Information on EC 4.4.1.B1 - holocytochrome-c1 synthase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
4.4.1.B1
preliminary BRENDA-supplied EC number
RECOMMENDED NAME
GeneOntology No.
holocytochrome-c1 synthase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
holocytochrome c1 = apocytochrome c1 + heme
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
covalent attachment of heme
SYSTEMATIC NAME
IUBMB Comments
holocytochrome-c1 apocytochrome-c1-lyase
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
apocytochrome c1 + heme
holocytochrome c1
show the reaction diagram
additional information
?
-
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
comparison of the amino acid sequence with Saccharomyces cerevisiae and Neurospora crassa cytochrome-c-heme lyases
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
of wild type and the mutant proteins in Saccharomyces cerevisiae in pYEX4Tps and in CHO-K1 cells
ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
R217C
by site directed mutagenesis of the human gene, expression in Saccharomyces cerevisiae and in CHO-K1 cells
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
microphthalmia with linear skin defects syndrome are associated with mutations-a missense mutation or a nonsense mutation in the HCCS gene, the inability of HCCS-deficient cells to undergo cytochrome c–mediated apoptosis may push cell death toward necrosis that gives rise to severe deterioration of the affected tissues