4.2.3.127: beta-copaene synthase
This is an abbreviated version!
For detailed information about beta-copaene synthase, go to the full flat file.
Reaction
Synonyms
Cop4, CoTPS2, sesquiterpene synthase, TPS2
ECTree
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Metals Ions
Metals Ions on EC 4.2.3.127 - beta-copaene synthase
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Mg2+
additional information
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required, enzyme CoTPS2 has the conserved aspartate-rich motif (DDXXD) and NSE/DTE motifs that chelate divalent metal ions, typically Mg2+, in the C-terminal domain
Mg2+
dependent on, two consensus sequences - an aspartate rich DDXXD/E and a NSE/DTE motif - located at the entrance of the active site coordinate a trinuclear Mg2+ cluster. In reactions where Mg2+ is replaced with either Mn2+ or K+ is the disappearance of beta-copaene
in presence of the divalent cation Mn2+, Cop4 favors a reaction path that ends after one cyclization in (-)-germacrene D
additional information
the enzyme contains the metal-binding DDXXD motif