5.3.1.23: S-methyl-5-thioribose-1-phosphate isomerase
This is an abbreviated version!
For detailed information about S-methyl-5-thioribose-1-phosphate isomerase, go to the full flat file.
Word Map on EC 5.3.1.23
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5.3.1.23
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salvage
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phosphorylase
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mta
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dehydratase
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s-adenosylmethionine
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ribose-1,5-bisphosphate
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mill
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5'-deoxy-5'-methylthioadenosine
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aci-reductone
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universally
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avocado
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persea
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nucleosidase
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auxotrophic
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klebsiella
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transaminase
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pyrococcus
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horikoshii
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americana
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polyamine
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brewing
- 5.3.1.23
-
salvage
- phosphorylase
- mta
- dehydratase
- s-adenosylmethionine
-
ribose-1,5-bisphosphate
-
mill
- 5'-deoxy-5'-methylthioadenosine
-
aci-reductone
-
universally
- avocado
- persea
- nucleosidase
-
auxotrophic
-
klebsiella
- transaminase
-
pyrococcus
- horikoshii
- americana
- polyamine
- brewing
Reaction
Synonyms
1-PMTR isomerase, 5'-methylthioribose-1-phosphate isomerase, 5-methylthio-5-deoxy-D-ribose-1-phosphate ketol-isomerase, 5-methylthioribose 1-phosphate isomerase, 5-methylthioribose-1-phosphate isomerase, Bs-M1Pi, Isomerase, methylthioribose 1-phosphate, M1Pi, methylthioribose-1-phosphate isomerase, Meu1p, MRDI, MRI1, Mri1p, mtnA, MTR-1-P, MTR-1-P isomerase, PH0702, PhM1Pi, Ypr118w, Ypr118wp
ECTree
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Reaction
Reaction on EC 5.3.1.23 - S-methyl-5-thioribose-1-phosphate isomerase
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S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate
catalytic reaction mechanism, structure-function relationship, overview. Proposed reaction mechanism of M1Pi proceeds via a cis-phosphoenolate intermediate and through the following steps: (1) transfer of proton from Asp247 to the O4 atom of MTR-1-P, (2) proton abstraction from C2 atom of the substrate by the thiolate anion of Cys167 as well as cleavage of the C1-O4 bond, (3) simultaneous proton abstraction from O2 atom by the deprotonated Asp247 and transfer of proton from the thiol group of Cys167 to C1 atom, and (4) generation of the product, MTRu-1-P
S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate
proposed reaction mechanism probably including residue Asp240, overview
S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate
structure-function analysis and catalytic mechanism, overview. Two variants of isomerization mechanism are possible, the enediol and the hydride transfer mechanism, overview
S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate
proposed reaction mechanism probably including residue Asp240, overview
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S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate
structure-function analysis and catalytic mechanism, overview. Two variants of isomerization mechanism are possible, the enediol and the hydride transfer mechanism, overview
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