4.3.2.1: argininosuccinate lyase

This is an abbreviated version!
For detailed information about argininosuccinate lyase, go to the full flat file.

Word Map on EC 4.3.2.1

4.3.2.1

ornithine

arginase

citrulline

transcarbamylase

ammonia

aciduria

l-arginine

hyperammonemia

duck

delta-crystallins

carbamyl

lenses

carbamoyltransferase

carbamoylphosphate

citrullinemia

urea-cycle

n-acetylglutamate

ureotelic

medicine

ureogenesis

6.3.4.5

reptilian

pharmacology

drug development

diagnostics

analysis

Reaction

Synonyms

AL, ARG4, ArgH, arginine-succinate lyase, argininosuccinase, Argininosuccinate lyase, argininosuccinic acid lyase, Arginosuccinase, ASAL, ASL, delta2 crystallin, delta2-crystallin, hASL, L-argininosuccinate arginine-lyase, lyase, argininosuccinate, Rv1659

ECTree

4 Lyases

4.3 Carbon-nitrogen lyases

4.3.2 Amidine-lyases

4.3.2.1 argininosuccinate lyase

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Results	in table
2	Activating Compound
40461	AA Sequence
16	Application
1	CAS Registry Number
26	Cloned(Commentary)
1	Cofactor
8	Crystallization (Commentary)
841	Disease/ Diagnostics
6	Expression
35	General Information
4	General Stability
22	Inhibitors
2	kcat/KM [mM/s]
71	KM Value [mM]
9	Localization
27	Molecular Weight [Da]
32	Natural Substrates/ Products (Substrates)
159	Organism
15	Pathway
73	PDB ID
6	pH Optimum
4	pH Stability
1	pI Value
2	Posttranslational Modification
65	Protein Variants
20	Purification (Commentary)
7	Reaction
5	Reaction Type
96	Reference
106	Source Tissue
23	Specific Activity [micromol/min/mg]
3	Storage Stability
92	Substrates and Products (Substrate)
21	Subunits
78	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
24	Temperature Stability [°C]
12	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 4.3.2.1 - argininosuccinate lyase

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1-ethyl-3-(3-diethylaminopropyl)carbodiimide

Bos taurus

at pH 6

34424

acetylenedicarboxylate

Bos taurus

34426

Arg

Bos taurus

noncompetitive versus argininosuccinate

34427

argininosuccinate

Arabidopsis thaliana

0.3 mM inhibits the reaction by 97%

679780

bromomesaconic acid

Bos taurus

argininosuccinate completely protects, Lys51 has an essential role in binding of argininosuccinate and consequently is essential in catalysis; inactivation follows pseudo-first-order kinetics

34421

citrulline

2 entries

D-glucose

Homo sapiens

12.5 mM glucose decreases activity of ASL by 20%, 25 mM glucose by 50%

710563

diethyl dicarbonate

3 entries

difluorofumarate

Bos taurus

pseudo-first-order process

34426

fumarate

2 entries

monofluorofumarate

Bos taurus

reversible, pseudo-first-order process

34426

N3-(L-1-carboxy-2-nitroethyl)-L-arginine

succinate

Urea

competitive

additional information

3 entries