3.4.24.60: dactylysin
This is an abbreviated version!
For detailed information about dactylysin, go to the full flat file.
Word Map on EC 3.4.24.60
-
3.4.24.60
-
metalloendopeptidase
-
dibasic
-
convertase
-
n-arginine
-
ectodomain
-
factor-like
-
adam17
-
heparin-binding
-
disintegrin
-
hb-egf
- 3.4.24.60
- metalloendopeptidase
-
dibasic
-
convertase
-
n-arginine
-
ectodomain
-
factor-like
-
adam17
-
heparin-binding
-
disintegrin
-
hb-egf
Reaction
Hydrolysis of peptides of at least six residues, with bulky hydrophobic residues in the P1' position. Shows a preference for hydrophobic doublets such as -Phe-/-Phe- and -Phe-/-Leu- in somatostatin-(1-14)-peptide and dynorphin A-(1-6)-peptide, respectively =
Synonyms
Peptide hormone inactivating endopeptidase, peptide hormone inactivating enzyme, PHIE
ECTree
Advanced search results
Substrates Products
Substrates Products on EC 3.4.24.60 - dactylysin
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REACTION DIAGRAM
(19-28)ANF peptide + H2O
?
-
i.e. atrial natriuretic factor derived peptide, cleavage site: Gly20-Leu21
-
-
?
(20-28)ANF peptide + H2O
?
-
i.e. atrial natriuretic factor derived peptide
-
-
?
(21-28)ANF octapeptide + H2O
?
-
i.e. atrial natriuretic factor derived peptide
-
-
?
(22-28)ANF heptapeptide + H2O
?
-
i.e. atrial natriuretic factor derived peptide
-
-
?
(23-28)ANF hexapeptide + H2O
?
-
i.e. atrial natriuretic factor derived peptide
-
-
?
(5-11)Substance P heptapeptide + H2O
?
-
i.e. Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2, cleavage site: Gly9-Leu10
-
-
?
(6-11)Substance P hexapeptide + H2O
?
-
i.e. Gln-Phe-Phe-Gly-Leu-Met-NH2, cleavage site: Gly9-Leu10
-
-
?
ANP-(103-126) + H2O
ANP-(103-123) + Phe124-Arg125-Tyr126
-
i.e. atrial natriuretic peptide, cleavage sites: Xaa-Phe, Xaa-Leu or Xaa-Ile bonds
-
?
Asp-Ala-Asp-Thr-Cys-[D-Arg8]-kermit + H2O
?
-
model substrate, derivative of kermit, cleavage site: Ser12-Phe13
-
-
?
atrial natriuretic factor + H2O
LGCNS + Phe-Arg-Tyr
-
cleavage of Ser-Phe
-
-
?
Neuromedin B + H2O
?
-
i.e. Gly-Asn-Leu-Trp-Ala-Thr-Gly-His-Phe-Met-NH2, major cleavage site: His8-Phe9, minor site: Gly7-His8
-
-
?
peptide PglA + H2O
?
-
antimicrobial peptide of Xenopus laevis skin secretion predominantly cleaved at the Lys12-Ile13 bond
-
-
?
substance P + H2O
RPKQQF + Phe-Gly + Leu-Met-NH2
-
cleavage of Gly9-Leu10
-
-
?
[Arg0,Leu5,Arg6]enkephalin + H2O
?
-
heptapeptide Arg-Tyr-Gly-Gly-Phe-Leu-Arg, cleavage site: Phe5-Leu6
-
-
?
[Arg0,Leu5]enkephalin + H2O
?
-
hexapeptide Arg-Tyr-Gly-Gly-Phe-Leu, cleavage site: Phe4-Leu5
-
-
?
[D-Arg8]-kermit + H2O
?
-
model substrate, derivative of kermit i.e. Asp-Val-Asp-Glu-Arg-Asp-Val-Arg-Gly-Phe-Ala-Ser-Phe-Leu-NH2, cleavage site: Ser12-Phe13
-
-
?
[Leu5,Arg6]enkephalin + H2O
?
-
hexapeptide Tyr-Gly-Gly-Phe-Leu-Arg, cleavage site: Phe4-Leu5
-
-
?
[Leu5,Ile6]enkephalin + H2O
?
-
hexapeptide Tyr-Gly-Gly-Phe-Leu-Ile, cleavage site: Phe4-Leu5
-
-
?
[Leu5,Lys6]enkephalin + H2O
?
-
hexapeptide Tyr-Gly-Gly-Phe-Leu-Lys, cleavage site: Phe4-Leu5
-
-
?
(5-28)ANF + H2O
ANF(5-25) + Phe26-Arg27-Tyr28
-
i.e. atrial natriuretic factor, cleavage site: exclusively Ser25-Phe26
-
?
?
-
i.e. Asp-Arg-Val-Tyr-Ile-His-Pro-Phe, cleavage site: Tyr4-Ile5
-
-
?
angiotensin II + H2O
?
-
i.e. Asp-Arg-Val-Tyr-Ile-His-Pro-Phe, cleavage site: Tyr4-Ile5
-
-
?
Antibacterial peptide PGLa + H2O
?
-
i.e. Gly-Met-Ala-Ser-Lys-Ala-Gly-Ala-Ile-Ala-Gly-Lys-Ile-Ala-Lys-Val-Ala-Leu-Lys-Ala-Leu-NH2, a peptide of Xenopus laevis skin secretion, cleavage site: Lys12-Ile13
-
-
?
?
-
i.e. Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg, major cleavage site: Gly4-Phe5, minor site: Pro7-Pro8
-
-
?
bradykinin + H2O
?
-
i.e. Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg, major cleavage site: Gly4-Phe5, minor site: Pro7-Pro8
-
-
?
?
-
i.e. substance K or neuromedin L, His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2, cleavage site: Gly8-Leu9, not Ser5-Phe6
-
-
?
?
-
Gly-Asn-His-Trp-Ala-Val-Gly-His-Leu-Met-NH2, major cleavage site: His8-Leu9, minor site: Gly7-His8
-
-
?
Neuromedin C + H2O
?
-
Gly-Asn-His-Trp-Ala-Val-Gly-His-Leu-Met-NH2, major cleavage site: His8-Leu9, minor site: Gly7-His8
-
-
?
?
-
i.e. Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys, cleavage site: Phe6-Phe7 within disulfide bridged segment yielding one single product
-
-
?
Somatostatin-14 + H2O
?
-
i.e. Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys, cleavage site: Phe6-Phe7 within disulfide bridged segment yielding one single product
-
-
?
Somatostatin-14 + H2O
?
-
cleavage of Phe-Phe in the intersulfide bridge motif
-
-
?
?
-
major cleavage site: Gly9-Leu10, minor site: Phe7-Phe8
-
-
?
Substance P + H2O
?
-
i.e. Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
-
-
?
Substance P + H2O
?
-
major cleavage site: Gly9-Leu10, minor site: Phe7-Phe8
-
-
?
?
-
-
no cleavage of analogous bonds in [Leu5]-enkephalin, oxytocin, vasopressin
-
-
?
additional information
?
-
-
minimal peptide chain length required: 6 amino acids
-
-
?
additional information
?
-
-
exhibits preference for cleavage on amino-terminal side of Phe, Leu or Ile in Xaa-Leu, Xaa-Phe or Xaa-Ile dipeptide
-
-
?
additional information
?
-
-
no cleavage of analogous bonds in [Leu5]-enkephalin, oxytocin, vasopressin
-
-
?
additional information
?
-
-
substance P-(7-11)-peptide, [Val26]-(21-28)ANF-peptide or [Ala26]-(21-28)ANF-peptide
-
-
?
additional information
?
-
-
hydrolyzes bonds on amino-terminus of hydrophobic amino acids, thermolysin-like cleavage
-
-
?
additional information
?
-
-
might be involved in inactivation of a great number of peptide hormones
-
-
?
additional information
?
-
-
might be involved in inactivation of a great number of peptide hormones
-
-
?
additional information
?
-
-
no cleavage of (Leu5)-enkephalin and (Met5)-enkephalin
-
-
?