4.1.3.45: 3-hydroxybenzoate synthase
This is an abbreviated version!
For detailed information about 3-hydroxybenzoate synthase, go to the full flat file.
Word Map on EC 4.1.3.45
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4.1.3.45
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polyketide
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hygroscopicus
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arene
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nonconserved
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shikimate
- 4.1.3.45
- polyketide
- hygroscopicus
- arene
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nonconserved
- shikimate
Reaction
Synonyms
3-HBA synthase, 3-hydroxybenzoate synthase, 3HBA synthase, arcB, bra8, CH-Hyg5, chorismatase, chorismatase/3-hydroxybenzoate synthase, Cuv10, hyg5, S-citramalyl-CoA lyase, S-citramalyl-coenzyme A lyase, XanB2
ECTree
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Engineering
Engineering on EC 4.1.3.45 - 3-hydroxybenzoate synthase
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C327A
C327A/G240A
the Hyg5 double mutant shows the same behavior as the single mutants, but along with a more dramatic loss of activity
G240A
the mutation leads to decreased activity (6%) compared to the wild type enzyme and results in a complete loss of product selectivity
C327A
the Hyg5 mutant shows 6% decreased activity compared to the wild-type, and results in a complete loss of product selectivity. The FkbO product (4R,5R)-4,5-dihydroxycyclohexa-1(6),2-diene-1-carboxylate as well as the XanB2 product 4-hydroxybenzoate are produced
G240A
the mutation leads to decreased activity (55%) compared to the wild type enzyme and results in a complete loss of product selectivity
G240A
the Hyg5 mutant shows 55% decreased activity compared to the wild-type, and results in a complete loss of product selectivity. The FkbO product (4R,5R)-4,5-dihydroxycyclohexa-1(6),2-diene-1-carboxylate as well as the XanB2 product 4-hydroxybenzoate are produced