3.6.1.61: diadenosine hexaphosphate hydrolase (ATP-forming)
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For detailed information about diadenosine hexaphosphate hydrolase (ATP-forming), go to the full flat file.
Reaction
Synonyms
Ndx1, ygdP
ECTree
3.6.1.61 diadenosine hexaphosphate hydrolase (ATP-forming)Advanced search results
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Substrates Products on EC 3.6.1.61 - diadenosine hexaphosphate hydrolase (ATP-forming)
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
P1,P5-bis(5'-adenosyl)pentaphosphate + H2O
ATP + ADP
preferred substrate
-
-
?
P1,P6-bis(5'-adenosyl)hexaphosphate + H2O
2 ATP
hydrolyzed at about 70% compared to P1,P5-bis(5'-adenosyl)pentaphosphate
-
-
?
P1,P6-bis(5'-adenosyl)hexaphosphate + H2O
2 ATP
P1,P6-bis(5'-adenosyl)hexaphosphate is the most preferred substrate. Glu46 and Glu50 are conserved residues in the Nudix motif and are involved in catalysis
-
-
?
additional information
?
-
YgdP does not act on other nucleoside diphosphate derivatives such as ADP-ribose, NADH, UDP-glucose and P1,P3-bis(5'-adenosyl)triphosphate
-
-
?
additional information
?
-
-
homology modeling techniques shows Glu46, Arg88, and Glu90 are three important determinant residues in binding as they have strong hydrogen bonding interactions and electrostatic interactions with P1,P6-bis(5'-adenosyl)hexaphosphate
-
-
?
