5.5.1.26: nogalonic acid methyl ester cyclase

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For detailed information about nogalonic acid methyl ester cyclase, go to the full flat file.

Word Map on EC 5.5.1.26

5.5.1.26

polyketide

nogalamycine

cyclases

stereochemistry

interior

alpha+beta

nogalater

barrel

anthracyclines

galilaeus

aldol

Reaction

Synonyms

methyl nogalonate cyclase, SnoaL

ECTree

5 Isomerases

5.5 Intramolecular lyases

5.5.1 Intramolecular lyases (only sub-subclass identified to date)

5.5.1.26 nogalonic acid methyl ester cyclase

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Results	in table
4	AA Sequence
3	Cloned(Commentary)
2	Crystallization (Commentary)
2	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
4	Organism
3	Pathway
1	pH Optimum
5	Protein Variants
2	Reaction
4	Reference
3	Substrates and Products (Substrate)
2	Subunits
4	Synonyms
1	Systematic Name

Engineering

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Engineering on EC 5.5.1.26 - nogalonic acid methyl ester cyclase

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Go to Protein Variants Search

D121A

Streptomyces nogalater

Q9RN59

inactive mutant enzyme

729639

D121N

Streptomyces nogalater

Q9RN59

mutant enzyme forms insoluble inclusion bodies

729639

F15Y

Streptomyces nogalater

Q9RN59

mutant enzyme shows 5% of the activity compared to the wild-type enzyme

729639

Q105A

Streptomyces nogalater

Q9RN59

mutant enzyme shows 16% of the activity compared to the wild-type enzyme

729639

Q105E

Streptomyces nogalater

Q9RN59

mutant enzyme forms insoluble inclusion bodies

729639