Literature summary for 4.2.1.24 extracted from

Gacond, S.; Frere, F.; Nentwich, M.; Faurite, J.P.; Frankenberg-Dinkel, N.; Neier, R.
Synthesis of bisubstrate inhibitors of porphobilinogen synthase from Pseudomonas aeruginosa (2007), Chem. Biodivers., 4, 189-202.

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Inhibitors

Inhibitors	Comment	Organism	Structure
5,5'-iminobis(4-oxopentanoic acid)	-	Pseudomonas aeruginosa
5,5'-oxybis(4-oxopentanoic acid)	-	Pseudomonas aeruginosa
5,5'-sulfinylbis(4-oxopentanoic acid)	-	Pseudomonas aeruginosa
5,5'-sulfonylbis(4-oxopentanoic acid)	-	Pseudomonas aeruginosa
5,5'-thiobis(4-oxopentanoic acid)	-	Pseudomonas aeruginosa

Organism

Organism	UniProt	Comment	Textmining
Pseudomonas aeruginosa	-	-	-

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.06	-	5,5'-thiobis(4-oxopentanoic acid)	-	Pseudomonas aeruginosa
0.098	-	5,5'-oxybis(4-oxopentanoic acid)	-	Pseudomonas aeruginosa
0.2	-	5,5'-iminobis(4-oxopentanoic acid)	-	Pseudomonas aeruginosa
10.8	-	5,5'-sulfinylbis(4-oxopentanoic acid)	-	Pseudomonas aeruginosa
11	-	5,5'-sulfonylbis(4-oxopentanoic acid)	-	Pseudomonas aeruginosa

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.31	-	-	Pseudomonas aeruginosa	5,5'-iminobis(4-oxopentanoic acid)
0.34	-	-	Pseudomonas aeruginosa	5,5'-thiobis(4-oxopentanoic acid)
0.96	-	-	Pseudomonas aeruginosa	5,5'-oxybis(4-oxopentanoic acid)
9.9	-	-	Pseudomonas aeruginosa	5,5'-sulfonylbis(4-oxopentanoic acid)
38	-	-	Pseudomonas aeruginosa	5,5'-sulfinylbis(4-oxopentanoic acid)

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Release 2023.1 (January 2023)