4.2.1.79: 2-methylcitrate dehydratase
This is an abbreviated version!
For detailed information about 2-methylcitrate dehydratase, go to the full flat file.
Word Map on EC 4.2.1.79
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4.2.1.79
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propionate
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propionyl-coa
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enterica
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isocitrate
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tuberculosis
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methylisocitrate
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oneidensis
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cis-aconitate
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prpbcde
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odd-chain
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shewanella
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glyoxylate
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prpf
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beta-oxidation
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serovar
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smegmatis
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propionyl
- 4.2.1.79
- propionate
- propionyl-coa
- enterica
- isocitrate
- tuberculosis
- methylisocitrate
- oneidensis
- cis-aconitate
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prpbcde
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odd-chain
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shewanella
- glyoxylate
- prpf
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beta-oxidation
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serovar
- smegmatis
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propionyl
Reaction
Synonyms
2-MC dehydratase, 2-methylcitrate dehydratase, 2-methylcitrate dehydratase 1, 2-Methylcitrate hydro-lyase, Dehydratase, 2-methylcitrate, methylcitrate dehydratase, mmgE, PrpD, SePrpD, STM0370
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General Information
General Information on EC 4.2.1.79 - 2-methylcitrate dehydratase
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metabolism
physiological function
additional information
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2-methylcitrate dehydratase and 1, 2-methylcitrate synthase are involved in energy metabolism and participate in the methylcitrate cycle, which is an important source of energy in the cell
metabolism
the enzyme is involved in the 2-methylcitric acid cycle, overview
metabolism
the enzyme is involved in the 2-methylcitric acid cycle, overview
metabolism
the enzyme is involved in the 2-methylcitric acid cycle, overview. The three genes, mmgDE and yqiQ (mmgF), provide three of the five steps of the methylcitric acid cycle, encoded in the mmg operon. The fourth step can be supplied by citB (aconitase), and the fifth probably missing step, the propionyl-CoA synthetase, is probably skipped because the beta-oxidation of methyl-branched fatty acids by the enzymes encoded by mmgABC produce propionyl-CoA. The 2-methylisocitrate produced by CitB is converted to pyruvate and succinate by the enzyme YqiQ(MmgF)
metabolism
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the enzyme is involved in the 2-methylcitric acid cycle, overview. The three genes, mmgDE and yqiQ (mmgF), provide three of the five steps of the methylcitric acid cycle, encoded in the mmg operon. The fourth step can be supplied by citB (aconitase), and the fifth probably missing step, the propionyl-CoA synthetase, is probably skipped because the beta-oxidation of methyl-branched fatty acids by the enzymes encoded by mmgABC produce propionyl-CoA. The 2-methylisocitrate produced by CitB is converted to pyruvate and succinate by the enzyme YqiQ(MmgF)
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metabolism
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2-methylcitrate dehydratase and 1, 2-methylcitrate synthase are involved in energy metabolism and participate in the methylcitrate cycle, which is an important source of energy in the cell
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metabolism
Salmonella enterica subsp. enterica serovar Typhimurium LT2 / SGSC1412 / ATCC 700720
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the enzyme is involved in the 2-methylcitric acid cycle, overview
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the MmgE enzyme is not a stereospecific 2-methylcitrate dehydratase because it can dehydrate at least two of the four diastereomers of 2-methylcitrate to yield either (E)-2-methylaconitate or (Z)-2-methylaconitate, but the physiological pathways proceed via (Z)-2-methylaconitate, which serves as the substrate for the citB enzyme in the synthesis of 2-methylisocitrate
physiological function
the PrpD enzyme from Escherichia coli is not a stereospecific 2-methylcitrate dehydratase because it can dehydrate at least two of the four diastereomers of 2-methylcitrate to yield either (E)-2-methylaconitate or (Z)-2-methylaconitate, but the physiological pathways proceed via (Z)-2-methylaconitate, which serves as the substrate for the citB enzyme in the synthesis of 2-methylisocitrate
physiological function
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the MmgE enzyme is not a stereospecific 2-methylcitrate dehydratase because it can dehydrate at least two of the four diastereomers of 2-methylcitrate to yield either (E)-2-methylaconitate or (Z)-2-methylaconitate, but the physiological pathways proceed via (Z)-2-methylaconitate, which serves as the substrate for the citB enzyme in the synthesis of 2-methylisocitrate
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ipon silver stess 2-methylcitrate dehydratase and 2-methylcitrate synthase are strongly overexpressed
additional information
construction of enzyme-deficient DELTA prpD mutant. The two genes acnD and prpF, encoding 2-methylcitrate dehydratase (AcnD, EC 4.2.1.117) and 2-methyl-aconitate isomerase (SoPrpF, EC 5.3.3.-) from Shewanella oneidensis together can replace gene prpD in Salmonella enterica. SoAcnD and SePrpD synthesize different methylaconitate isomers. The SoPrpF protein isomerizes the product of the AcnD reaction into the PrpD product. Mutant SoPrpF variants with substitutions of residues K73 or C107 fail to support growth with propionate as the sole source of carbon and energy
additional information
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ipon silver stess 2-methylcitrate dehydratase and 2-methylcitrate synthase are strongly overexpressed
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additional information
Salmonella enterica subsp. enterica serovar Typhimurium LT2 / SGSC1412 / ATCC 700720
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construction of enzyme-deficient DELTA prpD mutant. The two genes acnD and prpF, encoding 2-methylcitrate dehydratase (AcnD, EC 4.2.1.117) and 2-methyl-aconitate isomerase (SoPrpF, EC 5.3.3.-) from Shewanella oneidensis together can replace gene prpD in Salmonella enterica. SoAcnD and SePrpD synthesize different methylaconitate isomers. The SoPrpF protein isomerizes the product of the AcnD reaction into the PrpD product. Mutant SoPrpF variants with substitutions of residues K73 or C107 fail to support growth with propionate as the sole source of carbon and energy
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