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Literature summary for 1.14.11.29 extracted from

  • Fan, L.; Li, J.; Yu, Z.; Dang, X.; Wang, K.
    The hypoxia-inducible factor pathway, prolyl hydroxylase domain protein inhibitors, and their roles in bone repair and regeneration (2014), BioMed Res. Int., 2014, 239356 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.29

Inhibitors

Inhibitors Comment Organism Structure
3,4-dihydroxybenzoate
-
 Homo sapiens
ciclopirox olamine
-
 Homo sapiens
cobalt chloride
-
 Homo sapiens
Cu2+
-
 Homo sapiens
deferoxamine
-
 Homo sapiens
dimethyloxalylglycine
-
 Homo sapiens
FG-2216
-
 Homo sapiens
FG-4497
-
 Homo sapiens
FG-4592
-
 Homo sapiens
FKBP38
-
 Homo sapiens
GSK360A
-
 Homo sapiens
L-mimosine
-
 Homo sapiens
Mn2+
-
 Homo sapiens
Morg-1
-
 Homo sapiens
TM6008
-
 Homo sapiens
TM6089
-
 Homo sapiens
Zn2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2 Homo sapiens
-
 hypoxia-inducible factor-trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
additional information Homo sapiens isozyme PHD2 is more active on hypoxia-inducible factor-1alpha than on hypoxia-inducible factor-2alpha, whereas PHD1 and PHD3 hydroxylate hypoxia-inducible factor-2alpha more efficiently ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
mesenchymal stem cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2
-
 Homo sapiens hypoxia-inducible factor-trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
additional information isozyme PHD2 is more active on hypoxia-inducible factor-1alpha than on hypoxia-inducible factor-2alpha, whereas PHD1 and PHD3 hydroxylate hypoxia-inducible factor-2alpha more efficiently Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
PHD
-
 Homo sapiens
prolyl hydroxylase domain protein
-
 Homo sapiens