6.3.2.16: D-alanine-alanyl-poly(glycerolphosphate) ligase

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For detailed information about D-alanine-alanyl-poly(glycerolphosphate) ligase, go to the full flat file.

Reaction

Synonyms

D-Alanine-membrane acceptor-ligase, D-Alanine:membrane acceptor ligase, D-Alanine:membrane-acceptor ligase, D-Alanyl-alanyl-polyglycerolphosphate synthetase, D-Alanyl-poly(phosphoglycerol) synthetase, Synthetase, D-alanylalanylpoly(phosphoglycerol)

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.2 Acid—amino-acid ligases (peptide synthases)

                6.3.2.16 D-alanine-alanyl-poly(glycerolphosphate) ligase

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1	CAS Registry Number
7	Inhibitors
3	KM Value [mM]
5	Metals/Ions
1	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
1	Organism
1	Pathway
1	pH Optimum
1	Reaction
2	Reaction Type
1	Reference
7	Substrates and Products (Substrate)
6	Synonyms
1	Systematic Name

Substrates Products

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Substrates Products on EC 6.3.2.16 - D-alanine-alanyl-poly(glycerolphosphate) ligase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

ADP + D-Ala + membrane-acceptor

AMP + phosphate + D-alanyl-membrane acceptor

Lacticaseibacillus casei

-

83% of the activity relative to ATP

1056

-

-

?

ATP + D-2-amino-n-butanoate + membrane-acceptor

ADP + phosphate + D-2-aminobutanoyl-membrane acceptor

Lacticaseibacillus casei

-

-

1056

-

-

?

ATP + D-Ala + membrane-acceptor

?

Lacticaseibacillus casei

-

reaction is responsible for the incorporation of D-Ala into membranes of Lactobacillus casei, involved in the synthesis of teichoic acids

1056

-

-

?

ATP + D-Ala + membrane-acceptor

ADP + phosphate + D-alanyl-membrane acceptor

Lacticaseibacillus casei

-

no activity with L-Ala

1056

-

1056

?

CTP + D-Ala + membrane-acceptor

CDP + phosphate + D-alanyl-membrane acceptor

Lacticaseibacillus casei

-

107% of the activity relative to ATP

1056

-

-

?

GTP + D-Ala + membrane-acceptor

GDP + phosphate + D-alanyl-membrane acceptor

Lacticaseibacillus casei

-

84% of the activity relative to ATP

1056

-

-

?

UTP + D-Ala + membrane-membrane acceptor

UDP + phosphate + D-alanyl-membrane acceptor

Lacticaseibacillus casei

-

126% of the activity relative to ATP

1056

-

-

?