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4.1.1.18: lysine decarboxylase

This is an abbreviated version!
For detailed information about lysine decarboxylase, go to the full flat file.

Word Map on EC 4.1.1.18

Reaction

L-lysine
=
cadaverine
 +
CO2

Synonyms

AsLdc, CadA, constitutive LDCc, constitutive lysine decarboxylase, DesA, EcLDCc, ECORLD, gtLDC, inducible lysine decarboxylase, L-Lys-OD, L-lysine decarboxylase, LDC, ldcC, LdcI, LdcI/CadA, LysA, lysine decarboxylase, MaLDC, multimeric lysine decarboxylase, SrLDC, VSAL_I2491

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.18 lysine decarboxylase

pH Range

pH Range on EC 4.1.1.18 - lysine decarboxylase

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pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
4 - 10
activity range
4.5 - 7
-
pH 4.5: about 35% of maximal activity, pH 7.0: about 60% of maximal activity
4.5 - 8
-
pH 4.5: about 30% of maximal activity, pH 8: about 35% of maximal activity
4.7 - 6.6
-
50% of maximal activity at pH 4.7 and 6.6
5 - 8.5
high activity within this range
5.2 - 8.8
-
pH 5.2: 40% of maximal activity, pH 8.8: 30% of maximal activity
5.5 - 8
maximal activity at pH 5.5, 30% of maximal activity at pH 8.0
6.2 - 8.8
soluble wild-type enzyme, maximal activity at pH 6.2-8.0, 30% of maximal activity at pH 8.8
7 - 8
-
pH 7.0: about 70% of maximal activity, pH 9.0: about 25% of maximal activity
7.5 - 9
recombinant enzyme inclusion bodies, EcLDCc-CatIBs, range of higher activity
8 - 9
-
enzyme gtLDC does not exhibit effective activity in alkaline pH conditions, the conversion rate of about 8% is similar at pH 8.0 and pH 9.0, no activity at pH 10.0
additional information