6.2.1.39: [butirosin acyl-carrier protein]-L-glutamate ligase

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For detailed information about [butirosin acyl-carrier protein]-L-glutamate ligase, go to the full flat file.

Reaction

Synonyms

BtrJ, [BtrI acyl-carrier protein]L-glutamate ligase

ECTree

     6 Ligases

         6.2 Forming carbon-sulfur bonds

             6.2.1 Acid-thiol ligases

                6.2.1.39 [butirosin acyl-carrier protein]-L-glutamate ligase

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Results	in table
22	AA Sequence
1	Cloned(Commentary)
1	Cofactor
4	General Information
2	Metals/Ions
3	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
2	Organism
3	Pathway
2	Reaction
2	Reference
10	Substrates and Products (Substrate)
4	Subunits
4	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 6.2.1.39 - [butirosin acyl-carrier protein]-L-glutamate ligase

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SYSTEMATIC NAME

IUBMB Comments

[BtrI acyl-carrier protein]:L-glutamate ligase (ADP-forming)

Catalyses two steps in the biosynthesis of the side chain of the aminoglycoside antibiotics of the butirosin family. The enzyme adds one molecule of L-glutamate to a dedicated acyl-carrier protein, and following decarboxylation of the product by EC 4.1.1.95, L-glutamyl-[BtrI acyl-carrier protein] decarboxylase, adds a second L-glutamate molecule. Requires Mg2+ or Mn2+, and activity is enhanced in the presence of Mn2+.