4.1.1.65: phosphatidylserine decarboxylase

This is an abbreviated version!
For detailed information about phosphatidylserine decarboxylase, go to the full flat file.

Word Map on EC 4.1.1.65

4.1.1.65

phospholipid

phosphatidylcholine

kennedy

cdp-ethanolamine

decarboxylases

3hserine

ptdetn

cdp-diacylglycerol

phosphatidylglycerophosphate

dowhan

spinothalamic

base-exchange

aminophospholipids

interorganelle

cdp-diglyceride

medicine

analysis

Reaction

Synonyms

CT699, Decarboxylase, phosphatidylserine, phosphatidyl serine decarboxylase, Phosphatidylserine decarboxylase, phosphatidylserine decarboxylase 1, phosphatidylserine decarboxylase 2, phosphatidylserine decarboxylase2, PISD, PKH_072580, PS decarboxylase, PSD, PSD1, Psd1 enzyme, Psd1p, PSD2, Psd2p, PSD3, PSDC, Tb927.9.10080, type I PtdSer decarboxylase

ECTree

4 Lyases

4.1 Carbon-carbon lyases

4.1.1 Carboxy-lyases

4.1.1.65 phosphatidylserine decarboxylase

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Results	in table
13	Activating Compound
32015	AA Sequence
4	Application
1	CAS Registry Number
8	Cloned(Commentary)
25	Disease/ Diagnostics
2	Expression
30	General Information
2	General Stability
40	Inhibitors
9	KM Value [mM]
98	Localization
6	Metals/Ions
27	Molecular Weight [Da]
31	Natural Substrates/ Products (Substrates)
287	Organism
6	Pathway
48	PDB ID
5	pH Optimum
1	pH Range
1	pH Stability
11	Posttranslational Modification
53	Protein Variants
4	Purification (Commentary)
4	Reaction
2	Reaction Type
111	Reference
24	Source Tissue
5	Specific Activity [micromol/min/mg]
6	Storage Stability
109	Substrates and Products (Substrate)
17	Subunits
98	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]

Inhibitors

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Inhibitors on EC 4.1.1.65 - phosphatidylserine decarboxylase

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4-Bromo-3-hydroxybenzyloxyamine

Escherichia coli

4769, 4775

7-chloro-N-(4-ethoxyphenyl)-4-quinolinamine

Plasmodium falciparum

Q9GPP8

inhibitor with potent activity against Plasmodium falciparum, and low toxicity toward mammalian cells

748688

7-chloro-N-(4-propylphenyl)-4-quinolinamine

Plasmodium falciparum

Q9GPP8

0.01 mM, 29% inhibition, 0.1 mM, 76% inhibition of catalysis. Compound inhibits PSD activity and blocks Plasmodium falciparum blood stage development in the malaria murine model

748688

Bile salt detergents

Escherichia coli

inactivation by dissociating the oligomeric enzyme

4773

Cu2+

Clostridium butyricum

Cyanoborohydride

cycloserine

D-penicillamine

deoxypyridoxine

reversion by pyridoxal phosphate

Hydrazines

hydroxylamine

ionic detergents

Isonicotinic acid hydrazide

L-Penicillamine

N-Dodecyl-N,N-dimethyl-3-ammonio-1-propanesulfonate

Escherichia coli

4773

NaBH4

Escherichia coli

in presence of an amine

4786

NaCNBH3

Escherichia coli

in presence of an amine

4786

NEM

Clostridium butyricum

4781

nitrophene

Rattus norvegicus

4791

nonionic detergents

Clostridium butyricum

e.g. Brij 35 or Tween 80, partial

4781

O-Benzylhydroxylamine

Escherichia coli

4769

p-hydroxymercuribenzoate

phosphatidylinositol

Thiosemicarbazide

Triton X-100

Zwitterionic detergents

Escherichia coli

inactivation by dissociating the oligomeric enzyme

4773

additional information

Homo sapiens

DMSO has no discernable effect on product formation

680942