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4.2.3.40: (Z)-gamma-bisabolene synthase

This is an abbreviated version!
For detailed information about (Z)-gamma-bisabolene synthase, go to the full flat file.

Reaction

(2E,6E)-farnesyl diphosphate
=
(Z)-gamma-bisabolene
+
diphosphate

Synonyms

(Z)-gamma-bisabolene synthase K11, (Z)-gamma-bisabolene synthase K7, Os08g07100, TPS12, TPS12_K7, TPS13

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.3 Acting on phosphates
                4.2.3.40 (Z)-gamma-bisabolene synthase

Engineering

Engineering on EC 4.2.3.40 - (Z)-gamma-bisabolene synthase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
L405V
products are 1.9% 7-epi-sesquithujene, 8.1% (E)-alpha-bergamotene, 8.9% sesquiabinene A, 23.9% (E)-beta-farnesene, 0% gamma-curcumene, 9.7% zingiberene, 12.0% beta-bisabolene, 26.6% beta-sesquiphellandrene, 8.9% (E)-gamma-bisabolene
L405V/Y373S
products are 1.2% 7-epi-sesquithujene, 23.6% (E)-alpha-bergamotene, 17.7% sesquiabinene A, 53.0% (E)-beta-farnesene, 0% gamma-curcumene, 0.6% zingiberene, 1.3% beta-bisabolene, 2.6% beta-sesquiphellandrene, 0% (E)-gamma-bisabolene
Y373S
products are 7.6% 7-epi-sesquithujene, 24.8% (E)-alpha-bergamotene, 18.2% sesquiabinene A, 38.5% (E)-beta-farnesene, 0% gamma-curcumene, 4.7% zingiberene, 2.5% beta-bisabolene, 3.7% beta-sesquiphellandrene, 0% (E)-gamma-bisabolene