3.5.4.B9: cytosine deaminase APOBEC3G

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For detailed information about cytosine deaminase APOBEC3G, go to the full flat file.

Reaction

Synonyms

A3G, ABOBEC3G, activation-induced deaminase, Apo3G, Apobec 3G, APOBEC3G, APOBEC3G cytidine deaminase, APOBEC3G DNA deaminase, apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G, apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G, apolipoprotein B mRNA-editing, enzyme-catalytic, polypeptide-like 3G, CEM15, DNA cytidine deaminase, More, single-stranded DNA deoxycytidine deaminase, single-stranded DNA-dependent deoxycytidine deaminase, ssDNA deoxycytidine deaminase

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.4 In cyclic amidines

                3.5.4.B9 cytosine deaminase APOBEC3G

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Results	in table
1	Activating Compound
1	AA Sequence
1	Application
15	Cloned(Commentary)
6	Crystallization (Commentary)
23	Disease/ Diagnostics
16	General Information
38	IC50 Value
40	Inhibitors
39	kcat/KM [mM/s]
40	KM Value [mM]
4	Localization
8	Metals/Ions
2	Molecular Weight [Da]
27	Natural Substrates/ Products (Substrates)
30	Organism
4	pH Optimum
2	Posttranslational Modification
79	Protein Variants
11	Purification (Commentary)
1	Reaction
30	Reference
8	Source Tissue
42	Substrates and Products (Substrate)
7	Subunits
61	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
39	Turnover Number [1/s]

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Application on EC 3.5.4.B9 - cytosine deaminase APOBEC3G

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

medicine

Homo sapiens

Q9HC16

APOBEC3G mediated checkpoint activation through checkpoint kinase 2 (Chk2) is one of the critical regulatory mechanisms that underlies the preferential DNA damage checkpoint response and radioresistance of Glioma Initiating Cells. Thus, anti-APOBEC3G therapy may synergize with radiotherapy and other current treatments to overcome the therapeutic resistance of gliomas. APOBEC3G represents a potential molecular target for novel therapeutics that will improve the treatment outcome of glioma patients

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