4.1.3.B3: 4-carboxy-4-hydroxy-2-oxoadipate aldolase

This is an abbreviated version!
For detailed information about 4-carboxy-4-hydroxy-2-oxoadipate aldolase, go to the full flat file.

Reaction

Synonyms

4-carboxy-4-hydroxy-2-oxoadipate aldolase/oxaloacetate decarboxylase, 4-hydroxy-4-methyl-2-oxoglutarate/4-carboxy-4-hydroxy-2-oxoadipate aldolase, CHA aldolase, HMG/CHA aldolase, PmdF

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.3 Oxo-acid-lyases

                4.1.3.B3 4-carboxy-4-hydroxy-2-oxoadipate aldolase

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Results	in table
2	AA Sequence
2	Cloned(Commentary)
1	Crystallization (Commentary)
7	General Information
1	Inhibitors
2	kcat/KM [mM/s]
2	KM Value [mM]
4	Metals/Ions
1	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
4	Organism
5	Protein Variants
2	Purification (Commentary)
1	Reaction
4	Reference
2	Source Tissue
1	Specific Activity [micromol/min/mg]
1	Storage Stability
7	Substrates and Products (Substrate)
2	Subunits
9	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
2	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 4.1.3.B3 - 4-carboxy-4-hydroxy-2-oxoadipate aldolase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

4-carboxy-4-hydroxy-2-oxoadipate

oxaloacetate + pyruvate

3 entries

4-carboxy-4-hydroxy-2-oxoadipate

pyruvate + oxaloacetate

Pseudomonas putida

A5W059

-

715556

-

-

r

additional information

?

-

3 entries

4-carboxy-4-hydroxy-2-oxoadipate

oxaloacetate + pyruvate

Comamonas testosteroni

Q93PS8

-

726779

-

-

?

4-carboxy-4-hydroxy-2-oxoadipate

oxaloacetate + pyruvate

Comamonas testosteroni CNB-1

Q93PS8

-

726779

-

-

?

4-carboxy-4-hydroxy-2-oxoadipate

oxaloacetate + pyruvate

Pseudomonas putida

A5W059

-

727049

-

-

?

additional information

?

-

Comamonas testosteroni

Q93PS8

the bifunctional enzyme PmdF shows obvious aldolase activity when 4-carboxy-4-hydroxy-2-oxoadipate is used as substrate and obvious oxalacetate decarboxylase activity when oxaloacetate is used as substrate

726779

-

-

?

additional information

?

-

Comamonas testosteroni CNB-1

Q93PS8

the bifunctional enzyme PmdF shows obvious aldolase activity when 4-carboxy-4-hydroxy-2-oxoadipate is used as substrate and obvious oxalacetate decarboxylase activity when oxaloacetate is used as substrate

726779

-

-

?

additional information

?

-

Pseudomonas putida

A5W059

the enzyme is a class II, divalent metal ion-dependent, pyruvate aldolase that catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate and 4-carboxy-4-hydroxy-2-oxoadipate into two molecules of pyruvate in the former and a molecule of each pyruvate and oxaloacetate in the latter, cf. EC 4.1.3.17. The enzyme also contains a secondary oxaloacetate decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retroaldol and decarboxylase reactions

727049

-

-

?