4.4.1.B1: holocytochrome-c1 synthase
This is an abbreviated version!
For detailed information about holocytochrome-c1 synthase, go to the full flat file.
Reaction
Synonyms
CC1HL, cytochrome c1 synthetase, HCCS, Holocytochrome c-type synthase, holocytochrome-c1 synthase
ECTree
4.4.1.B1 holocytochrome-c1 synthaseAdvanced search results
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Substrates Products on EC 4.4.1.B1 - holocytochrome-c1 synthase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
apocytochrome c1 + heme
holocytochrome c1
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no activity with apocytochrome c as substrate
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?
additional information
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Saccharomyces cerevisiae has another, similar enzyme: cytochrome-c-heme lyase, encoded by gene CYT2
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?
additional information
?
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enzyme does not require the presence of putative redox protein Cyc2p, which is dedicated to the reaction of holocytochrome-c synthase, EC 4.4.1.17. A cytochrome c1 mutant with a CAPCH heme-binding site instead of the wild-type CAACH is strictly dependent upon Cyc2p for assembly. Overexpression of CC1HL, as well as mutations of the proline in the CAPCH site to H, L, S, or T residues, can bypass the absence of Cyc2p. The identity of the second intervening residue in the CXXCH motif is key in determining the holocytochrome-c synthase-dependent versus holocytochrome-c1 synthase-dependent assembly of holocytochrome c1
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