3.4.24.48: ruberlysin
This is an abbreviated version!
For detailed information about ruberlysin, go to the full flat file.
Word Map on EC 3.4.24.48
Reaction
Cleavage of His10-/-Leu, Ala14-/-Leu, Tyr16-/-Leu and Gly23-/-Phe bonds in the B chain of insulin; His-/-Pro, Pro-/-Phe, and Trp-/-Ser of angiotensin I; and Gly-/-Phe of Met enkephalin =
Synonyms
Crotalus ruber metalloendopeptidase II, Hemorrhagic toxin II, HT-2, red rattlesnake metalloendopeptidase
ECTree
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Substrates Products on EC 3.4.24.48 - ruberlysin
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
angiotensin I + H2O
?
-
i.e. Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu, cleaved at His-Pro and Pro-Phe
-
-
?
luteinizing hormone releasing hormone + H2O
?
-
cleavage at Gly6-Leu7 and Trp3-Ser4
-
-
?
Luteinizing hormone-releasing hormone + H2O
?
-
cleavage sites: Trp3-Ser4, Gly6-Leu7
-
-
?
Met-enkephalin + H2O
Tyr-Gly-Gly + Phe-Met
-
i.e. Tyr-Gly-Gly-Phe-Met, cleavage site: Gly3-Phe4
-
?
Oxidized insulin B-chain + H2O
Hydrolyzed insulin B-chain
-
cleavage sites: His10-Leu11, Ala14-Leu15, Tyr16-Leu17, Gly23-Phe24
-
?
additional information
?
-
-
exhibits proteolytic, hemorrhatic and myonecrotic activity
-
-
?
Fibrinogen + H2O
?
-
hydrolysis of Aalpha and Bbeta chains, whereas the gamma chain is resistant to hydrolysis
-
-
?
