4.3.1.27: threo-3-hydroxy-D-aspartate ammonia-lyase

This is an abbreviated version!
For detailed information about threo-3-hydroxy-D-aspartate ammonia-lyase, go to the full flat file.

Reaction

Synonyms

D-THA DH, D-threo-3-hydroxyaspartate ammonia-lyase, D-threo-3-hydroxyaspartate dehydratase

ECTree

     4 Lyases

         4.3 Carbon-nitrogen lyases

             4.3.1 Ammonia-lyases

                4.3.1.27 threo-3-hydroxy-D-aspartate ammonia-lyase

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Results	in table
165	AA Sequence
1	Application
2	Cloned(Commentary)
2	Cofactor
2	Crystallization (Commentary)
2	Expression
1	General Stability
3	Inhibitors
5	kcat/KM [mM/s]
5	KM Value [mM]
8	Metals/Ions
5	Molecular Weight [Da]
3	Organism
16	PDB ID
2	pH Optimum
3	Protein Variants
2	Purification (Commentary)
1	Reaction
3	Reference
4	Specific Activity [micromol/min/mg]
9	Substrates and Products (Substrate)
1	Subunits
8	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
5	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 4.3.1.27 - threo-3-hydroxy-D-aspartate ammonia-lyase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

D-serine

?

Delftia sp. HT23

B2DFG5

poor substrate

712323

-

-

?

D-threo-3-hydroxyaspartate

oxaloacetate + NH3

Delftia sp. HT23

B2DFG5

-

712323

-

-

?

L-erythro-3-hydroxyaspartate

?

Delftia sp. HT23

B2DFG5

-

712323

-

-

?

L-serine

?

Delftia sp. HT23

B2DFG5

poor substrate

712323

-

-

?

L-threo-3-hydroxyaspartate

?

Delftia sp. HT23

B2DFG5

-

712323

-

-

?

L-threo-3-hydroxyaspartate

oxaloacetate + NH3

Delftia sp. HT23

B2DFG5

-

712323

-

-

?

threo-3-hydroxy-D-aspartate

oxaloacetate + NH3

Delftia sp. HT23

B2DFG5

the substrate specificity of the enzyme is determined by the orientation of the Cbeta-OH at the active site, whose spatial arrangement is compatible with the 3R configuration of 3-hydroxyaspartate. The enzyme also catalyzes the dehydration of erythro-3-hydroxy-L-aspartate

746895

-

-

?

additional information

?

-

2 entries

additional information

?

-

Delftia sp. HT23

B2DFG5

D-erythro-3-hydroxyaspartate is not a substrate

712323

-

-

?

additional information

?

-

Delftia sp. HT23

B2DFG5

the purified enzyme shows no alanine racemase activity

712323

-

-

?