5.1.3.24: N-acetylneuraminate epimerase

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For detailed information about N-acetylneuraminate epimerase, go to the full flat file.

Reaction

Synonyms

N-acetylneuraminate mutarotase, sialic acid epimerase, YjhT

ECTree

     5 Isomerases

         5.1 Racemases and epimerases

             5.1.3 Acting on carbohydrates and derivatives

                5.1.3.24 N-acetylneuraminate epimerase

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Results	in table
1322	AA Sequence
1	Cloned(Commentary)
1	Crystallization (Commentary)
1	General Information
1	Localization
2	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
1	Organism
7	Protein Variants
1	Purification (Commentary)
3	Reaction
1	Reference
2	Substrates and Products (Substrate)
1	Subunits
6	Synonyms
1	Systematic Name

Substrates Products

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Substrates Products on EC 5.1.3.24 - N-acetylneuraminate epimerase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

N-acetyl-alpha-neuraminate

N-acetyl-beta-neuraminate

2 entries

N-acetyl-alpha-neuraminate

N-acetyl-beta-neuraminate

Escherichia coli

P39371

probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in he beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses

715495

-

-

?

N-acetyl-alpha-neuraminate

N-acetyl-beta-neuraminate

Escherichia coli

P39371

the enzyme converts alpha-N-acetylneuranimic acid to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers

715495

-

-

?