4.1.2.46: aliphatic (R)-hydroxynitrile lyase

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For detailed information about aliphatic (R)-hydroxynitrile lyase, go to the full flat file.

Reaction

Synonyms

(R)-HNL, (R)-hydroxynitrile lyase, (R)-Oxynitrilase, Acetone cyanohydrin lyase, EC 4.1.2.37, Hydroxynitrile lyase, LuHNL

ECTree

4 Lyases

4.1 Carbon-carbon lyases

4.1.2 Aldehyde-lyases

4.1.2.46 aliphatic (R)-hydroxynitrile lyase

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1	Activating Compound
1	AA Sequence
2	Application
4	Cloned(Commentary)
1	Cofactor
1	General Stability
3	Inhibitors
2	KM Value [mM]
1	Localization
1	Metals/Ions
7	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
12	Organism
7	Pathway
12	PDB ID
2	pH Optimum
1	pH Range
3	pH Stability
1	pI Value
2	Protein Variants
4	Purification (Commentary)
1	Reaction
11	Reference
4	Source Tissue
4	Specific Activity [micromol/min/mg]
1	Storage Stability
44	Substrates and Products (Substrate)
4	Subunits
16	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 4.1.2.46 - aliphatic (R)-hydroxynitrile lyase

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(2R)-2-hydroxy-2-methylbutanenitrile butan-2-one lyase (cyanide forming)

The enzyme contains Zn2+ [1]. The enzyme catalyses the stereoselective synthesis of aliphatic (R)-cyanohydrins [1]. No activity towards mandelonitrile and 4-hydroxymandelonitrile [5]. Natural substrates for the (R)-oxynitrilase from Linum usitatissimum are acetone and butan-2-one, which are the building blocks of the cyanogen glycosides in Linum, linamarin and lotaustralin, or linustatin and neolinustatin, respectively [4].