Information on EC 4.2.3.130 - tetraprenyl-beta-curcumene synthase

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The expected taxonomic range for this enzyme is: Bacillus

EC NUMBER
COMMENTARY hide
4.2.3.130
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RECOMMENDED NAME
GeneOntology No.
tetraprenyl-beta-curcumene synthase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
all-trans-heptaprenyl diphosphate = tetraprenyl-beta-curcumene + diphosphate
show the reaction diagram
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SYSTEMATIC NAME
IUBMB Comments
all-trans-heptaprenyl-diphosphate diphosphate-lyase (cyclizing, tetraprenyl-beta-curcumene-forming)
Isolated from Bacillus subtilis. This sesquarterpene is present in a number of Bacillus species.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
gene ytpB
UniProt
Manually annotated by BRENDA team
gene ytpB
E3E331
UniProt
Manually annotated by BRENDA team
gene ytpB
E3E331
UniProt
Manually annotated by BRENDA team
gene Bcell_3320
UniProt
Manually annotated by BRENDA team
gene ytpB
UniProt
Manually annotated by BRENDA team
gene BMD_4842
UniProt
Manually annotated by BRENDA team
gene ytpB
UniProt
Manually annotated by BRENDA team
gene ytpB or ts
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Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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the ts gene or ytpB gene forms an operon with a lysophospholipase gene ytpA, which is responsible for the biosynthesis of the antibiotic bacilysocin in Bacillus subtilis
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
all-trans-heptaprenyl diphosphate
tetraprenyl-beta-curcumene + diphosphate
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
all-trans-heptaprenyl diphosphate
tetraprenyl-beta-curcumene + diphosphate
show the reaction diagram
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
recombinant fusion protein YtpB from Escherichia coli strain BL21(DE3) by affinity chromatography
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
gene ytpB, expression as fusion protein in Escherichia coli strain BL21(DE3) from pColdTF. The ts gene or ytpB gene forms an operon with a lysophospholipase gene ytpA, which is responsible for the biosynthesis of the antibiotic bacilysocin in Bacillus subtilis
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