3.5.2.B3: (-)-gamma-lactamase

This is an abbreviated version!
For detailed information about (-)-gamma-lactamase, go to the full flat file.

Reaction

Synonyms

(-)-gamma-lactamase, mHG, MhIHL, SvGL

ECTree

3 Hydrolases

3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

3.5.2 In cyclic amides

3.5.2.B3 (-)-gamma-lactamase

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Results	in table
2	Activating Compound
4	AA Sequence
4	Application
5	Cloned(Commentary)
3	Crystallization (Commentary)
7	General Information
1	kcat/KM [mM/s]
3	KM Value [mM]
4	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
11	Organism
5	pH Optimum
1	pH Range
1	pI Value
27	Protein Variants
2	Purification (Commentary)
2	Reaction
9	Reference
1	Specific Activity [micromol/min/mg]
19	Substrates and Products (Substrate)
1	Subunits
9	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
2	Temperature Range [°C]
3	Temperature Stability [°C]
2	Turnover Number [1/s]

Reference

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Reference on EC 3.5.2.B3 - (-)-gamma-lactamase

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735828

Yang, M.; Gao, Q.; Wu, S.; Wang, J.; Zheng, G.

Characterization of a recombinant (-)gamma-lactamase from Microbacterium hydrocarbonoxydans

Biotechnol. Lett.

275-279

2012

Microbacterium hydrocarbonoxydans (E3SVS0)

21968479

736630

Line, K.; Isupov, M.N.; Littlechild, J.A.

The crystal structure of a (-) gamma-lactamase from an Aureobacterium species reveals a tetrahedral intermediate in the active site

J. Mol. Biol.

338

519-532

2004

uncultured Microbacterium sp. (Q8GJP7)

15081810

749661

Yan, X.; Wang, J.; Sun, Y.; Zhu, J.; Wu, S.

Facilitating the evolution of esterase activity from a promiscuous enzyme (Mhg) with catalytic functions of amide hydrolysis and carboxylic acid perhydrolysis by engineering the substrate entrance tunnel

Appl. Environ. Microbiol.

6748-6756

2016

Microbacterium hydrocarbonoxydans (E3SVS0), Microbacterium hydrocarbonoxydans NBRC 103074 (E3SVS0)

27613682

752551

Gao, S.; Zhu, S.; Huang, R.; Li, H.; Wang, H.; Zheng, G.

Engineering the enantioselectivity and thermostability of a (+)-?-lactamase from Microbacterium hydrocarbonoxydans for kinetic resolution of Vince lactam (2-azabicyclo[2.2.1]hept-5-en-3-one)

Appl. Environ. Microbiol.

e01780-17

2018

Microbacterium hydrocarbonoxydans (A0A0K0XHU0)

29054871

752582

Sun, Y.; Zhao, H.; Wang, J.; Zhu, J.; Wu, S.

Identification and regulation of the catalytic promiscuity of (-)-gamma-lactamase from Microbacterium hydrocarbonoxydans

Appl. Microbiol. Biotechnol.

7559-7568

2015

Microbacterium hydrocarbonoxydans (E3SVS0), Microbacterium hydrocarbonoxydans NBRC 103074 (E3SVS0)

25773976

753162

Yin, J.; Gong, Y.; Zhang, X.; Zheng, G.; Xu, J.

Green access to chiral Vince lactam in a buffer-free aqueous system using a newly identified substrate-tolerant (-)-gamma-lactamase

Catal. Sci. Technol.

6305-6310

2016

Streptomyces viridochromogenes (D9XDN2)

755471

Gao, S.; Zhou, Y.; Zhang, W.; Wang, W.; Yu, Y.; Mu, Y.; Wang, H.; Gong, X.; Zheng, G.; Feng, Y.

Structural insights into the ?-lactamase activity and substrate enantioselectivity of an isochorismatase-like hydrolase from Microbacterium hydrocarbonoxydans

Sci. Rep.

44542

2017

Microbacterium hydrocarbonoxydans (E3SVS0)

28295028