3.5.1.97: acyl-homoserine-lactone acylase

This is an abbreviated version!
For detailed information about acyl-homoserine-lactone acylase, go to the full flat file.

Reaction

Synonyms

AAC, acyl-homoserine lactone acylase, acyl-HSL acylase, acylhomoserine-lactone acylase, AHL acylase, AHL amidase, AHL-acylase, AhlM, AIBP, AiiC, AiiD, AiiO, AmiE, APTM01, AtPVA, auto-inducer inhibitor from Cyanobacteria, FaGL1422, HacA, HacB, KcPGA, long-chain AHL acylase, MacQ, More, N-acyl-homoserine lactone acylase, N-acylhomoserine lactone acylase, N-acylhomoserine lactone-acylase, PA0305, PA2385, PA2385 protein, PaPVA, pfmA, PvdQ, PvdQ acylase, QqaR, QuiP, quorum quenching acylhomoserine lactone acylase, quorum quenching enzyme, quorum-quenching AHL acylase, quorum-quenching enzyme, quorum-quenching N-acyl homoserine lactone acylase PvdQ, quorum-quenching N-acylhomoserine lactone acylase, SlPVA

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.1 In linear amides

                3.5.1.97 acyl-homoserine-lactone acylase

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Results	in table
839	AA Sequence
11	Application
1	CAS Registry Number
18	Cloned(Commentary)
1	Crystallization (Commentary)
22	General Information
12	Inhibitors
5	kcat/KM [mM/s]
4	KM Value [mM]
7	Localization
3	Metals/Ions
12	Molecular Weight [Da]
31	Natural Substrates/ Products (Substrates)
56	Organism
36	PDB ID
8	pH Optimum
1	pH Range
2	Posttranslational Modification
8	Protein Variants
8	Purification (Commentary)
2	Reaction
1	Reaction Type
49	Reference
2	Source Tissue
9	Specific Activity [micromol/min/mg]
236	Substrates and Products (Substrate)
9	Subunits
128	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
1	Temperature Range [°C]
6	Temperature Stability [°C]
3	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 3.5.1.97 - acyl-homoserine-lactone acylase

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SYSTEMATIC NAME

IUBMB Comments

N-acyl-L-homoserine-lactone amidohydrolase

Acyl-homoserine lactones (AHLs) are produced by a number of bacterial species and are used by them to regulate the expression of virulence genes in a process known as quorum-sensing. Each bacterial cell has a basal level of AHL and, once the population density reaches a critical level, it triggers AHL-signalling which, in turn, initiates the expression of particular virulence genes. Plants or animals capable of degrading AHLs would have a therapeutic advantage in avoiding bacterial infection as they could prevent AHL-signalling and the expression of virulence genes in quorum-sensing bacteria. This quorum-quenching enzyme removes the fatty-acid side chain from the homoserine lactone ring of AHL-dependent quorum-sensing signal molecules. It has broad specificity for AHLs with side changes ranging in length from 11 to 14 carbons. Substituents at the 3'-position, as found in N-(3-oxododecanoyl)-L-homoserine lactone, do not affect this activity.