Reference on EC 1.1.1.42 - isocitrate dehydrogenase (NADP+)

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Plaut, G.W.E.
Isocitrate dehydrogenase
The Enzymes, 2nd Ed. (Boyer, P. D. , Lardy, H. , Myrbäck, K. , eds. )
7
105-126
1963
Aspergillus niger, Citrobacter freundii, Mycobacterium tuberculosis, Saccharomyces cerevisiae, Sus scrofa, Trypanosoma cruzi
-
Manually annotated by BRENDA team
Ramaley, R.F.; Hudock, M.O.
Purification and properties of isocitrate dehydrogenase (NADP) from Thermus aquaticus YT-1, Bacillus subtilis-168 and Chlamydomonas reinhardti-Y-2
Biochim. Biophys. Acta
315
22-36
1973
Azotobacter vinelandii, Bacillus subtilis, Chlamydomonas reinhardtii, Escherichia coli, Geobacillus stearothermophilus, Thermus aquaticus
Manually annotated by BRENDA team
Saiki, T.; Arima, K.
Studies on NADP+-specific isocitrate dehydrogenase from an extreme thermophile, Thermus flavus AT-62
J. Biochem.
77
233-240
1975
Thermus thermophilus
Manually annotated by BRENDA team
Kleber, H.P.
Egenschaften der NADP+-abhängigen Isocitratdehydrogenasen aus Acinetobacter calcoaceticus
Z. Allg. Mikrobiol.
15
431-435
1975
Acinetobacter calcoaceticus
Manually annotated by BRENDA team
Curry, R.A.; Ting, I.P.
Purification, properties, and kinetic observations on the isoenzymes of NADP isocitrate dehydrogenase of maize
Arch. Biochem. Biophys.
176
501-509
1976
Azotobacter sp., Geobacillus stearothermophilus, Rhodobacter sphaeroides, Sus scrofa, Zea mays
Manually annotated by BRENDA team
Macfarlane, N.; Mathews, B.; Dalziel, K.
The purification and properties of NADP-dependent isocitrate dehydrogenase from ox-heart mitochondria
Eur. J. Biochem.
74
553-559
1977
Bos taurus
Manually annotated by BRENDA team
Miake, F.; Torikata, T.; Koga, K.; Hayashi, K.
Isolation and characterization of NADP+-specific isocitrate dehydrogenase from the pupa of Bombyx mori
J. Biochem.
82
449-454
1977
Bombyx mori
Manually annotated by BRENDA team
Macfarlane, N.; Reynolds, H.; Matthews, B.; Dalziel, K.
Purification and molecular properties of NADP-linked isocitrate dehydrogenase from ox heart mitochondria
Biochem. Soc. Trans.
5
790-793
1977
Bos taurus
Manually annotated by BRENDA team
Seelig, G.F.; Colman, R.F.
Characterization of the physicochemical and catalytic properties of human heart NADP-dependent isocitrate dehydrogenase
Arch. Biochem. Biophys.
188
394-409
1978
Escherichia coli, Homo sapiens
Manually annotated by BRENDA team
Ochiai, T.; Fukunaga, N.; Sasaki, S.
Purification and some properties of two NADP+-specific isocitrate dehydrogenases from an obligately psychrophilic marine bacterium, Vibrio sp., strain ABE-1
J. Biochem.
86
377-384
1979
Vibrio sp., Vibrio sp. ABE-1
Manually annotated by BRENDA team
Farrell, H.M.
Purification and properties of NADP+:isocitrate dehydrogenase from lactating bovine mammary gland
Arch. Biochem. Biophys.
204
551-559
1980
Bos taurus
Manually annotated by BRENDA team
Head, E.J.H.
NADP-dependent isocitrate dehydrogenase from the mussel Mytilus edulis L. 1. Purification and characterisation
Eur. J. Biochem.
111
575-579
1980
Mytilus edulis
Manually annotated by BRENDA team
Vasquez, B.; Reeves, H.C.
NADP-specific isocitrate dehydrogenase from Escherichia coli. V. Multiple forms of the enzyme
Biochim. Biophys. Acta
660
16-22
1981
Escherichia coli
Manually annotated by BRENDA team
Ochiai, T.; Fukunaga, N.; Sasaki, S.
Two structurally different NADP-specific isocitrate dehydrogenases in an obligately psychrophilic bacterium, Vibrio sp. strain ABE-1
J. Gen. Appl. Microbiol.
30
479-487
1984
Halobacterium salinarum, Vibrio sp., Vibrio sp. ABE-1
-
Manually annotated by BRENDA team
Gonzalez-Villasenor, L.I.; Powers, D.A.
A multilocus system for studying tissue and subcellular specialization. The three NADP-dependent isocitrate dehydrogenase isozymes of the fish Fundulus heteroclitus
J. Biol. Chem.
260
9106-9113
1985
Fundulus heteroclitus
Manually annotated by BRENDA team
Meixner-Monori, B.; Kubicek, C.P.; Harrer, W.; Schreferl, G.; Rohe, M.
NADP-specific isocitrate dehydrogenase from the citric acid-accumulating fungus Aspergillus niger
Biochem. J.
236
549-557
1986
Aspergillus niger, Blastocladiella emersonii, Phycomyces blakesleeanus
Manually annotated by BRENDA team
Ni, W.; Robertson, E.F.; Reeves, H.C.
Purification and characterization of cytosolic NADP specific isocitrate dehydrogenase from Pisum sativum
Plant Physiol.
83
785-788
1987
Pisum sativum
Manually annotated by BRENDA team
Dhariwal, K.R.; Venkitasubramanian, T.A.
NADP-specific isocitrate dehydrogenase of Mycobacterium phlei ATCC 354: purification and characterization
J. Gen. Microbiol.
133
2457-2460
1987
Brevibacterium flavum, Crithidia fasciculata, Mycobacterium phlei, Starkeya novella
Manually annotated by BRENDA team
Shikata, S.; Ozaki, K.; Kawai, S.; Ito, S.; Okamoto, K.
Purification and characterization of NADP+-linked isocitrate dehydrogenase from an alkalophilic Bacillus
Biochim. Biophys. Acta
952
282-289
1988
Bacillus sp.
Manually annotated by BRENDA team
Grissom, C.B.; Cleland, W.W.
Isotope effect studies of the chemical mechanism of pig heart NADP isocitrate dehydrogenase
Biochemistry
27
2934-2943
1988
Sus scrofa
Manually annotated by BRENDA team
Aoshima, M.; Oshima, T.
Purification and characterization of isocitrate dehydrogenase from a hyperthermophilic archaebacterium, Caldococcus noboribetus
Biochim. Biophys. Acta
1340
227-234
1997
Caldococcus noboribetus
Manually annotated by BRENDA team
Pardo, M.A.; Llama, M.J.; Serra, J.L.
Purification, properties and enhanced expression under nitrogen starvation of the NADP+-isocitrate dehydrogenase from the cyanobacterium Phormidium laminosum
Biochim. Biophys. Acta
1431
87-96
1999
Phormidium laminosum
Manually annotated by BRENDA team
Galvez, S.; Hodges, M.; Bismuth, E.; Samson, I.; Teller, S.; Gadal, P.
Purification and characterization of a fully active recombinant cytosolic NADP-dependent isocitrate dehydrogenase in Escherichia coli: evidence for a role for the N-terminal region in enzyme activity
Arch. Biochem. Biophys.
323
164-168
1995
Nicotiana tabacum
Manually annotated by BRENDA team
Doyle, S.A.; Beernink, B.T.; Koshland, Jr., D.E.
Structural basis for a change in substrate specificity: crystal structur of S113E isocitrate dehydrogenase in a complex with isopropylmalate, Mg2+, and NAPD
Biochemistry
40
4234-4241
2001
Escherichia coli
Manually annotated by BRENDA team
Leyland, M.L.; Kelly, D.J.
Purification and characterization of a monomeric isocitrate dehydrogenase with dual coenzyme specificity from the photosynthetic bacterium Rhodomicrobium vannielii
Eur. J. Biochem.
202
85-93
1991
Rhodomicrobium vannielii
Manually annotated by BRENDA team
Muro-Pastor, M.I.; Florencio, F.J.
Purification and properties of NADP-isocitrate dehydrogenase from the unicellular cyanobacterium Synechocystis sp. PCC 6803
Eur. J. Biochem.
203
99-105
1992
Synechocystis sp.
Manually annotated by BRENDA team
Chen, R.; Greer, A.F.; Dean, A.M.
Structural constrains in protein engineering. The coenzyme specificity of Escherichia coli isocitrate dehydrogenase
Eur. J. Biochem.
250
578-582
1997
Escherichia coli
Manually annotated by BRENDA team
Palomo, J.; Gallardo, F.; Suarez, M.F.; Canovas, F.M.
Purification and characterization of NADP+-linked isocitrate dehydrogenase from scots pine
Plant Physiol.
118
617-626
1998
Pinus spp.
Manually annotated by BRENDA team
Martinez-Rivas, J.M.; Garcia-Diaz, M.T.; Vega, J.M.
Purification and properties of cytosolic NADP-isocitrate dehydrogenase from Chlamydomonas reinhardtii
Plant Physiol. Biochem.
34
673-676
1996
Chlamydomonas reinhardtii
-
Manually annotated by BRENDA team
Steen, I.H.; Steine Madsen, M.; Birkeland, N-K.; Lien.T.
Purification and characterization of a monomeric isocitrate dehydrogenase from Desulfobacter vibrioformis and demonstration of the presence of a monomeric enzyme in other bacteria
FEMS Microbiol. Lett.
160
75-79
1998
Desulfobacter vibrioformis
Manually annotated by BRENDA team
Steen, I.H.; Lien.T.; Birkeland, N-K.
Biochemical and phylogenetic characterization of isocitrate dehydrogenase from a hyperthermophilic archaeon, Archaeoglobus fulgidus
Arch. MIcrobiol.
168
412-420
1997
Archaeoglobus fulgidus (O29610)
Manually annotated by BRENDA team
Novotny, J.F.; Perry, J.J.
Characterization of a heat-stable NADP-dependent isocitrate dehydrogenase from the obligate thermophile Thermoleophilum minutum YS-4
Appl. Microbiol. Biotechnol.
35
461-465
1991
Thermoleophilum minutum, Thermoleophilum minutum YS-4
-
Manually annotated by BRENDA team
Galvez, S.; Bismuth, E.; Sarda, C.; Gadal, P.
Purification and characterization of chloroplastic NADP-isocitrate dehydrogenase from mixotrophic tobacco cells
Plant Physiol.
105
593-600
1994
Nicotiana tabacum
Manually annotated by BRENDA team
Fukunaga, N.; Imagawa, S.; Sahara, T.; Ishii, A.; Suzuki, M.
Purification and characterization of monomeric isocitrate dehydrogenase with NADP+-specificity from Vibrio parhaemolyticus Y-4
J. Biochem.
112
849-855
1992
Vibrio parahaemolyticus, Vibrio parahaemolyticus Y-4
Manually annotated by BRENDA team
Sechi, S.; Parmalee, D.; Roller, P.P.; Jennings, G.T.
Structural characterization of cytosolic NADP(+)-dependent isocitrate dehydrogenase from rat ovary
Enzyme Protein
48
27-36
1994
Rattus norvegicus
Manually annotated by BRENDA team
Audette, G.F.; Quail, J.W.; Hayakawa, K.; Bai, C.; Chen, R.; Delbaere, L.T.
Crystallization and preliminary X-ray diffraction studies of monomeric isocitrate dehydrogenase from Corynebacterium glutamicum
Acta Crystallogr. Sect. D
55
1584-1585
1999
Corynebacterium glutamicum
Manually annotated by BRENDA team
Lee, P.; Colman, R.F.
Implication by site-directed mutagenesis of Arg314 and Tyr316 in the coenzyme site of pig mitochondrial NADP-dependent isocitrate dehydrogenase
Arch. Biochem. Biophys.
401
81-90
2002
Sus scrofa
Manually annotated by BRENDA team
Contreras-Shannon, V.; McAlister-Henn, L.
Influence of compartmental localization on the function of yeast NADP+-specific isocitrate dehydrogenases
Arch. Biochem. Biophys.
423
235-246
2004
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Huang, Y.C.; Colman, R.F.
Evaluation by mutagenesis of the roles of His309, His315, and His319 in the coenzyme site of pig heart NADP-dependent isocitrate dehydrogenase
Biochemistry
41
5637-5643
2002
Sus scrofa
Manually annotated by BRENDA team
Anderson, S.L.; Schirf, V.; McAlister-Henn, L.
Effect of AMP on mRNA binding by yeast NAD+-specific isocitrate dehydrogenase
Biochemistry
41
7065-7073
2002
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Morgunov, I.G.; Solodovnikova, N.Y.; Sharyshev, A.A.; Kamzolova, S.V.; Finogenova, T.V.
Regulation of NAD(+)-dependent isocitrate dehydrogenase in the citrate producing yeast Yarrowia lipolytica
Biochemistry
69
1391-1398
2004
Yarrowia lipolytica
Manually annotated by BRENDA team
Igamberdiev, A.U.; Gardestrom, P.
Regulation of NAD- and NADP-dependent isocitrate dehydrogenases by reduction levels of pyridine nucleotides in mitochondria and cytosol of pea leaves
Biochim. Biophys. Acta
1606
117-125
2003
Pisum sativum
Manually annotated by BRENDA team
Pinheiro de Carvalho, M.A.A.; Popova, T.N.; Dos Santos, T.M.M.; Zherebtsov, N.A.
Effect of metabolites of gamma-aminobutyric shunt on activities of NAD- and NADP-isocitrate dehydrogenases and aconitate hydratase from higher plants
Biol. Bull.
30
236-242
2003
Pisum sativum, Zea mays
-
Manually annotated by BRENDA team
Yoon, J.J.; Hattori, T.; Shimada, M.
Purification and characterization of NADP-linked isocitrate dehydrogenase from the copper-tolerant wood-rotting basidiomycete Fomitopsis palustris
Biosci. Biotechnol. Biochem.
67
114-120
2003
Fomitopsis palustris
Manually annotated by BRENDA team
Alvarado, A.; Flores, M.E.
Characterization and regulation of NADP+-isocitrate dehydrogenase from Saccharopolyspora erythraea
Biotechnol. Lett.
25
1175-1178
2003
Saccharopolyspora erythraea, Saccharopolyspora erythraea CA340
Manually annotated by BRENDA team
Munin, F.S.; Schwantes, M.L.; Schwantes, A.R.; Moreira-Filho, O.
NADP-dependent isocitrate dehydrogenase of Astyanax scabripinnis (Pisces, Characidae) from three altitudes at Grande Stream, Campos do Jordao, SP
Braz. J. Biol.
64
273-282
2004
Astyanax scabripinnis
Manually annotated by BRENDA team
Kanao, T.; Kawamura, M.; Fukui, T.; Atomi, H.; Imanaka, T.
Characterization of isocitrate dehydrogenase from the green sulfur bacterium Chlorobium limicola. A carbon dioxide-fixing enzyme in the reductive tricarboxylic acid cycle
Eur. J. Biochem.
269
1926-1931
2002
Chlorobium limicola
Manually annotated by BRENDA team
Wrenger, C.; Mueller, S.
Isocitrate dehydrogenase of Plasmodium falciparum. Energy metabolism or redox control?
Eur. J. Biochem.
270
1775-1783
2003
Plasmodium falciparum
Manually annotated by BRENDA team
Camacho, M.; Rodriguez-Arnedo, A.; Bonete, M.J.
NADP-dependent isocitrate dehydrogenase from the halophilic archaeon Haloferax volcanii: cloning, sequence determination and overexpression in Escherichia coli
FEMS Microbiol. Lett.
209
155-160
2002
Haloferax volcanii, Haloferax volcanii (Q8X277)
Manually annotated by BRENDA team
Yang, J.H.; Yang, E.S.; Park, J.W.
Inactivation of NADP+-dependent isocitrate dehydrogenase by lipid peroxidation products
Free Radic. Res.
38
241-249
2004
Homo sapiens
Manually annotated by BRENDA team
Ceccarelli, C.; Grodsky, N.B.; Ariyaratne, N.; Colman, R.F.; Bahnson, B.J.
Crystal structure of porcine mitochondrial NADP+-dependent isocitrate dehydrogenase complexed with Mn2+ and isocitrate. Insights into the enzyme mechanism
J. Biol. Chem.
277
43454-43462
2002
Sus scrofa (P33198), Sus scrofa
Manually annotated by BRENDA team
Kim, T.K.; Lee, P.; Colman, R.F.
Critical role of Lys212 and Tyr140 in porcine NADP-dependent isocitrate dehydrogenase
J. Biol. Chem.
278
49323-49331
2003
Sus scrofa (P33198), Sus scrofa
Manually annotated by BRENDA team
Xu, X.; Zhao, J.; Xu, Z.; Peng, B.; Huang, Q.; Arnold, E.; Ding, J.
Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity
J. Biol. Chem.
279
33946-33957
2004
Homo sapiens, Saccharomyces cerevisiae
Manually annotated by BRENDA team
Koh, H.J.; Lee, S.M.; Son, B.G.; Lee, S.H.; Ryoo, Z.Y.; Chang, K.T.; Park, J.W.; Park, D.C.; Song, B.J.; Veech, R.L.; Song, H.; Huh, T.L.
Cytosolic NADP+-dependent isocitrate dehydrogenase plays a key role in lipid metabolism
J. Biol. Chem.
279
39968-39974
2004
Mus musculus
Manually annotated by BRENDA team
Haraguchi, C.M.; Mabuchi, T.; Yokota, S.
Localization of a mitochondrial type of NADP-dependent isocitrate dehydrogenase in kidney and heart of rat: an immunocytochemical and biochemical study
J. Histochem. Cytochem.
51
215-226
2003
Rattus norvegicus
Manually annotated by BRENDA team
Minich, T.; Yokota, S.; Dringen, R.
Cytosolic and mitochondrial isoforms of NADP+-dependent isocitrate dehydrogenases are expressed in cultured rat neurons, astrocytes, oligodendrocytes and microglial cells
J. Neurochem.
86
605-614
2003
Rattus norvegicus (P41562)
Manually annotated by BRENDA team
Popova, T.N.; Rakhmanova, T.I.; Appenroth, K.J.
Cytosolic and chloroplastic NADP-dependent isocitrate dehydrogenases in Spirodela polyrhiza. I. Regulation of activity by metabolites in vitro
J. Plant Physiol.
159
231-237
2002
Spirodela polyrhiza
-
Manually annotated by BRENDA team
Lebedeva, N.V.; Malinina, N.V.; Ivanovsky, R.N.
A comparative study of the isocitrate dehydrogenases of Chlorobium limicola forma thiosulfatophilum and Rhodopseudomonas palustris
Microbiology
71
657-662
2002
Chlorobium limicola, Rhodopseudomonas palustris, Rhodopseudomonas palustris 285
-
Manually annotated by BRENDA team
Kim, T.K.; Colman, R.F.
Ser95, Asn97, and Thr78 are important for the catalytic function of porcine NADP-dependent isocitrate dehydrogenase
Protein Sci.
14
140-147
2005
Sus scrofa
Manually annotated by BRENDA team
Corpas, F.J.; Barroso, J.B.; Sandalio, L.M.; Palma, J.M.; Lupianez, J.A.; del Rio, L.A.
Peroxisomal NADP-dependent isocitrate dehydrogenase. Characterization and activity regulation during natural senescence
Plant Physiol.
121
921-928
1999
Pisum sativum
Manually annotated by BRENDA team
Lee, P.; Colman, R.F.
Thr373, Asp375, and Lys260 are in the coenzyme site of porcine NADP-dependent isocitrate dehydrogenase
Arch. Biochem. Biophys.
450
183-190
2006
Sus scrofa (P33198), Sus scrofa
Manually annotated by BRENDA team
Rakhmanova, T.I.; Popova, T.N.
Regulation of 2-oxoglutarate metabolism in rat liver by NADP-isocitrate dehydrogenase and aspartate aminotransferase
Biochemistry (Moscow)
71
211-217
2006
Rattus norvegicus
Manually annotated by BRENDA team
Banerjee, S.; Nandyala, A.; Podili, R.; Katoch, V.M.; Hasnain, S.E.
Comparison of Mycobacterium tuberculosis isocitrate dehydrogenases (ICD-1 and ICD-2) reveals differences in coenzyme affinity, oligomeric state, pH tolerance and phylogenetic affiliation
BMC Biochem.
6
20
2005
Mycobacterium tuberculosis
Manually annotated by BRENDA team
Beriault, R.; Chenier, D.; Singh, R.; Middaugh, J.; Mailloux, R.; Appanna, V.
Detection and purification of glucose 6-phosphate dehydrogenase, malic enzyme, and NADP-dependent isocitrate dehydrogenase by blue native polyacrylamide gel electrophoresis
Electrophoresis
26
2892-2897
2005
Pseudomonas fluorescens
Manually annotated by BRENDA team
Karlstroem, M.; Steen, I.H.; Madern, D.; Fedoey, A.E.; Birkeland, N.K.; Ladenstein, R.
The crystal structure of a hyperthermostable subfamily II isocitrate dehydrogenase from Thermotoga maritima
FEBS J.
273
2851-2868
2006
Thermotoga maritima (Q9X0N2)
Manually annotated by BRENDA team
Kil, I.S.; Huh, T.L.; Lee, Y.S.; Lee, Y.M.; Park, J.W.
Regulation of replicative senescence by NADP+ -dependent isocitrate dehydrogenase
Free Radic. Biol. Med.
40
110-119
2006
Mus musculus
Manually annotated by BRENDA team
Kil, I.S.; Park, J.W.
Regulation of mitochondrial NADP+-dependent isocitrate dehydrogenase activity by glutathionylation
J. Biol. Chem.
280
10846-10854
2005
Sus scrofa
Manually annotated by BRENDA team
Huang, Y.C.; Colman, R.F.
Location of the coenzyme binding site in the porcine mitochondrial NADP-dependent isocitrate dehydrogenase
J. Biol. Chem.
280
30349-30353
2005
Sus scrofa (P33198), Sus scrofa
Manually annotated by BRENDA team
Ronnebaum, S.M.; Ilkayeva, O.; Burgess, S.C.; Joseph, J.W.; Lu, D.; Stevens, R.D.; Becker, T.C.; Sherry, A.D.; Newgard, C.B.; Jensen, M.V.
A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion
J. Biol. Chem.
281
30593-30602
2006
Rattus norvegicus (P41562)
Manually annotated by BRENDA team
Popova, T.; Carvalho, M.A.; Matasova, L.; Medvedeva, L.
Regulation of mitochondrial NADP-isocitrate dehydrogenase in rat heart during ischemia
Mol. Cell. Biochem.
294
97-105
2006
Rattus norvegicus (P56574), Rattus norvegicus
Manually annotated by BRENDA team
Kil, I.S.; Shin, S.W.; Yeo, H.S.; Lee, Y.S.; Park, J.W.
Mitochondrial NADP+-dependent isocitrate dehydrogenase protects cadmium-induced apoptosis
Mol. Pharmacol.
70
1053-1061
2006
Mus musculus, Sus scrofa
Manually annotated by BRENDA team
Marino, D.; Gonzalez, E.M.; Frendo, P.; Puppo, A.; Arrese-Igor, C.
NADPH recycling systems in oxidative stressed pea nodules: a key role for the NADP(+)-dependent isocitrate dehydrogenase
Planta
225
413-421
2006
Pisum sativum, Pisum sativum (Q6R6M7)
Manually annotated by BRENDA team
Rodriguez-Arnedo, A.; Camacho, M.; Llorca, F.; Bonete, M.J.
Complete reversal of coenzyme specificity of isocitrate dehydrogenase from Haloferax volcanii
Protein J.
24
259-266
2005
Haloferax volcanii (Q8X277)
Manually annotated by BRENDA team
Imabayashi, F.; Aich, S.; Prasad, L.; Delbaere, L.T.
Substrate-free structure of a monomeric NADP isocitrate dehydrogenase: an open conformation phylogenetic relationship of isocitrate dehydrogenase
Proteins
63
100-112
2006
Corynebacterium glutamicum
Manually annotated by BRENDA team
Ogawa, T.; Murakami, K.; Mori, H.; Ishii, N.; Tomita, M.; Yoshin, M.
Role of phosphoenolpyruvate in the NADP-isocitrate dehydrogenase and isocitrate lyase reaction in Escherichia coli
J. Bacteriol.
189
1176-1178
2007
Escherichia coli
Manually annotated by BRENDA team
Margittai, E.; Banhegyi, G.
Isocitrate dehydrogenase: A NADPH-generating enzyme in the lumen of the endoplasmic reticulum
Arch. Biochem. Biophys.
471
184-190
2008
Rattus norvegicus
Manually annotated by BRENDA team
Lu, Q.; Minard, K.I.; McAlister-Henn, L.
Dual compartmental localization and function of mammalian NADP+-specific isocitrate dehydrogenase in yeast
Arch. Biochem. Biophys.
472
17-25
2008
Mus musculus, Mus musculus (O88844), Mus musculus (P54071), Saccharomyces cerevisiae (P21954), Saccharomyces cerevisiae (P41939), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Shin, S.W.; Kil, I.S.; Park, J.W.
Silencing of mitochondrial NADP+-dependent isocitrate dehydrogenase by small interfering RNA enhances heat shock-induced apoptosis
Biochem. Biophys. Res. Commun.
366
1012-1018
2008
Homo sapiens (P48735)
Manually annotated by BRENDA team
Yang, E.S.; Lee, J.H.; Park, J.W.
Ethanol induces peroxynitrite-mediated toxicity through inactivation of NADP(+)-dependent isocitrate dehydrogenase and superoxide dismutase
Biochimie
90
1316-1324
2008
Homo sapiens
Manually annotated by BRENDA team
Kil, I.S.; Kim, S.Y.; Lee, S.J.; Park, J.W.
Small interfering RNA-mediated silencing of mitochondrial NADP+-dependent isocitrate dehydrogenase enhances the sensitivity of HeLa cells toward tumor necrosis factor-alpha and anticancer drugs
Free Radic. Biol. Med.
43
1197-1207
2007
Homo sapiens
Manually annotated by BRENDA team
Leterrier, M.; Del Rio, L.A.; Corpas, F.J.
Cytosolic NADP-isocitrate dehydrogenase of pea plants: genomic clone characterization and functional analysis under abiotic stress conditions
Free Radic. Res.
41
191-199
2007
Pisum sativum, Pisum sativum (Q6R6M7)
Manually annotated by BRENDA team
Park, S.Y.; Lee, S.M.; Shin, S.W.; Park, J.W.
Inactivation of mitochondrial NADP+-dependent isocitrate dehydrogenase by hypochlorous acid
Free Radic. Res.
42
467-473
2008
Homo sapiens, Homo sapiens (P48735), Mus musculus (O88844)
Manually annotated by BRENDA team
Lee, J.H.; Kim, S.Y.; Kil, I.S.; Park, J.W.
Regulation of ionizing radiation-induced apoptosis by mitochondrial NADP+-dependent isocitrate dehydrogenase
J. Biol. Chem.
282
13385-13394
2007
Homo sapiens (P48735)
Manually annotated by BRENDA team
Fedoy, A.E.; Yang, N.; Martinez, A.; Leiros, H.K.; Steen, I.H.
Structural and functional properties of isocitrate dehydrogenase from the psychrophilic bacterium Desulfotalea psychrophila reveal a cold-active enzyme with an unusual high thermal stability
J. Mol. Biol.
372
130-149
2007
Desulfotalea psychrophila, Desulfotalea psychrophila (Q6AQ66)
Manually annotated by BRENDA team
Kim, S.Y.; Lee, S.M.; Tak, J.K.; Choi, K.S.; Kwon, T.K.; Park, J.W.
Regulation of singlet oxygen-induced apoptosis by cytosolic NADP+-dependent isocitrate dehydrogenase
Mol. Cell. Biochem.
302
27-34
2007
Mus musculus
Manually annotated by BRENDA team
Peng, Y.; Zhong, C.; Huang, W.; Ding, J.
Structural studies of Saccharomyces cerevesiae mitochondrial NADP-dependent isocitrate dehydrogenase in different enzymatic states reveal substantial conformational changes during the catalytic reaction
Protein Sci.
17
1542-1554
2008
Saccharomyces cerevisiae (P21954)
Manually annotated by BRENDA team
Kim, J.; Kim, K.Y.; Jang, H.S.; Yoshida, T.; Tsuchiya, K.; Nitta, K.; Park, J.W.; Bonventre, J.V.; Park, K.M.
Role of cytosolic NADP+-dependent isocitrate dehydrogenase in ischemia-reperfusion injury in mouse kidney
Am. J. Physiol. Renal Physiol.
296
F622-F633
2009
Mus musculus
Manually annotated by BRENDA team
Tsuchiya, D.; Shimizu, N.; Tomita, M.
Versatile architecture of a bacterial aconitase B and its catalytic performance in the sequential reaction coupled with isocitrate dehydrogenase
Biochim. Biophys. Acta
1784
1847-1856
2008
Escherichia coli (P08200)
Manually annotated by BRENDA team
Yang, E.S.; Park, J.W.
Regulation of ethanol-induced toxicity by mitochondrial NADP+-dependent isocitrate dehydrogenase
Biochimie
91
1020-1028
2009
Mus musculus
Manually annotated by BRENDA team
Zhang, B.; Wang, B.; Wang, P.; Cao, Z.; Huang, E.; Hao, J.; Dean, A.M.; Zhu, G.
Enzymatic characterization of a monomeric isocitrate dehydrogenase from Streptomyces lividans TK54
Biochimie
91
1405-1410
2009
Streptomyces lividans (B2ZAA4), Streptomyces lividans TK54 (B2ZAA4), Streptomyces lividans TK54
Manually annotated by BRENDA team
Ishii, N.; Umemura, K.; Miyazaki, K.
Supramolecular complex formation and crystallization of isocitrate dehydrogenase from Thermus thermophilus HB8: preliminary studies with X-ray crystallography and atomic force microscopy
Biosci. Biotechnol. Biochem.
72
2369-2376
2008
Thermus thermophilus (P33197)
Manually annotated by BRENDA team
Batinic-Haberle, I.; Benov, L.T.
An SOD mimic protects NADP+-dependent isocitrate dehydrogenase against oxidative inactivation
Free Radic. Res.
42
618-624
2008
Escherichia coli, Rattus norvegicus
Manually annotated by BRENDA team
Lee, S.M.; Park, S.Y.; Shin, S.W.; Kil, I.S.; Yang, E.S.; Park, J.W.
Silencing of cytosolic NADP(+)-dependent isocitrate dehydrogenase by small interfering RNA enhances the sensitivity of HeLa cells toward staurosporine
Free Radic. Res.
43
165-173
2009
Homo sapiens
Manually annotated by BRENDA team
Shin, S.W.; Oh, C.J.; Kil, I.S.; Park, J.W.
Glutathionylation regulates cytosolic NADP+-dependent isocitrate dehydrogenase activity
Free Radic. Res.
43
409-416
2009
Homo sapiens
Manually annotated by BRENDA team
Vinekar, R.; Ghosh, I.
Determination of phosphorylation sites for NADP-specific isocitrate dehydrogenase from Mycobacterium tuberculosis
J. Biomol. Struct. Dyn.
26
741-754
2009
Mycobacterium tuberculosis (A5U813), Mycobacterium tuberculosis, Mycobacterium tuberculosis (O53611)
Manually annotated by BRENDA team
Hartong, D.T.; Dange, M.; McGee, T.L.; Berson, E.L.; Dryja, T.P.; Colman, R.F.
Novel insights into the contributions of isocitrate dehydrogenases to the Krebs cycle from patients with retinitis pigmentosa
Nat. Genet.
40
1230-1234
2008
Homo sapiens
Manually annotated by BRENDA team
Sawada, K.; Taki, A.; Yamakawa, T.; Seki, M.
Key role for transketolase activity in erythritol production by Trichosporonoides megachiliensis SN-G42
J. Biosci. Bioeng.
108
385-390
2009
Moniliella megachiliensis, Moniliella megachiliensis SN-G42
Manually annotated by BRENDA team
Lu, Q.; McAlister-Henn, L.
Peroxisomal localization and function of NADP+-specific isocitrate dehydrogenases in yeast
Arch. Biochem. Biophys.
493
125-134
2010
Aspergillus nidulans, Saccharomyces cerevisiae, Saccharomyces cerevisiae MMY011
Manually annotated by BRENDA team
Murugan, A.K.; Bojdani, E.; Xing, M.
Identification and functional characterization of isocitrate dehydrogenase 1 (IDH1) mutations in thyroid cancer
Biochem. Biophys. Res. Commun.
393
555-559
2010
Homo sapiens (O75874), Homo sapiens (P48735)
Manually annotated by BRENDA team
Lopez, G.Y.; Reitman, Z.J.; Solomon, D.; Waldman, T.; Bigner, D.D.; McLendon, R.E.; Rosenberg, S.A.; Samuels, Y.; Yan, H.
IDH1(R132) mutation identified in one human melanoma metastasis, but not correlated with metastases to the brain
Biochem. Biophys. Res. Commun.
398
585-587
2010
Homo sapiens, Homo sapiens (O75874), Homo sapiens (P48735)
Manually annotated by BRENDA team
McKinnon, D.J.; Brzezowski, P.; Wilson, K.E.; Gray, G.R.
Mitochondrial and chloroplastic targeting signals of NADP+-dependent isocitrate dehydrogenase
Biochem. Cell Biol.
87
963-974
2009
Nicotiana tabacum, Nicotiana tabacum (O65853)
Manually annotated by BRENDA team
Shin, S.W.; Kil, I.S.; Park, J.W.
Cytosolic NADP(+)-dependent isocitrate dehydrogenase regulates cadmium-induced apoptosis
Biochem. Pharmacol.
79
1072-1080
2010
Homo sapiens
Manually annotated by BRENDA team
Kim, S.Y.; Park, J.W.
Modulation of hypoxia-inducible factor-1alpha expression by mitochondrial NADP+-dependent isocitrate dehydrogenase
Biochimie
92
908-913
2010
Homo sapiens
Manually annotated by BRENDA team
Kil, I.S.; Chung, K.H.; Park, J.W.
Silencing of mitochondrial NADP+-dependent isocitrate dehydrogenase gene enhances selenite-induced apoptosis
Free Radic. Res.
44
332-339
2010
Homo sapiens
Manually annotated by BRENDA team
Kang, M.R.; Kim, M.S.; Oh, J.E.; Kim, Y.R.; Song, S.Y.; Seo, S.I.; Lee, J.Y.; Yoo, N.J.; Lee, S.H.
Mutational analysis of IDH1 codon 132 in glioblastomas and other common cancers
Int. J. Cancer
125
353-355
2009
Homo sapiens
Manually annotated by BRENDA team
Sanson, M.; Marie, Y.; Paris, S.; Idbaih, A.; Laffaire, J.; Ducray, F.; El Hallani, S.; Boisselier, B.; Mokhtari, K.; Hoang-Xuan, K.; Delattre, J.Y.
Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas
J. Clin. Oncol.
27
4150-4154
2009
Homo sapiens
Manually annotated by BRENDA team
Gross, S.; Cairns, R.A.; Minden, M.D.; Driggers, E.M.; Bittinger, M.A.; Jang, H.G.; Sasaki, M.; Jin, S.; Schenkein, D.P.; Su, S.M.; Dang, L.; Fantin, V.R.; Mak, T.W.
Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations
J. Exp. Med.
207
339-344
2010
Homo sapiens, Homo sapiens (O75874), Homo sapiens (P48735)
Manually annotated by BRENDA team
Andrulis, M.; Capper, D.; Luft, T.; Hartmann, C.; Zentgraf, H.; von Deimling, A.
Detection of isocitrate dehydrogenase 1 mutation R132H in myelodysplastic syndrome by mutation-specific antibody and direct sequencing
Leuk. Res.
34
1091-1093
2010
Homo sapiens
Manually annotated by BRENDA team
Dang, L.; White, D.W.; Gross, S.; Bennett, B.D.; Bittinger, M.A.; Driggers, E.M.; Fantin, V.R.; Jang, H.G.; Jin, S.; Keenan, M.C.; Marks, K.M.; Prins, R.M.; Ward, P.S.; Yen, K.E.; Liau, L.M.; Rabinowitz, J.D.; Cantley, L.C.; Thompson, C.B.; Vander Heiden, M.G.; Su, S.M.
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
Nature
462
739-744
2009
Homo sapiens, Homo sapiens (O75874)
Manually annotated by BRENDA team
Labussiere, M.; Idbaih, A.; Wang, X.W.; Marie, Y.; Boisselier, B.; Falet, C.; Paris, S.; Laffaire, J.; Carpentier, C.; Criniere, E.; Ducray, F.; El Hallani, S.; Mokhtari, K.; Hoang-Xuan, K.; Delattre, J.Y.; Sanson, M.
All the 1p19q codeleted gliomas are mutated on IDH1 or IDH2
Neurology
74
1886-1890
2010
Homo sapiens
Manually annotated by BRENDA team
Mhamdi, A.; Mauve, C.; Gouia, H.; Saindrenan, P.; Hodges, M.; Noctor, G.
Cytosolic NADP-dependent isocitrate dehydrogenase contributes to redox homeostasis and the regulation of pathogen responses in Arabidopsis leaves
Plant Cell Environ.
33
1112-1123
2010
Arabidopsis thaliana, Arabidopsis thaliana Columbia ecotype
Manually annotated by BRENDA team
Zhao, S.; Lin, Y.; Xu, W.; Jiang, W.; Zha, Z.; Wang, P.; Yu, W.; Li, Z.; Gong, L.; Peng, Y.; Ding, J.; Lei, Q.; Guan, K.L.; Xiong, Y.
Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha
Science
324
261-265
2009
Homo sapiens, Sus scrofa
Manually annotated by BRENDA team
Camacho, M.L.; Brown, R.A.; Bonete, M.J.; Danson, M.J.; Hough, D.W.
Isocitrate dehydrogenases from Haloferax volcanii and Sulfolobus solfataricus: enzyme purification, characterisation and N-terminal sequence
FEMS Microbiol. Lett.
134
85-90
1995
Haloferax volcanii, Haloferax volcanii DSM 3757, Sulfolobus solfataricus (Q9UWG7), Sulfolobus solfataricus DSM 1616 (Q9UWG7)
Manually annotated by BRENDA team
Sidhu, N.S.; Delbaere, L.T.; Sheldrick, G.M.
Structure of a highly NADP+-specific isocitrate dehydrogenase
Acta Crystallogr. Sect. D
67
856-869
2011
Corynebacterium glutamicum, Corynebacterium glutamicum (P50216)
Manually annotated by BRENDA team
Prasad, U.V.; Vasu, D.; Kumar, Y.N.; Kumar, P.S.; Yeswanth, S.; Swarupa, V.; Phaneendra, B.V.; Chaudhary, A.; Sarma, P.V.
Cloning, expression and characterization of NADP-dependent isocitrate dehydrogenase from Staphylococcus aureus
Appl. Biochem. Biotechnol.
169
862-869
2013
Staphylococcus aureus (D7RIE8), Staphylococcus aureus, Staphylococcus aureus ATCC12600 (D7RIE8)
Manually annotated by BRENDA team
Vornolt, J.; Kunow, J.; Stetter, K.; Thauer, R.
Enzymes and coenzymes of the carbon monoxide dehydrogenase pathway for autotrophic CO2 fixation in Archaeoglobus lithotrophicus and the lack of carbon monoxide dehydrogenase in the heterotrophic A. profundus
Arch. Microbiol.
163
112-118
1995
Archaeoglobus fulgidus, Archaeoglobus lithotrophicus, Archaeoglobus lithotrophicus TF-2, Archaeoglobus profundus, Archaeoglobus profundus DSM 5631
-
Manually annotated by BRENDA team
Quartararo, C.E.; Hazra, S.; Hadi, T.; Blanchard, J.S.
Structural, kinetic and chemical mechanism of isocitrate dehydrogenase-1 from Mycobacterium tuberculosis
Biochemistry
52
1765-1775
2013
Mycobacterium tuberculosis, Mycobacterium tuberculosis (P9WKL1), Mycobacterium tuberculosis H37Rv (P9WKL1)
Manually annotated by BRENDA team
Leterrier, M.; Barroso, J.; Palma, J.; Corpas, F.
Cytosolic NADP-isocitrate dehydrogenase in Arabidopsis leaves and roots
Biol. Plant.
56
705-710
2012
Arabidopsis thaliana (Q9SRZ6)
-
Manually annotated by BRENDA team
Stokke, R.; Birkeland, N.K.; Steen, I.H.
Thermal stability and biochemical properties of isocitrate dehydrogenase from the thermoacidophilic archaeon Thermoplasma acidophilum
Extremophiles
11
397-402
2007
Thermoplasma acidophilum (Q9HLV8), Thermoplasma acidophilum, Thermoplasma acidophilum DSMZ 1728 (Q9HLV8)
Manually annotated by BRENDA team
Stokke, R.; Karlstroem, M.; Yang, N.; Leiros, I.; Ladenstein, R.; Birkeland, N.K.; Steen, I.H.
Thermal stability of isocitrate dehydrogenase from Archaeoglobus fulgidus studied by crystal structure analysis and engineering of chimers
Extremophiles
11
481-493
2007
Archaeoglobus fulgidus, Archaeoglobus fulgidus (O29610), Escherichia coli, Escherichia coli (P08200), Escherichia coli K12 (P08200)
Manually annotated by BRENDA team
Deng, M.H.; Wen, J.F.; Huo, J.L.; Zhu, H.S.; Dai, X.Z.; Zhang, Z.Q.; Zhou, H.; Zou, X.X.
Molecular cloning, sequence characterization of a novel pepper gene NADP-ICDH and its effect on cytoplasmic male sterility
Genet. Mol. Res.
11
3020-3031
2012
Capsicum annuum (J9Q6L4), Capsicum annuum CMS-9704A (J9Q6L4)
Manually annotated by BRENDA team
Zera, A.J.; Newman, S.; Berkheim, D.; Black, C.; Klug, L.; Crone, E.
Purification and characterization of cytoplasmic NADP+-isocitrate dehydrogenase, and amplification of the NADP+-IDH gene from the wing-dimorphic sand field cricket, Gryllus firmus
J. Insect Sci.
11
53
2011
Gryllus firmus
Manually annotated by BRENDA team
Leroux, A.E.; Maugeri, D.A.; Cazzulo, J.J.; Nowicki, C.
Functional characterization of NADP-dependent isocitrate dehydrogenase isozymes from Trypanosoma cruzi
Mol. Biochem. Parasitol.
177
61-64
2011
Trypanosoma cruzi (Q4DG65), Trypanosoma cruzi (Q4E4L7), Trypanosoma cruzi
Manually annotated by BRENDA team
Zhang, B.; Wang, P.; Wang, A.; Wang, W.; Tang, W.; Zhu, G.
Expression and characterization of a novel isocitrate dehydrogenase from Streptomyces diastaticus No. 7 strain M1033
Mol. Biol. Rep.
40
1615-1623
2013
Streptomyces diastaticus, Streptomyces diastaticus M1033
Manually annotated by BRENDA team
Jin, M.M.; Wang, P.; Li, X.; Zhao, X.Y.; Xu, L.; Song, P.; Zhu, G.P.
Biochemical characterization of NADP+-dependent isocitrate dehydrogenase from Microcystis aeruginosa PCC7806
Mol. Biol. Rep.
40
2995-3002
2013
Microcystis aeruginosa, Microcystis aeruginosa PCC 7806
Manually annotated by BRENDA team
Aoshima, M.; Yamagishi, A.; Oshima, T.
Eubacteria-type isocitrate dehydrogenase from an archaeon: cloning, sequencing, and expression of a gene encoding isocitrate dehydrogenase from a hyperthermophilic archaebacterium, Caldococcus noboribetus
Arch. Biochem. Biophys.
336
77-85
1996
Caldococcus noboribetus (P96318)
Manually annotated by BRENDA team
Karlström, M.; Chiaraluce, R.; Giangiacomo, L.; Steen, I.H.; Birkeland, N.K.; Ladenstein, R.; Consalvi, V.
Thermodynamic and kinetic stability of a large multi-domain enzyme from the hyperthermophile Aeropyrum pernix
Extremophiles
14
213-223
2010
Aeropyrum pernix (Q9YE81), Aeropyrum pernix DSM 11879 (Q9YE81)
Manually annotated by BRENDA team
Madern, D.; Camacho, M.; Rodríguez-Arnedo, A.; Bonete, M.J.; Zaccai, G.
Salt-dependent studies of NADP-dependent isocitrate dehydrogenase from the halophilic archaeon Haloferax volcanii
Extremophiles
8
377-384
2004
Haloferax volcanii, Haloferax volcanii (Q8X277)
Manually annotated by BRENDA team
Iwabata, H.; Watanabe, K.; Ohkuri, T.; Yokobori, S.; Yamagishi, A.
Thermostability of ancestral mutants of Caldococcus noboribetus isocitrate dehydrogenase
FEMS Microbiol. Lett.
243
393-398
2005
Caldococcus noboribetus (P96318)
Manually annotated by BRENDA team
Steen, I.H.; Madern, D.; Karlström, M.; Lien, T.; Ladenstein, R.; Birkeland, N.K.
Comparison of isocitrate dehydrogenase from three hyperthermophiles reveals differences in thermostability, cofactor specificity, oligomeric state, and phylogenetic affiliation
J. Biol. Chem.
276
43924-43931
2001
Aeropyrum pernix, Aeropyrum pernix (Q9YE81), Aeropyrum pernix DSM 11879 (Q9YE81), Thermotoga maritima (Q9X0N2), Thermotoga maritima, Thermotoga maritima DSM 3109 (Q9X0N2)
Manually annotated by BRENDA team
Karlström, M.; Stokke, R.; Steen, I.H.; Birkeland, N.K.; Ladenstein, R.
Isocitrate dehydrogenase from the hyperthermophile Aeropyrum pernix: X-ray structure analysis of a ternary enzyme-substrate complex and thermal stability
J. Mol. Biol.
345
559-577
2005
Aeropyrum pernix, Aeropyrum pernix (Q9YE81), Aeropyrum pernix DSM 11879 (Q9YE81)
Manually annotated by BRENDA team
Jeong, J.J.; Sonoda, T.; Fushinobu, S.; Shoun, H.; Wakagi, T.
Crystal structure of isocitrate dehydrogenase from Aeropyrum pernix
Proteins
55
1087-1089
2004
Aeropyrum pernix (Q9YE81), Aeropyrum pernix DSM 11879 (Q9YE81)
Manually annotated by BRENDA team