4.1.1.65: phosphatidylserine decarboxylase
This is an abbreviated version!
For detailed information about phosphatidylserine decarboxylase, go to the full flat file.
Word Map on EC 4.1.1.65
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4.1.1.65
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phospholipid
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phosphatidylcholine
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kennedy
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cdp-ethanolamine
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decarboxylases
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3hserine
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ptdetn
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cdp-diacylglycerol
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phosphatidylglycerophosphate
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dowhan
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spinothalamic
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base-exchange
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aminophospholipids
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interorganelle
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cdp-diglyceride
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medicine
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analysis
- 4.1.1.65
- phospholipid
- phosphatidylcholine
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kennedy
- cdp-ethanolamine
- decarboxylases
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3hserine
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ptdetn
- cdp-diacylglycerol
- phosphatidylglycerophosphate
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dowhan
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spinothalamic
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base-exchange
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aminophospholipids
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interorganelle
- cdp-diglyceride
- medicine
- analysis
Reaction
Synonyms
CT699, Decarboxylase, phosphatidylserine, phosphatidyl serine decarboxylase, Phosphatidylserine decarboxylase, phosphatidylserine decarboxylase 1, phosphatidylserine decarboxylase 2, phosphatidylserine decarboxylase2, PISD, PKH_072580, PS decarboxylase, PSD, PSD1, Psd1 enzyme, Psd1p, PSD2, Psd2p, PSD3, PSDC, Tb927.9.10080, type I PtdSer decarboxylase
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Substrates Products
Substrates Products on EC 4.1.1.65 - phosphatidylserine decarboxylase
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REACTION DIAGRAM
phosphatidyl-L-serine
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the enzyme catalyzes the final step in the biosynthesis of phosphatidylethanolamine
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phosphatidyl-L-serine
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important enzyme in the synthesis of phosphatidylethanolamine
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phosphatidyl-L-serine
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important enzyme in the synthesis of phosphatidylethanolamine
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phosphatidyl-L-serine
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important enzyme in the synthesis of phosphatidylethanolamine
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Phosphatidyl-L-serine
Phosphatidylethanolamine + CO2
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Phosphatidyl-L-serine
Phosphatidylethanolamine + CO2
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Phosphatidyl-L-serine
Phosphatidylethanolamine + CO2
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localization of the phosphatidylserine-specific binding site in the enzyme
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Phosphatidyl-L-serine
Phosphatidylethanolamine + CO2
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phosphatidyl-L-serine species with a 20:4 fatty acid on the sn-2 position are preferentially decarboxylated
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Phosphatidyl-L-serine
Phosphatidylethanolamine + CO2
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disruption of the phosphatidylserine decarboxylase gene in mice causes embryonic lethality and mitochondrial defects
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Phosphatidyl-L-serine
Phosphatidylethanolamine + CO2
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Phosphatidyl-L-serine
Phosphatidylethanolamine + CO2
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phosphatidyl-L-serine species with a 20:4 fatty acid on the sn-2 position are preferentially decarboxylated
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Phosphatidyl-L-serine
Phosphatidylethanolamine + CO2
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Phosphatidyl-L-serine
Phosphatidylethanolamine + CO2
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phosphatidylethanolamine formed by phosphatidylserine decarboxylase 2 is the preferred substrate for phosphatidylcholine synthesis, phosphatidylethanolamine formed by phosphatidylserine decarboxylase 2 can be imported into mitochondria, although with moderate efficiency
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Phosphatidyl-L-serine
Phosphatidylethanolamine + CO2
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phosphatidylserine decarboxylase 1 is the major source of cellular and mitochondrial phosphatidylethanolamine
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Phosphatidyl-L-serine
Phosphatidylethanolamine + CO2
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high selectivity, preference for the formation of C34:2 and C32:2 species, phosphatidylserine decarboxylase 1
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Phosphatidyl-L-serine
Phosphatidylethanolamine + CO2
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high selectivity, preference for the formation of C34:2 and C32:2 species, phosphatidylserine decarboxylase 2
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Phosphatidyl-L-serine
Phosphatidylethanolamine + CO2
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Phosphatidyl-L-serine
Phosphatidylethanolamine + CO2
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Phosphatidyl-L-serine
Phosphatidylethanolamine + CO2
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Phosphatidyl-L-serine
Phosphatidylethanolamine + CO2
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Phosphatidyl-L-serine
Phosphatidylethanolamine + CO2
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Phosphatidyl-L-serine
Phosphatidylethanolamine + CO2
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Phosphatidyl-L-serine
Phosphatidylethanolamine + CO2
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Phosphatidyl-L-serine
Phosphatidylethanolamine + CO2
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activity towards natural phosphatidylserine is greater than towards saturated phosphatidylserine
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Phosphatidyl-L-serine
Phosphatidylethanolamine + CO2
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liposomal phosphatidyl-L-serine
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Phosphatidyl-L-serine
Phosphatidylethanolamine + CO2
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liposomal phosphatidyl-L-serine
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additional information
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the enzyme has both phosphatidylserine decarboxylase activity and phospholipid N-methyltransferase activity or two enzymes with identical electrophotetic properties
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additional information
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side chain preferrence of phosphatidylserine in liver in decreasing order: 18:0/18:1, 18:0/22:6, 18:0/20:4, side chain preferrence of phosphatidylserine in brain in decreasing order: 18:0/22:6, 18:0/18:1, 18:0/20:4
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additional information
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substrate preference of liver and cerebellum enzyme concerning 22:6n-3 content changes during aging
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additional information
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effect of the enzyme in neural excitation. The carboxyl groups of phosphatidylserine function as ion exchange sites in the nerve membrane
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additional information
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substrate transport to enzyme implicates specific lipid domains with pure phosphatidylserine vesicles being most effective
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additional information
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the level of enzyme activity is partially and reversibly suppressed by inositol and further diminished by the combination of inositol and choline
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additional information
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enzyme of the phospholipid metabolism
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