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5.1.3.24: N-acetylneuraminate epimerase

This is an abbreviated version!
For detailed information about N-acetylneuraminate epimerase, go to the full flat file.

Reaction

aceneuramate
=
N-acetyl-beta-neuraminate

Synonyms

N-acetylneuraminate mutarotase, sialic acid epimerase, YjhT

ECTree

     5 Isomerases
         5.1 Racemases and epimerases
             5.1.3 Acting on carbohydrates and derivatives
                5.1.3.24 N-acetylneuraminate epimerase

Systematic Name

Systematic Name on EC 5.1.3.24 - N-acetylneuraminate epimerase

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SYSTEMATIC NAME
IUBMB Comments
N-acetyl-alpha-neuraminate 2-epimerase
Sialoglycoconjugates present in vertebrates are linked exclusively by alpha-linkages and are released in alpha form during degradation. This enzyme accelerates maturotation to the beta form via the open form (which also occurs as a slow spontaneous reaction). The open form is necessary for further metabolism by the bacteria.