor and mesenchymal stem cells by a novel PTD.
Cancer Gene Ther
15
703-12
2008
Rattus
Ladroue, C; Carcenac, R; Leporrier, M; Gad, S; Le Hello, C; Galateau-Salle, F; Feunteun, J; Pouysségur, J; Richard, S; Gardie, B
PHD2 mutation and congenital erythrocytosis with paraganglioma.
N Engl J Med
359
2685-92
2008
Homo sapiens
Luukkaa, M; Jokilehto, T; Kronqvist, P; Vahlberg, T; Grenman, R; Jaakkola, P; Minn, H
Expression of the cellular oxygen sensor PHD2 (EGLN-1) predicts radiation sensitivity in squamous cell cancer of the head and neck.
Int J Radiat Biol
1-9
2009
Homo sapiens
Leung, IK; Flashman, E; Yeoh, KK; Schofield, CJ; Claridge, TD
Using NMR solvent water relaxation to investigate metalloenzyme-ligand binding interactions.
J Med Chem
53
867-75
2010
Homo sapiens
Bigham, A; Bauchet, M; Pinto, D; Mao, X; Akey, JM; Mei, R; Scherer, SW; Julian, CG; Wilson, MJ; Lpez Herrez, D; Brutsaert, T; Parra, EJ; Moore, LG; Shriver, MD
Identifying signatures of natural selection in tibetan and andean populations using dense genome scan data.
PLoS Genet
6
2010
Homo sapiens
Lee, FS; Percy, MJ
The HIF Pathway and Erythrocytosis.
Annu Rev Pathol
2010
Homo sapiens
Xu, S; Li, S; Yang, Y; Tan, J; Lou, H; Jin, W; Yang, L; Pan, X; Wang, J; Shen, Y; Wu, B; Wang, H; Jin, L
A Genome-Wide Search for Signals of High Altitude Adaptation in Tibetans.
Mol Biol Evol
2010
Homo sapiens
Peng, Y; Yang, Z; Zhang, H; Cui, C; Qi, X; Luo, X; Tao, X; Wu, T; , ; , ; , ; , ; Chen, H; Shi, H; Su, B
Genetic variations in Tibetan populations and high altitude adaptation at the Himalayas.
Mol Biol Evol
2010
Areas, Homo sapiens
MacInnis, MJ; Rupert, JL
'ome on the Range: altitude adaptation, positive selection, and himalayan genomics.
High Alt Med Biol
12
133-9
2011
Homo sapiens
Jamadarkhana, P; Chaudhary, A; Chhipa, L; Dubey, A; Mohanan, A; Gupta, R; Deshpande, S
Treatment with a Novel Hypoxia-Inducible Factor Hydroxylase Inhibitor (TRC160334) Ameliorates Ischemic Acute Kidney Injury.
Am J Nephrol
36
208-218
2012
Rattus
Forristal, CE; Winkler, IG; Nowlan, B; Barbier, V; Walkinshaw, G; Levesque, JP
Pharmacologic stabilization of HIF-1? increases hematopoietic stem cell quiescence in vivo and accelerates blood recovery after severe irradiation.
Blood
121
759-69
2013
Mus sp.
Speer, RE; Karuppagounder, SS; Basso, M; Sleiman, SF; Kumar, A; Brand, D; Smirnova, N; Gazaryan, I; Khim, SJ; Ratan, RR
Hypoxia-inducible factor prolyl hydroxylases as targets for neuroprotection by "antioxidant" metal chelators: From ferroptosis to stroke.
Free Radic Biol Med
2013
animal
Pacak, K; Jochmanova, I; Prodanov, T; Yang, C; Merino, MJ; Fojo, T; Prchal, JT; Tischler, AS; Lechan, RM; Zhuang, Z
New Syndrome of Paraganglioma and Somatostatinoma Associated With Polycythemia.
J Clin Oncol
2013
Homo sapiens
Laoui, D; Van Overmeire, E; Di Conza, G; Aldeni, C; Keirsse, J; Morias, Y; Movahedi, K; Houbracken, I; Schouppe, E; Elkrim, Y; Karroum, O; Jordan, B; Carmeliet, P; Gysemans, C; De Baetselier, P; Mazzone, M; Van Ginderachter, JA
Tumor hypoxia does not drive differentiation of tumor-associated macrophages but rather fine-tunes the M2-like macrophage population.
Cancer Res
74
24-30
2014
Mus sp.
Jeong, C; Alkorta-Aranburu, G; Basnyat, B; Neupane, M; Witonsky, DB; Pritchard, JK; Beall, CM; Di Rienzo, A
Admixture facilitates genetic adaptations to high altitude in Tibet.
Nat Commun
5
3281
2014
Homo sapiens
Ichiki, T; Sunagawa, K
Novel roles of hypoxia response system in glucose metabolism and obesity.
Trends Cardiovasc Med
24
197-201
2014
Metazoa
Lee, CL; Moding, EJ; Kirsch, DG
Reining in radiation injury: HIF2? in the gut.
Sci Transl Med
6
236fs20
2014
Mus sp.
Zhou, Y; Liang, QL; Ou, WT; Liu, QL; Zhang, XN; Li, ZY; Huang, X
Effect of stable transfection with PHD3 on growth and proliferation of HepG2 cells in vitro and in vivo.
Int J Clin Exp Med
7
2197-203
2014
Homo sapiens, Mus musculus
Ge, RL; Simonson, TS; Gordeuk, V; Prchal, JT; McClain, DA
Metabolic aspects of high-altitude adaptation in Tibetans.
Exp Physiol
100
1247-55
2015
Homo sapiens
Xie, L; Pi, X; Townley-Tilson, WH; Li, N; Wehrens, XH; Entman, ML; Taffet, GE; Mishra, A; Peng, J; Schisler, JC; Meissner, G; Patterson, C
PHD2/3-dependent hydroxylation tunes cardiac response to ?-adrenergic stress via phospholamban.
J Clin Invest
125
2759-71
2015
Mus sp., animal
Li, Y; Zhang, D; Wang, X; Yao, X; Ye, C; Zhang, S; Wang, H; Chang, C; Xia, H; Wang, YC; Fang, J; Yan, J; Ying, H
Hypoxia-inducible miR-182 enhances HIF1? signaling via targeting PHD2 and FIH1 in prostate cancer.
Sci Rep
5
12495
2015
Mus musculus
Deschoemaeker, S; Di Conza, G; Lilla, S; Martn-Prez, R; Mennerich, D; Boon, L; Hendrikx, S; Maddocks, OD; Marx, C; Radhakrishnan, P; Prenen, H; Schneider, M; Myllyharju, J; Kietzmann, T; Vousden, KH; Zanivan, S; Mazzone, M
PHD1 regulates p53-mediated colorectal cancer chemoresistance.
EMBO Mol Med
2015
Mus sp.
Abe, S; Yamamoto, K; Kurata, M; Abe-Suzuki, S; Horii, R; Akiyama, F; Kitagawa, M
Targeting MCM2 function as a novel strategy for the treatment of highly malignant breast tumors.
Oncotarget
6
34892-909
2015
Mus musculus
Simonson, TS; Huff, CD; Witherspoon, DJ; Prchal, JT; Jorde, LB
Adaptive genetic changes related to haemoglobin concentration in native high-altitude Tibetans.
Exp Physiol
100
1263-8
2015
Homo sapiens
Veidenberg, A; Medlar, A; Lytynoja, A
Wasabi: An Integrated Platform for Evolutionary Sequence Analysis and Data Visualization.
Mol Biol Evol
33
1126-30
2016
Panthera tigris
Dong, H; Zhang, Y; Song, L; Kim, DS; Wu, H; Yang, L; Li, S; Morgan, KA; Adams, DB; Wang, H
Cell-permeable Peptide Blocks TLR4 signaling and Improves Islet Allograft Survival.
Cell Transplant
2016
Mus sp.
Rajagopalan, S; Rane, A; Chinta, SJ; Andersen, JK
Regulation of ATP13A2 via PHD2-HIF1? Signaling Is Critical for Cellular Iron Homeostasis: Implications for Parkinson's Disease.
J Neurosci
36
1086-95
2016
Homo sapiens, Compacta
Fehren-Schmitz, L; Georges, L
Ancient DNA reveals selection acting on genes associated with hypoxia response in pre-Columbian Peruvian Highlanders in the last 8500 years.
Sci Rep
6
23485
2016
Homo sapiens, Andes
Haase, VH
Therapeutic targeting of the HIF oxygen-sensing pathway: Lessons learned from clinical studies.
Exp Cell Res
356
160-165
2017
Homo sapiens
Francis, BN; Salameh, M; Khamisy-Farah, R; Farah, R
Tetrahydrobiopterin (BH
Cardiovasc Ther
36
2018
Mus sp., Rattus, animal
Ko, SH; Nauta, AC; Morrison, SD; Hu, MS; Zimmermann, AS; Chung, MT; Glotzbach, JP; Wong, VW; Walmsley, GG; Peter Lorenz, H; Chan, DA; Gurtner, GC; Giaccia, AJ; Longaker, MT
PHD-2 Suppression in Mesenchymal Stromal Cells Enhances Wound Healing.
Plast Reconstr Surg
141
55e-67e
2018
Homo sapiens, Mus musculus
Dai, Z; Zhu, MM; Peng, Y; Jin, H; Machireddy, N; Qian, Z; Zhang, X; Zhao, YY
Endothelial and Smooth Muscle Cell Interaction via FoxM1 Signaling Mediates Vascular Remodeling and Pulmonary Hypertension.
Am J Respir Crit Care Med
198
788-802
2018
Mus sp.
Wu, DD; Ding, XD; Wang, S; Wjcik, JM; Zhang, Y; Tokarska, M; Li, Y; Wang, MS; Faruque, O; Nielsen, R; Zhang, Q; Zhang, YP
Pervasive introgression facilitated domestication and adaptation in the Bos species complex.
Nat Ecol Evol
2
1139-1145
2018
Bos taurus, Bos grunniens
Zhou, LY; Zeng, H; Wang, S; Chen, JX
Regulatory Role of Endothelial PHD2 in the Hepatic Steatosis.
Cell Physiol Biochem
48
1003-1011
2018
Mus musculus, Mus sp.
Wu, G; Xu, G; Chen, DW; Gao, WX; Xiong, JQ; Shen, HY; Gao, YQ
Hypoxia Exacerbates Inflammatory Acute Lung Injury via the Toll-Like Receptor 4 Signaling Pathway.
Front Immunol
9
1667
2018
Rattus
Sanghani, NS; Haase, VH
Hypoxia-Inducible Factor Activators in Renal Anemia: Current Clinical Experience.
Adv Chronic Kidney Dis
26
253-266
2019
Homo sapiens
Ishii, T; Tanaka, T; Nangaku, M
Profile of Daprodustat in the Treatment of Renal Anemia Due to Chronic Kidney Disease.
Ther Clin Risk Manag
17
155-163
2021
Homo sapiens
Burmakin, M; Fasching, A; Kobayashi, H; Urrutia, AA; Damdimopoulos, A; Palm, F; Haase, VH
Pharmacological HIF-PHD inhibition reduces renovascular resistance and increases glomerular filtration by stimulating nitric oxide generation.
Acta Physiol (Oxf)
233
e13668
2021
Homo sapiens, Rattus, animal
html completed
