4.2.1.119: enoyl-CoA hydratase 2

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For detailed information about enoyl-CoA hydratase 2, go to the full flat file.

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Synonyms

(3R)-hydroxyacyl-CoA dehydrogenase/2-enoyl-CoA hydratase 2, (R)-specific ECH, (R)-specific enoyl coenzyme A hydratase, (R)-specific enoyl-CoA hydratase, (R)-specific enoyl-coenzyme A hydratase, 2-enoyl-CoA hydratase, 2-enoyl-CoA hydratase 2, 2-enoyl-hydratase 2, 2E-enoyl-CoA hydratase 2, At1g76150, AtECH2, D-(-)-3-hydroxyacyl-CoA hydro-lyase, D-3-hydroxyacyl-CoA dehydratase, D-3-hydroxyacyl-CoA hydro-lyase, D-bifunctional enzyme, D-BP, D-specific 2-trans-enoyl-CoA hydratase, ECH-2, ECH2, enoyl-CoA hydratase 2, HFX_1483, hydratase 2, MaoC, MaoC-like protein, MFE-2, MFE2, MFE2 hydratase, Mfe2p [CtMfe2p(dha+bdelta)], multifunctional enzyme type 2, multifunctional enzyme type 2 hydratase, perMFE-II, peroxisomal enoyl-CoA hydratase 2, phaJ, PhaJ1, PhaJ1Pa, PhaJ1Pp, PhaJ4, PhaJ4aRe, PhaJ4bRe, PhaJ4cRe, PhaJAc, PhaJYB4, R-ECH, R-hydratase, R-specific enoyl coenzyme A hydratase, R-specific enoyl-CoA hydratase

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.1 Hydro-lyases

                4.2.1.119 enoyl-CoA hydratase 2

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Results	in table
30318	AA Sequence
1	Application
1	CAS Registry Number
19	Cloned(Commentary)
8	Crystallization (Commentary)
11	Disease/ Diagnostics
34	General Information
4	Inhibitors
3	kcat/KM [mM/s]
3	Ki Value [mM]
41	KM Value [mM]
19	Localization
19	Molecular Weight [Da]
28	Natural Substrates/ Products (Substrates)
241	Organism
14	Pathway
6	PDB ID
11	pH Optimum
1	pH Range
2	pI Value
63	Protein Variants
14	Purification (Commentary)
1	Reaction
3	Reaction Type
36	Reference
19	Source Tissue
37	Specific Activity [micromol/min/mg]
2	Storage Stability
95	Substrates and Products (Substrate)
17	Subunits
105	Synonyms
1	Systematic Name
10	Temperature Optimum [°C]
1	Temperature Range [°C]
13	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 4.2.1.119 - enoyl-CoA hydratase 2

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SYSTEMATIC NAME

IUBMB Comments

(3R)-3-hydroxyacyl-CoA hydro-lyase

This enzyme catalyses a hydration step in peroxisomal beta-oxidation. The human multifunctional enzyme type 2 (MFE-2) is a 79000 Da enzyme composed of three functional units: (3R)-hydroxyacyl-CoA dehydrogenase, 2-enoyl-CoA hydratase 2 and sterol carrier protein 2-like units [1]. The enzymes from Aeromonas caviae [4] and Arabidopsis thaliana [5] are monofunctional enzymes. 2-Enoyl-CoA hydratase 3 from Candida tropicalis is a part from multifunctional enzyme type 2 [3].