5.3.3.9: prostaglandin-A1 DELTA-isomerase

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For detailed information about prostaglandin-A1 DELTA-isomerase, go to the full flat file.

Reaction

Synonyms

Isomerase, prostaglandin A1DELTA-, PGA isomerase, Prostaglandin A isomerase

ECTree

     5 Isomerases

         5.3 Intramolecular oxidoreductases

             5.3.3 Transposing C=C bonds

                5.3.3.9 prostaglandin-A1 DELTA-isomerase

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Results	in table
1	CAS Registry Number
9	General Stability
20	Inhibitors
4	KM Value [mM]
3	Molecular Weight [Da]
33	Organism
5	pH Optimum
3	pH Range
2	pH Stability
4	Purification (Commentary)
1	Reaction
2	Reaction Type
33	Reference
23	Source Tissue
3	Specific Activity [micromol/min/mg]
41	Substrates and Products (Substrate)
3	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
22	Temperature Stability [°C]

Substrates Products

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Substrates Products on EC 5.3.3.9 - prostaglandin-A1 DELTA-isomerase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid

(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid

24 entries

(5Z,13E)-(15S)-15-Hydroxy-9-oxoprosta-5,10,13-trien-1-oic acid

?

2 entries

15-Epiprostaglandin A2

?

2 entries

19-Hydroxyprostaglandin A1

?

Felis catus

-

-

3029

-

-

?

prostaglandin A1

?

2 entries

(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid

(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid

Canis lupus familiaris

-

i.e. prostaglandin A1

3029, 3030, 3032

-

-

?

(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid

(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid

Cavia porcellus

-

i.e. prostaglandin A1

3032

-

-

?

(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid

(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid

Equus caballus

-

i.e. prostaglandin A1

3028

-

-

?

(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid

(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid

Felis catus

-

i.e. prostaglandin A1

3030

-

3030

?

(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid

(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid

Felis catus

-

i.e. prostaglandin A1

3029

the product is prostaglandin C1, which is unstable under mild alkaline conditions and isomerizes to prostaglandin B1

3029

?

(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid

(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid

Felis catus

-

i.e. prostaglandin A1

3032

the product is prostaglandin C1, which is unstable under mild alkaline conditions and isomerizes to prostaglandin B1

3032

?

(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid

(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid

Felis catus

-

i.e. prostaglandin A1

3027

i.e. prostaglandin B1

3027

?

(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid

(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid

Felis catus

-

i.e. prostaglandin A1

3028

i.e. prostaglandin B1

3028

?

(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid

(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid

Homo sapiens

-

i.e. prostaglandin A1

3028

-

3028

?

(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid

(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid

Homo sapiens

-

i.e. prostaglandin A1

3032

the product is prostaglandin C1, which is unstable under mild alkaline conditions and isomerizes to prostaglandin B1

3032

?

(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid

(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid

Mus musculus

-

i.e. prostaglandin A1

3028, 3032

-

-

?

(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid

(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid

Oryctolagus cuniculus

-

i.e. prostaglandin A1

3030

-

3030

?

(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid

(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid

Oryctolagus cuniculus

-

i.e. prostaglandin A1

3033

-

3033

?

(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid

(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid

Oryctolagus cuniculus

-

i.e. prostaglandin A1

3029

the product is prostaglandin C1, which is unstable under mild alkaline conditions and isomerizes to prostaglandin B1

3029

?

(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid

(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid

Oryctolagus cuniculus

-

i.e. prostaglandin A1

3031

the product is prostaglandin C1, which is unstable under mild alkaline conditions and isomerizes to prostaglandin B1

3031

?

(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid

(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid

Oryctolagus cuniculus

-

i.e. prostaglandin A1

3032

the product is prostaglandin C1, which is unstable under mild alkaline conditions and isomerizes to prostaglandin B1

3032

?

(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid

(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid

Oryctolagus cuniculus

-

i.e. prostaglandin A1

3028

i.e. prostaglandin B1

3028

?

(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid

(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid

Ovis aries

-

i.e. prostaglandin A1

3032

-

-

?

(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid

(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid

Platyrrhini

-

i.e. prostaglandin A1

3028

-

-

?

(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid

(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid

Rattus norvegicus

-

i.e. prostaglandin A1

3029

-

3029

?

(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid

(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid

Rattus norvegicus

-

i.e. prostaglandin A1

3030

-

3030

?

(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid

(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid

Rattus norvegicus

-

i.e. prostaglandin A1

3032

-

3032

?

(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid

(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid

Rattus norvegicus

-

i.e. prostaglandin A1

3028

i.e. prostaglandin B1

3028

?

(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid

(13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid

Sus scrofa

-

i.e. prostaglandin A1

3029, 3030, 3032

-

-

?

(5Z,13E)-(15S)-15-Hydroxy-9-oxoprosta-5,10,13-trien-1-oic acid

?

Felis catus

-

i.e. prostaglandin A2

3029, 3030

-

-

?

(5Z,13E)-(15S)-15-Hydroxy-9-oxoprosta-5,10,13-trien-1-oic acid

?

Oryctolagus cuniculus

-

i.e. prostaglandin A2

3029, 3030

-

-

?

15-Epiprostaglandin A2

?

Felis catus

-

-

3029, 3030

-

-

?

15-Epiprostaglandin A2

?

Oryctolagus cuniculus

-

-

3029, 3030

-

-

?

prostaglandin A1

?

Felis catus

-

-

3029

-

-

?

prostaglandin A1

?

Oryctolagus cuniculus

-

-

3031, 3033

-

-

?