6.2.1.4: succinate-CoA ligase (GDP-forming)

This is an abbreviated version!
For detailed information about succinate-CoA ligase (GDP-forming), go to the full flat file.

Reaction

Synonyms

ATP-specific SCS, G-SCS, G-STK, G-SUCL, GDP-forming SUCL, GTP-dependent succinate:CoA ligase, GTP-forming SUCL, GTP-specific succinate:CoA ligase, GTP-specific succinyl-CoA synthetase, GTP-specific SUCL, GTPSCS, SCS, SCS-alpha, SCS-beta, SCS-betaG, ScsA, SCSalpha, SucCDAm, Succinate thiokinase, succinate-CoA ligase, Succinic thiokinase, Succinyl CoA synthetase, Succinyl coenzyme A synthetase, Succinyl coenzyme A synthetase (GDP-forming), Succinyl coenzyme A synthetase (guanosine diphosphate-forming), succinyl-CoA synthase, Succinyl-CoA synthetase, Succinyl-CoA synthetase (GDP-forming), succinyl-CoA synthetase subunit beta, succinyl-coenzyme A synthetase, SUCL, SUCLG1, SUCLG2, Synthetase, succinyl coenzyme A (guanosine diphosphate-forming)

ECTree

     6 Ligases

         6.2 Forming carbon-sulfur bonds

             6.2.1 Acid-thiol ligases

                6.2.1.4 succinate-CoA ligase (GDP-forming)

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Results	in table
2363	AA Sequence
1	CAS Registry Number
12	Cloned(Commentary)
26	Cofactor
5	Crystallization (Commentary)
135	Disease/ Diagnostics
9	General Information
10	Inhibitors
5	kcat/KM [mM/s]
27	KM Value [mM]
14	Localization
8	Metals/Ions
9	Molecular Weight [Da]
28	Natural Substrates/ Products (Substrates)
59	Organism
9	Pathway
39	PDB ID
3	pH Optimum
1	pI Value
1	Posttranslational Modification
16	Protein Variants
8	Purification (Commentary)
2	Reaction
1	Reaction Type
59	Reference
2	Renatured (Commentary)
44	Source Tissue
2	Specific Activity [micromol/min/mg]
90	Substrates and Products (Substrate)
10	Subunits
72	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Stability [°C]
5	Turnover Number [1/s]

KM Value

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KM Value on EC 6.2.1.4 - succinate-CoA ligase (GDP-forming)

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.145 - 0.265

ATP

3 entries

0.004 - 0.036

CoA

5 entries

0.007

GDP

Pigeon

-

pH 8.0, 30°C

651897

0.009 - 0.63

GTP

9 entries

2.26

phosphate

Pigeon

-

pH 8.0, 30°C

651897

0.39 - 5.1

succinate

6 entries

0.086

succinyl-CoA

Pigeon

-

pH 8.0, 30°C

651897

additional information

additional information

Sus scrofa

-

kinetic mechanism and thermodynamic parameter values, quasi-steady-state models, evaluation of five different proposed mechanisms, overview. The ordered ter-ter mechanism with dead-end product inhibition of succinate against succinyl-CoA effectively matches kinetic data on pig heart enzyme, thermodynamic-constrained kinetic model

727203

-

0.145

ATP

Blastocystis hominis

-

wild type enzyme, at pH 7.4 and 21°C

744369

0.23

ATP

Blastocystis hominis

-

mutant enzyme K46E/K114D, at pH 7.4 and 21°C

744369

0.265

ATP

Blastocystis hominis

-

mutant enzyme V113L/L227F, at pH 7.4 and 21°C

744369

0.004

CoA

Sus scrofa

-

enzyme form pI 6.4

789

0.005

CoA

Sus scrofa

-

enzyme form pI 5.8

789

0.006

CoA

Sus scrofa

-

enzyme forms pI 6.2 and pI 6.0

789

0.007

CoA

Sus scrofa

-

enzyme form pI 5.9

789

0.036

CoA

Pigeon

-

pH 8.0, 30°C

651897

0.009

GTP

Sus scrofa

-

enzyme form pI 6.4

789

0.01

GTP

Sus scrofa

-

enzyme form 6.0

789

0.011

GTP

Sus scrofa

-

enzyme forms pI 6.2, pI 5.9 and pI 5.8

789

0.014

GTP

Sus scrofa

-

refolded enzyme

785

0.027

GTP

Sus scrofa

-

native enzyme

785

0.036

GTP

Pigeon

-

pH 8.0, 30°C

651897

0.082

GTP

Blastocystis hominis

-

mutant enzyme K46E/K114D/V113L/L227F, at pH 7.4 and 21°C

744369

0.143

GTP

Blastocystis hominis

-

mutant enzyme K46E/K114D, at pH 7.4 and 21°C

744369

0.63

GTP

Homo sapiens

-

at pH 8.0 and 37°C

745498

0.39

succinate

Sus scrofa

-

enzyme form pI 6.4

789

0.43

succinate

Sus scrofa

-

enzyme forms pI 5.9 and pI 5.8

789

0.45

succinate

Sus scrofa

-

enzyme form pI 6.0

789

0.49

succinate

Pigeon

-

pH 8.0, 30°C

651897

0.49

succinate

Sus scrofa

P53590

wild type enzyme, at pH 7.4 and 21°C

743947

5.1

succinate

Sus scrofa

P53590

mutant enzyme V330M, at pH 7.4 and 21°C

743947