4.2.3.130: tetraprenyl-beta-curcumene synthase
This is an abbreviated version!
For detailed information about tetraprenyl-beta-curcumene synthase, go to the full flat file.
Reaction
Synonyms
Bcl-TS, BmeTC, More, sesterterpene/triterpene/sesquarterpene synthase, tetraprenyl-beta-curcumene cyclase, ytpB
ECTree
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General Information
General Information on EC 4.2.3.130 - tetraprenyl-beta-curcumene synthase
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metabolism
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GFPP and HexPP, the enzyme Bcl-TS substrates, are biosynthesized by enzymes E-IDS2-S/L in Bacillus clausii, and the tetraprenyl-beta-curcumene cyclase forms baciterpenol A from tetraprenyl-beta-curcumene. Proposed pathways for the biosynthesis of acyclic terpenes and menaquinones by Bacillus clausii, overview
physiological function
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the tetraprenyl-beta-curcumene synthase homologue from Bacillus clausii (Bcl-TS) catalyzes the conversion of (all-E)-geranylfarnesyl diphosphate (GFPP) and (all-E)-hexaprenyl diphosphate (HexPP) into beta-geranylfarnesene and beta-hexaprene, respectively, in vitro, and both compounds are produced in Bacillus clausii. THe enzyme is involved in the biosynthesis of menaquinones
additional information
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the ts gene or ytpB gene forms an operon with a lysophospholipase gene ytpA, which is responsible for the biosynthesis of the antibiotic bacilysocin in Bacillus subtilis
additional information
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only one sesterterpene synthase (ophiobolin F synthase, EC 4.2.3.145) that utilizes GFPP as a substrate has been identified other than Bcl-TS to date