4.3.2.1: argininosuccinate lyase

This is an abbreviated version!
For detailed information about argininosuccinate lyase, go to the full flat file.

Word Map on EC 4.3.2.1

4.3.2.1

ornithine

arginase

citrulline

transcarbamylase

ammonia

aciduria

l-arginine

hyperammonemia

duck

delta-crystallins

carbamyl

lenses

carbamoyltransferase

carbamoylphosphate

citrullinemia

urea-cycle

n-acetylglutamate

ureotelic

medicine

ureogenesis

6.3.4.5

reptilian

pharmacology

drug development

diagnostics

analysis

Reaction

Synonyms

AL, ARG4, ArgH, arginine-succinate lyase, argininosuccinase, Argininosuccinate lyase, argininosuccinic acid lyase, Arginosuccinase, ASAL, ASL, delta2 crystallin, delta2-crystallin, hASL, L-argininosuccinate arginine-lyase, lyase, argininosuccinate, Rv1659

ECTree

4 Lyases

4.3 Carbon-nitrogen lyases

4.3.2 Amidine-lyases

4.3.2.1 argininosuccinate lyase

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Results	in table
2	Activating Compound
40461	AA Sequence
16	Application
1	CAS Registry Number
26	Cloned(Commentary)
1	Cofactor
8	Crystallization (Commentary)
841	Disease/ Diagnostics
6	Expression
35	General Information
4	General Stability
22	Inhibitors
2	kcat/KM [mM/s]
71	KM Value [mM]
9	Localization
27	Molecular Weight [Da]
32	Natural Substrates/ Products (Substrates)
159	Organism
15	Pathway
73	PDB ID
6	pH Optimum
4	pH Stability
1	pI Value
2	Posttranslational Modification
65	Protein Variants
20	Purification (Commentary)
7	Reaction
5	Reaction Type
96	Reference
106	Source Tissue
23	Specific Activity [micromol/min/mg]
3	Storage Stability
92	Substrates and Products (Substrate)
21	Subunits
78	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
24	Temperature Stability [°C]
12	Turnover Number [1/s]

Subunits

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Subunits on EC 4.3.2.1 - argininosuccinate lyase

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4 entries

hexamer

Chlamydomonas reinhardtii

5 or 6 * 39000, SDS-PAGE

34431

homotetramer

3 entries

pentamer

Chlamydomonas reinhardtii

5 or 6 * 39000, SDS-PAGE

34431

tetramer

11 entries

additional information

Homo sapiens

small heat shock protein, alphaA-crystallin, functions as a molecular chaperone, and enhances thermal stability of both delta-crystallin and ASL. Thermal unfolding of delta-crystallin or ASL in the presence of alphaA-crystallin follows a similar three-state model. A stable intermediate which retains about 30% alpha-helical structure is observed. Protection from thermal denaturation by alphaA-crystallin is by interaction with partly unfolded ASL to form high molecular weight heteroligomers. Aggregate formation of ASL is significantly reduced in the presence of alphaA-crystallin. The extent of protection of ASL at different ratios of alpahA-crystallin is described by hyperbolic curves, suggesting the preferential recognition of partly unfolded ASL by alphaA-crystallin

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