4.2.1.24: porphobilinogen synthase

This is an abbreviated version!
For detailed information about porphobilinogen synthase, go to the full flat file.

Reaction

2 5-aminolevulinate =

Synonyms

5-aminolaevulinic acid dehydratase, 5-aminolevulinate dehydrase, 5-aminolevulinate dehydratase, 5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing), 5-aminolevulinic acid dehydrase, 5-aminolevulinic acid dehydratase, 5-levulinic acid dehydratase, Al-D, ALA dehydratase, ALA synthetase, ALA-D, ALAD, ALADH, aminolevulinate dehydrase, aminolevulinate dehydratase, aminolevulinic dehydratase, CF-2, d-ALAD, delta aminolevulinic acid dehydratase, delta-ALA-D, delta-ALAD, delta-aminolevulinate dehydrase, delta-aminolevulinate dehydratase, delta-aminolevulinate dehydrataseALAD, delta-aminolevulinic acid dehydrase, delta-aminolevulinic acid dehydratase, delta-aminolevulinic dehydratase, gamma-aminolevulinic acid dehydratase, HemB, PaPBGS, PBG synthase, PBG-S, PBG-synthase, PBGS, Pcal_1709, PfALAD, PGBS, Porphobilinogen synthase, porphobilinogen synthetase, synthase, porphobilinogen, TgPBGS

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.1 Hydro-lyases

                4.2.1.24 porphobilinogen synthase

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Results	in table
8	Activating Compound
38384	AA Sequence
13	Application
1	CAS Registry Number
20	Cloned(Commentary)
15	Crystallization (Commentary)
736	Disease/ Diagnostics
3	Expression
11	General Information
3	General Stability
34	IC50 Value
220	Inhibitors
1	kcat/KM [mM/s]
27	Ki Value [mM]
36	KM Value [mM]
11	Localization
89	Metals/Ions
70	Molecular Weight [Da]
30	Natural Substrates/ Products (Substrates)
522	Organism
2	Oxidation Stability
8	Pathway
81	PDB ID
42	pH Optimum
7	pH Range
1	pH Stability
1	pI Value
25	Protein Variants
35	Purification (Commentary)
8	Reaction
3	Reaction Type
194	Reference
116	Source Tissue
27	Specific Activity [micromol/min/mg]
3	Storage Stability
117	Substrates and Products (Substrate)
36	Subunits
109	Synonyms
1	Systematic Name
14	Temperature Optimum [°C]
2	Temperature Range [°C]
7	Temperature Stability [°C]
2	Turnover Number [1/s]

KI Value

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KI Value on EC 4.2.1.24 - porphobilinogen synthase

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Ki VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

26.52

1-amino-4-hydroxy-2-butanone

Rattus sp.

-

-

691205

7

2,2-difluorosuccinic acid

Pseudomonas aeruginosa

-

-

664001

73.04

4-oxo-pentanenitrile

Rattus sp.

-

-

691205

2.93

4-oxo-sebacic acid

Rattus sp.

-

-

691205

0.2 - 0.313

5,5'-iminobis(4-oxopentanoic acid)

2 entries

0.098 - 0.963

5,5'-oxybis(4-oxopentanoic acid)

2 entries

9.94 - 10.8

5,5'-sulfinylbis(4-oxopentanoic acid)

2 entries

0.342 - 11

5,5'-sulfonylbis(4-oxopentanoic acid)

2 entries

0.06 - 38.4

5,5'-thiobis(4-oxopentanoic acid)

2 entries

18.48

5-amino-4-oxopentanenitrile

Rattus sp.

-

-

691205

4.05

5-hydroxylevulinic acid

Pseudomonas aeruginosa

Q59643

37°C, pH 8.5

678204

3.05

5-oxo-hexanoic acid

Rattus sp.

-

-

691205

1.07

6-amino-5-oxohexanoic acid

Rattus sp.

-

-

691205

1.33

alaremycin

Pseudomonas aeruginosa

Q59643

-

701747

0.00364

alloxan

Mus musculus

-

pH 6.4 and 37°C

728984

0.03

diethyl dicarbonate

Pseudomonas aeruginosa

-

-

664001

0.96 - 1.5

levulinic acid

2 entries

0.0025

protoporphyrin IX

Pseudomonas aeruginosa

-

-

664001

0.03

pyridoxal phosphate

Pseudomonas aeruginosa

-

-

664001

9

succinic acid

Pseudomonas aeruginosa

-

-

664001

1.9

succinic acid monomethyl ester

Pseudomonas aeruginosa

-

-

664001

0.2

5,5'-iminobis(4-oxopentanoic acid)

Pseudomonas aeruginosa

-

-

679158

0.313

5,5'-iminobis(4-oxopentanoic acid)

Pseudomonas aeruginosa

Q59643

37°C, pH 8.5

678204

0.098

5,5'-oxybis(4-oxopentanoic acid)

Pseudomonas aeruginosa

-

-

679158

0.963

5,5'-oxybis(4-oxopentanoic acid)

Pseudomonas aeruginosa

Q59643

37°C, pH 8.5

678204

9.94

5,5'-sulfinylbis(4-oxopentanoic acid)

Pseudomonas aeruginosa

Q59643

37°C, pH 8.5

678204

10.8

5,5'-sulfinylbis(4-oxopentanoic acid)

Pseudomonas aeruginosa

-

-

679158

0.342

5,5'-sulfonylbis(4-oxopentanoic acid)

Pseudomonas aeruginosa

Q59643

37°C, pH 8.5

678204

11

5,5'-sulfonylbis(4-oxopentanoic acid)

Pseudomonas aeruginosa

-

-

679158

0.06

5,5'-thiobis(4-oxopentanoic acid)

Pseudomonas aeruginosa

-

-

679158

38.4

5,5'-thiobis(4-oxopentanoic acid)

Pseudomonas aeruginosa

Q59643

37°C, pH 8.5

678204

0.96

levulinic acid

Rattus sp.

-

-

691205

1.5

levulinic acid

Pseudomonas aeruginosa

-

-

664001