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3.6.1.61: diadenosine hexaphosphate hydrolase (ATP-forming)

This is an abbreviated version!
For detailed information about diadenosine hexaphosphate hydrolase (ATP-forming), go to the full flat file.

Reaction

P1,P4-bis(5'-adenosyl)tetraphosphate
+
H2O
=
ATP
+
AMP

Synonyms

Ndx1, ygdP

ECTree

     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.1 In phosphorus-containing anhydrides
                3.6.1.61 diadenosine hexaphosphate hydrolase (ATP-forming)

Engineering

Engineering on EC 3.6.1.61 - diadenosine hexaphosphate hydrolase (ATP-forming)

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
E46Q
2200fold reduction in kcat
E49Q
mutation has very little effect on activity
E50Q
130000fold reduction in kcat
W26S
no decrease in fluorescence intensity upon the addition of ATP